CN109620948A

CN109620948A - The full nature cell Opsonizing method of high lithemia/gout

Info

Publication number: CN109620948A
Application number: CN201910044808.2A
Authority: CN
Inventors: 陈玉祥; 赵刚强; 赵佩钦
Original assignee: Hunan Nengjiang Ventilation Rehabilitation Co Ltd
Current assignee: Hunan Nengjiang Ventilation Rehabilitation Co Ltd
Priority date: 2019-01-17
Filing date: 2019-01-17
Publication date: 2019-04-16

Abstract

The present invention provides a kind of full nature cell Opsonizing methods of high lithemia/gout, this method includes first Selenium Supplement and the anti-oxidant repair cell of Zn-ef ficiency, supplement anserine enhances hypoxanthine-guanine phosphoribosyl transferase (hypoxanthine-guanine phosphoribosyl transferase on this basis, HGPRT) active, achieve the purpose that reducing uric acid releases gout in conjunction with anti-trioxypurine composition is taken.Full nature cell Opsonizing method of the invention, it solves in the prior art, high lithemia/patient with gout needs the problem of lifelong medication prevention and treatment, and Opsonizing method is without any side effects, can reach prevention by improving comprehensive repair cell and cure high lithemia/gout basic goal.

Description

The full nature cell Opsonizing method of high lithemia/gout

Technical field

The invention belongs to field of medical technology, and in particular to the full nature cell Opsonizing method of high lithemia/gout.

Background technique

Early in 2004, according to the statistics of Chinese disease and the report of health survey center analysis, the patient with gout in China was about There are 75,000,000 people, and the excessively high person of uric acid accounts for about the 10% of total population there are about 1.2 hundred million.In recent years, with economic development and diet knot Structure changes, and high protein and high purine food intake increase, and high lithemia and/or patient with gout are increasing.

High lithemia/gout cause of disease is cell problem, and part uric acid is decomposited after many cell ageings and makes blood uric acid liter It is high.Alleviating the conditioning of gout at present mainly includes two aspect contents: pain and inflammatory when on the one hand breaking out mainly for gout Reaction is alleviated；It on the other hand is to prevent gout breaking-out by reducing blood uric acid < 6mg/dl (357 μm of ol/L).For upper Two aspect contents are stated, patient with gout is required to lifelong anti-trioxypurine treatment, unless not tolerating or occurring adverse reaction.

Therefore, it still needs to develop a kind of new high lithemia/gout Opsonizing method.

Summary of the invention

To solve the problem of that high lithemia/patient with gout needs to face lifelong medication treatment, mesh of the invention in the prior art Be a kind of full nature cell Opsonizing method of high lithemia/gout is provided, reach thoroughly treat and prevent high lithemia/gout Purpose.

To achieve the above object, the invention adopts the following technical scheme:

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(2) enhance hypoxanthine-guanine phosphoribosyl transferase (hypoxanthine-guanine Phosphoribosyl transferase, HGPRT) activity；

(3) anti-trioxypurine composition is taken；

(4) uric acid content is detected, it is up to standard to uric acid content to repeat step (1)~(3).

Selenium element is to constitute the important essential component such as glutathione peroxidase and niacin hydroxylase.Glutathione mistake Oxide enzyme can be catalyzed reduced glutathione and become oxidized form of glutathione, while prevent macromolecular from response to oxidative stress occurs； Make to be reduced into harmless hydroxy compounds to the harmful peroxide of body, and decompose hydrogen peroxide, thus can protect thin The structure and function of after birth.Zn-ef ficiency is the nutrient of immune organ thymus development, is potent immunosuppressant regulator, and cell is promoted to exempt from Epidemic disease function promotes the growth and development of human body, maintains human normal appetite.

It preferably, further include taking joint repair composition after step (3).

Preferably, the method for the anti-oxidant cell repair is to take selenium and Zn-ef ficiency, and the selenium element is daily Amount is 200~400ug/ days, and the daily amount of the Zn-ef ficiency is 5~15mg/ days.

Preferably, the active method of the enhancing HGPRT includes taking anserine 70~80mg/ days.

Anserine can enhance the activity of HGPRT, allow guanine, hypoxanthine to return to the state of nucleotide, avoid the formation of Xanthine, and then form uric acid；Anserine can increase the lactic dehydrogenase (LDH) that lactic acid is converted to pyruvic acid, and lactic acid quickly divides Solution, uric acid have enough channels to excrete.

Preferably, the dose of the anti-trioxypurine composition is 5~30g/ days.(specific numberical range please be supplement)

It is further preferred that the anti-trioxypurine composition includes the following raw material of parts by weight meter:

5~20 parts of probiotics,

5~20 parts of green plum,

15~50 parts of inulin.

It is further preferred that the anti-trioxypurine composition further includes the following raw material of parts by weight meter:

5~10 parts of adlay,

5~10 parts of Poria cocos,

1~5 part of chitosan.

Green plum sweet in flavor and neutral in nature, fruit is big, thin skin, glossy, and meat is thick, and core is small, and matter is crisp thin, and juice is more, and acidity is high, is rich in human body institute Need a variety of amino acid, have acid in the fragrance with sweet tea, especially because its be rich in tartaric acid and vitamin C, be known as " fruit jelly it King ", " environmental protective hygienic food ".Be expressly recited according to the Compendium of Materia Medica of Li Shizhen (1518-1593 A.D.), " plum " that the flowers are in blossom is ripe in the summer in the winter, obtain it is wooden it Full gas.Taste is most sour, have lower gas, feel at ease, cough-relieving is only coughed, relieve pain and is stopped typhoid fever dysphoria with smothery sensation, can the effect of only cold and hot dysentery, subdhing swelling and detoxicating Control 32 kinds of diseases." legendary god of farming's book on Chinese herbal medicine " is recorded, " definiteness sweet taste can enter liver, spleen, lung, large intestine, there is the convergence effect of promoting the production of body fluid ". Modern medicine study shows that green plum can assist preventing and treating high lithemia/gout, and main effect and effect significantly improve intestines Stomach function, the catechuic acid of Mei Shizhong can promote intestines to wriggle and improve intestines, while play the role of promoting to shrink intestinal wall again, promote Defecation.The secrete digestive juicess such as its tart flavour energy saliva stimulating gland, gastric gland, promote digestion, and moistening intestine and stomach improves functions of intestines and stomach, and promotees Into the absorption of enteron aisle.

