CN104622912A - Pharmaceutical composition free of periplaneta Americana odor - Google Patents
Pharmaceutical composition free of periplaneta Americana odor Download PDFInfo
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- CN104622912A CN104622912A CN201510096351.1A CN201510096351A CN104622912A CN 104622912 A CN104622912 A CN 104622912A CN 201510096351 A CN201510096351 A CN 201510096351A CN 104622912 A CN104622912 A CN 104622912A
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Abstract
The invention provides a pharmaceutical composition free of a periplaneta Americana odor. The pharmaceutical composition contains periplaneta Americana and milk powder. The composition is free of the periplaneta Americana odor when being orally taken under the premise of ensuring the original curative effect of the periplaneta Americana, and is high in compliance of patients.
Description
Invention field
The present invention relates to medicine, particularly a kind of pharmaceutical composition without periplaneta americana abnormal flavour, belong to medical art.
Background technology
Periplaneta americana belongs to Insecta, Blattaria Blattidae animal, and " Blatta seu periplaneta " is loaded in Shennong's Herbal for its popular name, the beginning of being used as medicine, and is listed in middle product, meaning " taste: salty, cold; Control: the hard cold and heat of Blood stasis, removing mass are poly-, laryngopharynx numbness, endogenous cold loss of fecundity ".Now there are some researches show, the large sickle in America has and has good tissue repair activity to various traumatic surface and digestive tract ulcer; There is boosting, improve sanguimotor activity; There is the activity of anti-bacteria and anti-virus; There is antitumor, strengthen immunologic function activity.
Medicine prepared by the large sickle in prior art America, abnormal flavour is extra heavy, and mouthfeel is very poor, although medicine prepared by the large sickle in America is to various diseases determined curative effect, patient also keeps someone at a respectful distance.Be prepared into the pharmaceutical composition without periplaneta americana abnormal flavour, very necessary.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition without periplaneta americana abnormal flavour.
The object of the present invention is achieved like this:
Without a pharmaceutical composition for periplaneta americana abnormal flavour, it is characterized in that: containing periplaneta americana and milk powder in pharmaceutical composition.
A kind of pharmaceutical composition without periplaneta americana abnormal flavour of the present invention, is characterized in that: periplaneta americana 1 part by weight, more than milk 0.1-5 part.
A kind of pharmaceutical composition without periplaneta americana abnormal flavour of the present invention, is characterized in that: periplaneta americana 1 part by weight, 1 part, milk.
Pharmaceutical composition without periplaneta americana abnormal flavour of the present invention comprises powder, granule, suspensoid and oral liquid containing periplaneta americana; The preparation method of various preparation uses preparation method preparation conventional on galenic pharmacy.
So far the present invention is completed.Pharmaceutical composition of the present invention, under the former medicable prerequisite of maintenance periplaneta americana, the oral abnormal flavour without periplaneta americana, mouthfeel is good, and the compliance of patient is high.
Below by test example, usefulness of the present invention is described.Test example is intended to further illustrate beneficial effect of the present invention below, but not restriction of the present invention.
Test example one, different American cockroach medicament composition mouthfeel compare
1, different American cockroach medicament compositions is prepared
With a collection of periplaneta americana, powder will be prepared into by following material combination respectively.
1) compositions 1: periplaneta americana 50g, glucose 10g; Mixing, pulverizes, is distributed into 10 bags;
2) compositions 2: periplaneta americana 50g, glucose 10g, milk powder 10g; Mixing, pulverizes, is distributed into 10 bags.
Be made up of 10 people and appraise group through discussion, everyone is the warm water for oral use compositions 1 of mixing well and compositions 2 respectively, evaluates the mouthfeel concept such as " very well ", " better ", " can accept ", " poor ", " very poor ".Evaluation result is in table 1
Table 1 different components mouthfeel compares
| Very well | Better | Can accept | Poor | Very poor | |
| Compositions 1 | 0 people | 0 people | 1 people | 4 people | 5 people |
| Compositions 2 | 1 people | 3 people | 6 people | 0 people | 0 people |
Result shows, and compositions of the present invention, oral abnormal flavour is little, and mouthfeel is good.
Test example two, different American cockroach medicament composition mouthfeel and liver protective effect compare
1, with a collection of periplaneta americana, oral liquid will be prepared into by following material combination respectively.
