CN104147059A - Drying method of penthorum chinense pursh - Google Patents
Drying method of penthorum chinense pursh Download PDFInfo
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- CN104147059A CN104147059A CN201410418683.2A CN201410418683A CN104147059A CN 104147059 A CN104147059 A CN 104147059A CN 201410418683 A CN201410418683 A CN 201410418683A CN 104147059 A CN104147059 A CN 104147059A
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- penthorum chinense
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Abstract
The invention relates to an application of a freeze-drying technology in a drying method of penthorum chinense pursh. The application is characterized in that fresh penthorum chinense pursh is semi-dried through the freeze-drying technology, is taken out, is placed in stacks for 1-2 days, is taken out and is packaged in a sealing manner. Prepared penthorum chinense pursh is high in content of main active ingredients flavonoids. The application is low in energy consumption. The penthorum chinense pursh is good in liver-protective effect.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of drying means of Penthorum chinense, belongs to medical technical field.
Background technology
Penthorum chinense is the dry aerial parts of saxifragaceae plant Herba Lysimachiae Clethroids.History is loaded in Ming Dynasty's herbal for Relief of Famines and now records in " 13 of Ministry of Health of the People's Republic of China's ministry standard Traditional Chinese medicine historical preparations ", and " Chinese medicine voluminous dictionary " and " Traditional Chinese Medicine in Sichuan will " is also all on the books.Penthorum chinense is Miao ethnic group's conventional medicament, among the people with its all herbal medicine.Its herb is warm in nature, sweet in the mouth, nontoxic, tool heat clearing away, diuresis elimination of urine, detoxify, invigorate blood circulation, suppressing the hyperactive liver, spleen invigorating, the effects such as yellow cellulitis of dispelling.Cure mainly yellow cellulitis, edema, amenorrhea, metrorrhagia, leukorrhagia, traumatic injury, and various hepatitis, cholecystitis, fatty liver etc.Modern study shows that in Penthorum chinense, total flavones, to the protective effect of hepatic injury tool, can recover liver function, lowers and drinks and the infringement of medicine to liver, suppresses hepatic fibrosis, liver cirrhosis, and to hepatitis A, hepatitis B, chronic active hepatitis tool has significant therapeutic effect.
Penthorum chinense is mainly wild, is mainly distributed in North China, East China, the Central-South and ground such as Shaanxi, Sichuan and Guizhou.Domestication becomes family's kind gradually in recent years, and there is wild and plantation in Shandong.
Traditional Chinese medicine drying has very long history in China, the Chinese herbal medicine of drying can keep certain medicinal ingredient and be difficult for putrid and deteriorated, the dry important measures as ensureing Chinese herbal medicine quality, it is a requisite technical process in Chinese herbal medicine processing, it is in close relations that dry and Chinese medicine are produced, and dry method will directly affect the quality of product.
The lyophilizing of prior art refers to be freezed medical material at low temperatures, and then sublimation drying under vacuum condition is removed ice crystal, after distillation finishes, carries out adsorption stripping and dry again, and remove portion is in conjunction with the drying means of water.Freeze-drying process mainly can be divided into primary drying (sublimation drying), and redrying (adsorption stripping and dry) is to dry.The dry run pumpdown time is long, and energy consumption is high.The present invention in freeze dryer without redrying process.Energy consumption is low, can reduce by 50% through test of many times power consumption.
Further illustrate usefulness of the present invention below by test example, test example is intended to further illustrate usefulness of the present invention, but not limitation of the present invention.
Fresh Penthorum chinense picks up from Xi Ying town, suburb, Jinan.To, with a collection of fresh Penthorum chinense, process by the following method.
1) dry Penthorum chinense: fresh Penthorum chinense is put in shady and cool ventilation place, spreads out and dries.
2) dry Penthorum chinense: fresh Penthorum chinense, 60 DEG C of following oven dry.
3) Penthorum chinense of the present invention: fresh Penthorum chinense, be refrigerated to below-20 DEG C, be evacuated to below drying chamber pressure 45Pa, subliming by heating, the temperature of distillation should be controlled at below 40 DEG C, when state before condenser temperature drops to distillation, takes out, and packs.