Inulin, scientific name polyfructosan, Inulin polysaccharide are good water-soluble dietary fibers, are described as that " mankind the 7th by the world Big nutrient ".Inulin cannot by upper digestive tract digest, hydrolysis or absorb, remain stable in gastric acid environment, thus not by Liver is absorbed, thus almost can all, the arrival colon of safety, have to Bifidobacterium in enteron aisle and lactic acid bacteria powerful Directional proliferation effect, is universally acknowledged prebiotics product, real bifidus factor.Its major function include: exclude enteron aisle and Respiratory system toxin, enhancing digestion and bowel movement function；Reducing blood lipid, norcholesterol；Weight-reducing, control weight；Protect liver；Increase intestines Bifidobacteria in road.Green plum can significantly improve our functions of intestines and stomach, promote the wriggling of stomach, defaecation, expelling intestinal toxin；Chrysanthemum Powder contains a large amount of dietary fibers, can promote the wriggling ability of enteron aisle, while water-soluble fibre contained by inulin can also help to improve The population structure of probiotics in enteron aisle improves intestinal health；

Adlay has very high nutritive value, and Chinese medicine thinks that its property slightly sweet flavor is slightly cold, there is inducing diuresis for removing edema, invigorating spleen to remove dampness, relaxing muscles and tendons Eliminating impediment, clearing away heat and eliminating pus and other effects are common damp-clearing drugs, play inducing diuresis for removing edema, the function of heat-clearing toxin expelling to our body Effect, Semen Coicis can reduce blood cholesterol and triglyceride, and can prevent hyperlipemia hypertension, apoplexy, cardiovascular disease And heart disease, and Semen Coicis water-soluble fibre also rich in, cholate (being responsible for digestion fat) can be adsorbed, makes enteron aisle to rouge The absorptivity of fat is deteriorated, and then reduces blood fat, hypoglycemic.

Semen Coicis and Poria cocos enhance uric acid excretion, and natural polymer chitosan oligosaccharide improves human body acidic environment, effectively PH value is adjusted, the activity of XOR can be inhibited, uric acid salts substances is reduced in the deposition of kidney, accelerates the metabolism of uric acid, auxiliary reduces Uric acid content.

Natural polymer chitosan oligosaccharide improves human body acidic environment, effectively adjusting pH value, can inhibit the activity of XOR, Uric acid salts substances are reduced in the deposition of kidney, accelerate the metabolism of uric acid, auxiliary reduces uric acid content.

It is further preferred that the probiotics includes clostridium butyricum, lactic acid bacteria, Bifidobacterium, lactobacillus acidophilus, actinomyces With at least two in saccharomycete.

Probiotics helps the digestion and absorption of nutriment, inhibits the growth of harmful bacteria, and the infection for resisting bacterial virus is promoted Immunity.

Anti-trioxypurine composition the preparation method comprises the following steps: weigh each component according to the ratio, mixed after crushing.

Preferably, the joint repair composition includes the following raw material of parts by weight meter:

5~20 parts of ammonia sugar,

5~15 parts of chondroitin.

Ammonia sugar is " street cleaner " in articular cavity, can not only inhibit the inflammatory reaction of nonspecific factor, releases pain, and And harmful enzyme can be eliminated in articular cavity, the immunity in joint and body is improved, inhibits to destroy ferment (such as the collagen of cartilage Enzyme, elastoser and cathepsin), in case cartilage is decomposed or dissolves.Opsonizing method of the invention can be from the root of problem Set about at source, inhibit the activity of COX-2, to prevent Joint Inflammation.

Chondroitin (chondroitin) molecular weight is generally 2-5 ten thousand, white powder, has compared with strong absorptive, soluble easily in water And become viscous solution, do not dissolve in ethyl alcohol, ether, acetone and other organic solvent.Its chemical composition is D-Glucose aldehydic acid and acetyl The high polymer that amidohexose (glucose and galactolipin) is connected by 1,3-b-- glycosidic bond.

It is further preferred that the joint repair composition further includes 50~100 parts of Isin glue collagen of parts by weight meter.

Isin glue collagen (polypeptide) orients shearing skill by biological enzyme mainly from Tilapia mossambica, the new fresh hide of gadus, fish scale Art is extracted, predominantly I-type collagen, and product is rich in 19 kinds of amino acid, and molecular weight has between 2000~5000D length Very high digestion and absorption, the thermal stability of this product in aqueous solution is fabulous, has fabulous compatibility with human skin, can The functions such as its infiltration, moisturizing, reparation are played well.

Joint repair composition the preparation method comprises the following steps: weigh each component according to the ratio, mixed after crushing.

Opsonizing method of the invention is cell problem based on high lithemia/gout cause of disease, is decomposited after many cell ageings Part uric acid increases blood uric acid, is a kind of full nature cell Opsonizing method.By including anti-oxidant repair cell (Selenium Supplement And Zn-ef ficiency), enhance the activity (supplement anserine) of HGPRT, promotes renal excretion uric acid (taking anti-trioxypurine composition), improve intestines Road functions of expelling toxin is repaired joint (taking joint repair composition), human body blood purification, is promoted body immunity and (is drunk daily Hydrogen-rich water), improve host's microecological balance (probiotic supplemented), comprehensive nature cell reparation is without any side effects, reaches tune High lithemia/gout basic goal is managed, there is important clinical meaning and theoretical value.

Hyperuricemia (hyperuricemia, HUA) in the world is defined as: under normal purine diet state, non-on the same day two Secondary empty stomach serum uric acid level: male blood uric acid > 420 μm ol/L, women blood uric acid > 360 μm ol/L.When serum uric acid level is more than to close Section monosodium urate salt loading degree and be precipitated when being deposited on periphery joint and surrounding tissue, referred to as gout.Table when gouty attack,acute Now for the serious pain of affected joints, swelling, erythema, it is stiff, fever, and symptom occur suddenly, stage of attack general last from days By 1 week.Gout is directly related with hyperuricemia caused by purine metabolic disturbance and (or) underexcretion, refers in particular to acute spy Sign property arthritis and chronic gout stone disease mainly include acute attack arthritis, tophus formation, the chronic pass of tophaceous Section inflammation, urate nephropathy and uric acid lithangiuria, severe one may occur in which joint deformity and renal insufficiency.Patient with gout often occurs Tophus, it is visible in surrounding subcutaneous such as patient's auricle, periarticular, tendon, soft tissues.Tophus is faint yellow or white size Different protuberance or neoplasm, texture is too hard, similar stone.The tophus that especially four limbs are formed at each position of body, Limbs shape is not only seriously affected, it is prolonged not to result even in joint deformity, dysfunction, neurothlipsis, skin ulceration, sinus More, it must be treated surgically.Gout is often with the performance such as Central obesity, hyperlipidemia, hypertension, diabetes B and cardiovascular disease.

The HUA for not having gout to break out is known as asymptomatic HUA, because it does not have apparent clinical symptoms, not yet causes people sufficient Enough attention.The illness rate of gout is cumulative with age increase.The peak age of male is one's mid-40s, and the ratio between men and women is 20: 1.Many patients have Positive family history, and belonging to autosomal dominant inheritance minority mostly is X- sex-linked inheritance.

