CN101549098A - Pandan leaf extract for treating gout and preparation method thereof - Google Patents
Pandan leaf extract for treating gout and preparation method thereof Download PDFInfo
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- CN101549098A CN101549098A CNA2008100664083A CN200810066408A CN101549098A CN 101549098 A CN101549098 A CN 101549098A CN A2008100664083 A CNA2008100664083 A CN A2008100664083A CN 200810066408 A CN200810066408 A CN 200810066408A CN 101549098 A CN101549098 A CN 101549098A
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Abstract
The invention discloses a pandan leaf extract for treating gout and a preparation method thereof. The pandan leaf extract is prepared by taking pandan leaves as raw material, extracting the pandan leaves by polar solvent and concentrating and refining the extract. The preparation method comprises the following steps: the bandan leaves are decorated and extracted by taking alkaline ionized water as solvent, and the extract is obtained by filtering and concentrating. The invention provides the pandan leaf extract which has good treatment effect and is safer in treating gout. The pandan leaf extract can relieve or even eliminate gout symptoms and is applied for preventing and treating gout. The preparation method has simple process and low cost.
Description
Technical field
The present invention relates to a kind of plant extract that is used for the treatment of gout and preparation method thereof, relate in particular to a kind of Pandan leaf extract that is used for the treatment of gout and preparation method thereof.
Background technology
Gout is a kind of common arthritis disease, the cause of disease is because personal intravital purine (Purine)---planting the uric acid material can't smooth and easy metabolism, make the interior uric acid of blood too high, uric acid reaches to saturated level in blood, just can form metabolic arthritis salt acicular crystals, be deposited in intraarticular or the tendon, as parts of body such as toe and finger-joint, knee, muscle aponeurosis (aponeuroses) or subcutaneous tissue.Urate accumulates in intraarticular and causes inflammation and pain, serious gout can make the joint become lopsided.Except that the joint, excessive urate also may accumulate in other positions of health, and for example kidney, heart etc. are located, and can cause nephropathy, coronary heart disease, may cause renal failure, heart disease, apoplexy etc. when serious.The diagnosis gout can be made a definite diagnosis by the content that detects uric acid in the blood, uric acid content in the normal human blood should be at 3.6mg/dl (about 214 μ mol/l)～8.3mg/dl (about 494 μ mol/l), the uric acid saturation solubility is about 6.4mg/dl, the uric acid level that draws via blood test is in case surpass 7mg/dl when above, just can be diagnosed as hyperuricemia, must regularly be checked and be measured.If surpass 8mg/dl, will accept Drug therapy.
The kind of treatment gout medicine can be divided into acute and chronic two kinds:
(1) acute gout disease drug: can alleviate acute joint pain Chu rapidly, it is normal that joint motion is replied.For example on-steroidal anti-inflammation analgesic (NSAID) and colchicine (Colchicine) etc.
(2) chronic gout disease drug: can prevent the gout outbreak.A kind of medicine that suppresses the uric acid generation is " uric acid synthesizes Inhibitors ", and another kind of medicine is " uricosuric drug " that impels uric acid to discharge from kidney.Medicine commonly used has probenecid (Probenecid) and allopurinol (Allopurinol) etc.
These on-steroidals commonly used are anti-inflammatory analgesic, synthetic Inhibitors of uric acid and uricosuric drug, but mitigate the disease after though the patient takes, but all can not effect a radical cure gout, also has toxic and side effects in various degree, can cause dependence as taking anti-inflammatory and analgesic agents for a long time, also can cause gastrointestinal upset, hemolytic anemia, gastrorrhagia, so that liver and renal failure etc., anti-uric acid medicine is only to suppressing the synthetic Inhibitors of uric acid that uric acid produces, another kind is the uricosuric drug that impels uric acid to discharge, the two does not all have analgesia, antiinflammation, thus invalid to acute gout, also may have erythra, headache and the reaction of some intestines and stomaches, therefore, the use of these medicines is restricted.