4) lyophilizing Penthorum chinense: fresh Penthorum chinense, be refrigerated to below-20 DEG C, be evacuated to below drying chamber pressure 45Pa, subliming by heating, the temperature of distillation should be controlled at below 40 DEG C, and the temperature of resolution phase is controlled at below 45 DEG C, to dry, takes out, and packs.
5) fresh Penthorum chinense: without any processing.
One, the content side definite proportion of the dry Penthorum chinense total flavones of distinct methods
1, instrument and reagent
Instrument: the visible spectrophotometer of ultraviolet one; Electronic balance; Control substance of Rutin.
2, detect determining of wavelength
After the colour developing of control substance of Rutin aluminum nitrate, have absorption maximum at 500-510nm wavelength place, in conjunction with document, test and Selection 500nm is for detecting wavelength.
3, the preparation of reference substance solution
Precision takes the control substance of Rutin 10mg to constant weight at 120 DEG C of drying under reduced pressure, puts in 50mL measuring bottle, adds 70% ethanol 35mL, puts slight fever in water-bath and makes to dissolve, and lets cool, and adds 70% ethanol to scale, shakes up, and obtains (in every mL, containing anhydrous rutin 0.2mg).
4, test sample preparation and assay
Get the each 0.1g of Penthorum chinense medical material of above preparation, accurately weighed, put in l00mL volumetric flask, add 70% ethanol 70mL, after jolting, add ethanol to scale, place lh, filter rapidly with dry filter, precision measures subsequent filtrate 6mL, put in 25mL volumetric flask, add 5% sodium nitrite solution 1mL, mix, place 6min; Add 10% aluminum nitrate solution lmL, shake up, place 6min; Hydro-oxidation sodium test solution 10mL, then add water to scale, shake up, place 15min.
5, measure
Measure trap according to spectrophotography at 500nm wavelength place, calculate, to obtain final product.The results are shown in Table 1.
The content of the dry Penthorum chinense total flavones of table 1 distinct methods
| Medical material | Dry | Dry | The present invention is dry | Lyophilizing | Fresh ▲ |
| General flavone content (%) | 5.34 | 5.13 | 9.16 | 9.16 | 9.15 |
▲ fresh Penthorum chinense is in dry product.
Found out by table 1, the present invention is dry, lyophilizing and fresh Penthorum chinense general flavone content all higher.
Two, different dry drying method Penthorum chinense friability comparison
1, instrument friability somascope, analytical balance, 60 mesh sieves.
2, inspection method
The rotating speed that regulates instrument before 2.1 adjusting instrument speed tests is per minute 25 to turn ± 1 turn, and setting test period is 4 minutes, and the total degree of rotary drum is 100 times.
The amount of taking of 2.2 test samples, gets test sample and crosses 60 mesh sieves sieves and remove powder, gets test sample 10g.
2.3 check
Test sample after above-mentioned weighed weight is put in cylinder, started motor and rotate 100 times.After rotation finishes, then remove powder with 60 mesh sieves sieves, precise weighing, is the weight of less loss with the difference of the amount of taking, and calculates percentage ratio.The results are shown in 2.
Table 2 different dry drying method Folium Eucommiae friability
| ? | Less loss amount (%) |
| Dry | 0.96 |
| Dry | 0.98 |
| The present invention is dry | 1.64 |
| Lyophilizing | 5.37 |
Table 2 result is known, and Penthorum chinense friability of the present invention is good, and antivibration wear resistant ability is strong, and product is non-friable, and storage, transport easily keep decoction pieces shape, constant product quality.
Three, the dry Penthorum chinense liver protective effect comparison of distinct methods
This test adopts CCl
4due to the impact test of Liver Damage in Rats.
The healthy rat of body weight 150-170g, random group, 10 every group, Normal group gives same volume distilled water; Moulding contrast and medicine group are in experiment the 1st, 5 days subcutaneous injection 50% CCl
4vegetable oil rod suspension 5mL/kg gavages respectively water and Penthorum chinense water extract from experiment starts day, and continuous 9 days, 24 hours eye sockets of drug withdrawal were got blood, surveyed serum glutamic pyruvic transminase with reitman-frankel method.The results are shown in Table 3.