In recent years, since economic development and dietary structure change, high protein and high purine food intake increase, China Hyperuricemia and patient with gout are increasing.The hyperuricemia disease incidence of 500 adults of 1980 In Guangzhou Areas is 1.4%, it is counted according to Chinese diseases in 2004 and the report of health survey center analysis, there are about 75,000,000 people for China's patient with gout, and The excessively high person of uric acid accounts for about the 10% of total population there are about 1.2 hundred million.In China 20 years old or more crowd, 2.4~5.7% there are blood uric acids It is worth excessively high.The disease incidence of the hyperuricemia of 2700 In Guangzhou Area adult residents in 2007 is 27% or so, increases tens Times.4000,11 streets, 40 years old or so the male and female hyperuricemia disease incidence tune of Jiangxi Province's meeting Nanchang subordinate in 2016 It looks into, the illness rate of male is 26%, and the illness rate of women is 15%.The disease incidence 2.6% of male's gout, the gout morbidity of women Rate is 0.01%.In May, 2012 to the standard compliant resident in May, 2013 Changsha city 2961, acquires resident's items data, And fasting blood-glucose, blood lipid 4 [triacylglycerol (TG), serum total cholesterol (TC), high-density lipoprotein are carried out to 2961 residents Cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)], the measurement of blood uric acid, analyze Changsha city hyperuricemia Illness rate status and risk factor, the result is that HUA total prevalence rate is 22.62%, with the increase at age, HUA illness rate is presented The trend being gradually increasing, wherein male HUA illness rate is 37.68%, is higher than women 8.50%, per capita income, gender, frequency of drinking Rate, hyperlipidemia, eating habit, physical exertion frequency are the single factor tests of HUA illness.

Taiwan causes patient with gout to sharply increase, gout patients number is with China because of economic and food change Economy of taiwan level improves and is incremented by, and 1960~1963 years gouts account for 5% to 1982~the 1985 of rheumatism special outpatient clinic number Year, statistics was up to 15.6%, and there are many hyperuricemia person of 30 years old or more crowd, disease incidence 17.3%, wherein male 20.3% (542 people of sample) is higher than 14.6% (616 people of sample) of women.4.8 ± 1.8mg/dl of uric acid average value, male in blood For 6.4 ± 1.8mg/dl, it is higher than 5.2 ± 1.5mg/dl of women.In young period, the risk factor of hyperuricemia is mainly height Blood lipid, for example, high triglyceride and high cholesterol etc., this result reflects the formation and eating habit of early stage hyperuricemia There is important correlation.Once hyperuricemia and some living habits have significant phase into the middle age other than hyperlipidemia It closes such as drinking, obesity.Occur in addition, such as hypertension, renal dysfunction clinical symptoms may also start to merge, has arrived old In period in year, most important risk factor is then the use of diuretics and the generation of renal complication.Since diuretics itself is being permitted The First Line drug that more areas are used as always hypertension therapeutic replaces although blood pressure has obtained opposite control Be then the rising of uric acid level in blood.

" 2016 Chinese gout practice guidelines " display, patient with gout is most important medical, and (male is the reason is that arthralgia 41.2%, women 29.8%), it is secondly out of strength and fever.Men and women's predisposing factors has very big difference, and male patient is main to be It drinks induction (25.5%), is secondly high purine diet (22.9%) and strenuous exercise's (6.2%)；Female patient is main for height Purine diet induces (17.0%), secondly to be cooled suddenly (11.2%) and strenuous exercise's (9.6%).

Asymptomatic hyperuricemia develops main as the risk factor mode of gout are as follows: and first, uric acid concentration is most heavy The factor wanted, 1 unit (mg/dl) of the asymptomatic every increase of the existing uric acid concentration of Patients with Hyperuricemia, the generation of the following gout Chance is consequently increased 5 times.Second, in existing conditions, creatinine values can also predict that future suffers from gouty opposite danger in blood It is dangerous.Third, the increase of other factors such as weight, the use of diuretics, habit etc. of drinking hyperuricemia progression of disease It may cause the rapid fluctuation of uric acid level in blood in the process, and then lead to acute gout.Therefore, for asymptomatic hyperuricemia Patient should first be conceived to the long-term monitoring of existing uric acid concentration and creatinine values, furthermore control weight, avoid using diuretics Treatment hypertension controls habit etc. of drinking, and the generation of acute gout is avoided to prevent the rapid fluctuation of uric acid level in blood.

As a kind of chronic crystal-induced arthritis --- gout, hyperuricemia are the bases that gout occurs.Inherent cause The overall process of gout and hyperuricemia occurrence and development is influenced, single gene inheritance disease may influence the pass on uric acid metabolism access Key enzyme, single nucleotide polymorphism (SNP) then can lead to the difference of urate transporter and the degree of inflammatory reaction.Antihyperuricemic Disease and urine uric acid supersaturation, deposit to lithate in renal tubule lumen or interstitial, lead to acute inflammatory response.If height urine Hematic acid and gout treatment not in time or cure time length and will generate complication, are embodied in the metabolism function of patient's body sugar and fat It can be substantially reduced, cause diabetes, hypertension/hyperlipidemia, myocardial infarction/angina pectoris, cerebrovascular disorder etc., serious initiation Renal dysfunction even kidney failure.

Gout is the higher result of long-term uric acid.Organism inhereditary material-nucleotide forms purine, purine by metabolism It is further oxidized, forms uric acid, uric acid long time integration is formed monosodium urate salt (tophus).

In normal life, uric acid content is external except generating and excluding in human body, can maintain a metastable dynamic Within the scope of.Once the dynamic equilibrium between nucleotide and purine is broken, renal function is abnormal, and uric acid cannot be discharged in time, Uric acid will be higher.

