CN101584708A - Pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes - Google Patents

Abstract

A pharmaceutical composition used for reducing blood sugar and blood fat and treating diabetes comprises the following components: berberine, asiatic cornelian cherry fruit, vitamin A, beta-carotene, vitamin B complex, vitamin C, vitamin D, vitamin E, invariable elements of calcium, magnesium and minor elements of zinc, selenium, chromium and molybdenum. The pharmaceutical composition is mainly suitable for the people suffering from high blood sugar, high blood fat and diabetes. The pharmaceutical composition is quite effective in reducing blood sugar and blood fat and treating diabetes, and can be used for a long time or applied according to the treatment course.

Description

The pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes

Technical field:

The present invention relates to the Medicines and Health Product technical field, in particular for the pharmaceutical composition of blood sugar lowering and blood fat and treatment diabetes.

Background technology:

Said composition comprises berberine, the Radix Astragali, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese.

Berberine is from the crude drug Rhizoma Coptidis, and Cortex Phellodendri etc. contain the alkaloid that extracts in the medicine of berberine, but also synthetic; Modern clinical its treatment antibacterial dysentery commonly used, diseases such as acute gastroenteritis; There is scholar's research to show that Rhizoma Coptidis can improve high fat diet rat insulin opposing, makes that liver glycogen is synthetic to be increased; Clinical report is used berberine treatment diabetes separately has significant difference before the treatment; Berberine not only has significant hypoglycemic activity, and to diabetics with complication hypertension, hyperlipidemia, thrombosis etc. good preventive and therapeutic effect, clinical practice safety are arranged.

The Radix Astragali be a kind of be food be again the QI invigorating class natural Chinese medicine of medicine, have tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, holder skin ulcer granulation promoting, the effect of diuretic detumescent; Clinical deficiency-weakness of spleen-QI card, syndrome of qi failing to control blood, the middle Qi collapse syndrome of being used for the treatment of, syndrome of qi deficiency of spleen and lung, the two cards that lose of QI and blood, syndrome of fever due to qi deficiency, the empty hyperhidrosis card of body, deficiency of vital energy edema syndrome, the numb card of arthralgia due to stagnation of blood, apoplexy sequela, diabete, diseases such as carbuncle does not close up after with the passing of time not bursting or bursting for a long time, modern pharmacological research confirms that berberine has: 1, enhancing human body immunity and two-ways regulation body's immunity; 2, blood sugar regulation effect; 3, increase the effect of intelligence and reinforcement learning and memory; 4, antifatigue effect; 5, oxygen lack resistant function; 6, radiation resistance; 7, anti-cold effect; 9, antimutagenic effect; 10, tumor-inhibiting action; 11, antibiotic, antiviral, antiinflammatory action; 12, protect the liver, protect kidney, diuresis, protect the stomach effect; 13, promote osteogenesis effect; 14, estrogenic promoting action is arranged; 15, heart tonifying, blood vessel dilating, hypotensive effect; 16, promote protein synthesis; 17, anti-senescence function; 18. prolong the effect in zooblast life-span etc.

Vitamin A also claims retinol, the effect that improves vision, prevents nyctalopia is arranged, participate in glycogen and proteinic synthetic, can promote mucopolysaccharide synthetic, influence renewal, the growth of osseous tissue, long bone is grown to both-end, beta-carotene can change vitamin A under the effect of enzyme in vivo, the effect of performance vitamin A, beta-carotene has the effect that suppresses LDL cholesterol oxidation reaction with vitamin E, vitamin C in the mode of cooperative compensating.

