CN102961499A - Traditional Chinese medicine nigrum fruit product and preparation method and application thereof - Google Patents
Traditional Chinese medicine nigrum fruit product and preparation method and application thereof Download PDFInfo
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- CN102961499A CN102961499A CN2012104427632A CN201210442763A CN102961499A CN 102961499 A CN102961499 A CN 102961499A CN 2012104427632 A CN2012104427632 A CN 2012104427632A CN 201210442763 A CN201210442763 A CN 201210442763A CN 102961499 A CN102961499 A CN 102961499A
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- solani nigri
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Abstract
The invention provides a traditional Chinese medicine nigrum fruit product, wherein coramsine accounts for 1.3-1.55% of the nigrum fruit product by weight. The invention also provides a preparation method and an application of the traditional Chinese medicine nigrum fruit product. The traditional Chinese medicine nigrum fruit product provided by the invention reduces the toxicity of nigrum fruit and is sweet and easy to take. The preparation method of the traditional Chinese medicine nigrum fruit product provided by the invention is simple in technology, and reduces the content of toxic substances while ensuring that the active ingredients are not damaged; a high-temperature treatment process is saved; and meanwhile, an ideal sterilization effect can be realized on medicinal slices, and a positive effect is realized in promoting the effect enhancement and toxicity reduction and the improvement of quality standard of the nigrum fruit slices and related products thereof.
Description
Technical field
The invention belongs to the Chinese crude drug manufacture field, be specifically related to a kind of Chinese medicine Fructus Solani Nigri processed product and concocting method and purposes.
Background technology
Fructus Solani Nigri is the almost ripe fruit of plant of Solanaceae Herba Solani Nigri.Function is given birth to do to give birth to and is trembled with fear heat clearing and inflammation relieving, removing pathogenic heat from blood and toxic substance from the body, softening hardness and disperse swelling.Cure mainly humid or blood matter disease, such as hot hepatitis, gastritis, pharyngolaryngitis, nephritis, moist edema." annotating doctor's allusion quotation ": " heat clearing away convergence.It is swollen to cure mainly inside and outside various hot inflammation, glossitis, headache, otalgia, parotitis, meningitis, eye inflammation, gastritis, nephritis etc." " visit according to the medicine book ": " and antipyretic and itching-stopping, the detumescence softening the hard mass, eliminating dampness and astringing sores, anticorrosion except pus, give birth to cold controlling nocturnal emission with astringent drugs.Cure mainly various hot skin pruritus, carbuncle, thirsty, burn, suppurative variola, tumor, road essence etc." contain the multiple alkaloids such as solanine (solanine), solasonine (solaso-nine), solamargine (solamargine), and exist with the form of glycosides, and contain vitamin C, A and saponin.This product alkaloid blood glucose that can raise has antitussive, eliminates the phlegm, bacteriostasis.
Give birth to Fructus Solani Nigri bladder is had certain toxic action, solanine has genotoxicity, damages significantly embryo's growth promoter and differentiation.Herba Solani Nigri red pigment thermal degradation speed is fast, conventional its effective ingredient of hyperthermia drying destructible.Therefore, need to carry out systematic study to the Fructus Solani Nigri processing procedure in conjunction with the special efficacy of Fructus Solani Nigri, to determine the best processing procedure of efficacy enhancing and toxicity reducing.
Summary of the invention
Therefore, one object of the present invention is to provide a kind of Chinese medicine Fructus Solani Nigri processed product, and this Chinese medicine Fructus Solani Nigri processed product has reduced toxicity and the sweet easily clothes of Fructus Solani Nigri.
Another object of the present invention is to provide the concocting method of above-mentioned Chinese medicine Fructus Solani Nigri processed product, and the method technique is simple, and bactericidal action and the preferably effect of efficacy enhancing and toxicity reducing are arranged, and when improving the decoction pieces sanitary index, reduces the destruction of Herba Solani Nigri red pigment.
Another purpose of the present invention is to provide the application of above-mentioned Chinese medicine Fructus Solani Nigri processed product.
The objective of the invention is to be achieved through the following technical solutions:
On the one hand, the invention provides a kind of Chinese medicine Fructus Solani Nigri processed product, wherein, the content of Herba Solani Nigri total flavones is 1.3 % by weight ~ 1.55 % by weight in the described Fructus Solani Nigri processed product.