Uric acid sodium salt organizes the formation of microcrystal precipitating in joint and periarticular, and it is a multiple for causing non-specific arthritis Miscellaneous process, it may be possible to the result of many factors comprehensive function.The solubility of lithate is pH7.0, temperature under normal physiological conditions It is 381 μm of ol/L (6.4mg/dl) when spending 37 DEG C, reaches over-saturation state more than this concentration.Because of articular cartilage, intrasynovial and pass It is less to save surrounding tissue blood vessel, it is relatively abundant containing glutinous polysaccharide acid and connective tissue in matrix, when lithate reaches over-saturation shape in body fluid When state, under certain induced conditions, such as damage, local temperature are reduced, local ph reduces or whole body fatigue, excessive drinking, or because of blood Slurry 1 alpha2 Globulin of α is reduced and lithate easily crystallizes precipitation when lithate reduction in connection.Urate crystal can chemotactic it is white thin Born of the same parents.In leucocyte and joint capsule synovial cell swallow lithate after in several minutes releasable leukotriene B4 (LTB4) and glycoprotein Chemokine, the rapid degranulation of leucocyte, decomposition make lysosome membrane destroy release hydrolase and leucocyte necrosis are caused to discharge The multiple inflammatory factors such as kassinin kinin cause acute inflammation to break out and aggravate, and the immobilized artificial membrane of organelle is right if containing cholesterol and testosterone The reaction of plasmarrhexis caused by lithate is sensitive as contained beta estradiol, then inhibits above-mentioned reaction, therefore gout is apt to occur in male and absolutely Women's especially joint of lower extremity after menstrual period, toe joint bear pressure maximum, are easy to damage, and local temperature is low, therefore are gout Predilection site.Acute gouty arthritis has self limiting, may be related with following factors: local temperature increases when a. inflammatory episode Add, uric acid dissolution increases, and the crystal newly formed is reduced.B. increase local blood flow, lithate is absorbed into blood circulation.C. it is gulped down The lithate bitten can be destroyed by the myeloperoxidase of leucocyte, reduce the lithate quantity discharged when leucocyte rupture. D. inflammation stress excited adrenal cortex, hormone secretion increases, and inhibits inflammatory process.Blood uric acid value, which fluctuates rapidly, can cause urgency Property urarthritis breaking-out the dissolution of intra-articular tophus can be made to release insoluble needle-shaped if the unexpected reduction of blood uric acid Crystallization.This interpretable patient with gout application uricotelic drugs and when uric acid being inhibited to generate drug why acute gout joint Inflammation breaking-out.

Gout is a kind of metabolic disease, is divided into primary and two kinds secondary according to cause of disease difference.Primary gout is It is the defect because of patient's body purine metabolic enzymes caused by inherent cause, results in disorders of purine metabolism and uric acid excretion barrier Hinder；Secondary gout refers to secondary to underexcretion caused by kidney trouble or some drugs, myeloproliferative disease and tumour The generation of uric acid caused by chemotherapy such as increases at the pathologic conditions.People has a kind of substance for being called purine by feed in vivo, and purine passes through one Range of metabolic variation, ultimately forms uric acid.Uric acid does not have any physiological function in human body, under normal circumstances, generates in vivo Uric acid 2/3 be discharged by kidney, 1/3 is discharged by large intestine.Under normal circumstances, intracorporal uric acid is to constantly generate and draining, Therefore it maintains certain concentration in blood.

The root of gout is exactly to be deposited on joint part after intracorporal uric acid forms crystallization, and joint part is caused inflammatory occur Reaction, a kind of red and swollen with severe pain, inflammatory disease that burning heat sensation is characterized.Therefore, essentially, the high generation of uric acid is The basic metabolism of body there is a problem, explicitly point out in version China gout guides in 2016: gout is a kind of monosodium urate salt (MSU) the crystal correlation arthropathy caused by deposition, with purine metabolic disturbance and (or) high lithemia caused by underexcretion Mass formed by blood stasis is directly related, belongs to metabolic rheumatic disorder scope.Be exactly that uric acid is not high there are also one kind, but break out gout the case where, it is this Situation also happens occasionally, mainly related with individual physique, that is to say, that may under normal circumstances, uric acid level is in 360 μm of ol/ L, not will form lithate deposition leads to gout, but in special circumstances, it is possible to can occur.Such case, if passing through ultrasound It checks, discovery lithate is in joint, and tendon, the deposition of soft tissue can effective auxiliary diagnosis goat.

The main reason for Chinese medicine thinks, forms primary gout is congenital spleen renal dysfunction.The transportation capabilities of spleen Lower, then the turbid interior life of phlegm；The functional disturbance of kidney department stool and urine, then wet turbid excretion is slowly measured less so that the turbid cohesion of phlegm, experiences at this time The damp and hot heresy of chill, overstrain, damaged by excess of seven emotions or excessive drinking food wound or arthrotrauma etc. then aggravate and phlegm turbidity current note are promoted to close Section, muscle, bone QI-blood circulation is unsmooth and forms numbness pain, that is, urarthritis.So the cause of disease of gout, can be divided into interior 3 cause, external cause and inducement aspects.Internal cause is mainly native endowment deficiency and healthy tendency virtual loss.Insufficiency of natural endowment, liver-kidney deficiency, essence and blood Insufficient then muscles and bones passages through which vital energy circulates dystrophy or the imbalance of kidney department fecal and urinary functions, wet turbid cohesion, streamer joint, muscle, impatency passages through which vital energy circulates can shape At numbness pain；Insufficiency of natural endowment yin and yang imbalance then involves other internal organs, mainly involves in spleen, transporting imbalance is allowed to, especially to savoury, wine It is too late to eat transporting, causes the turbid interior life of phlegm, stagnates in joint, or changes source deficiency, qi and blood is difficult joint passages through which vital energy circulates of supplementing nutrition, also can lead to numbness Disease.Healthy tendency virtual loss, can be weak for ferritic, can also be hurt by other diseases in-fighting, postpartum insufficiency of vital energy and blood or overstrain, diet feelings will, Or it crosses and takes caused by certain chemicals internal injury vigour.Healthy tendency virtual loss, first muscles and bones passages through which vital energy circulates dystrophy, second powerless to resist exopathogen.With Upper internal cause, then meet external cause and be added with inducement, then passages through which vital energy circulates impatency, QI-blood circulation is unsmooth and to send out be this disease.External cause mainly experience wind, Cold, wet, hot heresy.Due to moist at residence, work environment is clammy or underwater work or paddles in spite of the rain, or overcast and rainy, summer-heat and damp weather twines Enter the medium reason of water after continuous or exposure to wind when sweating, sweating healthy energy is insufficient, when weakened defensive QI, the heresy of wind-cold damp pathogen or rheumatism, or The heresy or rheumatism heat evil of cold-dampness or damp and hot heresy can invade human body passages through which vital energy circulates, keep between limbs, muscles and bones, joint, impatency It is obstructed, it sends out as this disease.Since the evil different or perverse trend of sense wins partially and form different, corresponding bi Zheng.Furthermore caused by wind-cold damp pathogen The long numbness of bi Zheng be not cured, strongly fragrant longization heat can also be converted into beriberoid pyretic arthralgia or damp and hot bi Zheng.Inducement is mainly invaded or evil in weakened body resistance heresy When stagnant passages through which vital energy circulates, it is added with overworked, damaged by excess of seven emotions, in-fighting healthy tendency；Or eating and drinking without temperance excessive drinking savoury, impairing the spleen and stomach, interior raw phlegm It is turbid more；Or wound is felt again, or operation or joint injury etc., it can aggravate to hinder through vessle-Bi symptom-complex, QI-blood circulation is unsmooth and induces this Disease.The interpretation of the cause, onset and process of an illness of this disease is mainly inadequate natural endowment, healthy tendency virtual loss, passages through which vital energy circulates dystrophy；Or few, passages through which vital energy circulates of being detained is delayed in wet turbid excretion；Or spleen fortune Mistake department, the turbid sluggish joint of phlegm；Or being invaded by exogenous pathogen,invasion of exogenous pathogen, evil numbness passages through which vital energy circulates, QI-blood circulation is unsmooth, causes joint, muscles and bones, myalgia, swells Swollen red heat, weighs joint stuffiness and forms this disease numbness.Then blood-vessel obstructive body fluid agglomerates obstinate disease, phlegm-turbidity and blood stasis blood impatency warp Network and arthrocele is lopsided, stiff, periarticular ecchymosis tubercle and interior damage internal organs, can concurrent related Zang-Fu syndrome, then the state of an illness It is complicated and serious.Its sick position initial stage shows limbs, joint and passages through which vital energy circulates, and internal organs are damaged in muscles and bones after then corroding.In fact, this disease is going out Before existing symptom, that is, there are congenital kidney deficiency and liver and spleen fortune mistake department, can not ignore.The property of this disease is asthenia in origin and asthenia in superficiality, with liver deficiency of the kidney Void, dys-splenism are this, and afterwards and he is dirty；, hemostasis impatency passages through which vital energy circulates turbid with chill wet hot phlegm is mark.