Summary of the invention
The technical problem to be solved in the present invention is, the Pandan leaf extract that is used for the treatment of gout that a kind of therapeutic effect is good, safer, have no side effect is provided, and this extract can alleviate even eliminate the gout symptom, is used for prevention and treatment gout.
The technical problem that the present invention further will solve is, the preparation method of the Pandan leaf extract that a kind of technology is simple, cost is low is provided.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Pandan leaf extract that is used for the treatment of gout is a raw material with the BANLANYE, extracts the back with polar solvent and concentrates the refining extract that obtains.
Described polar solvent is an alkali ion water.
Described extract is to be that 8～9.5 alkali ion water decocts BANLANYE and extracts the extract that obtains by pH value, described extract adopts silica gel g thin-layer plate to carry out chromatography according to thin layer chromatography after filtration, wherein using volume ratio is that 4: 1: 1 butanols, the mixed solvent of second alcohol and water are done developing solvent, chromatography is placed under the ultra-violet lamp and inspects, and active component has the Rf value in 0.29-0.35,0.40-0.44 or the 0.79-0.83 scope in the extract.
The preparation method that is used for the treatment of the Pandan leaf extract of gout is to be raw material with the BANLANYE, obtains Pandan leaf extract after extracting with the polar solvent decoction.
The preparation method that is used for the treatment of the Pandan leaf extract of gout is a BANLANYE alkali ion water as solvent, decocts to extract, and filtering and concentrating obtains extract.
The preparation method that is used for the treatment of the Pandan leaf extract of gout is that the alkali ion water that is taken at the formation of brine electrolysis negative pole decocts extraction to BANLANYE, and filtering and concentrating obtains extract.
The preparation method that is used for the treatment of the Pandan leaf extract of gout, preferred following steps: select for use to do to add alkali ion water after BANLANYE is pulverized and soak 30min～3 hour, heating decocted 1～3 hour then, perhaps selected bright BANLANYE soaking-free for use, direct heating decocted 1～3 hour, filter, filtering residue adds alkali ion water once more, decocts 30min～1 hour, filter, merge filtrate twice, heating be concentrated into total liquid measure 25%～75% after, cooling, sterilization encapsulation.
The preparation method that is used for the treatment of the Pandan leaf extract of gout, following steps most preferably: select for use and do the alkali ion water that adds 3～5 times of medical material weight after BANLANYE is pulverized and soak 30min～1 hour, select then soaking-free of bright BANLANYE for use, being heated to 80-100 ℃ then decocted 1～1.5 hour, filter, the alkali ion water that filtering residue adds 1～1.5 times of medical material weight once more is heated to 80-100 ℃ and decocts 30min～1 hour, merge filtrate twice, heating be concentrated into total liquid measure 25%～50% after, cooling, sterilization encapsulation.
The pH value of described alkali ion water is 8～9.5.
The dosage form for preparing of extract of the present invention is not limited to the described dosage form of above-mentioned method, extract of the present invention can also be added different auxiliary material, as disintegrating agent, lubricant, binding agent, cosolvent etc., and be prepared into any common formulations with the traditional pharmaceutical methods of routine.The present invention can also make medicine or health composition with many suitable medicines known in the art or health care carrier.Utilize commercial size production of the present invention, above-described raw material is decocted, after filtration, concentrate, add different auxiliary material again, make multi-form liquid preparations such as mixture, syrup, Emulsion; Also these raw materials can be decocted, after filtration, concentrate, after the spray drying, add corresponding adjuvant again, make granule; Can also prepare with excipient, inserting capsule becomes capsule; Tablet forming is made tablet; Be dissolved in a kind of commercial applicable carrier as multi-form solid preparations such as pill, powder, drop pill; Also these raw materials can be extracted with the Spirit of variable concentrations and make medicated wine etc.
