CN104338054A - Traditional Chinese medicine composition containing pandan leaves for treating gout - Google Patents
Traditional Chinese medicine composition containing pandan leaves for treating gout Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition, and particularly relates to a traditional Chinese medicine composition containing pandan leaves for treating gout, which belongs to the technical field of medicines. The traditional Chinese medicine composition for treating gout is prepared from the following medicinal raw materials in parts by weight: 5 to 22 parts of salvia miltiorrhiza, 3 to 10 parts of pawpaw, 2 to 9 parts of trigone, 2 to 9 pats of trident maple, 5 to 15 parts of radix angelicae pubescentis, 1 to 5 parts of cicada slough and 1 to 5 parts of pandan leaf. According to the traditional Chinese medicine composition for treating gout, after the seven medicinal raw materials are proportionally combined, the traditional Chinese medicine composition for treating gout has a synergy function and has an obvious curative effect on treating gout, and obvious side effects and untoward effects are not found.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of the treatment gout containing Pandan Leaves, belong to medical art.
Background technology
Gout is also known as hyperuricemia, and sickness rate is high, healing is difficult, recurrent exerbation, belongs to the metabolic disease that disorders of purine metabolism causes.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker, the gouty acute arthritis recurrent exerbation that its clinical characters is hyperuricemia and causes thus, tophaceous deposition, tophaceous chronic arthritis and joint deformity etc., dumb for main clinical manifestation with redness and swelling of joints, burning pain, recurrent exerbation, joint motion.Often involving kidney causes chronic interstitial nephritis and uric acid kidney stones to be formed.Increase reason according to uric acid in blood and can be divided into constitutional and the large class of Secondary cases two.The cause of disease of primary gout is caused by congenital purine metabolic disturbance, belongs to heritability.The cause of disease of secondary gout, can be caused by many reasons such as nephropathy, leukemia, medicine, foods, be apt to occur in male and menopausal woman.
The Western medicine being used for the treatment of gout at present mainly contains: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only stablize the state of an illness mostly, gout can not be effected a radical cure; Serious side effect also can be caused to cause the infringement of hepatic and renal function; Even if Emergent therapy effectively can not recur by symptom management, and drug resistance and repellence can be produced, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes.
In Chinese medicine, gout belongs to " arthromyodynia " category, " treatise on blood trouble ": " gout, general numbness and hypoesthesia, limbs pain, modern name gout, Gu say arthromyodynia ".Increasing expert thinks, from the organic conception of the traditional Chinese medical science, treats with Chinese medicine integral syndrome differentiation, the good footpath of another bar for the treatment of gout of can yet be regarded as; Not only the toxic and side effects of Chinese medicine itself is little, and can reduce Western medicine dose, overcomes the huge toxic and side effects taken merely Western medicine for a long time and bring.
Summary of the invention
To the object of the invention is to overcome in prior art existing Western medicine side effect large, treat halfway above-mentioned deficiency, a kind of Chinese medicine composition of the treatment gout containing Pandan Leaves is provided, this traditional Chinese medicine composition for treating gout good effect, instant effect, and little to patient body side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a Chinese medicine composition for the treatment gout of Pandan Leaves, it is prepared from by the medicinal raw material of following weight proportion: Radix Salviae Miltiorrhizae 5 ~ 22 parts, Fructus Chaenomelis 3 ~ 10 parts, Rhizoma Sparganii 2 ~ 9 parts, Acer buergerianum Miq． 2 ~ 9 parts, Radix Angelicae Pubescentis 5 ~ 15 parts, Periostracum Cicadae 1 ~ 5 part, Pandan Leaves 1 ~ 5 part.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Radix Salviae Miltiorrhizae is 8 ~ 16 parts.Preferred, part by weight shared by Radix Salviae Miltiorrhizae is 12 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Fructus Chaenomelis is 4 ~ 7 parts.Preferred, part by weight shared by Fructus Chaenomelis is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Rhizoma Sparganii is 4 ~ 7 parts.Preferred, part by weight shared by Rhizoma Sparganii is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Acer buergerianum Miq． is 4 ~ 7 parts.Preferred, part by weight shared by Acer buergerianum Miq． is 6 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Radix Angelicae Pubescentis is 7 ~ 12 parts.Preferred, part by weight shared by Radix Angelicae Pubescentis is 9 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Periostracum Cicadae is 2 ~ 4 parts.Preferred, part by weight shared by Periostracum Cicadae is 3 parts.
