CN101584706A - Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes - Google Patents

Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes Download PDF

Info

Publication number
CN101584706A
CN101584706A CNA2009100816409A CN200910081640A CN101584706A CN 101584706 A CN101584706 A CN 101584706A CN A2009100816409 A CNA2009100816409 A CN A2009100816409A CN 200910081640 A CN200910081640 A CN 200910081640A CN 101584706 A CN101584706 A CN 101584706A
Authority
CN
China
Prior art keywords
vitamin
calcium
magnesium
zinc
chromium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2009100816409A
Other languages
Chinese (zh)
Inventor
陈欣晶
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Liqianqiu Technology Development Co Ltd
Original Assignee
Beijing Liqianqiu Technology Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Liqianqiu Technology Development Co Ltd filed Critical Beijing Liqianqiu Technology Development Co Ltd
Priority to CNA2009100816409A priority Critical patent/CN101584706A/en
Publication of CN101584706A publication Critical patent/CN101584706A/en
Pending legal-status Critical Current

Links

Abstract

A pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes comprises the following components: berberine, asiatic cornelian cherry fruit, vitamin A, beta-carotene, vitamin B complex, vitamin C, vitamin D, vitamin E, invariable elements of calcium, magnesium and minor elements of zinc, selenium, chromium and molybdenum. The pharmaceutical composition is mainly suitable for the people suffering from high blood sugar, high blood fat and diabetes. The pharmaceutical composition is quite effective in reducing blood sugar and blood fat and treating diabetes, and can be used for a long time or applied according to the treatment course.