1) compositions 1: periplaneta americana 500g, sucrose 50g;
Method for making: periplaneta americana is ground into coarse powder, adds 10 times of water gagings, and extract 2 times, each 1 hour, merge extractive liquid, 10 DEG C of placements are spent the night, and filters, is evaporated to 500ml, adds sucrose, stir evenly, subpackage 10ml/ bottle.
2) compositions 2: periplaneta americana 500g, sucrose 50g, milk powder 50g.
Method for making: periplaneta americana is ground into coarse powder, adds 10 times of water gagings, and extract 2 times, each 1 hour, merge extractive liquid, 10 DEG C of placements are spent the night, and filters, is evaporated to 500ml, adds sucrose, milk powder, stir evenly, subpackage 10ml/ bottle.
2, different components mouthfeel compares
Be made up of 10 people and appraise group through discussion, everyone is the warm water for oral use compositions 1 of mixing well and compositions 2 respectively, evaluates the mouthfeel concept such as " very well ", " better ", " can accept ", " poor ", " very poor ".Evaluation result is in table 2
Table 2 different components mouthfeel compares
| Very well | Better | Can accept | Poor | Very poor | |
| Compositions 1 | 0 people | 0 people | 2 people | 6 people | 2 people |
| Compositions 2 | 2 people | 5 people | 3 people | 0 people | 0 people |
Result shows, and compositions of the present invention, oral abnormal flavour is little, and mouthfeel is good.
3, different components liver protective effect compares
Adopt CCl
4the impact test of caused Liver Damage in Rats.The healthy SD rat of body weight 180-220g, is divided into compositions 1 group, compositions 2 groups, matched group at random, often organizes 10; Contrast with test group in experiment the 1st, 5 days subcutaneous injection 50%CCl
4vegetable oil suspension 5mL/kg, difference gastric infusion every day 1 time from experiment starts day, 1 time 3g/kg(is equivalent to periplaneta americana), matched group gives equal-volume distilled water, continuous 9 days, and drug withdrawal 24 hours eye sockets get blood, survey serum glutamic pyruvic transminase with reitman-frankel method.The results are shown in Table 3.
The preparation of table 3 distinct methods is to CCl
4the impact of caused hepatic injury rat blood serum glutamate pyruvate transaminase
| Group | Dosage (g/kg) | Glutamate pyruvate transaminase in serum |
| Matched group | 363.4±127.5 | |
| Compositions 1 group | 3 | 183.6±115.7 |
| Compositions 2 groups | 3 | 183.6±115.4 |
Result shows, two kinds of compositionss are to rat CCl
4the protective effect of caused hepatic injury is suitable, illustrates that milk powder and periplaneta americana combine, maintains original curative effect.
Detailed description of the invention
embodiment 1
[prescription] periplaneta americana 300g, milk powder 30g, glucose 70g, saccharin sodium 0.7g, vanillin 0.4g.
[method for making] is pulverized, and fully mixes, and is distributed into every bag of powder containing periplaneta americana 5g.Oral free from extraneous odour.
embodiment 2
[prescription] periplaneta americana 3kg, milk powder 15kg, glucose 0.7kg, saccharin sodium 7g, vanillin 4g.
[method for making] periplaneta americana is ground into coarse powder, adds 10 times of water gagings, extracts 2 times, each 1 hour, merge extractive liquid, 10 DEG C of placements are spent the night, filter, being evaporated to relative density is 1.10 ~ 1.15, drying under reduced pressure, add milk powder, glucose, saccharin sodium, vanillin, mixing, pulverizes, and granulates, drying, obtains free from extraneous odour granule.
embodiment 3
[prescription] periplaneta americana 3kg, milk powder 1.5kg, sucrose 0.5kg, saccharin sodium 7g, sodium benzoate 5g.
[method for making] periplaneta americana is ground into impalpable powder, adds water to 30000ml, adds milk powder, glucose, saccharin sodium, vanillin, stirs, and obtains free from extraneous odour suspensoid.
embodiment 4
[prescription] periplaneta americana 3kg, milk powder 10kg, Ganoderma 3kg, Rhizoma Corydalis 1kg, protein sugar 7g, dextrin 2kg.
