CN106266561A - A kind of Sugarless type liver-benefiting eye-brightening oral liquid and preparation method thereof - Google Patents
A kind of Sugarless type liver-benefiting eye-brightening oral liquid and preparation method thereof Download PDFInfo
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- CN106266561A CN106266561A CN201610765041.9A CN201610765041A CN106266561A CN 106266561 A CN106266561 A CN 106266561A CN 201610765041 A CN201610765041 A CN 201610765041A CN 106266561 A CN106266561 A CN 106266561A
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- parts
- radix
- oral liquid
- brightening
- sugarless type
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- 239000007788 liquid Substances 0.000 title claims abstract description 22
- 238000005282 brightening Methods 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims description 10
- 241000628997 Flos Species 0.000 claims abstract description 12
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 12
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 241000242759 Actiniaria Species 0.000 claims abstract description 11
- 235000019640 taste Nutrition 0.000 claims abstract description 11
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 8
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 7
- 238000004821 distillation Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 239000000341 volatile oil Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 241001302750 Psychotria rubra Species 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 abstract description 4
- 230000000873 masking effect Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 238000001647 drug administration Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 7
- 238000003556 assay Methods 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
A kind of Sugarless type liver-benefiting eye-brightening oral liquid, including the component of following weight portion: Radix Rehmanniae Preparata 110 ~ 120 parts, Radix Angelicae Sinensis 95 ~ 105 parts, Fructus Lycii 145 ~ 155 parts, the Radix Paeoniae Alba 95 ~ 105 parts, Radix Ophiopogonis 118 ~ 122 parts, Flos Chrysanthemi 98 ~ 101 parts, Rhizoma Anemones Altaicae 28 ~ 31 parts, Rhizoma Polygonati Odorati 148 ~ 152 parts, Rhizoma Chuanxiong 48 ~ 53 parts, Pericarpium Citri Reticulatae 98 ~ 103 parts, Semen Cassiae 97 ~ 101 parts, Radix Bupleuri 14 ~ 16 parts.In this product every milliliter, the content of peoniflorin is high: the content being above the peoniflorin that National Drug Administration specifies must not be less than the standard of 0.30mg/mL, the Mel taste masking of former technique is instead of with steviosin, it is converted into Sugarless type product, not only relieve and need the use limiting sugar and the diabetics of Energy intaking and obese people to limit, also maintain good mouthfeel simultaneously.
Description
Technical field
The present invention relates to medicine field, be specifically related to a kind of Sugarless type liver-benefiting eye-brightening oral liquid and preparation method thereof.
Background technology
Liver-benefiting eye-brightening oral liquid has the effect of liver and kidney tonifying, it is adaptable to deficiency of the liver and kindey disease sees soreness of the waist and knees, dizzy mesh
The diseases such as paste, hypomnesis, fatigue and asthenia.
In the production technology of existing liver-benefiting eye-brightening oral liquid, adding substantial amounts of Mel taste masking, high sugar high energy, for sugar
Urine patient and obese people etc. need to limit sugar and the absorption of energy, should not take, and are suitable for crowd's scope and are restricted, and
People's medication idea increasingly trends towards the use of Sugarless type product, so prior art needs to be converted to Sugarless type product.
Summary of the invention
It is an object of the invention to be a kind of sugar-free is provided and the oral liquid of Sugarless type liver-benefiting eye-brightening effect can be played.
To achieve these goals, this invention takes following technical scheme:
A kind of Sugarless type liver-benefiting eye-brightening oral liquid, including the component of following weight portion: Radix Rehmanniae Preparata 110 ~ 120 parts, Radix Angelicae Sinensis 95 ~ 105
Part, Fructus Lycii 145 ~ 155 parts, the Radix Paeoniae Alba 95 ~ 105 parts, Radix Ophiopogonis 118 ~ 122 parts, Flos Chrysanthemi 98 ~ 101 parts, Rhizoma Anemones Altaicae 28 ~ 31 parts, jade
148 ~ 152 parts of bamboo, Rhizoma Chuanxiong 48 ~ 53 parts, Pericarpium Citri Reticulatae 98 ~ 103 parts, Semen Cassiae 97 ~ 101 parts, Radix Bupleuri 14 ~ 16 parts.
Further, above-mentioned Sugarless type liver-benefiting eye-brightening oral liquid, including the component of following weight portion: steviosin 0.1 part with
And ethyl hydroxybenzoate 0.3 part.