Natural plants BANLANYE (Latin title Pandanus latifolius, Pandanus amaryllifolius) claims Pandan Leaves again, is at the very general a kind of spice food materials of country in Southeast Asia, and especially utilization is the most extensive in the sweets group food.According to Flavor and Chemistry of Ethnic Foods (Proceedings of aMeeting held during the 5th Chemical Congress of North America], Cancun, Nov.11-15,1997 (1999) meeting and Phytochemistry, 34,1159,1993 and Phytochemistry, 21,1653-1657,1982.) secretary carries, and contains various active compositions such as piperine type alkaloid, vitamin, mineral, flavonoid, ferment, quintessence oil in the BANLANYE:
Wherein, (a) composition such as Piperidine-type alkaloids piperine type alkaloid, as pandamarine, pandamerilactones etc.;
(b) the compounds composition of effumability: as 3-methyl-2-(5H)-furanone, 3-hexanol, 4-methylpentanol, 3-hexanone and 2-hexanone etc.;
(c) the natural materials composition of fragrant: as 2-acetyl-1-pyrroline, ethyl formiate, styrene, β-farnesene, β-caryophyllene, formylthiphene, linalool, 1,2-dimethoxybenzeneand β-selinene etc.;
Because a lot of alkaloids, flavone etc. have the pharmacology to influence to people and other animals, extract of the present invention finds to dissolve more urate crystal body clinically excretes uric acid naturally, plays the uric acid reducing effect, regulates uric acid to normal range.Wherein, mainly be that piperine type alkaloids can make the dissolubility of uric acid in blood rise, make the dissolving of urate crystal body, reduce urate in tissue and IA deposition, thereby alleviate patient's misery, for light patient preventive effect is preferably arranged.
The present invention also finds to have diuretic actions clinically, increases the urine amount, promotes kidney that the uric acid of cylinder accumulation is excreted in urine as far as possible.Because uric acid absorbs a large amount of moisture originally as water-soluble substances, when the urine amount increases, urine will thin out, thereby reduces the concentration of blood plasma uric acid, reduces urate and deposits in tissue, therefore also excretion metabolism refuse simultaneously when urinating is the best diuretic that promotes that bodily tissue is sound.
The alkali ion water that the present invention adopts is exactly the alkaline water that negative pole produced after the electrolysis of water process.Wherein the water of that side of negative electrode is called " alkali ion water ", water is when electrolysis, under effect of electric field, water clusters is broken up, diminish, rearrange, making wherein, the ORP of a part of water (Oxidative redox potentia oxidation-reduction potential) is positive potential, another part water ORP is nagative potential, calcium in the water, potassium, magnesium, sodium ... wait cation to move to negative electrode, enrichment a large amount of mineral, especially ionized calcium, alkali ion water can in and acid poison in the body, change acidic physique, be micromolecular water: the micel of general water is about 13～16 micels, water clusters is contracted to 5～6 micels after electrolysis, and mineral is ionized, and dissolubility is big, penetration is strong, water clusters is very similar to the interior molecular structure water of body, easily participates in the mass exchange of cell, and the human absorptivity reaches more than 95%.More effectively the old refuse in scavenger cell and the blood enhances metabolism.
Alkali ion water can make the decline of uric acid concentration in the blood, and increases the dissolubility of urine uric acid, and auxiliary minimizing urate deposits in tissue.Its pH value of common people's urine is 5.5～6.0 faintly acid.Hyperuricemia patient mostly is the aciduria below 5.5.When health presented alkalescence, uric acid just was excreted than being easier to.If make body fluid be alkalescence for a long time, prevention of recurrence and alleviate gout early just.Drink the water of weak base degree, metabolic waste can be excreted, also can blood circulation promoting, make mineral Zhi such as sodium and potassium isoequilibrium between blood capillary and the cell, enhance metabolism useful whole body health.
When the mixed alkali ion water of Pandan leaf extract was drunk together, the active component in the extract and alkali ion water synergism can further promote the effect of effect uric acid resisting, regularly drink the uric acid concentration that can make in the blood and recover normally.Thereby the uric acid resisting that can effectively and have no side effect, prevention and alleviation gout.