Uric acid (7,9- dihydros -2,6,8 (3H) triketone -1H- purine, chemical formula C₅H₄N₄O₃) be birds and reptiles master Metabolite is wanted, water is slightly soluble in, easily formation crystal, white crystals.Product is mainly urea in normal human's urine, containing a small amount of urine Acid.Uric acid is the final product of purine metabolism.For three oxygroup purine, alcohol of formula is weakly acidic.The urine generated after various purine oxidations Acid is excreted with urine.Uric acid in human body in blood is from two aspects, first is that the metabolite of autogenous cell, especially blood are thin The nucleotide that the metabolism of born of the same parents generates forms uric acid after peroxidating, accounts for about 80% or so, remaining uric acid is from external food The purine of middle intake is converted into uric acid after being metabolized in vivo.This substance of uric acid, it has a characteristic, is exactly that dissolubility is bad, belongs to In a kind of substance for being slightly soluble in water.Under normal circumstances, the metabolism of uric acid maintains opposite balance, the uric acid generated daily and row The uric acid removed maintains balance, and remain has a reasonable uric acid concentration in vivo, if the balance of uric acid is broken, production it is more Or that arranges lacks, and can all lead to the raising of blood uric acid, the raising of blood uric acid just largely has to form the wind of urate crystal Danger.

Under normal circumstances, about 1200 milligrams of intracorporal uric acid, newly-generated about 600 milligrams daily, while draining 600 Milligram, the state in balance.But if generation in vivo excessively has little time excretion or uric acid excretion mechanism is degenerated, then urinate in vivo Acid is detained excessive, when blood uric acid concentration is greater than 7 milligrams/deciliter, leads to human body fluid souring, influences the normal function of human body cell Can, gout will be caused for a long time by ignoring.In addition the excessively insufficient metabolism relative delay that also can lead to of fatigue or rest causes Gout morbidity.

Uric acid is all from glomerular filtration in blood, wherein 98% in proximal convoluted tubule middle section to be secreted into glomerulus again intracavitary, Then it is intracavitary in proximal convoluted tubule middle section to be secreted into renal tubule again for 50% re-absorbed uric acid, have 40 again in proximal convoluted tubule straight section~ 44% by reabsorption, the discharge of only 6~10% uric acid.The generation of uric acid and drainage rate are more constant in normal human.In body fluid Uric acid content variation can sufficiently reflect the situation of the functions such as human body metabolism, immune.

The reason for causing uric acid high includes:

(1) purine intake is excessive: uric acid high-content is directly proportional to purine content in food.RNA in the food of intake The 25% of 50%, DNA will be drained in the form of uric acid in urine, and the stringent purine intake that limits can be such that serum uric acid drops 1.2mmol/d (200mg/d) is down in secretion to 60umol/L (1.0mg/dL), and the interior uric acid of urine.

(2) endogenous purine generates excessive: endogenous purine metabolic disorder is even more important compared with extrinsic factor.Purine is by non- Cyclic annular to be reacted to cricoid de novo formation process by 11 steps, wherein the exception of enzyme will lead to purine synthesis excessively.? It was found that have: phosphoribosylpyrophosphate (PRPP) synthase activity increase.Hypoxanthine-guanine phosphoribosyl converting Enzyme (HGPRT) lack.Glucose-6-phasephate dehydrogenase (glucose-6-phosphatase) lacks.

(3) purine metabolism increases: such as chronic hemolytic anemia, rhabdomyolysis, polycythemia, myeloproliferative disease Uric acid height can be generated when disease and chemotherapy or radiotherapy.Overexercise, Status Epilepticus, glycogen storage disease (glycogenstoragediseases), the degradation of muscle ATP can all be accelerated.Myocardial infarction, smoking, acute respiratory failure It is related with ATP accelerated degradation.

Nucleic acid is a kind of high-molecular compound, and nucleic acid is made of countless nucleotide.Each nucleotide is by three It is grouped as, a phosphoric acid molecules, a pentose (pentose) and a base (purine or pyrimidine).Heredity in biological cell core RNA (ribonucleic acid) is by hundreds of thousands, millions of or even several ten million nucleotide in matter DNA (DNA) and cytoplasm Composition.One of product after nucleic acid oxygenolysis is exactly purine in turn, and thus purine is the constituent of cell.In vivo Old cell, there are also foods, especially food (such as pluck, seafood) metabolic processes in vivo rich in purine In, nucleic acid oxidative degradation products just have purine (the 80% of this endogenic total purine of purine Zhan).After generating purine in vivo, It can re-oxidation be that (2,6,8-- trioxypurine) is also known as uric acid in liver.2/3 uric acid is excreted through kidney with urine, 1/3 is discharged by excrement and sweat.As it can be seen that purine is the metabolite of the oxygenolysis of nucleic acid, and uric acid is the metabolism of purine Final product, purine ring therein are not unlocked.