Vitamin B group participates in body internal protein, fat and sugar metabolism, makes the excitement of brain cell and inhibition be in poised state, and it comprises vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid etc., collaborative in vivo performance physiological action.Vitamin B ₁Participate in body internal protein, fat, breakdown of carbohydrates metabolism and anabolism, can show vitamin B1 deficiency during shortage is the various dysbolismus of representative, vitamin B in addition ₁Also participate in the neural impulse reaction, keep myocardium normal function, keep normal appetite, gastrointestinal peristalsis and digestive juice secretion etc.; Vitamin B ₂Have another name called riboflavin, it is the ingredient of many important coenzyme in the body, participate in intravital substance metabolism, guarantee that vivo oxidation reduction reaction and energy generate, participate in anti-oxidative defense system in the body, mainly show oral cavity reproductive system syndrome, retardation of growth, iron deficiency anemia, moisture dermatitis, minimizing erythropoiesis, the systemic-function that affects the nerves, the vision etc. that reduces during shortage; Nicotiamide claims niacin amide or vitamin PP again, and its physiological function is to participate in the body intracellular metabolic, keeps normal neurological function, and pellagra can take place during shortage in synthesizing of assurance gonadal hormone etc., mainly shows as dermatitis, diarrhoea, dull-witted three big symptoms; Pantothenic acid extensively exists in each organism, participates in metabolic activity widely, and known have 70 plurality of enzymes all to need pantothenic acid to participate in all kinds of biochemical reaction of catalysis body, otherwise just can Metabolic disorder; Biotin also is a kind of vitamin B group, coordinates to participate in the metabolism of human body matter and energy with other vitamin B group, and it is synthetic with nucleic acid, and the compositive relation of gonadal hormone is close, and it also has control poliosis, bareheaded effect; Vitamin B ₆Play the coenzyme effect of transaminase, amino acid decarboxylases in vivo, guarantee the metabolism of materials such as aminoacid, glycogen, fatty acid and one carbon unit, nicotinic acid, guarantee the normal propagation of nucleic acid and proteinic synthetic and cell, guarantee homergy with neurotransmitteies such as a hydroxytryptamine, taurine, dopamine, guarantee normal immunologic function, immunity degradation during shortage also can cause neural infringement; Vitamin B ₁₂Participate in nucleic acid in vivo, choline, amino acid whose synthetic and fat and sugared metabolism, to hemopoietic function of bone marrow, the gastrointestinal epithelial cells function, liver function and nervous system myelin functional integrity have certain effect, it is the necessary vitamin of intelligence of bringing into normal play, not only cause dysnoesia if lack, also nutritional anemia can occur, influence is to blood supply in the brain; Folic acid participates in the synthetic of aminoacid and nucleic acid, and and vitamin B ₁₂The common generation that promotes cell is with ripe, and normal cell can not carry out mitosis during shortage, the neurological symptom can occur, as: the loss of memory, depression and dementia etc.;

Vitamin C claims ascorbic acid again, vitamin C and collagen in close relations, the vessel softening effect is not only arranged, and the effect that purifies the blood in addition prevents arteriosclerosis, in cholesterol metabolism, play an important role, can effectively reduce neutral fat, can also promote the absorption of human body, for hemopoietic provides essential raw material ferrum in the food, simultaneously, vitamin C regain one's strength, aspect effect such as allaying tiredness, keeping tensions down emotion is obvious;

Vitamin D is the sterols derivant, and the subcutaneous dehydrocholesterol of human body produces vitamin D through ultraviolet radiation ₃, ergosterol produces vitamin D behind ultraviolet radiation ₂, the two originates different, the function unanimity, and the importance of vitamin D is to regulate the metabolism of calcium and phosphorus in human nutrition; Vitamin D promotes calcium in little intestinal absorption, the then a large amount of calcium of the D that is deficient in vitamin are discharged by feces, thereby cause the human body calcium deficiency, and rickets can take place the child, become the calcium phosphorus of storing in the human body to exhaust and can cause osteomalacia, modal osteomalacia crowd is anemia of pregnant woman, wet nurse and old people.

Vitamin E is all general designations with the bioactive chromone derivative of alpha-tocopherol, and wherein the activity of alpha-tocopherol is the highest, has antioxidation, avoids the effect of biomembrane generation lipid peroxidation; Stop the effect of LDL oxidation formation, thereby prevent the generation of atherosclerosis and cardiovascular disease; Also have to regulate immunity, slow down aging, inhibition tumor in addition, promote fetal development and reproductive performance to reach the protective effect of nerve and skeleton etc.