As the preferred technical scheme of one, a kind of Sugarless type liver-benefiting eye-brightening oral liquid, including the component of following weight portion:
Radix Rehmanniae Preparata 100 parts, Radix Angelicae Sinensis 100 parts, Fructus Lycii 150 parts, the Radix Paeoniae Alba 100 parts, Radix Ophiopogonis 120 parts, Flos Chrysanthemi 100 parts, Rhizoma Anemones Altaicae 30 parts,
Rhizoma Polygonati Odorati 150 parts, Rhizoma Chuanxiong 50 parts, Pericarpium Citri Reticulatae 100 parts, Semen Cassiae 100 parts, Radix Bupleuri 15 parts.
A kind of preparation method of Sugarless type liver-benefiting eye-brightening oral liquid, step is as follows:
S1, by after cataclasm to Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Chrysanthemi, Radix Bupleuri, Rhizoma Anemones Altaicae and Pericarpium Citri Reticulatae, mix according to recipe quantity, and the distillation that adds water
Extract volatile oil, distillation the another device of rear solution collect, wherein, the addition of water with when the mass ratio of normalized volume be 40:1；
S2, weigh the Radix Rehmanniae Preparata of recipe quantity, Fructus Lycii, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati Odorati and Semen Cassiae and mix with the medicinal residues obtained in S1
Obtaining mixture, and add mixture quality 12 times amount soak by water twice, 1.2 ~ 1.8 hours for the first time, 0.8 ~ 1.2 is little for the second time
Time, collecting decoction, it is filtrated to get filtrate；
S3, filtrate is merged with the aqueous solution obtained in S1, be concentrated into the clear paste that relative density is 1.15, add ethanol to alcohol content
Being 60%, stand 48 hours, take supernatant decompression recycling ethanol to without alcohol taste, add water and stir evenly, stand, filtration, filtrate is concentrated into phase
It is the clear paste of 1.07 (60 DEG C) to density, adds and steviosin 0.1 part, ethyl hydroxybenzoate 0.3 part and S1 obtain volatile oil, adjust pH
Value to about 6.0, add water to total amount be in S1 add the water yield 1/4, stir evenly, filter, to obtain final product.
Further, ethyl hydroxybenzoate is used after being dissolved by ethanol, the quality volume of ethyl hydroxybenzoate 0.3 part and ethanol
Ratio is 3:20～50g/ml.
Further, by adding the regulation that mass concentration is 10% sodium hydroxide in S3.
This kind of method is used to have a following advantage:
1, the content of peoniflorin is high in every milliliter: the content being above the peoniflorin that National Drug Administration specifies must not be low
Standard in 0 .30mg/mL.
2, instead of the Mel taste masking of former technique with steviosin, be converted into Sugarless type product, not only relieve and need to limit
The use of sugar and the diabetics of Energy intaking and obese people limits, and also maintains good mouthfeel simultaneously.
Detailed description of the invention
The present invention is explained further below in conjunction with embodiment, but the present invention is not done any type of limit by embodiment
Fixed.
Embodiment 1:
Sugarless type liver-benefiting eye-brightening oral liquid, including following component: Radix Rehmanniae Preparata 100g, Radix Angelicae Sinensis 100g, Fructus Lycii 150g, the Radix Paeoniae Alba
100g, Radix Ophiopogonis 120g, Flos Chrysanthemi 100g, Rhizoma Anemones Altaicae 30g, Rhizoma Polygonati Odorati 150g, Rhizoma Chuanxiong 50g, Pericarpium Citri Reticulatae 100g, Semen Cassiae 100g, bavin
15g recklessly.
Above 12 tastes, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Chrysanthemi, Radix Bupleuri, Rhizoma Anemones Altaicae, Pericarpium Citri Reticulatae give as one thinks fit cataclasm after, add 4L water distillation and extraction
Volatile oil, extracts 4～5 hours, and the distillation another device of rear solution is collected.Medicinal residues and Radix Rehmanniae Preparata, Fructus Lycii, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati Odorati with
And Semen Cassiae adds 12 times amount soak by water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, to filter, filtrate is with above-mentioned
Aqueous solution merges, and is concentrated into the clear paste that relative density is 1.15, and adding ethanol to alcohol content is 60%, stands 48 hours, takes supernatant
Decompression recycling ethanol, to without alcohol taste, adds water and stirs evenly, and stands, and filters, and filtrate is concentrated into the clear paste that relative density is 1.07 (60 DEG C),
Add steviosin 0.1g, ethyl hydroxybenzoate 0.3g (dissolving with a small amount of ethanol (2～5ml)) and above-mentioned volatile oil, add 10% hydroxide
Sodium pH value is to about 6.0, and adding water to total amount is 1000ml, stirs evenly, and filters, to obtain final product.