Description

The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes
Technical field:
The present invention relates to the Medicines and Health Product technical field; Pharmaceutical composition in particular for blood sugar lowering and blood fat and treatment diabetes.
Background technology:
Said composition comprises berberine, the Radix Astragali, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum.
Berberine is from the crude drug Rhizoma Coptidis, and Cortex Phellodendri etc. contain the alkaloid that extracts in the medicine of berberine, but also synthetic; Modern clinical its treatment antibacterial dysentery commonly used, diseases such as acute gastroenteritis; There is scholar's research to show that Rhizoma Coptidis can improve high fat diet rat insulin opposing, makes that liver glycogen is synthetic to be increased; Clinical report is used berberine treatment diabetes separately has significant difference before the treatment; Berberine not only has significant hypoglycemic activity, and to diabetics with complication hypertension, hyperlipidemia, thrombosis etc. good preventive and therapeutic effect, clinical practice safety are arranged.
The Radix Astragali be a kind of be food be again the QI invigorating class natural Chinese medicine of medicine, have tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, holder skin ulcer granulation promoting, the effect of diuretic detumescent; Clinical deficiency-weakness of spleen-QI card, syndrome of qi failing to control blood, the middle Qi collapse syndrome of being used for the treatment of, syndrome of qi deficiency of spleen and lung, the two cards that lose of QI and blood, syndrome of fever due to qi deficiency, the empty hyperhidrosis card of body, deficiency of vital energy edema syndrome, the numb card of arthralgia due to stagnation of blood, apoplexy sequela, diabete, diseases such as carbuncle does not close up after with the passing of time not bursting or bursting for a long time, modern pharmacological research confirms that berberine has: 1, enhancing human body immunity and two-ways regulation body's immunity; 2, blood sugar regulation effect; 3, increase the effect of intelligence and reinforcement learning and memory; 4, antifatigue effect; 5, oxygen lack resistant function; 6, radiation resistance; 7, anti-cold effect; 9, antimutagenic effect; 10, tumor-inhibiting action; 11, antibiotic, antiviral, antiinflammatory action; 12, protect the liver, protect kidney, diuresis, protect the stomach effect; 13, promote osteogenesis effect; 14, estrogenic promoting action is arranged; 15, heart tonifying, blood vessel dilating, hypotensive effect; 16, promote protein synthesis; 17, anti-senescence function; 18. prolong the effect in zooblast life-span etc.
Vitamin A also claims retinol, the effect that improves vision, prevents nyctalopia is arranged, participate in glycogen and proteinic synthetic, can promote mucopolysaccharide synthetic, influence renewal, the growth of osseous tissue, long bone is grown to both-end, beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A, beta-carotene has the effect that suppresses LDL cholesterol oxidation reaction with vitamin E, vitamin C in the mode of cooperative compensating.
Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B 1, vitamin B 2, nicotiamide, pantothenic acid, biotin, vitamin B 6, vitamin B 12, folic acid etc., collaborative in vivo performance physiological action.Vitamin B 1Participate in body internal protein, fat, breakdown of carbohydrates metabolism and anabolism, can show vitamin B1 deficiency during shortage is the various dysbolismus of representative, vitamin B in addition 1Also participate in the neural impulse reaction, keep myocardium normal function, keep normal appetite, gastrointestinal peristalsis and digestive juice secretion etc.; Vitamin B 2Have another name called riboflavin, it is the ingredient of many important coenzyme in the body, participate in intravital substance metabolism, guarantee that vivo oxidation reduction reaction and energy generate, participate in anti-oxidative defense system in the body, mainly show oral cavity reproductive system syndrome, retardation of growth, iron deficiency anemia, moisture dermatitis, minimizing erythropoiesis, the systemic-function that affects the nerves, the vision etc. that reduces during shortage; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B 6Play the coenzyme effect of transaminase, amino acid decarboxylases in vivo, guarantee the metabolism of materials such as aminoacid, glycogen, fatty acid and one carbon unit, nicotinic acid, guarantee the normal propagation of nucleic acid and proteinic synthetic and cell, guarantee homergy with neurotransmitteies such as a hydroxytryptamine, taurine, dopamine, guarantee normal immunologic function, immunity degradation during shortage also can cause neural infringement; Vitamin B 12Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B 12The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.;
Vitamin C claims ascorbic acid again, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, and the effect that purifies the blood in addition prevents arteriosclerosis, in cholesterol metabolism, play an important role, can effectively reduce neutral fat, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious;
Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation 3, ergosterol produces vitamin D behind ultraviolet radiation 2, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.
Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest, has antioxidation, avoids the effect of biomembrane generation lipid peroxidation; Stop the effect of LDL oxidation formation, thereby prevent the generation of atherosclerosis and cardiovascular disease; Also have to regulate immunity, slow down aging, inhibition tumor in addition, promote fetal development and reproductive performance to reach the protective effect of nerve and skeleton etc.
Calcium is the macroelement that body weight for humans is wanted, main two aspects that play a part, the one, constitute sclerous tissueses such as bone tooth, the 2nd, with protein bound or constitute the material of specific function with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning.
Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart in addition and is prevented and treated the function etc. of diabetes in addition.
Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve.
Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.
