CN105412817A - Rhodiola rosea compound oral liquid and preparation method thereof - Google Patents
Rhodiola rosea compound oral liquid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses rhodiola rosea compound oral liquid. The rhodiola rosea compound oral liquid is prepared from 30-80 parts of rhodiola rosea extract, 2-20 parts of American ginseng extract, 2-10 parts of acanthopanax senticosus extract, 2-10 parts of turmeric extract, 1-5 parts of pseudo-ginseng extract, 1-5 parts of medlar extract, 2-10 parts of astragalus extract, 2-10 parts of radix asparagi extract, 2-10 parts of angelica sinensis extract and 5-20 parts of a flavoring agent. Effective active substance is extracted from rhodiola rosea, American ginseng, acanthopanax senticosus, turmeric, pseudo-ginseng, medlar, astragalus and radix asparagi to be reasonably compatible with freshly squeezed hawthorn juice to form the rhodiola rosea compound oral liquid which is good in taste, clear in ingredient, high in safety, high in reliability, low in sugar content and suitable for more people. The compound oral liquid has the functions of resisting aging and enhancing body immunity, and also has the effects of resisting fatigue, anoxia, radiation and cancer and adjusting the human body function in two ways.
Description
Technical field
The present invention relates to health functional beverage technical field, be specifically related to a kind of compound Rohoodiola oral liquid and preparation method thereof.
Background technology
Rhodiola tibetica (Hook. f. et Thoms.) S. H. Fu, is grown on height above sea level 4, the area of 050 meter to 5,400 meters, and successive dynasties Tibetan medicine is regarded as " lucky three essentials-essence ", has long applicating history, and before more than 2,000 year, the people of Tibet plateau is just used as medicine with it, in order to building body, and the impact of opposing poor environment.Among the people being commonly used to is decocted water or steeps in wine, to banish fatigue or to resist mountain area cold.Simultaneously and diseases prevention is healthy and strong and nourishing lengthens one's life, because of magical effect of its strengthening healthy qi, benefiting qi and nourishing blood, YIN nourishing lung benefiting.Human body oxygen content is not enough, just there will be hypoxic conditions, comprises headache, tired, dyspnea, dizzy etc., serious or paroxysmal, can cause that stupor is even dead.In general, this phenomenon often betides highlands, causes high mountain disease, even some fatal complication.Anoxia is a kind of stressor, and health can be caused to produce a series of stress.The adaptive significances of Radix Rhodiolae, can promote the non-specific low resistance of body to destructive stimulus, strengthens the adaptability of body.Oxygen through reinforcement inner cell spreads, or oxygen uses benefit or antioxidative ability, and Radix Rhodiolae helps the adaptive faculty improving health and stimulate anoxia.
Altitude sickness and acute high altitude sickness, after human body reaches certain height above sea level, the air pressure that the person causes because of height above sea level is low, oxygen content is few, the change of air drying etc., and the natural physiological reaction produced, altitude sickness is all a huge threat to entering plateau person and short-term inhabitation plateau person rapidly; The control of altitude sickness more becomes an outstanding realistic problem and receives much concern.
Along with the quickening of Modern Live rhythm, the increasing pressure that human body will bear is large, this makes human body body immunity decline, and body's immunity to decline be one of important symbol of senescing of human body, be also that many people suffer from that various disease is as not good in: insomnia, spirit, the major reason of hypomnesis, easy catching a cold etc.Now health product are commercially a lot, but curative effect is very micro-and expensive mostly, take and much still lose effect, its main cause be the inside real contained can enhancing human body immunity power and antidotal effective ingredient is single, the less instability of content, and artificial adds some glucide, pigment and essence, cause having sugar-type oral liquid to be not suitable for diabetic to take.Moreover the extraction of existing commercially compound oral liquid raw material adopts decocting method more, and the method is not only for a long time consuming time, and yield is also extremely low, and the impurity phase inside extract is to also more.
Summary of the invention
The object of this invention is to provide a kind of compound Rohoodiola oral liquid.