[method for making] periplaneta americana, Ganoderma, Rhizoma Corydalis are ground into coarse powder, extracting in water 2 times, add 10 times of water gagings the 1st time, extract 1 hour, add 8 times of water gagings the 2nd time, extract 45 minutes, merge extractive liquid, placement is spent the night, and filters, being evaporated to relative density is 1.10 ~ 1.15, and drying under reduced pressure, adds milk powder, protein sugar, dextrin, mixing, pulverizes, and granulates, drying, obtains without periplaneta americana abnormal flavour granule.Be used for the treatment of hepatocarcinoma and have certain mitigation.
embodiment 5
[prescription] periplaneta americana 3kg, milk powder 4.5kg, Radix Stemonae (processed) 6kg, Rhizoma Bolbostematis 3kg, Radix Scrophulariae 6kg, Radix Adenophorae (Radix Glehniae) 8kg, Semen Lepidii (Semen Descurainiae) 6kg, Semen Coicis 8kg, Semen Armeniacae Amarum 2kg, Fructus Trichosanthis 10kg, Cortex Mori 8kg, process rake leaf 6kg, saccharin sodium 5g.
[method for making] periplaneta americana, Radix Stemonae (processed), Rhizoma Bolbostematis, Radix Scrophulariae, Radix Adenophorae (Radix Glehniae), Semen Lepidii (Semen Descurainiae), Semen Coicis, Semen Armeniacae Amarum, Fructus Trichosanthis, Cortex Mori, process rake leaf extracting in water 2 times, add 12 times of water gagings 1st time, extract 1.5 hours, add 8 times of water gagings 2nd time, extract 1 hour, merge extractive liquid, filter, get filtrate, being concentrated into relative density is 1.10 ~ 1.15(60 DEG C) time, adding ethanol makes alcohol content reach 70%, precipitation, leave standstill 36 hours, Aspirate supernatant, reclaim ethanol, be evaporated to 70L, filter, add milk powder, saccharin sodium stirs, must without periplaneta americana abnormal flavour oral liquid.Be used for the treatment of hepatocarcinoma and have certain mitigation.Be used for the treatment of the pulmonary disease such as bronchitis and have specially good effect.
Claims (3)
1. without a pharmaceutical composition for periplaneta americana abnormal flavour, it is characterized in that: containing periplaneta americana and milk powder in pharmaceutical composition.
2. a kind of pharmaceutical composition without periplaneta americana abnormal flavour according to claim 1, is characterized in that: periplaneta americana 1 part by weight, more than milk 0.1-5 part.
3. according to a kind of pharmaceutical composition without periplaneta americana abnormal flavour of claim 1 or claim 2, it is characterized in that: periplaneta americana 1 part by weight, 1 part, milk.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510096351.1A CN104622912A (en) | 2015-03-05 | 2015-03-05 | Pharmaceutical composition free of periplaneta Americana odor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510096351.1A CN104622912A (en) | 2015-03-05 | 2015-03-05 | Pharmaceutical composition free of periplaneta Americana odor |
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| CN104622912A true CN104622912A (en) | 2015-05-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510096351.1A Pending CN104622912A (en) | 2015-03-05 | 2015-03-05 | Pharmaceutical composition free of periplaneta Americana odor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109646462A (en) * | 2019-01-18 | 2019-04-19 | 昆明赛诺制药股份有限公司 | A method of extracting processing American cockroach |
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367596A (en) * | 2014-11-27 | 2015-02-25 | 济南康众医药科技开发有限公司 | Freeze-dried method for American cockroach |
-
2015
- 2015-03-05 CN CN201510096351.1A patent/CN104622912A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367596A (en) * | 2014-11-27 | 2015-02-25 | 济南康众医药科技开发有限公司 | Freeze-dried method for American cockroach |
Non-Patent Citations (1)
| Title |
|---|
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109646462A (en) * | 2019-01-18 | 2019-04-19 | 昆明赛诺制药股份有限公司 | A method of extracting processing American cockroach |
| CN114848680A (en) * | 2021-02-03 | 2022-08-05 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
| CN114848680B (en) * | 2021-02-03 | 2023-07-25 | 四川好医生攀西药业有限责任公司 | Composition for treating cow mastitis and preparation method thereof |
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Application publication date: 20150520 |