Preferably, in above-mentioned medicinal raw material proportioning, part by weight shared by Pandan Leaves is 2 ~ 4 parts.Preferred, part by weight shared by Pandan Leaves is 3 parts.
The Chinese medicine composition for the treatment of gout of the present invention, the active component of medicinal raw material can be extracted according to extracting method conventional on Chinese materia medica, add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
The extracting method of Chinese medicine composition of the present invention can adopt but be not limited to following methods:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is condensed into extractum, dry, obtain the extract of medicinal raw material of the present invention.
(2) in above-mentioned extract, add pharmaceutic adjuvant and be mixed and made into acceptable various pharmaceutical dosage form on pharmaceutics.
According to the needs of the various drug form of preparation, medicine of the present invention also can add suitable pharmaceutic adjuvant as filler, disintegrating agent, binding agent, lubricant, antiseptic etc. in preparation process.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of gout, be inventor based on the pathogenetic understanding of motherland's medical science to gout, according to oneself clinical experience for many years, first from numerous Chinese medicine, determine the effective Chinese medicine of a series for the treatment of gouts, repeatedly verify through clinical again, screen.Wherein, Radix Salviae Miltiorrhizae, has another name called Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, Arisaema balansae Engl. etc.; For the dry root and rhizome of labiate Radix Salviae Miltiorrhizae; Bitter in the mouth, cold nature; GUIXIN, Liver Channel; There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire; For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Fructus Chaenomelis, another name chaenomeles lagenaria, iron pin pear, wrinkled papaya, Fructus Chaenomelis are the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria; Acid, temperature; Return liver, spleen channel; There is effect of suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness; For diseases such as arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion, the beriberi edema of vomiting and diarrhoea.Rhizoma Sparganii is the dry tuber of Sparganiaceae plant rhizoma scirpi; Pungent, bitter, flat; Return liver, spleen channel; There is effect of removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving; For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, the diseases such as food stagnation distending pain.Acer buergerianum Miq．, Chinese medicine name Illicium micranthum maple, another name Radix Euphorbiae, pseudo-Radix Alangii, narrow leaf Radix Alangii; For root, the leaf of Alangiaceae plant Illicium micranthum maple; Acrid in the mouth, hardship; Slightly warm in nature; Return liver, stomach warp; There is effect of expelling wind and removing dampness, promoting blood circulation and stopping pain; The diseases such as main air pain of dampness syndrome, gastric abscess, traumatic injury.Radix Angelicae Pubescentis, calls fragrant Radix Angelicae Pubescentis, meat Radix Angelicae Pubescentis, RADIX ANGELICAE PUBESCENTIS from Sichuan of China, money mound Radix Angelicae Pubescentis; For the dry root of samphire Angelica pubescens; Acrid in the mouth, hardship, slightly warm in nature; Return kidney, urinary bladder channel; There is effect of expelling wind and removing dampness, numbness relieving and pain relieving; For anemofrigid-damp arthralgia, lumbocrural pain, the diseases such as few cloudy volt wind headache.Periostracum Cicadae, another name Cicadae move back, Periostracum Cicadae, larval moult, Cicadae shell, Zha Liao skin, cicada skin, Taurus etc.; Exuviae shell when larva for cicada Cryptotympana atrata Fabr. sprouts wings; Sweet in the mouth, cold in nature; Return lung, Liver Channel; There is loose wind heat extraction, sore-throat relieving, rash, nebula removing, the effects such as spasmolytic; For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, the diseases such as tetanus.Pandan Leaves, another name Pandan Leaves, bright-colored leaf, be called again seven aspidistra leaves; A kind of tropical green plants, very general in Malaysia, be usually used in and cook; It has a kind of very unique natural aromatic taste, and food can be allowed to increase pure and fresh, fragrant and sweet taste; Melancholia can be treated; Its juice is green Organic substance, is rich in antioxidant content, relieves summer heat, refrigerantly to reduce internal heat, calm the nerves, effect of calm and relaxing muscles and tendons and activating QI and blood in the collateral.Above-mentioned 7 taste Chinese herbal medicine, flavour of a drug are few but function is complete, 7 taste medicinal raw materials are by after described proportioning combination, treatment gout has Synergistic function, and through clinical research test, Chinese medicine composition of the present invention is used for the treatment of gout short treating period, instant effect, administration is after 4 days, can take effect, and evident in efficacy, there is not obvious adverse reaction during patient consumes.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, and all technology realized based on content of the present invention all belong to scope of the present invention.
