CN104180610A - Penthorum chinense pursh drying method - Google Patents
Penthorum chinense pursh drying method Download PDFInfo
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- CN104180610A CN104180610A CN201410418487.5A CN201410418487A CN104180610A CN 104180610 A CN104180610 A CN 104180610A CN 201410418487 A CN201410418487 A CN 201410418487A CN 104180610 A CN104180610 A CN 104180610A
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Abstract
The invention relates to a lamiophlomis rotata drying method. Fresh penthorum chinense pursh is taken and subjected to freezing and drying. The dried penthorum chinense pursh prepared according to the method is effective in liver protection and high in content of total flavonoid which is a major active ingredient.
Description
Invention field
The present invention relates to medicine method for making, particularly a kind of drying means of catching up with yellow grass, belongs to medical technical field.
Background technology
Catching up with yellow grass is the dry aerial parts that saxifragaceae plant pulls root vegetables.History is loaded in Ming Dynasty < < Herbal for Relief of Famines > > and now records in 13 > > of < < Ministry of Health of the People's Republic of China ministry standard Traditional Chinese medicine historical preparation, and < < Chinese medicine voluminous dictionary > > and < < Traditional Chinese Medicine in Sichuan will > > are also all on the books.Gan Huangcaowei Miao ethnic group conventional medicament, among the people with its all herbal medicine.Its herb is warm in nature, taste is sweet, nontoxic, tool heat-clearing, diuresis elimination of urine, detoxify, invigorate blood circulation, flat liver, invigorating the spleen, the effects such as yellow subcutaneous ulcer of dispelling.Cure mainly yellow subcutaneous ulcer, oedema, through closing, under metrorrhagia, band, traumatic injury, and various hepatitis, cholecystitis, fatty liver etc.Modern study shows to catch up with general flavone in yellow grass to the protective effect of hepatic injury tool, can recover liver function, lowers and drinks and the infringement of medicine to liver, suppresses liver fibrosis, cirrhosis, and to hepatitis A, hepatitis B, CAH tool has significant therapeutic effect.
Catch up with yellow grass to be mainly wild, be mainly distributed in North China, East China, the Central-South and ground such as Shaanxi, Sichuan and Guizhou.Domestication becomes family's kind gradually in recent years, and there is wild and plantation in Shandong.
Traditional Chinese medicine drying has very long history in China, the Chinese herbal medicine of drying can keep certain medicinal ingredient and be difficult for putrid and deteriorated, the dry important measures as guaranteeing Chinese herbal medicine quality, it is a requisite technical process in Chinese herbal medicine processing, it is in close relations that dry and Chinese medicine are produced, and dry method will directly affect the quality of product.
Summary of the invention
The object of this invention is to provide a kind of dry new method of yellow grass of catching up with, catching up with that the method is dry is yellow careless, and main active ingredient general flavone content is high, and liver protective effect is good.
A drying means of catching up with yellow grass, is characterized in that: get the fresh yellow grass of catching up with, and freezing rear dry.
A kind of drying means of catching up with yellow grass of the present invention, is characterized in that: freezing is to be refrigerated to freeze.
A kind of drying means of catching up with yellow grass of the present invention, is characterized in that: freezing is to be refrigerated to below-5 ℃.
A kind of drying means of catching up with yellow grass of the present invention, is characterized in that: freezing rear dry be dry or dry or dry after freezing.
So far completed the present invention, by of the present invention, caught up with the yellow grass of catching up with prepared by yellow careless drying means, main active ingredient general flavone content is high, and liver protective effect is good.
Below by test example, further illustrate usefulness of the present invention, test example is intended to further illustrate usefulness of the present invention, but not limitation of the present invention.
Freshly catch up with yellow grass to pick up from Xi Ying town, suburb, Jinan.To, with a collection of fresh yellow grass of catching up with, process by the following method.
1) dry and catch up with yellow grass: freshly catch up with yellow grass to be put in shady and cool ventilation place, spread out and dry;
2) dry and catch up with yellow grass: the fresh Huang grass of catching up with, 60 ℃ of following oven dry;
3) freezing post-drying is caught up with yellow grass: freshly catch up with yellow grass to be refrigerated to-5 ℃ with down to freezing, take out 60 ℃ of following oven dry;
One, distinct methods is dry catches up with the content side of yellow careless general flavone surely to compare
1, instrument and reagent
Instrument: the visible spectrophotometer of ultraviolet one; Electronic balance; Control substance of Rutin.
2, detect determining of wavelength
After the colour developing of control substance of Rutin aluminum nitrate, at 500-510nm wavelength place, have absorption maximum, in conjunction with document, test selects 500nm for detecting wavelength.
3, the preparation of reference substance solution
Precision takes the control substance of Rutin 10mg to constant weight at 120 ℃ of drying under reduced pressure, puts in 50mL measuring bottle, adds 70% ethanol 35mL, puts low-grade fever in water-bath and makes to dissolve, and lets cool, and adds 70% ethanol to scale, shakes up, and obtains (in every mL, containing anhydrous rutin 0.2mg).
4, test sample preparation and assay
Get yellow each 0.1g of herbal medicine material of catching up with of above preparation, accurately weighed, put in l00mL volumetric flask, add 70% ethanol 70mL, after jolting, add ethanol to scale, place lh, with dry filter, filter rapidly, precision measures subsequent filtrate 6mL, put in 25mL volumetric flask, add 5% sodium nitrite solution 1mL, mix, place 6min; Add 10% aluminum nitrate solution lmL, shake up, place 6min; Hydro-oxidation sodium test solution 10mL, then add water to scale, shake up, place 15min.