For reaching above-mentioned purpose, providing a kind of compound Rohoodiola oral liquid in one embodiment of the present of invention, comprising:
Radix Rhodiolae extract 30 parts ~ 80 parts; Radix Panacis Quinquefolii extract 2 parts ~ 20 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 2 parts ~ 10 parts; Rhizoma Curcumae Longae extract 2 parts ~ 10 parts;
Radix Notoginseng extract 1 part ~ 5 parts; Wolfberry fruit extract 1 part ~ 5 parts;
Radix Astragali extract 2 parts ~ 10 parts; Radix Asparagi extract 2 parts ~ 10 parts;
Radix Angelicae Sinensis extract 2 parts ~ 10 parts; Flavoring agent 5 parts ~ 20 parts.
As preferred version of the present invention, compound Rohoodiola oral liquid comprises:
Radix Rhodiolae extract 40 parts ~ 60 parts; Radix Panacis Quinquefolii extract 5 parts ~ 15 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts ~ 8 parts; Rhizoma Curcumae Longae extract 5 parts ~ 10 parts;
Radix Notoginseng extract 2 parts ~ 4 parts; Wolfberry fruit extract 2 parts ~ 4 parts;
Radix Astragali extract 5 parts ~ 10 parts; Radix Asparagi extract 5 parts ~ 10 parts;
Radix Angelicae Sinensis extract 5 parts ~ 10 parts; Flavoring agent 10 parts ~ 15 parts.
As preferred version of the present invention, compound Rohoodiola oral liquid comprises:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts; Radix Et Caulis Acanthopanacis Senticosi extract 5 parts;
Rhizoma Curcumae Longae extract 5 parts; Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts; Radix Angelicae Sinensis extract 5 parts;
Flavoring agent 10 parts.
As preferred version of the present invention, compound Rohoodiola oral liquid comprises:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 10 parts; Radix Et Caulis Acanthopanacis Senticosi extract 6 parts;
Rhizoma Curcumae Longae extract 8 parts; Radix Notoginseng extract 3 parts; Wolfberry fruit extract 4 parts;
Radix Astragali extract 6 parts; Radix Asparagi extract 6 parts; Radix Angelicae Sinensis extract 8 parts;
Flavoring agent 8 parts.
As preferred version of the present invention, flavoring agent is Fructus Crataegi juice.
Another object of the present invention is to provide a kind of preparation method of compound Rohoodiola oral liquid, comprising:
By the Radix Rhodiolae extract of formula ratio; Radix Panacis Quinquefolii extract; Radix Et Caulis Acanthopanacis Senticosi extract; Rhizoma Curcumae Longae extract; Radix Notoginseng extract; Wolfberry fruit extract; Radix Astragali extract; Radix Asparagi extract; Add flavoring agent mixing after Radix Angelicae Sinensis extract mixing, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
In another prioritization scheme of the present invention, in oral liquid, the content of each component is:
Radix Rhodiolae extract 30g/L ~ 80g/L; Radix Panacis Quinquefolii extract 2g/L ~ 20g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 2g/L ~ 10g/L; Rhizoma Curcumae Longae extract 2g/L ~ 10g/L;
Radix Notoginseng extract 1g/L ~ 5g/L; Wolfberry fruit extract 1g/L ~ 5g/L;
Radix Astragali extract 2g/L ~ 10g/L; Radix Asparagi extract 2g/L ~ 10g/L;
Radix Angelicae Sinensis extract 2g/L ~ 10g/L; Flavoring agent 5g/L ~ 20g/L.
In another prioritization scheme of the present invention, the preparation method of Radix Rhodiolae extract is: Radix Rhodiolae pulverizing medicinal materials become fine powder to load filter bag, add alcoholic solution and extract, keep pressure 200MPa ~ 300MPa; Drying after filtrate centrifugal segregation supernatant is obtained Radix Rhodiolae extract;
The preparation method of Radix Notoginseng extract and Radix Panacis Quinquefolii extract: add alcoholic solution after Radix Notoginseng or Radix Panacis Quinquefolii being pulverized, and extract several times under ul-trasonic irradiation, merge extractive liquid, drying obtains Radix Notoginseng extract or Radix Panacis Quinquefolii extract.