Possess the species of uric acid (oxidation) enzyme (uricase), uric acid can be converted in the urine that dissolubility is higher, is easier to discharge Bursin (allantoin) event serum uric acid level is low and exists without gout.People (Homo sapient) and several hominoids (hominoid species) is that urate oxidase gene mutability occurs during evolution to inactivate, from this point of view the mankind Hyperuricemia be caused by the birth defects of uric acid catabolism.The uric acid of dissolved state includes by oxygen as active oxygen Scavenger (scavenger) with peroxynitrite derived from super nitrogen oxide may be advantageous in people.Hyperuricemia blood Uric acid concentration depends on the balance between uric acid generation and drainage rate in clear.There are two sources for uric acid in human body, first is that from richness What the food nucleotide containing nucleoprotein decomposed, belong to exogenous, accounts for about the 20% of internal uric acid；Second is that from internal amino The category endogenous of acid, ribose phosphate and the synthesis of other small molecule compounds and nucleic acid decomposition metabolism accounts for about internal total uric acid 80%.It is even more important compared with extrinsic factor to the obvious endogenous metabolism disorder of the generation of hyperuricemia.Isotopic tagging research, The uric acid average out to 1200mg in uric acid pond generates about 750mg daily in normal human, and 500~1000mg is discharged, and about 2/3 arranges through urine It lets out, another 1/3 is discharged by enteron aisle or is decomposed in enteron aisle by bacterium urate oxidase.Serum uric acid concentration is at one in normal human Fluctuation in relatively narrow range, domestic normal male average value are 339 μm of ol/L (5.7mg/dl), and women average value is 256 μm of ol/ The height of L (4.3mg/dl) serum uric acid level is influenced by many factors such as race, eating habit age and body surface areas.One As for uric acid increase with the increase at age, especially to become apparent after female menopausal, male is often height, but women compared with women Serum uric acid level can be close with male person after menopause, clinically often with more than above-mentioned average value or equal higher than healthy subjects of same sex The above are hyperuricemias for two standard deviations (SD) of value.Due to gout be as uric acid crystal rather than caused by dissolved state uric acid because This " hyperuricemia " is the solubility by uric acid in body fluid rather than the statistical distribution of uric acid level determines.Unit time Interior uric acid production quantity is more than the ability that processing keeps dissolution, just has monosodium urate crystal under extracellular deposit.It closes periphery The temperature (about 32 DEG C of knee joint, about 29 DEG C of ankle-joint) of section, lowers uric acid solubility greatly.As triggered inflammatory reaction again i.e. Gout can occur.

It is disease caused by a kind of metabolic disorder, long-term obstinate, it will very big danger is caused to body that uric acid is higher Evil, influences other dysfunctions, uric acid height endangered caused by human body be it is various, many people think the harm of high lithemia just It is to lead to urarthritis, it is just not fearful without gout, so the hyperuricemia to not gout is not taken seriously.This is in fact It is a mistake in understanding, the harm of high lithemia is far longer than the imagination of people.

Hyperuricemia leads to urarthritis, tophus, kidney stone, gouty nephropathy and chronic renal failure, In addition, also causing other harm such as hypertension, diabetes, heart infarction and cerebral infarction.Therefore, hyperuricemia is after " three high " (high blood Pressure, hyperglycemia, hyperlipidemia) it is referred to as " the 4th is high " by people later, harm includes:

(1) urarthritis: hyperuricemia is that the basic reason of gout occurs, and blood uric acid is higher, and gout breaking-out is got over Frequently, and age of onset is also more early.Research confirms: the incidence of gout is 30.5% when the ol/L of blood uric acid >=600 μm, blood urine The incidence of gout is only 0.6% when acid < 420 μm of ol/L；And the average age that gout is broken out when the ol/L of blood uric acid < 420 μm is 55 years old, the average age of gout breaking-out was 39 years old when the ol/L of blood uric acid >=520 μm；

(2) gouty nephropathy and chronic renal failure: high lithemia can lead to kidney damage, meanwhile, impaired renal function Afterwards, blood uric acid excretion is reduced, and has more aggravated high lithemia.If blood uric acid > 392 μm ol/L, the risk male of chronic kidney hypofunction occurs Increase by 94%, women increases by 420%.And blood uric acid 60 μm of ol/L of every raising, the risk that acute renal failure occurs increase by 74%；

(3) uric acid kidney stone: according to statistics, in the kidney stone in China, 5.1% is uric acid kidney stone.And other reasons Caused kidney stone is the same, and uric acid nephrolith disease often shows as pain in the loins and blood urine, if plug ureter also result in fever, Oliguresis, anuria, uronephrosis, serum creatinine raising etc.；

(4) hypertension: hyperuricemia can also cause hypertension, according to statistics, blood uric acid 60 μm of ol of every increase, hypertension The risk of generation increases by 15~23%；

(5) diabetes: serum uric acid level increases the risk that can increase diabetes B, according to external research hair Now, caused by 25% diabetes are because of high lithemia.In addition, diabetes patient's serum uric acid level increases it is easier that diabetogenous nephrosis occurs Disease；

(6) coronary heart disease: serum uric acid level 60 μm of ol of every raising, the case fatality rate of Women with Coronary Heart Disease increase by 30%, and male increases 17%.Cardiovascular disease can be made to reduce 13~29% by anti-trioxypurine treatment；

(7) cerebral apoplexy: hyperuricemia can promote the generation of cerebral infarction, increase the death rate of cerebral infarction and the recurrence rate of cerebral infarction.

Gout treatment mainly includes two aspect contents at present: pain and inflammatory reaction when treatment gout breaking-out；Prevent gout Breaking-out reduces blood uric acid < 6mg/dl (357 μm of ol/L).Regardless of whether merging chronic kidney disease, patient with gout is required to drop all the life Uric acid and treating, unless not tolerating or occurring adverse reaction.

For fat patient with gout, while paying close attention to blood uric acid, pay attention to that patient's rule is guided to move, monitoring blood pressure, The indexs such as blood glucose, blood lipid, liver transaminases give complex treatment, maintain blood uric acid up to standard, as far as possible reduction affected joints number. Low purine diet keeps reasonable weight, and abstinence from alcohol is drunk more water, every daily drink 2000ml or more.Avoid gluttony, indulge in excessive drinking, suffer from cold by Tide, over fatigue and stress, wear Comfortable shoes, prevent joint injury, and for example certain diuresis of drug for influencing uric acid excretion are used with caution Agent and low-dosage aspirin etc..Prevent and treat concomitant disease such as hypertension, diabetes and coronary heart disease etc..

When colchicin early stage is used for gout breaking-out, the speed for controlling symptom is fast.2012 American Rheumatism Associations (ACR) refer to South is pointed out, colchicin is taken in gouty attack,acute 36h, and prodromal stage application can prevent gout from breaking out.When renal insufficiency It is still first-line drug, but is reduced, because renal insufficiency can substantially reduces its clearance rate, increase drug toxicity.Up to 20% Oral drugs are drained as former state by kidney, and in serious patients with renal failure, the half-life period of colchicin is normal kidney 2~3 times of function patient.Meanwhile colchicin cannot be removed by dialysis, therefore, toxicity is in Patients with Chronic Kidney Disease It is aggravation.

