CN104352995A - 一种治疗胆结石的药物及其制备方法 - Google Patents

一种治疗胆结石的药物及其制备方法 Download PDF

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CN104352995A
CN104352995A CN201410703685.6A CN201410703685A CN104352995A CN 104352995 A CN104352995 A CN 104352995A CN 201410703685 A CN201410703685 A CN 201410703685A CN 104352995 A CN104352995 A CN 104352995A
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李坤
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李坤
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

本发明公开了一种治疗胆结石的药物及其制备方法,其主要是由茵陈蒿、金钱草、蒲公英、通草、郁金、鸡内金、山楂、水牛角、柴胡、香附、丹参、枳壳、川楝子按一定重量配比制备而成,本发明药物具有清热解毒,利尿散结的功效,用于治疗胆结石疗程短,见效快,无毒副作用。

Description

一种治疗胆结石的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗胆结石的药物及其制备方法,属中药领域。
背景技术
[0002] 胆结石主要见于成人,女性多于男性,40岁后发病率随年龄增长而增高。结石为胆 固醇结石或以胆固醇为主的混合性结石和黑色胆色素结石。胆结石与多种因素有关。任何 影响胆固醇与胆汁酸浓度比例改变和造成胆汁淤滞的因素都能导致结石形成。目前,西药 治疗胆结石效果不佳,而长期服用西药有较多副作用,因此,人们对快速有效治疗胆结石的 中药存在很大的需求。
发明内容
[0003] 本发明人经过反复的研究及临床的试验和验证,终于找到了有效治疗胆结石的药 物,从而完成了本发明。
[0004] 本发明的目的就是提供一种能够有效治疗胆结石的组合药物。
[0005] 本发明的另一个目的就是提供了该组合药物的制备方法。
[0006] 本发明药物是选用茵陈蒿、金钱草、蒲公英、通草、郁金、鸡内金、山楂、水牛角、柴 胡、香附、丹参、枳壳、川楝子、黄芪、海螵蛸、白芍、乌梅、大黄、麦门冬、甘草药物进行组合 的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗胆结石的复发。其 中选用茵陈蒿是因为其性味苦辛,凉,入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小 便不利,风痒疮疥。选用金钱草是因为其性味苦辛,凉,有清热,利尿,镇咳,消肿,解毒的功 能,治黄疸,水肿,膀胱结石,疟疾,肺痈,咳嗽,吐血,淋浊,带下,风湿痹痛,小儿疳积,惊癎, 痈肿,疮癣,湿疹。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的 功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急 性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用通草是因为其性味甘淡,凉,入肺、胃经,有 泻肺,利小便,下乳汁的功能,治小便不利,淋病,水肿,产妇乳汁不通,目昏,鼻塞。选用郁金 是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失 心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用鸡内金是因为其性味甘, 平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉 痹乳蛾,牙疳口疮。选用山楂是因为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血, 驱绦虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不 尽,小儿乳食停滞。选用水牛角是因为其性味苦咸,寒,有清热、凉血、解毒的功能,治热病头 痛,壮热神昏,斑疹,吐衄,小儿^(风,喉痹咽肿。选用柴胡是因为其性味苦,凉,入肝、胆经, 有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱 肛,月经不调,子宫下垂。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁, 止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选 用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心 绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿 毒。选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行痰,消积的功能,治胸膈痰 滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用川楝子是因为其性味苦, 寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛, 虫积腹痛。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒, 生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳 倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用海螵蛸是因为其性味咸,微 温,入肝、肾经,有除湿,制酸,止血,敛疮的功能,治胃痛吞酸,吐、衄、呕血,便血,崩漏带下, 血枯经闭,腹痛癥瘕,虚疟泻痢,阴蚀烂疮。选用白芍是因为其性味苦酸,凉,入肝、脾经,有 养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月 经不调,崩漏,带下。选用乌梅是因为其性味酸,温,入肝,脾,肺,大肠经,有收敛生津,安蛔 驱虫的功能,治久咳,虚热烦渴,久疟,痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫病,牛皮 癣,胬肉。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功 能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫, 暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用麦门冬是因为 其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐 血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用甘草是因为其性味甘 平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛 便溏,劳倦发热,肺痿咳嗽,心t季,惊痈,生用治咽喉肿痛,消化性溃瘍,痈疽疮瘍,解药毒及 食物中毒。
[0007] 本发明组合的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好疗效: 茵陈蒿 25-30克 金钱草 25-30克 蒲公英 25-30克 通草 15-20克 郁金 15-20克 鸡内金 15-20克 山楂 15-20克 水牛角 15-20克 柴胡 10-15克 香附 10-15克 丹参 10-15克 枳壳 10-15克 川楝子 10-15克 黄芪 10-15克 海螵蛸 10-15克 白芍 10-15克 乌梅 3-5克 大黄3-5克 麦门冬 3-5克 甘草3-5克 优选用量为: 茵陈蒿 27克 金钱草 27克 蒲公英 27克 通草 17克 郁金17克 鸡内金 17克 山楂 17克 水牛角 17克 柴胡13克 香附 13克 丹参13克 枳壳13克 川楝子 13克 黄芪13克 海螵蛸 13克 白芍 13克 乌梅4克 大黄4克 麦门冬 4克 甘草4克 本发明药物的制备方法如下: 一、备料 1、 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥屑; 2、 金钱草:拣净杂质,筛去灰屑,晒干; 3、 蒲公英:拣去杂质,洗净泥土,切段,晒干; 4、 通草:拣去杂质,切片; 5、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 6、 鸡内金:拣去杂质,漂净晒干; 7、 山楂:拣净杂质,筛去核; 8、 水牛角:劈开,用热水浸泡,捞出,镑片,晒干; 9、 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; 10、 香附:拣去杂质,碾成碎粒,簸去细毛及细末; 11、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 12、 枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干; 13、 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; 14、 黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切 片,晒干; 15、 海螵蛸:刷洗干净,晒干,砸成小块; 16、 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒瞭,切片,干燥; 17、 乌梅:拣净杂质,筛去灰屑,洗净,晒干; 18、 大黄:取切成小块的生大黄,用黄酒拌匀,放蒸笼内蒸制,或置罐内密封,坐水锅中, 隔水蒸透,取出晒干,大黄块100斤,用黄酒40斤; 19、 麦门冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 20、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干。
[0008] 二、制备 1、将所述重量的茵陈蒿、金钱草、蒲公英、通草、郁金、鸡内金、山楂、水牛角、柴胡、香 附、丹参、枳壳、川楝子、黄芪、海螵蛸、白芍、乌梅、大黄、麦门冬、甘草药物加8倍量水进行 浸泡,浸泡60分钟后,武火煎煮沸腾10分钟,再用文火煎煮30分钟过滤得第一次煎煮液倒 入容器内。
[0009] 2、将过滤的药渣加水6倍量,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第二次 煎煮液。
[0010] 3、将两次煎煮液混合,即得药液,将药液分为4剂服用。
[0011] 本发明选用蒲公英为君药,柴胡、通草为臣药,丹参为佐,甘草为使,将上述药物与 诸药组合制成治疗胆结石的药物。
[0012] 本发明药物具有清热解毒,泄瘀清火,利尿散结的功效,用于治疗胆结石,疗程短、 见效快、治愈后不复发、无毒副作用。
[0013]
具体实施方式: 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括了本发明 药物的动物毒性试验报告和临床观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0 - 2. 5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不 良毒副作用。
[0015] [试验例2]本发明药物治疗胆结石的临床观察资料: 1、一般资料 收治门诊患者共36例。
[0016] 2、诊断标准 疾病症状: 病人常在饱餐、进食油腻食物后或睡眠中体位改变时,由于胆囊收缩或结石移位加上 迷走神经兴奋,结石嵌顿在胆囊壶腹部或颈部,胆囊排空受阻,胆囊内压力升高,胆囊强力 收缩而引起绞痛。疼痛位于右上腹或上腹部,呈阵发性,或者持续疼痛阵发性加剧,可向右 肩胛部和背部放射,可伴恶心、呕吐。部分病人因痛剧而不能准确说出疼痛部位。首次胆绞 痛出现后,约70%的病人一年内会复发。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续 服用3个疗程。
[0018] 4、疗效评定标准 显效:胆结石症状消失,体质恢复正常,观察半年无复发者; 好转:胆结石症状明显好转,疼痛发作期延长,发作时疼痛症状减轻; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN104352995AD00071
在上述的治疗中,用本发明药物治疗胆结石患者36例,结果显效28例,显效率为 77. 78%,好转6例,好转率为16. 67%,无效2例,总有效率为94. 45%。