Calcium is the macroelement that body weight for humans is wanted, main two aspects that play a part, the one, constitute sclerous tissueses such as bone tooth, the 2nd, with protein bound or constitute the material of specific function with the form of calcium ion, form in so-called miscible calcium pool and the bone tooth calcium and keep dynamic equilibrium, all cells all need its normal function of calcium competence exertion in the body; Calcium deficiency can cause that also endocrine dysfunction and cell cycle regulation are malfunctioning.

Magnesium topmost function in human body is the generation of containment free radical, and free radical is short old and feeble factor, also is the factor that mainly causes birth defect; Another function of magnesium is to bring into play the effect of protection skeleton with calcium and vitamin D, and osteoporosis takes place magnesium deficiency easily, fractures easily; Magnesium is protected heart in addition and is prevented and treated the function etc. of diabetes in addition.

Trace element zinc is merged in the biomacromolecule ligand---in protein, nucleic acid, the film (being mainly memebrane protein), generate stable metallic biomacromolecule complex---metalloprotein, metalloproteinase nucleic acid complex etc., at present, known these materials participate in the synthetic and degradation process of carbohydrate, lipid, protein and nucleic acid, and the existence of zinc enzyme is all arranged in six big fermentoids; Zinc also is the essential element of enhance immunity vigor; Zinc can promote that proinsulin is converted into insulin by activating protaminase, and zinc deficiency makes insulin be obstructed in the activity of peripheral tissues, and it is unusual to cause glucose tolerance curve.

Trace element-selenium has obvious reduction serum total cholesterol, triglyceride and lipid peroxide, improves high density lipoprotein, the metabolic effect of superabundant fats in the acceleration bodies; Selenium also has the strong anti-oxidation function, and the protection embryo is not subjected to the injury of superoxides, prevention of cardiac; Anticancer by enhance immunity recognition system removing cancerous cell; Remove and the drainage heavy metal ion, hydrargyrum, methyl mercury, cadmium, lead etc. are had Detoxication, and heavy metal pollution is mainly to cause the birth defect factor; Scarce selenium can make the human insulin secretion reduce, impaired glucose tolerance, and oxidation resistance descends and quickens human senility and intelligence decline.

Chromium is insulin " collaborative hormone ", to have the effect of active organochromium compounds " glucose tolerance factor (GTF) " form enhancing insulin, mainly be to keep normal carbohydrate metabolism of body and lipid metabolism, following symptom can occur when not enough: weaken glucose tolerance, increase the weight of hyperglycemia, glucose in urine, hypoglycemia, the circulation of acceleration insulin, reduce Insulin receptor INSR quantity, reduce the insulin binding ability, lose weight, increase fat content, increase vision pressure etc.The chromium of two kinds of valence states of stable existence in the environment, i.e. trivalent chromium and Cr VI, trivalent chromium has physiologically active, uses useful and harmlessly in an amount of scope, and Cr VI is a kind of strong oxidizer, and human body is had toxic and side effects.

Copper is the active component of 30 plurality of enzymes such as lysyl oxidase in the body, cytochrome oxidase, monoamine oxidase, MAO, participates in the redox reaction of cell.When lacking copper, 7 α-hydroxyl enzyme and 12 α-hydroxylase activity that the catalysis cholesterol changes cholic acid into reduce, and cholesterol is synthetic and eliminate minimizing, and cholesterol is discharged and is obstructed, and causes hyperlipemia.Absolute or relative copper lacks can make serum TC, TG level raise, and causes high-cholesterol disease.

Molybdenum is one of micro elements needed by human, it is the formation element of plurality of enzymes, participate in the utilization of ferrum, promote erythrocytic growth and maturation, can prevent anemia, and can help the metabolism of carbohydrate and fat, it participates in removing the murder by poisoning of poisonous aldehydes in the human body, eliminate human free radical, have anticancer, defying age, enhancing immunity and anticariogenic function; Scarce molybdenum can bring out cardiovascular disease, cancer and dental caries.