In another prioritization scheme of the present invention, the preparation method of Radix Et Caulis Acanthopanacis Senticosi extract, Radix Astragali extract, Radix Asparagi extract and wolfberry fruit extract: raw medicinal material is ground into fine powder, add the backflow of alcoholic solution post-heating, merge extractive liquid, sucking filtration is concentrated forms extractum, add ethanol sedimentation again, get filtrate and be dried to fine powder and be extract;
The preparation method of Rhizoma Curcumae Longae extract: raw medicinal material Rhizoma Curcumae Longae is pulverized, add ethanol and infiltrate, add soak with ethanol, carry out percolation after immersion after infiltration, collect liquid of filtering, concentrating under reduced pressure becomes paste, then is dried to fine powder, obtains Rhizoma Curcumae Longae extract;
The preparation method of Radix Angelicae Sinensis extract: add HAc-NaAc buffer solution and cellulase, adjust ph 6.0 after being pulverized by raw medicinal material Radix Angelicae Sinensis, extract 1h ~ 3h, cooled and filtered at 50 DEG C ~ 60 DEG C, filtrate drying is obtained Radix Angelicae Sinensis extract.
In another prioritization scheme of the present invention, flavoring agent is Fructus Crataegi juice, and the preparation method of Fructus Crataegi juice is: Fructus Crataegi is cleaned enucleation, and squeezing taking juice, filter and remove residue, obtains Fructus Crataegi juice.
In sum, the present invention has the following advantages:
The present invention extracts effective active matter inside Radix Rhodiolae, Radix Panacis Quinquefolii, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Curcumae Longae, Radix Notoginseng, Fructus Lycii, the Radix Astragali and Radix Asparagi 8 kinds of Chinese crude drugs, with fresh squeezing Fructus Crataegi juice reasonable compatibility, form good mouthfeel, composition is determined, safety is high, reliability is strong, and sugar content is low, is applicable to drunk by people widely.Compound oral liquid of the present invention not only has the function of defying age, enhancing human body immunity, is aided with resisting fatigue, effect of anti-hypoxia, radioprotective, anticancer, two-ways regulation bodily fuctions, but also can reduce blood sugar for human body, and applicable diabetics is taken.
Detailed description of the invention
Embodiment 1
Prescription:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts; Rhizoma Curcumae Longae extract 5 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts;
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
Preparation method:
Add flavoring agent mixing after being mixed by the raw material of formula ratio, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 50g/L; Radix Panacis Quinquefolii extract 8g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L; Rhizoma Curcumae Longae extract 5g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 2g/L;
Radix Astragali extract 5g/L; Radix Asparagi extract 5g/L;
Radix Angelicae Sinensis extract 5g/L; Flavoring agent 10g/L.
Embodiment 2
Prescription:
Radix Rhodiolae extract 40 parts; Radix Panacis Quinquefolii extract 6 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts; Rhizoma Curcumae Longae extract 7 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 3 parts;
Radix Astragali extract 4 parts; Radix Asparagi extract 8 parts;
Radix Angelicae Sinensis extract 6 parts; Fructus Crataegi juice 16 parts.
Add flavoring agent mixing after being mixed by the raw material of formula ratio, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 40g/L; Radix Panacis Quinquefolii extract 6g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L; Rhizoma Curcumae Longae extract 7g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 3g/L;
Radix Astragali extract 4g/L; Radix Asparagi extract 8g/L;
Radix Angelicae Sinensis extract 6g/L; Flavoring agent 16g/L.