Claims (3)

1. 一种治疗胆结石的药物,其特征求在于:它是由下列重量范围内的原料药制成: 茵陈蒿25-30克 金钱草25-30克 蒲公英25-30克 通草15-20克 郁金 15-20克 鸡内金 15-20克 山楂15-20克 水牛角 15-20克 柴胡 10-15克 香附10-15克 丹参10-15克 枳壳10-15克 川楝子10-15克 黄芪10-15克 海螵蛸10-15克 白芍10-15克 乌梅3-5克 大黄3-5克 麦门冬3-5克 甘草3-5克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 茵陈蒿27克 金钱草27克 蒲公英27克 通草17克 郁金17克 鸡内金17克 山楂17克 水牛角17克 柴胡13克 香附13克 丹参13克 枳壳13克 川楝子13克 黄芪13克 海螵蛸13克 白芍13克 乌梅4克 大黄4克 麦门冬4克 甘草4克。
3. 根据权利要求1或2所述药物的制备方法,其特征在于:它包括下列步骤: 一、备料 1、 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥屑; 2、 金钱草:拣净杂质,筛去灰屑,晒干; 3、 蒲公英:拣去杂质,洗净泥土,切段,晒干; 4、 通草:拣去杂质,切片; 5、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 6、 鸡内金:拣去杂质,漂净晒干; 7、 山楂:拣净杂质,筛去核; 8、 水牛角:劈开,用热水浸泡,捞出,镑片,晒干; 9、 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; 10、 香附:拣去杂质,碾成碎粒,簸去细毛及细末; 11、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 12、 枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干; 13、 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; 14、 黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切 片,晒干; 15、 海螵蛸:刷洗干净,晒干,砸成小块; 16、 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒瞭,切片,干燥; 17、 乌梅:拣净杂质,筛去灰屑,洗净,晒干; 18、 大黄:取切成小块的生大黄,用黄酒拌匀,放蒸笼内蒸制,或置罐内密封,坐水锅中, 隔水蒸透,取出晒干,大黄块100斤,用黄酒40斤; 19、 麦门冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 20、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 二、制备 1、 将所述重量的茵陈蒿、金钱草、蒲公英、通草、郁金、鸡内金、山楂、水牛角、柴胡、香 附、丹参、枳壳、川楝子、黄芪、海螵蛸、白芍、乌梅、大黄、麦门冬、甘草药物加8倍量水进行 浸泡,浸泡60分钟后,武火煎煮沸腾10分钟,再用文火煎煮30分钟过滤得第一次煎煮液倒 入容器内, 2、 将过滤的药渣加水6倍量,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第二次煎煮 液, 3、 将两次煎煮液混合,即得药液。
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