Manganese participates in the formation of some enzymes in human body, it is the metabolism of involved in sugar and lipid not only, and all works in protein, DNA and RNA are synthetic.

Application contains berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, vitamin B ₆, nicotiamide, pantothenic acid, biotin, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese has been known as the compositions of active component, but with berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, the manganese compatibility pharmaceutical composition report as yet that is used for blood sugar lowering and blood fat and treatment diabetes.

Current medicine that is used for blood sugar lowering and blood fat or health product kind have multiple, but action target spot is few, the link shortcoming, need perfectly, and have the medicine of side effect more, and cost and price are all very high in addition.

Summary of the invention:

In order to overcome the shortcoming and defect of existing blood sugar lowering and blood fat and treatment diabetes medicament, the purpose of this invention is to provide a kind of compositions, said composition is by berberine and collaborative vitamin A, beta-carotene, the vitamin B of increasing of the Radix Astragali ₁, vitamin B ₂, vitamin B ₆, nicotiamide, pantothenic acid, biotin, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese blood sugar lowering and blood fat effect, simultaneously by macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese and vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E, replenish and strengthen berberine and Radix Astragali blood sugar lowering and blood fat and treat the effect of diabetes, even chronic administration is also without any side effect; Because the result of broad research, the inventor has found berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin D vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese novel combination, this novel combination has synergy for blood sugar lowering and blood fat and treatment diabetes; And single with berberine, the Radix Astragali, vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese, its effect is all not as good as this compositions; There is not incompatibility in this compositions, have no side effect, and cost is low, thereby constitutes the present invention.

The invention provides the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes, it comprises berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B as active component ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese.

The used Radix Astragali of the present invention with its extract as raw material.

Be used for vitamin B of the present invention ₁(VitaminB ₁), vitamin B ₂(VitaminB ₂), nicotiamide (Nicotinamide), pantothenic acid (Pantothenic Acid), biotin (Vitamin H), vitamin B ₆(VitaminB ₆), vitamin B ₁₂(VitaminB ₁₂), folic acid (Folic Acid), vitamin C (VitaminC), all are water soluble vitamins, do not accumulate in vivo; Vitamin A (Vitamin A), vitamin D (VitaminD), vitamin E (Vitamin E) are fatsoluble vitamiies, and beta-carotene (BetaCarotene) is the precursor substance of vitamin A, and be useful and harmless by the used dosage of the present invention; Zinc (Zn), selenium (Se), chromium (Cr), copper (Cu), molybdenum (Mo) are micro elements needed by human, and manganese (Mn) is human body possibility essential trace element, and calcium (Ca), magnesium (Mg) are the macroelements of needed by human; Macroelement calcium among the present invention can be selected calcium gluconate for use, calcium lactate, calcium acetate, calcium caseinate, calcium chloride, calcium citrate, calcium malate, calcium cirate malate, calcium hydrogen phosphate, dalcium biphosphate, calcium phosphate, calcium sulfate, calcium ascorbate, calcium glycerophosphate, calcium carbonate etc., macroelement magnesium can be selected magnesium chloride for use, magnesium gluconate, magnesium citrate, magnesium hydrogen phosphate, magnesium phosphate, magnesium glycerophosphate, magnesium lactate, magnesium carbonate etc., trace element zinc can be selected zinc citrate for use, zinc acetate, zinc carbonate, zinc oxide, zinc chloride, zinc lactate, zinc sulfate, zinc gluconate, single zinc methionine etc., trace element-selenium can be selected Selenomethionine for use, methoxybenzyl cyanic acid selenium, the two cyanic acid selenium of phenylene, selenocarrageenan, selenocysteine, the selenizing methionine, sodium selenite, sodium selenate etc., trace element chromium can be selected chromium trichloride for use, nicotinic acid chromium, chromium picolinate, trivalent chromiums such as chromium yeast, trace copper can be selected curpic carbonate for use, copper citrate, copper gluconate, copper sulfate etc., trace element molybdenum can be selected ammonium molybdate for use, sodium molybdate etc., trace element manganese can be selected manganese sulfate for use, manganese chloride, manganese gluconate, manganese glycerophosphate, manganese citrates etc. all have professional production factory and supplier.