5, side is fixed
According to AAS, at 500nm wavelength place, measure trap, calculate, obtain.The results are shown in Table 1.
The dry content (%) of catching up with yellow careless general flavone of table 1 distinct methods
| Medicinal material | Dry | Dry | Freezing post-drying |
| General flavone content | 5.34 | 5.13 | 6.47 |
By table 1, found out, freeze-drying and freshly catch up with yellow careless general flavone content the highest, freezing post-drying catches up with yellow natural plant height to catch up with yellow grass in drying, drying.
Two, distinct methods is dried and catches up with yellow careless liver protective effect comparison
This test adopts CCl
4due to the impact test of Liver Damage in Rats.
The healthy rat of body weight 150-170g, random groups, 10 every group, Normal group gives same volume distilled water; Moulding contrast and medicine group are in experiment the 1st, 5 days hypodermic injection 50% CCl
4rape oil rod suspension 5mL/kg gavages respectively water and catches up with yellow careless water extract from experiment starts day, and continuous 9 days, 24 hours eye sockets of drug withdrawal were got blood, with reitman-frankel method, survey serum glutamic pyruvic transminase.The results are shown in Table 2.
Table 2 distinct methods is dry catches up with yellow grass to CCl
4the impact of hepatic injury rat blood serum glutamic-pyruvic transaminase
| Group | Dosage (g/kg) | Number of animals | Glutamic-pyruvic transaminase in serum |
| Normal control | ? | 10 | 19.6±3.4 |
| Moulding pair | ? | 10 | 377.5±120.4 |
| Dry | 3 | 10 | 297.3±123.7 |
| Dry | 3 | 10 | 306.4±125.1 |
| Freezing post-drying | 3 | 10 | 213.7±107.0 |
Distinct methods is dry catches up with yellow grass to rat CCl
4hepatic injury has protective effect, and that with the inventive method, prepares catches up with yellow careless action effect best.
The specific embodiment
embodiment 1
Get the fresh yellow grass of catching up with, be refrigerated to-5 ℃ to freezing, dry.
embodiment 2
Get the fresh yellow grass of catching up with, be refrigerated to below-10 ℃, dry.
embodiment 3
Get the fresh yellow grass of catching up with, be refrigerated to below-15 ℃, dry.
embodiment 4
Get the fresh yellow grass of catching up with, be refrigerated to-20 ℃ to freezing, dry.
Claims (4)
1. a drying means of catching up with yellow grass, is characterized in that: get fresh lamiophlomis rotata, and freezing rear dry.
2. according to a kind of drying means of catching up with yellow grass of claim 1, it is characterized in that: freezing is to be refrigerated to freeze.
3. according to a kind of drying means of catching up with yellow grass of claim 1, it is characterized in that: freezing is to be refrigerated to below-5 ℃.
4. according to claim 1 a kind of, catch up with the drying means of yellow grass, it is characterized in that: freezing rear dry be dry or dry or dry after freezing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418487.5A CN104180610A (en) | 2014-08-25 | 2014-08-25 | Penthorum chinense pursh drying method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410418487.5A CN104180610A (en) | 2014-08-25 | 2014-08-25 | Penthorum chinense pursh drying method |
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| Publication Number | Publication Date |
|---|---|
| CN104180610A true CN104180610A (en) | 2014-12-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410418487.5A Pending CN104180610A (en) | 2014-08-25 | 2014-08-25 | Penthorum chinense pursh drying method |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09152268A (en) * | 1995-11-30 | 1997-06-10 | Liquid Gas:Kk | Freeze dryer |
| CN103285063A (en) * | 2013-05-15 | 2013-09-11 | 孙玉平 | Preparation method of honeysuckle extract |
| CN103948638A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Drying method of medical fungi |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
| CN103977041A (en) * | 2014-05-15 | 2014-08-13 | 济南康众医药科技开发有限公司 | Drying method of ganoderma applanatum pat |
-
2014
- 2014-08-25 CN CN201410418487.5A patent/CN104180610A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09152268A (en) * | 1995-11-30 | 1997-06-10 | Liquid Gas:Kk | Freeze dryer |
| CN103285063A (en) * | 2013-05-15 | 2013-09-11 | 孙玉平 | Preparation method of honeysuckle extract |
| CN103948638A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Drying method of medical fungi |
| CN103948642A (en) * | 2014-05-15 | 2014-07-30 | 济南康众医药科技开发有限公司 | Application of refrigeration technique in phellinus igniarius drying |
| CN103977041A (en) * | 2014-05-15 | 2014-08-13 | 济南康众医药科技开发有限公司 | Drying method of ganoderma applanatum pat |
Non-Patent Citations (4)
| Title |
|---|
| 张美莲: "分光光度法测定独一味分散片中总黄酮的含量", 《海峡药学》 * |
| 李明: "《中药鉴定技术》", 31 August 2013 * |
| 湖南省食品药品监督管理局: "《湖南省中药材标准》", 28 February 2012 * |
| 潘永康等: "《现代干燥技术》", 31 May 2007 * |
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Application publication date: 20141203 |