Influence cell because being known as:

External toxin: sunlight, empty gas and water, food, chemistry, radiation pollution；

Internal toxin: metabolic waste, tension pressure etc., when the accumulation of toxin has been more than liver detoxification ability, it Will destroy all cells of whole body or more.Blood is toxic to be known as toxaemia, toxaemia and allergy, asthma, skin disease, cancer Many disease relationships such as disease, rheumatism, gout, arrhythmia cordis, headache, psychic problems are close.

Cell disorders include three phases, are respectively:

1, cell dysfunction (inferior health)；

2, tissue local is damaged (ulcer, inflammation)；

3, organ dysfunction decline (diseases such as diabetes, uremia, hypertension, heart disease).

Cell activation solution:

1, nutrient required for cell is supplemented, cellular energy is improved, accelerates cell repair and regeneration；

2, toxin is effectively excluded, body burden is mitigated.

The significance of cell activation be for into promote nutrient absorption, the exclusion of fast toxin.

The relationship of cytotrophy product and cytotrophy transportation system:

Step 1: food (nutriment, the nutrient rich in general equilibrium)

Step 2: digestive system (digestion decomposes, absorbs nutrient)

Step 3: the circulatory system (transport nutrition)

Step 4: each cell (utilizing nutrition) of each histoorgan of whole body

Currently, the drug of anti-trioxypurine treatment gout is mostly chemistry or Biochemical Drugs on the market, these drugs are generally all effective, but There are various toxicities, such as fash (being often maculopapule), itch, nettle rash skin allergy, or generates nausea, vomits It spits, diarrhea etc., the bone marrow suppressions such as leucocyte and decrease of platelet reaction, hemolytic anemia, hepatorenal damage, the visible whole body mistake of severe one The side effects such as quick property vasculitis, mental depression.Long-term use causes great damage to human body, palliative.In addition, plus using Medicine is improper, eats and stops, and causes complication.

It is cell problem based on high lithemia/gout cause of disease, method of the invention is full cell nature Opsonizing method, can be with Reach reduction high lithemia/gout basic goal, it is without any side effects.

The full nature cell Opsonizing method of high lithemia/gout of the invention further includes reference hydrogen molecule water and/or alkalescent Water.

Water quality determines constitution, and the water of safe and high quality is directly related to human health.Hydrogen-rich water, also referred to as water element water, are one Kind has hydrogen concentration high, can generate the alkalescent drinking water of small molecule water, not only clean, and there are also the energy of hydrogen, hydrogen-rich water is presented Small molecule running water group, anion depth absorbs the hydrogen ion up to 80%, in hydrogen-rich water can combine with extra active oxygen in vivo Cheng Shui, human body blood purification allow unobstructed blood, keep body metabolism vigorous, can prevention of various diseases, promote body immunity.With Science and technology development, at present there are mainly three types of hydrogen-rich water, that is, water element water manufacturing technologies: first is that direct current electrolysis water prepare Hydrogen water；Hydrogen water is prepared second is that hydrogen is filled in water；Third is that native alloy ceramics light electrolysis prepares hydrogen water.Direct current electrolytic hydrogen production Technical comparing is mature, and hydrogen content is high, and medical treatment effect is good, but the technology cost of manufacture is high.

Because hydrogen molecule is very fine, into it is internal can rapid osmotic to whole body, and penetrating cell film, take away in be difficult The pernicious active oxygen eliminated, and be neutralized into water and excrete, the running without will affect other benign activity oxygen and body function, It is most important, it can be being destroyed and oxidized cell restores." hydrogen " in water has strongest redox ability, Wo Menchang The most of antioxidant such as vitamin eaten is not easy to across cell membrane, and pointedly only pernicious active oxygen cannot be disappeared It goes out, still more, eats a large amount of vitamins, be also difficult to store and absorb in vivo.The antioxidant capacity and cell restorability of hydrogen be It is most severe so far.The oxidation lethality of oxygen radical can lead to tumour, inflammation, aging, leukaemia and the heart, liver, lung, The generation of skin etc. lesion, oxygen radical can also give rise to diseases such as arteriosclerosis, hypertension, heart disease, vein It is inflammation, osteoarthritis, cataract, cancer, immune system disease, metabolic system disease, allergy allergic disease and Parkinson's disease, senile Dementia etc., oxygen radical promote retrogression pathological changes, accelerate whole body aging.It has now been found that at least 70 kinds or more of disease all with Oxygen radical is related.And it removes during the most safe and reliable effective method of free radical is no more than and occurred using reactive hydrogen and oxygen radical And reaction, it generates and human life and health is needed most and most healthy water.

The applicable consumer groups of water element water are very extensive, are particularly suitable for the elderly, Ms, chronic and often smoke The personage to drink, the measurement index of water element water are oxidation-reduction potential (ORP), which reaches 100-200 negative millis It lies prostrate (mv).Modern hydrogen-rich water oxidation-reduction potential (ORP), which reaches 500 negative (mv), has selectivity anti-oxidant, anti-aging, anti-blood Pipe hardening and skin-whitening and other effects, have a vast market foreground.Its main performance index is negative oxidation-reduction potential (ORP)。

This water is drunk to diabetes, allergy, hypertension, gall stone, rheumatism, skin disease, insomnia, arthritis, digestion disease A variety of diseases such as trouble, tumour, cancer, bronchial asthma, myocardial infarction are cured and are obviously improved.

Hydrogen molecule rich in hydrogen water is drunk and is decomposed into hydrogen atom by intracorporal hydrogen catabolic enzyme after entering human body That is reactive hydrogen occurs reduction reaction with active oxygen-oxygen radical of human body, generates human body and need most most harmless water.Hydrogen is A kind of optimal natural, since the hydrogen molecule in hydrogen water is very subtle, the quick permeation cell of energy neutralizes human body " Health Killer " oxygen radical ultimately produces water and excludes in vitro.Hydrogen is insoluble in water, and uses the technology of hydrogen-oxygen separation that can solve Certainly this technical problem.Each hydrogen molecule can uniformly be wrapped up by hydrone, to form subset, subset is due to volume It is smaller, it can be very good to eliminate intracellular pernicious oxygen radical across cell wall.

Water quality determines constitution, but can really realize water to the people of importance of life, health and few, therefore, someone Claiming water is " nutrient to have passed into silence ".(WHO) mechanism, World Health Organization statistics, the disease of developing country 80% and the mankind 1/3 death is rooted in water.Good water determines the service life.Hydrogen water is not only clean, has hydrogen to have energy, and water is all that small molecule is presented to live Water body, anion depth absorb 80%, purify blood, make unobstructed blood, are metabolized vigorous, prevention of various diseases, and it is strong to promote human body Health.