Chromium is insulin " collaborative hormone ", to have the effect of active organochromium compounds " glucose tolerance factor (GTF) " form enhancing insulin, mainly be to keep normal carbohydrate metabolism of body and lipid metabolism, following symptom can occur when not enough: weaken glucose tolerance, increase the weight of hyperglycemia, glucose in urine, hypoglycemia, the circulation of acceleration insulin, reduce Insulin receptor INSR quantity, reduce the insulin binding ability, lose weight, increase fat content, increase vision pressure etc.The chromium of two kinds of valence states of stable existence in the environment, i.e. trivalent chromium and Cr VI, trivalent chromium has physiologically active, uses useful and harmlessly in an amount of scope, and Cr VI is a kind of strong oxidizer, and human body is had toxic and side effects.
Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of ferrum, promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.
Application contains berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B 1, vitamin B 2, vitamin B 6, nicotiamide, pantothenic acid, biotin, vitamin B 12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum be known as the compositions of active component, but with berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B 1, vitamin B 2, nicotiamide, pantothenic acid, biotin, vitamin B 6, vitamin B 12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, the molybdenum compatibility pharmaceutical composition report as yet that is used for blood sugar lowering and blood fat and treatment diabetes.
Current medicine that is used for blood sugar lowering and blood fat or health product kind have multiple, but action target spot is few, the link shortcoming, need perfectly, and have the medicine of side effect more, and cost and price are all very high in addition.
Summary of the invention:
In order to overcome the shortcoming and defect of existing blood sugar lowering and blood fat and treatment diabetes medicament, the purpose of this invention is to provide a kind of compositions, said composition increases vitamin A, beta-carotene, vitamin B by the berberine and the Radix Astragali 1, vitamin B 2, vitamin B 6, nicotiamide, pantothenic acid, biotin, vitamin B 12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum blood sugar lowering and blood fat effect, simultaneously by macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum and vitamin A, beta-carotene, vitamin B 1, vitamin B 2, nicotiamide, pantothenic acid, biotin, vitamin B 6, vitamin B 12, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen berberine and Radix Astragali blood sugar lowering and blood fat and treat the effect of diabetes, even chronic administration is also without any side effect; Because the result of broad research, the inventor has found berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B 1, vitamin B 2, nicotiamide, pantothenic acid, biotin, vitamin B 6, vitamin B 12, folic acid, vitamin C, vitamin D vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenic novel combination, this novel combination has synergy for blood sugar lowering and blood fat and treatment diabetes; And single with berberine, the Radix Astragali, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum, its effect is all not as good as this compositions; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.
The invention provides the pharmaceutical composition that is used for blood sugar lowering, hyperlipidemia and treatment diabetes, it comprises berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B as active component 1, vitamin B 2, nicotiamide, pantothenic acid, biotin, vitamin B 6, vitamin B 12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum.
The used Radix Astragali of the present invention with its extract as raw material.
Be used for vitamin B of the present invention 1(VitaminB 1), vitamin B 2(VitaminB 2), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B 6(VitaminB 6), vitamin B 12(VitaminB 12), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (BetaCarotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), chromium (Cr), molybdenum (Mo) are micro elements needed by human, and calcium (Ca), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate for use, calcium lactate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium carbonate etc., macroelement magnesium can be selected magnesium chloride for use, magnesium gluconate, magnesium lactate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium carbonate etc., trace element zinc can be selected zinc citrate for use, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, zinc gluconate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine for use, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, sodium selenite, selenocarrageenan, selenocysteine, the selenizing methionine, sodium selenate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, trivalent chromiums such as chromium yeast, trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc. all have professional production factory and supplier.
Compositions of the present invention mainly is applicable to hyperglycemia and hyperlipidemia and diabetic population, by the present invention, the effective dose of berberine is 600-1500mg/ days concerning the adult, and the effective dose of the Radix Astragali is 6000-60000mg/ days in whole crude drug concerning the adult, vitamin B 1Effective dose be 0.5-20mg/ days, vitamin B 2Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B 6Effective dose be 0.5-10mg/ days, vitamin B 12Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of macroelement calcium is counted 250-1000mg/ days with element calcium, the effective dose of magnesium is counted 100-300mg/ days with element magnesium, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, and molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum.
Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.
By the present invention, berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B 1, vitamin B 2, nicotiamide, pantothenic acid, biotin, vitamin B 6, vitamin B 12, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, molybdenum each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.
Advantage of the present invention is that this compositions is from too many levels, multisystem, many target spots blood sugar lowering and blood fat and treatment diabetes, the effect of collaborative performance effect is arranged between the each component, blood sugar lowering and blood fat there is significant effect with the treatment diabetes, sufficient raw, cost is low, each component has no side effect in the compositions, no incompatibility.