After taking Pandan leaf extract of the present invention, have the effect of following several respects:
1. quicken to drain too much uric acid in the body, regulate uric acid to normal range;
2. improve the red and swollen situation in joint;
3. improve urate crystal and be deposited on intraarticular;
4. alleviate the pain of redness and swelling of joints;
5. shorten the time that gout continues.
Extract of the present invention belongs to natural, and the character gentleness not only is fit to treatment, no matter also be suitable for health preserving, health care, event deficiency of vital energy weak person, or take for a long time and also can not cause uncomfortable and the generation adverse side effect.Take once every day, if gout outbreak, can increase as many as early, take evening.Taking flow process and effect can be along with different human body structure and metabolism and different, generally takes just to begin to produce effect in four hours, takes continuously, and effect is remarkable.
The specific embodiment
In order further to set forth technical scheme of the present invention, now enumerate specific embodiment and be described as follows:
The BANLANYE of using so long as food use then without any restriction, the BANLANYE of using in the present embodiment is the BANLANYE of Thailand.
Embodiment 1:
Do the fresh alkali ion water that adds 4000ml after BANLANYE 1kg pulverizes, its PH is 9, soak 30min, being heated to 100 ℃ decocted 1.5 hours, filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 100 ℃ of decoctions 1 hour, merges filtrate twice, heating is concentrated into amount of filtrate behind 1000ml, and mixture is promptly made in cooling, sterilization, encapsulation.
The production of alkali ion water: general earlier with common tap water or mineral water purification, then by the positive and negative electrode electrolysis,, collect the fresh alkali ion water of negative electrode by the membrane separation technique separation, directly add decoction BANLANYE container and get final product.
Instructions of taking: every day 1～3 time, each 30～60ml also takes behind 3～5 times of the dilutable waters, and the person of being in a bad way takes the circumstances into consideration dosage.
Embodiment 2:
Bright BANLANYE 1kg adds the fresh alkali ion water of 3000ml, and its PH is 8.5, is heated to 80 ℃ and decocts 3 hours, filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 80 ℃ of decoction 30min, merges filtrate twice, heating is concentrated into amount of filtrate behind 1000ml, cools off standby; Then with the concentrated solution of extract with after supplementary product starch, sucrose and disintegrating agent mix, add with the plain derivative solution of water-soluble adhesive fiber and mix, employing extrusion granulator method is made soft grit with medicine; The reuse baking oven for heating is carried out dried to soft grit; Dry back forms the single-size of certain particle size by sieving, oversize is suitably pulverized the back after sieve, until making whole homogeneous granules, promptly makes granule, is distributed into the fractional pack of 10g one bag.
The production of alkali ion water does not repeat them here with embodiment 1.
Instructions of taking: every day 1～3 time, each 2～4 bags, the person of being in a bad way takes the circumstances into consideration dosage.
Embodiment 3:
Bright BANLANYE 1kg adds the fresh alkali ion water of 5000ml, its PH is 9.5, being heated to 90 ℃ decocted 2 hours, filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 80 ℃ of decoction 40min, merge filtrate twice, heating is concentrated into amount of filtrate behind 1000ml, cools off, cools off standby; Then with the concentrated solution of extract with after supplementary product starch, sucrose and disintegrating agent mix, add with water-soluble adhesive fiber element derivative solution and mix, make soft grit; The reuse oven drying is handled; Dry back forms the single-size of certain particle size by sieving, mixes with powdered filler, lubricant, bonding agent then, tabletting, be distributed into fractional pack then.
The production of alkali ion water does not repeat them here with embodiment 1.
Instructions of taking: every day 1～3 time, each 4～6, the person of being in a bad way takes the circumstances into consideration dosage.
Embodiment 4:
Do the fresh alkali ion water that BANLANYE 1kg adds 4000ml, its PH is 8, soaks 3 hours, is heated to 90 ℃ and decocts 1 hour, filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 100 ℃ of decoction 40min, merges filtrate twice, and heating is concentrated into amount of filtrate behind 1000ml, it is standby to cool off, sterilize, add then and adjust agent, make beverage, drink for the patient is daily.