Embodiment 3
Prescription:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 10 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 6 parts; Rhizoma Curcumae Longae extract 8 parts;
Radix Notoginseng extract 3 parts; Wolfberry fruit extract 4 parts;
Radix Astragali extract 6 parts; Radix Asparagi extract 6 parts;
Radix Angelicae Sinensis extract 8 parts; Fructus Crataegi juice 8 parts.
Embodiment 4
Prescription:
Radix Rhodiolae extract 60 parts; Radix Panacis Quinquefolii extract 8 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 4 parts; Rhizoma Curcumae Longae extract 7 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 5 parts;
Radix Astragali extract 4 parts; Radix Asparagi extract 7 parts;
Radix Angelicae Sinensis extract 8 parts; Fructus Crataegi juice 9 parts.
Embodiment 5
Prescription:
Radix Rhodiolae extract 50 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts; Rhizoma Curcumae Longae extract 5 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts;
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
Add flavoring agent mixing after being mixed by the raw material of formula ratio, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 50g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L; Rhizoma Curcumae Longae extract 5g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 2g/L;
Radix Astragali extract 5g/L; Radix Asparagi extract 5g/L;
Radix Angelicae Sinensis extract 5g/L; Flavoring agent 10g/L.
Embodiment 6
Prescription:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts;
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
Add flavoring agent mixing after being mixed by the raw material of formula ratio, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 50g/L; Radix Panacis Quinquefolii extract 8g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 2g/L;
Radix Astragali extract 5g/L; Radix Asparagi extract 5g/L;
Radix Angelicae Sinensis extract 5g/L; Flavoring agent 10g/L.
Embodiment 7
Prescription:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts; Cupreol 5 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts;
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
By the Radix Rhodiolae extract of formula ratio; Radix Panacis Quinquefolii extract; Radix Et Caulis Acanthopanacis Senticosi extract; Rhizoma Curcumae Longae extract; Radix Notoginseng extract; Wolfberry fruit extract; Radix Astragali extract; Radix Asparagi extract; Add flavoring agent mixing after Radix Angelicae Sinensis extract mixing, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 50g/L; Radix Panacis Quinquefolii extract 8g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L; Cupreol 5g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 2g/L;
Radix Astragali extract 5g/L; Radix Asparagi extract 5g/L;
Radix Angelicae Sinensis extract 5g/L; Flavoring agent 10g/L.
Embodiment 8
Prescription:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts; Succinic acid 2 parts; Butenoic acid 3 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts;
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
Add flavoring agent mixing after being mixed by the raw material of formula ratio, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 50g/L; Radix Panacis Quinquefolii extract 8g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L; Succinic acid 2g/L, butenoic acid 3g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 2g/L;
Radix Astragali extract 5g/L; Radix Asparagi extract 5g/L;
Radix Angelicae Sinensis extract 5g/L; Flavoring agent 10g/L.
Embodiment 9
Prescription:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts; Curcumin 5 parts;
Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts;
Radix Angelicae Sinensis extract 5 parts; Fructus Crataegi juice 10 parts.
Preparation method:
Add flavoring agent mixing after being mixed by the raw material of formula ratio, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
After fill, in finished product oral liquid, the content of each component is:
Radix Rhodiolae extract 50g/L; Radix Panacis Quinquefolii extract 8g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 5g/L; Curcumin 5g/L;
Radix Notoginseng extract 2g/L; Wolfberry fruit extract 2g/L;
Radix Astragali extract 5g/L; Radix Asparagi extract 5g/L;
Radix Angelicae Sinensis extract 5g/L; Flavoring agent 10g/L.
In order to show curative effect of medication of the present invention, carry out following pharmacodynamic experiment:
1, anti-hypoxia, resisting fatigue: the binding ability that can improve rapidly hemoglobin and oxygen, improves blood oxygen saturation, reduces body oxygen consumption, increases motor capacity, recovers Fatique after Sports.
Experiment one: get white mice 50, male and female half and half, about body weight 20g.After training point two groups (experimental group and normal saline group equal 0.45ml/kg body weight lumbar injection), arbitrary Rhodiola root oral liquid in the experimental group embodiment of the present invention 1 ~ 9, matched group normal saline, observe white mice swimming with a load attached to the body experiment, result shows significant difference.