Subordinate list 1 adds Radix Astragali component for this compositions and berberine and vitamin added elements component causes diabetic mice blood sugar lowering test effect relatively to alloxan.
Subordinate list 2 adds Radix Astragali component for this compositions and berberine and vitamin added elements component causes diabetes model rat blood fat reducing test effect relatively to (STZ).
Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.
Embodiment 1:
Berberine 700mg,
Radix Astragali 8000mg,
Vitamin B 13mg,
Vitamin B 23mg,
Vitamin B 62mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium picolinate (in trace element chromium) 0.01mg,
Molybdic acid is received (in trace element molybdenum) 0.03mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 2:
Berberine 720mg,
Radix Astragali 8700mg,
Vitamin B 13mg,
Vitamin B 23mg,
Vitamin B 62mg,
Nicotiamide 10mg,
Vitamin C 90mg,
Zinc lactate (in trace element zinc) 8mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium yeast (in trace element chromium) 0.02mg,
Molybdic acid is received (in trace element molybdenum) 0.04mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 3:
Berberine 800mg,
Radix Astragali 9000mg,
Vitamin B 13mg,
Vitamin B 23mg,
Vitamin B 62mg,
Folic acid 0.3mg,
Vitamin B 120.003mg,
Nicotiamide 10mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.
Embodiment 4:
Berberine 880mg,
Radix Astragali 9500mg,
Vitamin B 13mg,
Vitamin B 23mg,
Vitamin B 62mg,
Folic acid 0.3mg,
Vitamin B 120.003mg,
Nicotiamide 10mg,
Biotin 0.08mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 5:
Berberine 980mg,
Radix Astragali 9800mg,
Vitamin B 13mg,
Vitamin B 23mg,
Vitamin B 62mg,
Folic acid 0.3mg,
Vitamin B 120.003mg,
Nicotiamide 10mg,
Pantothenic acid 5mg,
Biotin 0.06mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 10mg,
Sodium selenate (in trace element-selenium) 0.02mg,
Chromium yeast (in trace element chromium) 0.02mg,
Sodium molybdate (in trace element molybdenum) 0.03mg,
Calcium lactate (in element calcium) 600mg,
Magnesium lactate (in element magnesium) 200mg,
Vitamin D 0.002mg,
Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 6:
Berberine 600mg,
Radix Astragali 6000mg,
Vitamin B 10.5mg,
Vitamin B 20.5mg,
Vitamin B 60.5mg,
Folic acid 0.1mg,
Vitamin B 120.001mg,
Nicotiamide 5mg,
Pantothenic acid 2mg,
Biotin 0.01mg,
Vitamin C 30mg,
Zinc lactate (in trace element zinc) 5mg,
Sodium selenate (in trace element-selenium) 0.015mg,
Chromium yeast (in trace element chromium) 0.015mg,
Sodium molybdate (in trace element molybdenum) 0.02mg,
Calcium lactate (in element calcium) 250mg,
Magnesium lactate (in element magnesium) 100mg,
Retinol equivalent (vitamin A and/or beta-carotene) 200 μ g RE,
Vitamin D 0.015mg,
Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.
Embodiment 7:
Berberine 1500mg,
Radix Astragali 60000mg,
Vitamin B 120mg,
Vitamin B 220mg,
Vitamin B 610mg,
Folic acid 1mg,
Vitamin B 120.025mg,
Nicotiamide 50mg,
Pantothenic acid 20mg,
Biotin 0.1mg,
Vitamin C 500mg,
Zinc lactate (in trace element zinc) 20mg,
Sodium selenate (in trace element-selenium) 0.1mg,
Chromium yeast (in trace element chromium) 0.15mg,
Sodium molybdate (in trace element molybdenum) 0.06mg,
Calcium lactate (in element calcium) 1000mg,
Magnesium lactate (in element magnesium) 300mg,
Retinol equivalent (vitamin A and/or beta-carotene) 800 μ g RE,
Vitamin D 0.01mg,
Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.
Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 10, withdrew 5, obeyed again 10.
Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.
Embodiment 8: this compositions causes diabetic mice blood sugar lowering test effect relatively with each component to alloxan.
Select 60 of Kunming mouses, male female half and half; Wherein 48 mices are male female half and half, and fasting is after 16 hours, tail vein injection alloxan 70mg/kg -1, after 72 hours, measure fasting blood sugar, blood glucose value is higher than 16.7mmol/L -1The person is the hyperglycemia mice, according to blood sugar level the hyperglycemia mice is divided into 4 groups: model control group (B group), and the C group, the D group, the E group, each group of test is pressed 0.2mL/10g -1Continuous 10 days of body weight gastric infusion, fasting in the 10th day gastric infusion after 7 hours is measured after the administration 1 hour with method, 2 hours blood glucose value; 12 remaining mices, as normal control group (A group), model control group and normal control group irritate stomach once for the equal-volume normal saline every day.
Related data sees attached list 1.
Subordinate list 1: this compositions adds Radix Astragali component with berberine and vitamin added elements component causes diabetic mice blood sugar lowering test effect relatively to alloxan:
Figure A20091008164000251
Embodiment 9: this compositions causes diabetes model rat blood fat reducing test effect relatively with each component to (STZ).
Selecting SD is 48 feeds of male rat high lipid food, press an intraperitoneal injection STZ of 25mg/kg body weight (streptozotocin) after raising for 4 weeks, fasting is after 8 hours after 2 weeks, gavage the 20%D-glucose solution by the 2g/kg body weight, do the oral glucose tolerance test, all 0 and 2 hour blood glucose is respectively greater than 7.0 and the rat of 11.0mmol/L, as diabetes modeling success rat.Modeling success rat is divided into 4 groups at random, 12 every group, is respectively matched group (A group), the B group, C group, D group, test is respectively organized distilled water suspension oral gavage that every day, per os gave checking matter and equivalent once, matched group gives equivalent normal saline filling stomach once every day, in administration 12 week back fasting on the 3rd 10 hours, carotid artery blood sampling, measure T-CHOL respectively, triglyceride, high density lipoprotein, three indexs.
Related data sees attached list 2.
Subordinate list 2: this compositions adds Radix Astragali component with berberine and vitamin added elements component causes diabetes model rat blood fat reducing test effect relatively to (STZ):
Figure A20091008164000261
From table 1, can obviously find out, take this composite preparation and take berberine and add the difference that Radix Astragali component and vitamin added elements component contrast diabetic mice blood sugar lowering test effect has highly significant.
From table 2, can obviously find out, take this composite preparation and take berberine and add the difference that Radix Astragali component and vitamin added elements component contrast high blood lipid model rat blood fat reducing test effect has highly significant.