Beneficial effects of the present invention

1, full nature cell Opsonizing method of the invention, solves in the prior art, and high lithemia/patient with gout needs lifelong The problem of prevention and treatment of taking medicine；

2, full nature cell Opsonizing method of the invention is without any side effects, can reach pre- by comprehensive repair cell Anti- and healing high lithemia/gout basic goal.

Specific embodiment

The following is specific embodiments of the present invention, and further retouches to technical solution of the present invention work in conjunction with the embodiments It states, however, the present invention is not limited to these examples.

Embodiment 1

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(3) anti-trioxypurine composition is taken；

Wherein, the daily amount of selenium element is 200ug/ days, and the daily amount of the Zn-ef ficiency is 5mg/ days.

The enhancing active method of HGPRT includes taking anserine 70mg/ days.

The dose of anti-trioxypurine composition is 5g/ days.

Anti-trioxypurine composition includes the following raw material of parts by weight meter:

5 parts of probiotics, 5 parts of green plum, 15 parts of inulin.

Probiotics include in clostridium butyricum, lactic acid bacteria, Bifidobacterium, lactobacillus acidophilus, actinomyces and saccharomycete at least Two kinds.

Embodiment 2

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(3) anti-trioxypurine composition is taken；

Wherein, the daily amount of selenium element is 400ug/ days, and the daily amount of the Zn-ef ficiency is 15mg//day.

The enhancing active method of HGPRT includes taking anserine 80mg/ days.

The dose of anti-trioxypurine composition is 30g/ days.

20 parts of probiotics, 20 parts of green plum, 50 parts of inulin.

Anti-trioxypurine composition further includes the following raw material of parts by weight meter: 7 parts of adlay, 7 parts of Poria cocos, 3 parts of chitosan.

Embodiment 3

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(3) anti-trioxypurine composition is taken；

Wherein, the daily amount of selenium element is 300ug/ days, and the daily amount of the Zn-ef ficiency is 10mg/ days.

The enhancing active method of HGPRT includes taking anserine 75mg/ days.

The dose of anti-trioxypurine composition is 15g/ days.

12 parts of probiotics, 12 parts of green plum, 30 parts of inulin.

Embodiment 4

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(3) anti-trioxypurine composition is taken；

(4) joint repair composition is taken；

(5) uric acid content is detected, it is up to standard to uric acid content to repeat step (1)~(3).

The enhancing active method of HGPRT includes taking anserine 75mg/ days.

The dose of anti-trioxypurine composition is 15g/ days.

12 parts of probiotics, 12 parts of green plum, 30 parts of inulin, 5~10 parts of adlay, 5~10 parts of Poria cocos, 1~5 part of chitosan.

Joint repair composition includes the following raw material of parts by weight meter:

12 parts, 10 parts of chondroitin, 75 parts of Isin glue collagen of ammonia sugar.

Comparative example 1

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) enhance hypoxanthine-guanine phosphoribosyl transferase (hypoxanthine-guanine Phosphoribosyl transferase, HGPRT) activity；

(2) anti-trioxypurine composition is taken；

(3) uric acid content is detected, is repeated step (1) and (2).

Wherein, the enhancing active method of HGPRT includes taking anserine 75mg/ days.

The dose of anti-trioxypurine composition is 15g/ days.

12 parts of probiotics, 12 parts of green plum, 30 parts of inulin.

Comparative example 2

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(2) anti-trioxypurine composition is taken；

(3) uric acid content is detected, is repeated step (1) and (2).

The dose of anti-trioxypurine composition is 15g/ days.

12 parts of probiotics, 12 parts of green plum, 30 parts of inulin.

Comparative example 3

The full nature cell Opsonizing method of high lithemia/gout, step include:

(1) Selenium Supplement and Zn-ef ficiency；

(3) uric acid content is detected, is repeated step (1) and (2).

The enhancing active method of HGPRT includes taking anserine 75mg/ days.

Detect example

300 patients are divided into 5 groups, every group 60, number is respectively 3 groups of embodiment, 4 groups of embodiment, comparative example 1 Group, 2 groups of comparative example, 3 groups of comparative example, improve patient using the Opsonizing method of reference numeral, the results are shown in Table 1.

1 conditioning effect of table

Number	In vain	It improves	Recovery from illness
				Embodiment 3	0	60	45
Embodiment 4	0	60	52
				Comparative example 1	10	50	5
Comparative example 2	13	47	8
				Comparative example 3	17	43	2

Wherein, refer to that symptom and laboratory check unchanged (blood uric acid decline is no more than 30%) in vain；Improvement articulations digitorum manus is swollen Swollen abatement, pain relief, laboratory, which checks, improvement (blood uric acid)；Recovery from illness refers to that symptom disappears, and blood uric acid checks normal.

Claims

1. the full nature cell Opsonizing method of high lithemia/gout, which is characterized in that step includes:

(1) Selenium Supplement and Zn-ef ficiency；

(3) anti-trioxypurine composition is taken；

2. the full nature cell Opsonizing method of high lithemia/gout according to claim 1, which is characterized in that after step (3) It further include taking joint repair composition.

3. the full nature cell Opsonizing method of high lithemia/gout according to claim 1, which is characterized in that step (1) institute The daily amount for stating selenium element is 200~400ug/ days, and the daily amount of the Zn-ef ficiency is 5~15mg/ days.

4. the full nature cell Opsonizing method of high lithemia/gout according to claim 1, which is characterized in that the enhancing The active method of HGPRT includes taking anserine 70~80mg/ days.

5. the full nature cell Opsonizing method of high lithemia/gout according to claim 1, which is characterized in that the drop urine The dose of acid composition is 5~30g/ days.

6. the full nature cell Opsonizing method of high lithemia/gout according to claim 5, which is characterized in that the drop urine Acid composition includes the following raw material of parts by weight meter:

5~20 parts of probiotics,

5~20 parts of green plum,

15~50 parts of inulin.

7. the full nature cell Opsonizing method of high lithemia/gout according to claim 6, which is characterized in that the drop urine Acid composition further includes the following raw material of parts by weight meter:

5~10 parts of adlay,

5~10 parts of Poria cocos,

1~5 part of chitosan.

8. the full nature cell Opsonizing method of high lithemia/gout according to claim 6, which is characterized in that described prebiotic Bacterium bag includes at least two in clostridium butyricum, lactic acid bacteria, Bifidobacterium, lactobacillus acidophilus, actinomyces and saccharomycete.

9. the full nature cell Opsonizing method of high lithemia/gout according to claim 2, which is characterized in that the joint Remediation composition includes the following raw material of parts by weight meter:

5~20 parts of ammonia sugar,

5~15 parts of chondroitin.

10. the full nature cell Opsonizing method of high lithemia/gout according to claim 9, which is characterized in that the joint Remediation composition further includes 50~100 parts of Isin glue collagen of parts by weight meter.