Preferably, wherein, the content of Herba Solani Nigri water soluble polysaccharide is 0.08 % by weight ~ 0.095 % by weight in the described Fructus Solani Nigri processed product.
Preferably, wherein, the content of anthocyanin is 1 % by weight ~ 1.2 % by weight in the described Fructus Solani Nigri processed product.
On the other hand, the invention provides the concocting method of described Chinese medicine Fructus Solani Nigri processed product, described method comprises the steps:
1) selection: remove impurity and immature fruit in the Fructus Solani Nigri;
2) honey profit: stir the honey profit with the Fructus Solani Nigri drying and with dried Fructus Solani Nigri and Mel;
3) product of gained carries out microwave drying drying: with step 2), obtains the Fructus Solani Nigri processed product.
Preferably, step 2) Fructus Solani Nigri being dried to water content is: 5 ~ 15 % by weight.
Preferably, the mass ratio of dried Fructus Solani Nigri and Mel step 2) is 3:1 ~ 5:1.
Preferably, the time of honey profit is 12 ~ 24h step 2).
Preferably, the condition of microwave drying is 300 ~ 800KHz microwave drying, 2 ~ 8min in the step 3).
Another aspect the invention provides the purposes of above-mentioned Chinese medicine Fructus Solani Nigri processed product in the medicine of preparation treatment humid or blood matter disease.
Preferably, wherein said humid or blood matter disease are one or more in hot hepatitis, gastritis, pharyngolaryngitis, nephritis and the moist edema etc.
Chinese medicine Fructus Solani Nigri processed product of the present invention has reduced toxicity and the sweet easily clothes of Fructus Solani Nigri.The concocting method technique of Chinese medicine Fructus Solani Nigri processed product of the present invention is simple, when having guaranteed that its effective ingredient is not destroyed, reduced toxic chemical content, without high-temperature process, simultaneously decoction pieces can reach the effect of desirable sterilization, when improving the decoction pieces sanitary index, reduce the destruction of Herba Solani Nigri red pigment, the efficacy enhancing and toxicity reducing of Fructus Solani Nigri decoction pieces and correlated product thereof and the raising of quality standard are had positive impetus.
Description of drawings
Below, describe by reference to the accompanying drawings embodiment of the present invention in detail, wherein:
Fig. 1 is the absorbance curve chart of Herba Solani Nigri total flavones under different wave length.
The specific embodiment
By following specific embodiment and test example, can further understand the present invention, but following examples and test example not limitation of the invention.
1) selection: remove impurity and immature fruit in the Fructus Solani Nigri;
2) honey profit: to be dried to water content be 5 % by weight and dried Fructus Solani Nigri and Mel stirred honey profit 12h with the mass ratio of 3:1 with Fructus Solani Nigri;
3) product of gained obtains the Fructus Solani Nigri processed product in 300KHz microwave drying 8min drying: with step 2).
Embodiment 2
1) selection: remove impurity and immature fruit in the Fructus Solani Nigri;
2) honey profit: to be dried to water content be 10 % by weight and dried Fructus Solani Nigri and Mel stirred honey profit 24h with the mass ratio of 5:1 with Fructus Solani Nigri;
3) product of gained obtains the Fructus Solani Nigri processed product in 800KHz microwave drying 2min drying: with step 2).
Embodiment 3
1) selection: remove impurity and immature fruit in the Fructus Solani Nigri;
2) honey profit: to be dried to water content be 15 % by weight and dried Fructus Solani Nigri and Mel stirred honey profit 18h with the mass ratio of 4:1 with Fructus Solani Nigri;
3) product of gained obtains the Fructus Solani Nigri processed product in 500KHz microwave drying 6min drying: with step 2).
Comparative Examples 1
According to traditional concocting method: Fructus Solani Nigri is put 80 ℃ of oven dryings made processed product in 24 hours.