Experiment two: get white mice 50, male and female half and half, about body weight 20g.After training point two groups (experimental group and normal saline group equal 0.45ml/kg body weight lumbar injection), experimental group Rhodiola root oral liquid, matched group normal saline, the record pole-climbing time, result shows significant difference.
Experiment three: 1200 diabeticss are divided into 6 groups, often organize 200 people; Take the oral liquid of embodiment 1, embodiment 5 ~ embodiment 9 respectively, take 3 every day, each 20ml.The front blood sugar content with taking rear 30min is taken in inspection, inspection can learn that the blood sugar decreasing effect of embodiment 1 is best, the effect of embodiment 6 and embodiment 9 is poor, comparatively embodiment 1 is slightly almost for the blood pressure lowering effect of embodiment 5, embodiment 7 and embodiment 8, but compare effective than embodiment 6 with embodiment 9, still there is significant difference; Illustrate that cupreol in Radix Panacis Quinquefolii, Rhizoma Curcumae Longae extract and succinic acid, butenoic acid have certain assosting effect to blood sugar lowering.
Through the checking of inventor, cupreol and succinic acid, butenoic acid can not reduce the blood sugar content in Mice Body after giving mouse feeding separately, have hypoglycemic effect when Radix Asparagi extract of the present invention is used alone.By Radix Asparagi extract respectively compatibility independent with Radix Panacis Quinquefolii extract, cupreol, succinic acid and butenoic acid time, four can in the to a certain degree lower blood sugar lowering effect improving Radix Asparagi extract, and then make oral liquid of the present invention have better effect of lowering blood sugar.
The preparation method of raw material of the present invention
Radix Rhodiolae: after Radix Rhodiolae pulverizing medicinal materials being crossed No. 2 sieves, precision takes Radix Rhodiolae fine medicinal material powder end 50g, is placed in sealing bag, add 20 times of 70% ethanol extraction, drain bubble, and seal, pressure is increased to 250MPa, after pressurize 2.5min, fast pressure relief, obtains extracting solution, at a high speed (10000r/min) centrifugal 10min, supernatant is gone to be spray dried to fine powder, for subsequent use.
Radix Notoginseng, Radix Panacis Quinquefolii are extracted: after American ginseng medicine being pulverized No. 2 sieves, precision takes powder 8g as in 50ml conical flask, add 70% ethanol of 10 times of volumes, under 70 DEG C of conditions, conical flask is placed in ultrasonic cleaner, extract 3 times, merge the extracting solution of 3 times, extracting solution is spray dried to fine powder, for subsequent use
The extraction of Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Radix Asparagi and Fructus Lycii: get Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Radix Asparagi and Chinese wolfberry fruit dry medical material and break into powder, take Manyprickle Acanthopanax Root 8g respectively, Radix Astragali powder 5g, Radix Asparagi powder 5g, Fructus Lycii powder 2g, is placed in extraction pot, 80 DEG C of reflux 3 times, merge extractive liquid, sucking filtration, concentrated, when to be concentrated into density be the extractum of 1.12-1.15, add ethanol, ethanol content is made to reach 80%, filter after sedimentation 36h, filtrate is spray dried to fine powder, for subsequent use.
Rhizoma Curcumae Longae is extracted: by Rhizoma Curcumae Longae pulverizing medicinal materials powdered, cross 30 mesh sieves, precision takes 5g Turmeric Root, mixes thoroughly with 1 times amount 95% ethanol, infiltrate 1 hour, use 65% ethanol (dipped powder) to make solvent again, flood and carry out percolation after 24 hours, collect liquid of filtering, reclaim ethanol, being evaporated to relative density is 1.10 ~ 1.15(50 DEG C) extractum, be spray dried to fine powder, for subsequent use.