Claims (6)

1, a kind of pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:
Berberine 600-1500mg,
Radix Astragali 6000-60000mg,
Vitamin B 10.5-20mg,
Vitamin B 20.5-20mg,
Vitamin B 60.5-10mg,
Folic acid 0-1mg,
Vitamin B 120-0.025mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Chromium 0.015-0.15mg,
Molybdenum 0.02-0.06mg,
Calcium 0-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0-0.01mg,
Vitamin E 5-150mg a-TE.
2, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:
Berberine 600-1500mg,
Radix Astragali 6000-60000mg,
Vitamin B 10.5-20mg,
Vitamin B 20.5-20mg,
Vitamin B 60.5-10mg,
Folic acid 0-10mg,
Vitamin B 120-0.025mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Chromium 0.015-0.15mg,
Molybdenum 0.02-0.06mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
3, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:
Berberine 600-1500mg,
Radix Astragali 6000-60000mg,
Vitamin B 10.5-20mg,
Vitamin B 20.5-20mg,
Vitamin B 60.5-10mg,
Folic acid 0.1-1mg,
Vitamin B 120.001-0.025mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Chromium 0.015-0.15mg,
Molybdenum 0.02-0.06mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A/or beta-carotene] 0-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
4, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:
Berberine 600-1500mg,
Radix Astragali 6000-60000mg,
Vitamin B 10.5-20mg,
Vitamin B 20.5-20mg,
Vitamin B 60.5-10mg,
Folic acid 0.1-1mg,
Vitamin B 120.001-0.025mg,
Nicotiamide 5-50mg,
Pantothenic acid 0-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Chromium 0.015-0.15mg,
Molybdenum 0.02-0.06mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
5, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:
Berberine 600-1500mg,
Radix Astragali 6000-60000mg,
Vitamin B 10.5-20mg,
Vitamin B 20.5-20mg,
Vitamin B 60.5-10mg,
Folic acid 0.1-1mg,
Vitamin B 120.001-0.025mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Chromium 0.015-0.15mg,
Molybdenum 0.02-0.06mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
6, that be used for blood sugar lowering and blood fat and treatment Rezulin compositions according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:
Berberine 600-1500mg,
Radix Astragali 6000-60000mg,
Vitamin B 10.5-20mg,
Vitamin B 20.5-20mg,
Vitamin B 60.5-10mg,
Folic acid 0.1-1mg,
Vitamin B 120.001-0.025mg,
Nicotiamide 5-50mg,
Pantothenic acid 2-20mg,
Biotin 0.01-0.1mg,
Vitamin C 30-500mg,
Zinc 5-20mg,
Selenium 0.015-0.1mg,
Chromium 0.015-0.15mg,
Molybdenum 0.02-0.06mg,
Calcium 250-1000mg,
Magnesium 100-300mg,
Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,
Vitamin D 0.0015-0.01mg,
Vitamin E 5-150mg a-TE.
CNA2009100816409A 2009-04-07 2009-04-07 Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes Pending CN101584706A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNA2009100816409A CN101584706A (en) 2009-04-07 2009-04-07 Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA2009100816409A CN101584706A (en) 2009-04-07 2009-04-07 Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes

Publications (1)

Publication Number Publication Date
CN101584706A true CN101584706A (en) 2009-11-25

Family

ID=41369276

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2009100816409A Pending CN101584706A (en) 2009-04-07 2009-04-07 Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes

Country Status (1)

Country Link
CN (1) CN101584706A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109123655A (en) * 2018-08-23 2019-01-04 刘德平 A kind of special doctor's food and preparation method with three high crowd's generation meal regulatory functions
CN115702933A (en) * 2021-08-09 2023-02-17 深圳奥萨制药有限公司 Composition for assisting in reducing blood glucose

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109123655A (en) * 2018-08-23 2019-01-04 刘德平 A kind of special doctor's food and preparation method with three high crowd's generation meal regulatory functions
CN115702933A (en) * 2021-08-09 2023-02-17 深圳奥萨制药有限公司 Composition for assisting in reducing blood glucose
CN115702933B (en) * 2021-08-09 2024-04-16 深圳奥萨制药有限公司 Composition for assisting in reducing blood sugar

Similar Documents

Publication Publication Date Title
CN101474304A (en) Pharmaceutical composition for reducing blood sugar and blood fat
CN101601681A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat
CN101584706A (en) Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes
CN101574370A (en) Drug composition for reducing blood sugar and blood fat
CN101584709A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes
CN101601683A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes
CN101628027A (en) Drug combination for reducing blood sugar and lipid levels and treating diabetes
CN101584736A (en) Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes
CN101461868A (en) Pharmaceutical composition for reducing blood sugar, blood fat and treating diabetes
CN101574365A (en) Drug composition for reducing blood sugar and blood fat
CN101584710A (en) Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes
CN101596281A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat
CN101584708A (en) Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes
CN101596284A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat
CN101574368A (en) Drug composition for reducing blood sugar and blood fat
CN101584738A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes
CN101596212A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat
CN101601684A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes
CN101579399A (en) Pharmaceutical composition for reducing blood sugar and blood fat, and curing diabetes
CN101601685A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes
CN101569651A (en) Medicinal composition for lowering blood sugar
CN101632710A (en) Pharmaceutical composition for reducing blood glucose
CN101596210A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat
CN101632698A (en) Drug combination for reducing blood lipid level
CN101590150A (en) The pharmaceutical composition that is used for blood sugar lowering and blood fat

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20091125