Test example 1 solanine content is measured
Measure respectively by the following method the content of solanine in embodiment 1-3 and the Comparative Examples 1 gained Fructus Solani Nigri processed product:
Fructus Solani Nigri processed product with embodiment 1-3 and Comparative Examples 1 gained is ground into coarse granule respectively, gets 50g 70%v/v alcohol reflux 2 times, and the ethanol consumption is followed successively by 400ml, 400ml, and extraction time is followed successively by 1.5h, 1h;
Merge alcohol extract, be concentrated into about 200ml after the filtration, concentrated solution is cooled off the adding distil water standardize solution to 300ml;
Draw sample liquid 20 μ l with microsyringe, put in the 25ml conical flask, place 80 ℃ of solvent evaporated of water-bath, add bromothymol blue PH=7.6 buffer solution 6ml, chloroform 6ml, then inaccessible violent jolting 3min changes in the 60ml separatory funnel, leave standstill 2h, after water layer and chloroform layer are distinguished fully, divide and get chloroform layer in rub oral examination tube, (416nm is the Herba Solani Nigri total flavones maximum absorption wavelength at 416nm wavelength place, see Fig. 1) measure trap, not add alkaloidal chloroform extraction liquid as the retinue blank; Carry out quantitatively the results are shown in Table 1 with the external standard two-point method.
Herba Solani Nigri total flavones content (% by weight) before and after table 1 Fructus Solani Nigri is concocted
As shown in Table 1, the Fructus Solani Nigri behind the embodiment of the invention 1-3 processed with honey all further reduces with respect to its toxicant Herba Solani Nigri total flavones content of Fructus Solani Nigri of traditional concocting method (Comparative Examples 1) preparation, and is wherein remarkable with embodiment 3 reduction degree.
Test example 2
Measure respectively by the following method in embodiment 1-3 and the Comparative Examples 1 content of Herba Solani Nigri water soluble polysaccharide in the gained Fructus Solani Nigri processed product:
The Fructus Solani Nigri processed product is ground into coarse granule, after getting 1kg usefulness 95%v/v soak with ethanol 24h, add the 10kg distilled water, heat 6h in the boiling water bath, filter, be concentrated into 850ml, in concentrated solution, add 850ml ethanol, centrifugal, the dry brown solid that gets is with brown solid adding distil water 30ml dissolving, Sevage method isolating protein.Obtaining solid sample is Herba Solani Nigri water soluble polysaccharide extract, weighs, and the results are shown in Table 2.
Herba Solani Nigri water soluble polysaccharide content (g) before and after table 2 Fructus Solani Nigri is concocted
As shown in Table 2, tradition is concocted and has been destroyed to a certain extent water soluble polysaccharide composition in the Fructus Solani Nigri, reduced its active constituent content, and the processed with honey Fructus Solani Nigri all can improve Fructus Solani Nigri effective ingredient water soluble polysaccharide content, take embodiment 2 effects as excellent.
Confirmed to process by processed with honey by the result in test example 1 and 2, when improving the Fructus Solani Nigri active constituent content, can reduce its toxicity, the effect of performance efficacy enhancing and toxicity reducing.
Test example 3
According to " Chinese pharmacopoeia (2000 editions an one) appendix VIIIC " microbial limit test " measures total number of bacteria and the fungi count that tradition is concocted (Comparative Examples 1) and embodiment 1-3 gained Fructus Solani Nigri processed product, calculates sterilization rate:
Sterilization rate (%) before and after table 3 Fructus Solani Nigri is concocted
| ? | Antibacterial sterilization rate (%) | Mycete sterilization rate (%) |
| Comparative Examples 1 | 68.57 | 74.48 |
| |
92.25 | 95.93 |
| Embodiment 2 | 92.47 | 96.26 |
| Embodiment 3 | 94.37 | 97.87 |
As shown in Table 3, the concocting method that embodiment 1-3 adopts can play the effect of better kill bacteria and mycete with respect to traditional concocting method, can improve Fructus Solani Nigri prepared slice quality and drug safety.
Test example 4
Measure respectively by the following method in embodiment 1-3 and the Comparative Examples 1 anthocyanin total amount in the gained Fructus Solani Nigri processed product:
The Fructus Solani Nigri processed product is ground into coarse granule, accurately takes by weighing 5g, add 15 times of weight 50%v/v ethanol, 50 ℃ of lixiviate 30min filter, and get filtrate and measure absorbance at the 535nm place, calculate the anthocyanin total amount with improved Fulcki method, namely
Remarks: A: pigment is at the absorbance at 535nm wavelength place; V: the constant volume (ml) the when Fructus Solani Nigri of certain mass extracts pigment; N: the multiple that dilutes during colorimetric; 98.2: the anthocyanins pigment is at the average extinction coefficient at 535nm place; M: the quality of Fructus Solani Nigri (g)
Pigment total amount before and after table 4 Fructus Solani Nigri is concocted
As shown in Table 4, the concocting method that embodiment 1-3 adopts can play the effect that prevents that the Fructus Solani Nigri pigment is destroyed with respect to traditional concocting method, can improve the Fructus Solani Nigri prepared slice quality, guarantees that the original composition of decoction pieces is not destroyed.