The production of alkali ion water does not repeat them here with embodiment 1.
The extract of the embodiment of the invention 1 detects result such as following table through Hong Kong standard and calibrating center.
| Test event | Sample of the present invention | Illustrate notes ( *) |
| 1. antimony content | Do not have | The highest permission content: 1ppm |
| 2. arsenic content | Do not have | The highest permission content: 0.14ppm |
| 3. cadmium content | Do not have | The highest permission content: 0.1ppm |
| 4. chromium content | Do not have | The highest permission content: 1ppm |
| 5. lead content | Do not have | The highest permission content: 1ppm |
| 6. mercury content | Do not have | The highest permission content: 0.5ppm |
| 7. stannum content | Do not have | The highest permission content: 230ppm |
| 8. escherichia coli | ＜10CFU/g | A.＜20CFU/g be satisfied with degree b.20-＜100CFU/g represents can acceptance level c.＞100CFU/g meaning degree with thumb down. |
Annotate (
*): illustrated regulations see the Laws of Hong Kong's the one three two V chapter, subordinate list 2.
Test result shows that medicine of the present invention does not contain heavy metal and escherichia coli, and it is a kind of foolproof extract.
Clinical experiment
Medicine of the present invention wherein has acute gout 8 example and chronic gout 3 examples through the inventor and some volunteer's clinical experiments, drinks mixture of the present invention every day 1～3 time, and each 30～60ml takes March continuously～and 3 years.
| Case | There is not recurrence | Produce effects | Effectively | Invalid |
| Acute gout | 3 | 3 | 2 | 0 |
| Chronic gout | 0 | 2 | 1 | 0 |
Total effective rate of the present invention is 100%, produce effects and do not have the recurrence account for more than 70%.
Carry out labor with regard to three model cases below:
Case 1:
The man, 47 years old, office work was not smoked, and did not drink with not fat, and health one is to health.First outbreak is a late into the night several years ago, and is awake bitterly by right first metatarsophalangeal joints, and severe pain is as the sample that lancinates, and with red and swollen and scorching hot, the affected part articular sensation is stiff.This moment is any to be brushed up against wind and can make all that the pain increased.Pain peaked in 24 hours, was diagnosed as " acute pain syndrome caused by wind pathogen " through the doctor, after Drug therapy, slowed down pain, but timeliness one mistake, pain is still.After four days, redness fades away, and sole of the foot toe is replied normal.Afterwards in the course of disease, repeatedly in the outbreak at midnight, premorbid does not have any tendency, and site of pathological change also singly appears at finger-joint, ankle and knee endoprosthesis place, have extreme arthralgia and red and swollen symptom, but not whole body heating, headache, feel sick, malaise symptoms such as cardiopalmus, shiver with cold.Pain and red and swollen continuing after several days, the state of an illness is replied improvement again.
Through the initial stage that take extract of the present invention every day, during the gout acute attack, swelling is disappeared than very fast; Pain, redness and scorching hot also than slight and alleviation in the past, recurrent interval time has also prolonged several times.Chemical examination contrast before and after wherein taking, blood uric acid concentration is by the normal low value 0.28mmol/L that takes after preceding 0.38mmol/L drops to 2 years, all transference cures, Mental Health.
Case 2:
The woman, 73 years old now, the housewife, health one is to bad, suffers from gout surplus in the of 15 year, is diagnosed as " chronic gout and rheumatic arthritis " through how tame doctor, and wrist and finger-joint portion have formed tophus, more can't work, because of gout has caused inconvenient activity.Annual can the outbreak repeatedly, duration of symptoms prolongs, so that can not alleviate fully.And increase in the joint of getting involved, and experiences all sorts of and can not treat more, very painful.Pathological changes such as more serious urate nephropathy, uric acid lithangiuria fortunately do not take place.Take extract mixture of the present invention, blood uric acid concentration is dropped to normal value 0.31mmol/L taking more than a year by the 0.34mmol/L before taking, and all tophuses disappear, and hand activities is as usual, and health does not have discomfort, and spirit is rather good.