In embodiments of the invention and comparative example, ethanol used is the aqueous solution of ethanol, and the percentage composition of ethanol, if no special instructions, is volumn concentration.
Embodiment 1
The Chinese medicine composition of the treatment gout of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Salviae Miltiorrhizae 12g, Fructus Chaenomelis 6g, Rhizoma Sparganii 6g, Acer buergerianum Miq． 6g, Radix Angelicae Pubescentis 9g, Periostracum Cicadae 3g, Pandan Leaves 3g.
The extracting method of above-mentioned medicinal raw material:
(1) get each medicinal raw material by formula proportion, in medicinal raw material, add 60 ~ 80% ethanol or the water of medicinal raw material volume 8 ~ 10 times; Reflux, extract, 2 ~ 3 times; Extraction time is respectively 1 ~ 2h; Collect merge extractive liquid, and extracting solution is concentrated into relative density 1.20 (80 DEG C), obtain the extract of embodiment 1 medicinal raw material.
(2) in above-mentioned extract, add the soluble starch of extract weight 2 times of weight, granulate, dry, be distributed into bag, obtain granule.
Embodiment 2
The Chinese medicine composition of the treatment gout of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Salviae Miltiorrhizae 5g, Fructus Chaenomelis 10g, Rhizoma Sparganii 2g, Acer buergerianum Miq． 9g, Radix Angelicae Pubescentis 5g, Periostracum Cicadae 5g, Pandan Leaves 1g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 2 treats gout.
Embodiment 3
The Chinese medicine composition of the treatment gout of the present embodiment is be prepared from by the medicinal raw material of following weight proportion: Radix Salviae Miltiorrhizae 14g, Fructus Chaenomelis 5g, Rhizoma Sparganii 5g, Acer buergerianum Miq． 7g, Radix Angelicae Pubescentis 8g, Periostracum Cicadae 2g, Pandan Leaves 3g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition that embodiment 3 treats gout.
Comparative example
The Chinese medicine composition of the treatment gout of this comparative example is be prepared from by the medicinal raw material of following weight proportion: Radix Salviae Miltiorrhizae 12g, Fructus Chaenomelis 6g, Rhizoma Sparganii 6g, Acer buergerianum Miq． 6g, Radix Angelicae Pubescentis 9g, Periostracum Cicadae 3g.
Extract the active component of medicinal raw material by medicinal raw material extracting method in embodiment 1, obtain the Chinese medicine composition of comparative example treatment gout.
Pharmacodynamics and toxicity test:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to the Chinese medicine composition of embodiment 1 prepared by embodiment 1;
According to the Chinese medicine composition of comparative example prepared by comparative example;
Colchicine: be Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
2, test method and result
(1) on the impact of hyperuricemia Mouse Blood uric acid level
Get Kunming mouse 50, male and female are use all, and body weight 18 ~ 22g is divided into five groups at random, often organize 10, first group is normal saline group, and second group is drug study group of the present invention (8g raw medicinal herbs/kg), 3rd group is positive controls, and the 4th group is matched group 1, and the 5th group is model group.
Normal saline is gavaged by the dosage of 8g/kg to first group, second group gavages the Chinese medicine composition of the embodiment of the present invention 1 preparation by the dosage of 8g raw medicinal herbs/kg, 3rd group gavages colchicine by the drug dose of 0.1mg/kg, 4th group gavages Chinese medicine composition prepared by comparative example by the dosage of 8g raw medicinal herbs/kg, do not do any process for 5th group, every day 1 time, continuous 4 days.