Assay: this product is in good taste, and sugar-free, every 1ml C Han peoniflorin23H28O11 0.75mg, light brown, clear and bright, nothing
Visible foreign, good stability, within 10-25 days, room temperature is placed, and without swollen bottle, refrigerator cold-storage, without precipitation.
Embodiment 2
A kind of Sugarless type liver-benefiting eye-brightening oral liquid, including following component: Radix Rehmanniae Preparata 110g, Radix Angelicae Sinensis 95g, Fructus Lycii 145g, the Radix Paeoniae Alba
95g, 118g Radix Ophiopogonis, Flos Chrysanthemi 98g, Rhizoma Anemones Altaicae 31g, Rhizoma Polygonati Odorati 152 g, Rhizoma Chuanxiong 53 g, Pericarpium Citri Reticulatae 103 g, Semen Cassiae 101 g, bavin
16 g recklessly.
Preparation method is with reference to embodiment 1.
Assay: this product is in good taste, and sugar-free, every 1ml C Han peoniflorin23H28O110.55mg.Light brown, clear and bright, nothing
Visible foreign, good stability, within 10-25 days, room temperature is placed, and without swollen bottle, refrigerator cold-storage, without precipitation.
Embodiment 3
A kind of Sugarless type liver-benefiting eye-brightening oral liquid, including the component of following weight portion: Radix Rehmanniae Preparata 120g, Radix Angelicae Sinensis 105g, Fructus Lycii
155 g, Radix Paeoniae Alba 105g, 122g Radix Ophiopogonis, Flos Chrysanthemi 101g, Rhizoma Anemones Altaicae 28g, Rhizoma Polygonati Odorati 148g, Rhizoma Chuanxiong 48g, Pericarpium Citri Reticulatae 98g, Semen Cassiae
97g, Radix Bupleuri 14g.
Preparation method is with reference to embodiment 1.
Assay: this product is in good taste, and sugar-free, every 1ml C Han peoniflorin23H28O110.6mg.Light brown, clear and bright, can not
Seeing impurity, good stability, within 10-25 days, room temperature is placed, and without swollen bottle, refrigerator cold-storage, without precipitation.
Embodiment 4
A kind of Sugarless type liver-benefiting eye-brightening oral liquid, including the component of following weight portion: Radix Rehmanniae Preparata 116g, Radix Angelicae Sinensis 98g, Fructus Lycii
152g, Radix Paeoniae Alba 103g, 121g Radix Ophiopogonis, Flos Chrysanthemi 99g, Rhizoma Anemones Altaicae 29g, Rhizoma Polygonati Odorati 151g, Rhizoma Chuanxiong 51g, Pericarpium Citri Reticulatae 102g, Semen Cassiae
99g, Radix Bupleuri 15g.
Preparation method is with reference to embodiment 1.
Assay: this product is in good taste, and sugar-free, every 1ml C Han peoniflorin23H28O11 0.58mg.Light brown, clear and bright, nothing
Visible foreign, good stability, within 10-25 days, room temperature is placed, and without swollen bottle, refrigerator cold-storage, without precipitation.
Embodiment described above is only to be described the preferred embodiment of the present invention, the not model to the present invention
Enclose and be defined, on the premise of designing spirit without departing from the present invention, this area ordinary skill technical staff skill to the present invention
Various deformation that art scheme is made and improvement, within all should falling into the protection domain that claims of the present invention determines.
Claims (6)
1. a Sugarless type liver-benefiting eye-brightening oral liquid, it is characterised in that include the component of following weight portion: Radix Rehmanniae Preparata 110 ~ 120
Part, Radix Angelicae Sinensis 95 ~ 105 parts, Fructus Lycii 145 ~ 155 parts, the Radix Paeoniae Alba 95 ~ 105 parts, Radix Ophiopogonis 118 ~ 122 parts, Flos Chrysanthemi 98 ~ 101 parts, Psychotria rubra (Lour.) Poir.
Rhizoma Acori Graminei 28 ~ 31 parts, Rhizoma Polygonati Odorati 148 ~ 152 parts, Rhizoma Chuanxiong 48 ~ 53 parts, Pericarpium Citri Reticulatae 98 ~ 103 parts, Semen Cassiae 97 ~ 101 parts, Radix Bupleuri 14 ~ 16
Part.