Claims (10)
1. Chinese medicine Fructus Solani Nigri processed product, wherein, the content of Herba Solani Nigri total flavones is 1.3 % by weight ~ 1.55 % by weight in the described Fructus Solani Nigri processed product.
2. Chinese medicine Fructus Solani Nigri processed product according to claim 1, wherein, the content of Herba Solani Nigri water soluble polysaccharide is 0.08 % by weight ~ 0.095 % by weight in the described Fructus Solani Nigri processed product.
3. Chinese medicine Fructus Solani Nigri processed product according to claim 1, wherein, the content of anthocyanin is 1 % by weight ~ 1.2 % by weight in the described Fructus Solani Nigri processed product.
4. the concocting method of each described Chinese medicine Fructus Solani Nigri processed product in the claims 1 to 3, described method comprises the steps:
1) selection: remove impurity and immature fruit in the Fructus Solani Nigri;
2) honey profit: stir the honey profit with the Fructus Solani Nigri drying and with dried Fructus Solani Nigri and Mel;
3) product of gained carries out microwave drying drying: with step 2), obtains the Fructus Solani Nigri processed product.
5. method according to claim 4, wherein, step 2) Fructus Solani Nigri being dried to water content is: 5 ~ 15 % by weight.
6. the mass ratio of dried Fructus Solani Nigri and Mel is 3:1 ~ 5:1 according to claim 4 or 5 described methods, wherein, step 2).
7. the time of honey profit is 12 ~ 24h each described method in 6 according to claim 4, wherein, step 2).
8. each described method in 7 according to claim 4, wherein, the condition of microwave drying is 300 ~ 800KHz microwave drying, 2 ~ 8min in the step 3).
9. the purposes of each described Chinese medicine Fructus Solani Nigri processed product in the medicine of preparation treatment humid or blood matter disease in the claims 1 to 3.
10. purposes according to claim 9, wherein said humid or blood matter disease are one or more in hot hepatitis, gastritis, pharyngolaryngitis, nephritis and the moist edema.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877147A (en) * | 2012-12-19 | 2014-06-25 | 中国医学科学院药用植物研究所 | Method for processing fructus sophorae with honey |
| CN107260685A (en) * | 2017-06-02 | 2017-10-20 | 神威药业集团有限公司 | A kind of preparation method of Solanum nigrum granule |
| CN107397227A (en) * | 2017-08-28 | 2017-11-28 | 张锦超 | A kind of Solanum nigrum polysaccharide and Solanum nigrum total alkaloid extract and combinations thereof |
Citations (1)
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| CN1233473A (en) * | 1999-04-05 | 1999-11-03 | 李滋星 | Medicinal prepn. beverage contg. scorpion juice |
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2012
- 2012-11-07 CN CN2012104427632A patent/CN102961499A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1233473A (en) * | 1999-04-05 | 1999-11-03 | 李滋星 | Medicinal prepn. beverage contg. scorpion juice |
Non-Patent Citations (3)
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| 国家中医药管理局《中华本草》编委会: "《中华本草 维吾尔药卷》", 28 February 2005, 上海科学技术出版社 * |
| 曹熙敏等: "野生龙葵的开发利用研究进展", 《广东农业科学》 * |
| 黄华等: "龙葵开发研究新进展及应用", 《食品工业科技》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877147A (en) * | 2012-12-19 | 2014-06-25 | 中国医学科学院药用植物研究所 | Method for processing fructus sophorae with honey |
| CN107260685A (en) * | 2017-06-02 | 2017-10-20 | 神威药业集团有限公司 | A kind of preparation method of Solanum nigrum granule |
| CN107260685B (en) * | 2017-06-02 | 2020-11-24 | 神威药业集团有限公司 | Preparation method of solanum nigrum fruit formula granules |
| CN107397227A (en) * | 2017-08-28 | 2017-11-28 | 张锦超 | A kind of Solanum nigrum polysaccharide and Solanum nigrum total alkaloid extract and combinations thereof |
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Application publication date: 20130313 |