After last administration 1h, except normal saline group, all the other each group, namely second group to the 5th group, animal Intraperitoneal injection of hypoxanthine 1mg/kg, causes mice hyperuricemia, and normal saline group presses 1mg/kg injecting normal saline.0.5h after injection, plucks eyeball to each treated animal and gets blood, and the blood obtained after centrifugal 15min, is got serum and surveyed Level of Serum Uric Acid under the speed conditions of 3000r/min.Table 1 be each experimental group and matched group after treatment, the statistical result of blood uric acid measured value.
Table 1
Note: compare with model group:
*p<0.01; Compare with matched group 1:
▲ ▲p<0.01.
In table 1, it is 158 ± 45umol/l that drug study group of the present invention records Level of Serum Uric Acid: close with the Level of Serum Uric Acid 122 ± 36umol/l of normal saline group and the Level of Serum Uric Acid 144 ± 53umol/l of positive controls; Level of Serum Uric Acid 736 ± 95umol/l that relative model group records reduces about 580umol/l, and the statistical result of drug study group of the present invention is relative to model group P<0.01, has significant difference; The traditional Chinese medicine composition for treating gout that the present invention treats gout has good curative effect.
And in table 1, it is 233 ± 51umol/l that matched group 1 records Level of Serum Uric Acid, relative drug study group of the present invention records Level of Serum Uric Acid 158 ± 45umol/l and exceeds about 75umol/l.And the blood uric acid measured value of drug study group of the present invention is compared with the blood uric acid measured value P < 0.01 of matched group 1, has significant difference.Learn thus, 7 taste medicinal raw materials are by after described weight proportion combination, and have Synergistic function, can significantly improve the curative effect of Chinese medicine composition, lack any component, the curative effect of Chinese medicine composition all significantly declines.
In sum, the present invention treats the Chinese medicine composition of gout, and the short treating period for the treatment of gout, instant effect, administration can take effect for 4 days, evident in efficacy.Administration injected hypoxanthine after 4 days, and the blood uric acid measured value of drug study group of the present invention all can not occur significantly to raise phenomenon; 7 taste medicinal raw materials, by after described weight proportion combination, have Synergistic function, can significantly improve the curative effect of Chinese medicine composition.Lack any component, its curative effect all significantly declines, and as matched group 1, after injection hypoxanthine, the blood uric acid measured value recording the relative drug study group of the present invention of Level of Serum Uric Acid exceeds about 75umol/l.
Claims (10)
1., containing a Chinese medicine composition for the treatment gout of Pandan Leaves, it is characterized in that: it is prepared from by the medicinal raw material of following weight proportion: Radix Salviae Miltiorrhizae 5 ~ 22 parts, Fructus Chaenomelis 3 ~ 10 parts, Rhizoma Sparganii 2 ~ 9 parts, Acer buergerianum Miq． 2 ~ 9 parts, Radix Angelicae Pubescentis 5 ~ 15 parts, Periostracum Cicadae 1 ~ 5 part, Pandan Leaves 1 ~ 5 part.
2. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Radix Salviae Miltiorrhizae is 8 ~ 16 parts.
3. the Chinese medicine composition for the treatment of gout according to claim 2, is characterized in that: part by weight shared by Radix Salviae Miltiorrhizae is 12 parts.
4. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Fructus Chaenomelis is 4 ~ 7 parts.
5. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Rhizoma Sparganii is 4 ~ 7 parts.
6. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Acer buergerianum Miq． is 4 ~ 7 parts.
7. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Radix Angelicae Pubescentis is 7 ~ 12 parts.
8. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Periostracum Cicadae is 2 ~ 4 parts.
9. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: part by weight shared by Pandan Leaves is 2 ~ 4 parts.
10. the Chinese medicine composition for the treatment of gout according to claim 9, is characterized in that: part by weight shared by Pandan Leaves is 3 parts.
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| CN101549098A (en) * | 2008-03-31 | 2009-10-07 | 陈国华 | Pandan leaf extract for treating gout and preparation method thereof |
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| 旷惠桃等: "《中医本草疗法（珍藏本）超值版》", 31 August 2012, 湖南科学技术出版社 * |
| 王茂泓: "《痛风效验秘方》", 31 January 2014, 中国医药科技出版社 * |
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