Compositions of the present invention mainly is applicable to hyperglycemia, hyperlipidemia and diabetic population, by the present invention, the effective dose of berberine is 600-1500mg/ days concerning the adult, and the effective dose of the Radix Astragali is 6000-60000mg/ days in whole crude drug concerning the adult, vitamin B ₁Effective dose be 0.5-20mg/ days, vitamin B ₂Effective dose be 0.5-20mg/ days, the effective dose of nicotiamide is 5-50mg/ days, the effective dose of pantothenic acid is 2-20mg/ days, the effective dose of biotin is 0.01-0.1mg/ days, vitamin B ₆Effective dose be 0.5-10mg/ days, vitamin B ₁₂Effective dose be 0.001-0.025mg/ days, the effective dose of folic acid is 0.1-1mg/ days, ascorbic effective dose is 30-500mg/ days, the effective dose of vitamin A and/or beta-carotene (in retinol equivalent) is 250-800 μ gRE/ days; The effective dose of vitamin D is 0.0015-0.01mg/ days, the effective dose of vitamin E (in the alpha-tocopherol equivalent) is 5-150mg α-TE/ days, the effective dose of macroelement calcium is counted 250-1000mg/ days with element calcium, the effective dose of magnesium is counted 100-300mg/ days with element magnesium, the effective dose of trace element zinc is counted 5-20mg/ days with element zinc, selenic effective dose is counted 0.015-0.1mg/ days with elemental selenium, the effective dose of chromium is counted 0.015-0.15mg/ days with elemental chromium, the effective dose of copper is counted 0.5-1.5mg/ days with elemental copper, molybdenic effective dose is counted 0.02-0.06mg/ days with molybdenum, and the effective dose of manganese is counted 1-3mg/ days with element manganese.

Compositions of the present invention can or directly be taken by following pharmaceutical dosage forms dispenser, for example, oral formulations is (as granule, powder, capsule, ball, sheet, dry syrup, liquid formulation), or food such as food (as cookies), mix and prepare with other known additives, this class additive is for example: carrier, disintegrating agent, slow releasing agent, excipient, filler, covering, binding agent, lubricant, antioxidant, apply agent, coloring agent, correctives, sweeting agent, sucrose succedaneum, nutrition enhancer, flavouring agent, surfactant, plasticizer, the PH regulator, freshener, suspending agent, defoamer, antiseptic, thickening agent, solubilisation aids etc. are prepared or they are added food as functional component or additive by usual way.

By the present invention, berberine, the Radix Astragali, vitamin A, beta-carotene, vitamin B ₁, vitamin B ₂, nicotiamide, pantothenic acid, biotin, vitamin B ₆, vitamin B ₁₂, folic acid, vitamin C, vitamin D, vitamin E and macroelement calcium, magnesium and trace element zinc, selenium, chromium, copper, molybdenum, manganese each component can distinguish preparation, the preparation of each component can be mixed the back when using and use or do not mix simultaneously and use.

Advantage of the present invention is the effect of this compositions from too many levels, multisystem, many target spots collaborative performance blood sugar lowering and blood fat and treatment diabetes, blood sugar lowering and blood fat there is significant effect with the treatment diabetes, sufficient raw, cost is low, each component has no side effect in the compositions, no incompatibility.

Subordinate list 1 adds Radix Astragali component for this compositions and berberine and vitamin added elements component causes diabetic mice blood sugar lowering test effect relatively to alloxan.

Subordinate list 2 adds Radix Astragali component for this compositions and berberine and vitamin added elements component causes diabetes model rat blood fat reducing test effect relatively to (STZ).

Relatively tabulate below with reference to embodiment and test implementation example effect and to be described in detail the present invention.