Radix Angelicae Sinensis extracts: really take 5g Radix Angelicae Sinensis, be placed in beaker, add HAc-NaAc buffer solution, add cellulose enzyme amount 1.0%, at pH value 6.0,55 DEG C, extract 90min, and cooling, is transferred to 250mL volumetric flask, standardize solution, and filter, filtrate is spray dried to fine powder, for subsequent use.
Fructus Crataegi juice squeezes: take Fructus Crataegi 10g, cleans enucleation, with totally binding up with gauze squeeze juice, filtering, removing slag, get Fructus Crataegi juice for subsequent use.
The present invention adopts water to carry out the separating-purifying of rhodioside as solvent, and carry out the synthesis preparation of Rhodiola root oral liquid on this basis, obtained Rhodiola root oral liquid has medicinal ingredient and absorbs fast, be convenient for carrying, conveniently take, rapid-action, effectively can suppress the complication such as the Nausea and vomiting in altitude sickness institute place, and anti-hypoxia, improve memory, regain one's strength and spirit etc. invention play good action.
Claims (10)
1. a compound Rohoodiola oral liquid, comprising:
Radix Rhodiolae extract 30 parts ~ 80 parts; Radix Panacis Quinquefolii extract 2 parts ~ 20 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 2 parts ~ 10 parts; Rhizoma Curcumae Longae extract 2 parts ~ 10 parts;
Radix Notoginseng extract 1 part ~ 5 parts; Wolfberry fruit extract 1 part ~ 5 parts;
Radix Astragali extract 2 parts ~ 10 parts; Radix Asparagi extract 2 parts ~ 10 parts;
Radix Angelicae Sinensis extract 2 parts ~ 10 parts; Flavoring agent 5 parts ~ 20 parts.
2. compound Rohoodiola oral liquid as claimed in claim 1, comprising:
Radix Rhodiolae extract 40 parts ~ 60 parts; Radix Panacis Quinquefolii extract 5 parts ~ 15 parts;
Radix Et Caulis Acanthopanacis Senticosi extract 5 parts ~ 8 parts; Rhizoma Curcumae Longae extract 5 parts ~ 10 parts;
Radix Notoginseng extract 2 parts ~ 4 parts; Wolfberry fruit extract 2 parts ~ 4 parts;
Radix Astragali extract 5 parts ~ 10 parts; Radix Asparagi extract 5 parts ~ 10 parts;
Radix Angelicae Sinensis extract 5 parts ~ 10 parts; Flavoring agent 10 parts ~ 15 parts.
3. compound Rohoodiola oral liquid as claimed in claim 1, is characterized in that, comprising:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 8 parts; Radix Et Caulis Acanthopanacis Senticosi extract 5 parts;
Rhizoma Curcumae Longae extract 5 parts; Radix Notoginseng extract 2 parts; Wolfberry fruit extract 2 parts;
Radix Astragali extract 5 parts; Radix Asparagi extract 5 parts; Radix Angelicae Sinensis extract 5 parts;
Flavoring agent 10 parts.
4. compound Rohoodiola oral liquid as claimed in claim 1, is characterized in that, comprising:
Radix Rhodiolae extract 50 parts; Radix Panacis Quinquefolii extract 10 parts; Radix Et Caulis Acanthopanacis Senticosi extract 6 parts;
Rhizoma Curcumae Longae extract 8 parts; Radix Notoginseng extract 3 parts; Wolfberry fruit extract 4 parts;
Radix Astragali extract 6 parts; Radix Asparagi extract 6 parts; Radix Angelicae Sinensis extract 8 parts;
Flavoring agent 8 parts.
5. compound Rohoodiola oral liquid as claimed in claim 1, is characterized in that: described flavoring agent is Fructus Crataegi juice.
6. prepare the method for arbitrary described compound Rohoodiola oral liquid in claim 1 ~ 6, comprising:
By the Radix Rhodiolae extract of formula ratio; Radix Panacis Quinquefolii extract; Radix Et Caulis Acanthopanacis Senticosi extract; Rhizoma Curcumae Longae extract; Radix Notoginseng extract; Wolfberry fruit extract; Radix Astragali extract; Radix Asparagi extract; Add flavoring agent mixing after Radix Angelicae Sinensis extract mixing, finally add after pure water carries out homogenizing process and filter, aseptically fill after filtrate sterilizing.