Case 3:
The woman, 65 years old now, the housewife, and often participate in community activity.Morning on June 12nd, 2006, first big toe pain was waken up with a start, and red and swollen heating can not be taken action anorexia.Emergency case doctor is diagnosed as " acute pain syndrome caused by wind pathogen " with metabolic arthritis 0.35mmol/L, with Drug therapy, slows down pain.In therapeutic process after being ill, the doctor uses the uric acid resisting medicine, but gastrointestinal symptom side effect such as nausea and vomiting, diarrhoea occur.Patient more worries to take for a long time and can increase the weight of renal insufficiency, influences other vitals of health.The medicine of the present invention of migrating, taking after 3～5 days does not have discomfort, and use does not have other side effect yet continuously, and is respond well.Follow up a case by regular visits to after half a year, blood uric acid is kept low level＜0.32mmol/L, and all are normal for patient's readme whole body, no abnormalities feel.
Table one: take preceding situation
| Case | The course of disease | Average recurrent interval time | The gout degree | Blood uric acid concentration normal value (man: 0.21-0.42) mmol/L (woman: 0.14-0.34) mmol/L |
| Man (47 years old) | 3.5 year | 1.5 individual month | Medium | 0.38mmol/L |
| Woman (73 years old) | 15 years | Two weeks | Seriously | 0.34mmol/L |
| Woman (65 years old) | 8 months | 1 month | Seriously | 0.35mmol/L |
Table two: take situation behind the extract of the present invention
| Case | Time of Administration | Average recurrent interval time | The gout degree | Blood uric acid concentration normal value (man: 0.21-0.42) mmol/L (woman: 0.14-0.34) mmol/L |
| Man (47 years old) | 2.3 year | 1.8 a year back does not have recurrence | Slightly | 0.28mmol/L |
| Woman (73 years old) | 1.6 year | 7 months | Slightly | 0.31mmol/l |
| Woman (65 years old) | 6 months | There is not recurrence | There is not any symptom | 0.32mmol/l |
Annotate 1: the gout degree is divided: " slightly " is meant that there is a little redness in the patient joint, just can disappear every other day." medium " expression patient arthralgia, but still freely movable." seriously " is meant patient's arthralgia, and be stiff.
Annotate 2: behind physical examination, major organs comprises that eight kinds of main organs such as the heart, liver, spleen, lung, kidney are normal.
Effective evaluation:
(1) extract of the present invention is significantly effective to goat, and joint function recovery is fast, can alleviate the inflammatory reaction that local uric acid deposition is caused, has alleviated pathology damage.
(2) thing of the present invention has diuresis, obviously increases at the voided volume of taking in 4 hours.
(3) take front and back patient's blood uric acid difference own control relatively, significant difference illustrates that extract of the present invention can have the effect of reduction blood uric acid in various degree.
(4) with take preceding comparison, each side all has improvement.Prolong 7～15 times before wherein each recurrent interval time is taken, effective percentage is 100%.
Above-mentioned case is by just effective uric acid resisting of oral approach, prevention and alleviate gout, its effectiveness can be the same with the anti-uric acid medicine of Western medicine, but in not having, the toxic and side effects of Western medicine occurs.Its principle is to nurse one's health uric acid to normal range, drains too much uric acid in the body, reduces urate crystal Shen and amasss at intraarticular, thereby alleviate patient's misery.
In sum, the present invention by oral just can the regulating body function uric acid resisting, prevention and alleviate gout, and its each composition is all from natural plants, and human body is not had any toxicity and side effect, meets the condition of patent of invention, now proposes application for a patent for invention in accordance with the law.The above only is preferred embodiment of the present invention, and the equivalence that every those of ordinary skill in the art do according to creation spirit of the present invention is modified or changed, and all should be encompassed in the application's the protection domain.
Claims (10)
1, a kind of Pandan leaf extract that is used for the treatment of gout is characterized in that, is raw material with the BANLANYE, extracts the back with polar solvent and concentrates the refining extract that obtains.