A kind of Sugarless type liver-benefiting eye-brightening oral liquid the most according to claim 1, it is characterised in that above-mentioned Sugarless type the liver benefiting is bright
Mesh oral liquid, including the component of following weight portion: steviosin 0.1 part and ethyl hydroxybenzoate 0.3 part.
A kind of Sugarless type liver-benefiting eye-brightening oral liquid the most according to claim 2, it is characterised in that include following weight portion
Component: Radix Rehmanniae Preparata 100 parts, Radix Angelicae Sinensis 100 parts, Fructus Lycii 150 parts, the Radix Paeoniae Alba 100 parts, Radix Ophiopogonis 120 parts, Flos Chrysanthemi 100 parts, Rhizoma Anemones Altaicae
30 parts, Rhizoma Polygonati Odorati 150 parts, Rhizoma Chuanxiong 50 parts, Pericarpium Citri Reticulatae 100 parts, Semen Cassiae 100 parts, Radix Bupleuri 15 parts.
4. the preparation method of a Sugarless type liver-benefiting eye-brightening oral liquid, it is characterised in that step is as follows:
S1, by after cataclasm to Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Chrysanthemi, Radix Bupleuri, Rhizoma Anemones Altaicae and Pericarpium Citri Reticulatae, mix according to recipe quantity, and the distillation that adds water
Extract volatile oil, distillation the another device of rear solution collect, wherein, the addition of water with when the mass ratio of normalized volume be 40:1；
S2, weigh the Radix Rehmanniae Preparata of recipe quantity, Fructus Lycii, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Polygonati Odorati and Semen Cassiae and mix with the medicinal residues obtained in S1
Obtaining mixture, and add mixture quality 12 times amount soak by water twice, 1.2 ~ 1.8 hours for the first time, 0.8 ~ 1.2 is little for the second time
Time, collecting decoction, it is filtrated to get filtrate；
S3, filtrate is merged with the aqueous solution obtained in S1, be concentrated into the clear paste that relative density is 1.15, add ethanol to alcohol content
Being 60%, stand 48 hours, take supernatant decompression recycling ethanol to without alcohol taste, add water and stir evenly, stand, filtration, filtrate is concentrated into phase
It is the clear paste of 1.07 (60 DEG C) to density, adds and steviosin 0.1 part, ethyl hydroxybenzoate 0.3 part and S1 obtain volatile oil, adjust pH
Value to about 6.0, add water to total amount be in S1 add the water yield 1/4, stir evenly, filter, to obtain final product.
The preparation method of a kind of Sugarless type liver-benefiting eye-brightening oral liquid the most according to claim 4, it is characterised in that nipalgin
Ethyl ester is used after being dissolved by ethanol, and ethyl hydroxybenzoate 0.3 part is 3:20～50g/ml with the mass volume ratio of ethanol.
The preparation method of a kind of Sugarless type liver-benefiting eye-brightening oral liquid the most according to claim 4, it is characterised in that logical in S3
Cross and add the regulation that mass concentration is 10% sodium hydroxide.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107158160A (en) * | 2017-06-22 | 2017-09-15 | 德施普科技发展温州有限公司 | A kind of traditional Chinese medicine oral liquid for treating myopia and preparation method thereof |
| CN107898809A (en) * | 2017-12-15 | 2018-04-13 | 湖南千金协力药业有限公司 | A kind of Zinc calcium gluconate oral solution and preparation method thereof |
| CN109908234A (en) * | 2019-04-19 | 2019-06-21 | 中泰宜佳健康科技（北京）有限责任公司 | One kind is for composition for relieving asthenopia and its preparation and preparation method |
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2016
- 2016-08-31 CN CN201610765041.9A patent/CN106266561A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107158160A (en) * | 2017-06-22 | 2017-09-15 | 德施普科技发展温州有限公司 | A kind of traditional Chinese medicine oral liquid for treating myopia and preparation method thereof |
| CN107898809A (en) * | 2017-12-15 | 2018-04-13 | 湖南千金协力药业有限公司 | A kind of Zinc calcium gluconate oral solution and preparation method thereof |
| CN109908234A (en) * | 2019-04-19 | 2019-06-21 | 中泰宜佳健康科技（北京）有限责任公司 | One kind is for composition for relieving asthenopia and its preparation and preparation method |
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