7. preparation method as claimed in claim 6, it is characterized in that, in described oral liquid, the content of each component is:
Radix Rhodiolae extract 30g/L ~ 80g/L; Radix Panacis Quinquefolii extract 2g/L ~ 20g/L;
Radix Et Caulis Acanthopanacis Senticosi extract 2g/L ~ 10g/L; Rhizoma Curcumae Longae extract 2g/L ~ 10g/L;
Radix Notoginseng extract 1g/L ~ 5g/L; Wolfberry fruit extract 1g/L ~ 5g/L;
Radix Astragali extract 2g/L ~ 10g/L; Radix Asparagi extract 2g/L ~ 10g/L;
Radix Angelicae Sinensis extract 2g/L ~ 10g/L; Flavoring agent 5g/L ~ 20g/L.
8. preparation method as claimed in claim 6, is characterized in that:
The preparation method of Radix Rhodiolae extract is: Radix Rhodiolae pulverizing medicinal materials become fine powder to load filter bag, add alcoholic solution and extract, keep pressure 200MPa ~ 300MPa; Drying after filtrate centrifugal segregation supernatant is obtained Radix Rhodiolae extract;
The preparation method of Radix Notoginseng extract and Radix Panacis Quinquefolii extract: add alcoholic solution after Radix Notoginseng or Radix Panacis Quinquefolii being pulverized, and extract several times under ul-trasonic irradiation, merge extractive liquid, drying obtains Radix Notoginseng extract or Radix Panacis Quinquefolii extract.
9. preparation method as claimed in claim 6, is characterized in that:
The preparation method of Radix Et Caulis Acanthopanacis Senticosi extract, Radix Astragali extract, Radix Asparagi extract and wolfberry fruit extract: raw medicinal material is ground into fine powder, add the backflow of alcoholic solution post-heating, merge extractive liquid, sucking filtration is concentrated forms extractum, add ethanol sedimentation again, get filtrate and be dried to fine powder and be extract;
The preparation method of Rhizoma Curcumae Longae extract: raw medicinal material Rhizoma Curcumae Longae is pulverized, add ethanol and infiltrate, add soak with ethanol, carry out percolation after immersion after infiltration, collect liquid of filtering, concentrating under reduced pressure becomes paste, then is dried to fine powder, obtains Rhizoma Curcumae Longae extract;
The preparation method of Radix Angelicae Sinensis extract: add HAc-NaAc buffer solution and cellulase, adjust ph 6.0 after being pulverized by raw medicinal material Radix Angelicae Sinensis, extract 1h ~ 3h, cooled and filtered at 50 DEG C ~ 60 DEG C, filtrate drying is obtained Radix Angelicae Sinensis extract.
10. preparation method as claimed in claim 6, is characterized in that:
Described flavoring agent is Fructus Crataegi juice, and the preparation method of Fructus Crataegi juice is: Fructus Crataegi is cleaned enucleation, and squeezing taking juice, filter and remove residue, obtains Fructus Crataegi juice.
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| CN105832860A (en) * | 2016-05-04 | 2016-08-10 | 昆明理工大学 | Fulvic acid oral liquid capable of resisting altitude stress and preparation method thereof |
| CN105998140A (en) * | 2016-06-15 | 2016-10-12 | 雷娟 | Herba rhodiola buccal tablets |
| CN108743879A (en) * | 2018-08-20 | 2018-11-06 | 河北东医生物科技有限公司 | Antithrombotic youth element application in TCM |
| CN115120580A (en) * | 2022-07-14 | 2022-09-30 | 中国人民解放军军事科学院军事医学研究院 | Application of curcumin in preparation of hemoglobin oxygen supply efficiency regulator |
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