2, the Pandan leaf extract that is used for the treatment of gout according to claim 1 is characterized in that, described polar solvent is an alkali ion water.
3, the Pandan leaf extract that is used for the treatment of gout according to claim 2, it is characterized in that, described extract is to be that 8～9.5 alkali ion water decocts BANLANYE and extracts the extract that obtains by pH value, described extract adopts silica gel g thin-layer plate to carry out chromatography according to thin layer chromatography after filtration, wherein using volume ratio is that 4: 1: 1 butanols, the mixed solvent of second alcohol and water are done developing solvent, chromatography is placed under the ultra-violet lamp and inspects, and active component has the Rf value in 0.29-0.35,0.40-0.44 or the 0.79-0.83 scope in the extract.
4, being used for the treatment of the preparation method of the Pandan leaf extract of gout, it is characterized in that, is raw material with the BANLANYE, obtains Pandan leaf extract after extracting with the polar solvent decoction.
5, the preparation method of Pandan leaf extract according to claim 4 is characterized in that, BANLANYE alkali ion water as solvent decocts and extracts, and filtering and concentrating obtains extract.
6, the preparation method of Pandan leaf extract according to claim 5 is characterized in that, the alkali ion water that is taken at the formation of brine electrolysis negative pole decocts extraction to BANLANYE, and filtering and concentrating obtains extract.
7, the preparation method of Pandan leaf extract according to claim 6 is characterized in that, selects for use to do to add alkali ion water after BANLANYE is pulverized and soak 30min～3 hour, heating decocted 1～3 hour then, perhaps select bright BANLANYE soaking-free for use, direct heating decocted 1～3 hour, filtered, filtering residue adds alkali ion water once more, decoct 30min～1 hour, filter, merge filtrate twice, heating be concentrated into total liquid measure 25%～75% after, cooling, sterilization encapsulation.
8, the preparation method of Pandan leaf extract according to claim 7, it is characterized in that, select for use and do the alkali ion water that adds 3～5 times of medical material weight after BANLANYE is pulverized and soak 30min～1 hour, select then soaking-free of bright BANLANYE for use, being heated to 80-100 ℃ then decocted 1～1.5 hour, filter, the alkali ion water that filtering residue adds 1～1.5 times of medical material weight once more is heated to 80-100 ℃ and decocts 30min～1 hour, merge filtrate twice, heating be concentrated into total liquid measure 25%～50% after, cooling, sterilization encapsulation.
According to the preparation method of claim 6 or 7 described Pandan leaf extracts, it is characterized in that 9, the pH value of described alkali ion water is 8～9.5.
10, the preparation method of Pandan leaf extract according to claim 9 is characterized in that, Pandan leaf extract is prepared into all dosage forms that allow on the pharmaceutics after concentrating.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104338054A (en) * | 2014-11-07 | 2015-02-11 | 成都华熹科技有限公司 | Traditional Chinese medicine composition containing pandan leaves for treating gout |
| CN107929450A (en) * | 2018-01-12 | 2018-04-20 | 王生标 | A kind of application using Pandan Leaves in gout is treated |
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| CN113208019A (en) * | 2021-05-27 | 2021-08-06 | 海南国椰食品有限公司 | Multicolored coconut juice and preparation method thereof |
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2008
- 2008-03-31 CN CN2008100664083A patent/CN101549098B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338054A (en) * | 2014-11-07 | 2015-02-11 | 成都华熹科技有限公司 | Traditional Chinese medicine composition containing pandan leaves for treating gout |
| CN107929450A (en) * | 2018-01-12 | 2018-04-20 | 王生标 | A kind of application using Pandan Leaves in gout is treated |
| CN109699775A (en) * | 2018-12-03 | 2019-05-03 | 杭州娃哈哈科技有限公司 | A kind of sugar-free golden flower black tea drink and preparation method thereof using electrolysis water extraction tea |
| CN113208019A (en) * | 2021-05-27 | 2021-08-06 | 海南国椰食品有限公司 | Multicolored coconut juice and preparation method thereof |
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