The dry Penthorum chinense of table 3 distinct methods is to CCl
4the impact of hepatic injury rat blood serum glutamate pyruvate transaminase
| Group | Dosage (g/kg) | Number of animals | Glutamate pyruvate transaminase in serum |
| Normal control | ? | 10 | 19.6±3.4 |
| Moulding pair | ? | 10 | 377.5±120.4 |
| Dry | 3 | 10 | 297.3±123.7 |
| Dry | 3 | 10 | 306.4±125.1 |
| The present invention is dry | 3 | 10 | 235.4±119.3 |
| Fresh ▲ | 3 | 10 | 267.8±116.3 |
▲ fresh Penthorum chinense dosage is in dry product.
The dry Penthorum chinense of distinct methods is to rat CCl
4hepatic injury has protective effect, and the Penthorum chinense action effect of preparing with the inventive method is best.
Summary of the invention
The object of this invention is to provide a kind of drying means of Penthorum chinense, the Penthorum chinense that the method is dry, main effective ingredient general flavone content is high, and decoction pieces keeping quality is good, and quality of medicinal material is stable.
The present invention is achieved in that
A drying means for Penthorum chinense, is characterized in that: lyophilizing is that solidification point is controlled at below-10 DEG C, reaches and controls after temperature, is evacuated to below drying chamber pressure 30Pa subliming by heating; Sublimation temperature is controlled at below 40 DEG C, and distillation finishes, and takes out, and packs.
The drying means of a kind of Penthorum chinense of the present invention, is characterized in that: distillation finish a kind of judgement in by the following method 1. serviceability temperature Sensor monitoring temperature of charge judge whether the ice in material all distils; 2. condenser temperature drops to the state before distillation; 3. the pressure drop of freeze drying box is to the pressure that approaches cryoprobe.
So far completed the present invention, Penthorum chinense main active general flavone content prepared by the present invention is high, and liver protective effect is good, and product is non-friable, and storage, transport easily keep decoction pieces shape.
Detailed description of the invention
embodiment 1
Get fresh Penthorum chinense, put in freeze dryer, be refrigerated to-20 DEG C, be evacuated to drying chamber pressure 30Pa, subliming by heating, the temperature of distillation is controlled at below 40 DEG C, when judging that with temperature sensor monitors temperature of charge the ice in material all distils, distillation finishes, and takes out, and packs.
embodiment 2
Get fresh Penthorum chinense, put in freeze dryer, be refrigerated to-28 DEG C, be evacuated to drying chamber pressure 50Pa, subliming by heating, the temperature of distillation is controlled at 50 DEG C, the state before condenser temperature drops to distillation, distillation finishes, and takes out, and packs.
embodiment 3
Get fresh Penthorum chinense, put in freeze dryer, be refrigerated to-32 DEG C, be evacuated to drying chamber pressure 50Pa, subliming by heating, the temperature of distillation is controlled at 50 DEG C, and when the pressure drop of hothouse is when approaching the pressure of cryoprobe, distillation finishes, and takes out, and packs.
Claims (2)
1. the application of freeze drying technology in Penthorum chinense drying means, is characterized in that: get fresh Penthorum chinense, lyophilizing, to half-dried, is taken out, and the 1-2 days that banks up is dry.
2. the application in Penthorum chinense drying means according to the freeze drying technology of claim 1, it is characterized in that: get fresh Penthorum chinense, be refrigerated to below-10 DEG C, be evacuated to below drying chamber pressure 30Pa, subliming by heating, the temperature of distillation is controlled at below 40 DEG C, to half-dried, take out, the 1-2 days that banks up is dry.
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| CN201410418683.2A CN104147059A (en) | 2014-08-25 | 2014-08-25 | Drying method of penthorum chinense pursh |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147057A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-drying method as method of preparing high-activity penthorum chinense pursh |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103478345A (en) * | 2013-08-14 | 2014-01-01 | 刘珂 | Application of penthorum chinense pursh leaves and production process of penthorum chinense pursh leaf tea |
| CN103948652A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for drying lucid ganoderma |
| CN103948638A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Drying method of medical fungi |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
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- 2014-08-25 CN CN201410418683.2A patent/CN104147059A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103478345A (en) * | 2013-08-14 | 2014-01-01 | 刘珂 | Application of penthorum chinense pursh leaves and production process of penthorum chinense pursh leaf tea |
| CN103948652A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Method for drying lucid ganoderma |
| CN103948638A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Drying method of medical fungi |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147057A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Freeze-drying method as method of preparing high-activity penthorum chinense pursh |
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