Embodiment 1:

Berberine 680mg,

Radix Astragali 7200mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Nicotinic acid chromium (in trace element chromium) 0.08mg,

Magnesium chloride (in trace element magnesium) 250mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 2:

Berberine 720mg,

Radix Astragali 8000mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Vitamin C 100mg,

Zinc lactate (in trace element zinc) 8mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium picolinate (in trace element chromium) 0.06mg,

Copper citrate (in trace copper) 0.9mg,

Magnesium lactate (in element magnesium) 200mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 3:

Berberine 790mg,

Radix Astragali 8500mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Molybdic acid is received (in trace element molybdenum) 0.05mg,

Magnesium citrate (in trace element magnesium) 180mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Said components is further mixed equably with the additive of appropriate amount such as aluminosilicate magnesium, poly-solvate 60 and propylene glycol, the gained mixture is inserted capsule equably and 9 capsules, every day 3 times, each 3 capsules.

Embodiment 4:

Berberine 820mg,

Radix Astragali 9000mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Manganese citrate (in trace element manganese) 2mg,

Magnesium lactate (in element magnesium) 200mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 5:

Berberine 880mg,

Radix Astragali 9500mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Nicotiamide 10mg,

Pantothenic acid 12mg,

Biotin 0.06mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Manganese citrate (in trace element manganese) 2.5mg,

Magnesium lactate (in element magnesium) 200mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 6:

Berberine 900mg,

Radix Astragali 9800mg,

Vitamin B ₁3mg,

Vitamin B ₂3mg,

Vitamin B ₆2mg,

Folic acid 0.3mg,

Vitamin B ₁₂0.003mg,

Nicotiamide 10mg,

Pantothenic acid 2mg,

Biotin 0.01mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 10mg,

Sodium selenate (in trace element-selenium) 0.02mg,

Chromium yeast (in trace element chromium) 0.02mg,

Copper citrate (in trace copper) 0.8mg,

Sodium molybdate (in trace element molybdenum) 0.03mg,

Manganese citrate (in trace element manganese) 1.5mg,

Magnesium lactate (in element magnesium) 200mg,

Vitamin E (in the alpha-tocopherol equivalent) 10mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 7:

Berberine 600mg,

Radix Astragali 6000mg,

Vitamin B ₁0.5mg,

Vitamin B ₂0.5mg,

Vitamin B ₆0.5mg,

Folic acid 0.1mg,

Vitamin B ₁₂0.001mg,

Nicotiamide 5mg,

Pantothenic acid 2mg,

Biotin 0.01mg,

Vitamin C 30mg,

Zinc lactate (in trace element zinc) 5mg,

Sodium selenate (in trace element-selenium) 0.015mg,

Chromium yeast (in trace element chromium) 0.015mg,

Copper citrate (in trace copper) 0.5mg,

Sodium molybdate (in trace element molybdenum) 0.02mg,

Manganese citrate (in trace element manganese) 1mg,

Calcium lactate (in element calcium) 250mg,

Magnesium lactate (in element magnesium) 100mg,

Retinol equivalent (vitamin A and/or beta-carotene) 250 μ g RE,

Vitamin D 0.0015mg,

Vitamin E (in the alpha-tocopherol equivalent) 5mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn.

Embodiment 8:

Berberine 1500mg,

Radix Astragali 60000mg,

Vitamin B ₁20mg,

Vitamin B ₂20mg,

Vitamin B ₆10mg,

Folic acid 1mg,

Vitamin B ₁₂0.025mg,

Nicotiamide 50mg,

Pantothenic acid 20mg,

Biotin 0.1mg,

Vitamin C 500mg,

Zinc lactate (in trace element zinc) 20mg,

Sodium selenate (in trace element-selenium) 0.1mg,

Chromium yeast (in trace element chromium) 0.15mg,

Copper citrate (in trace copper) 1.5mg,

Sodium molybdate (in trace element molybdenum) 0.06mg,

Manganese citrate (in trace element manganese) 3mg,

Calcium lactate (in element calcium) 1000mg,

Magnesium lactate (in element magnesium) 300mg,

Retinol equivalent (vitamin A and/or beta-carotene) 250 μ g RE,

Vitamin D 0.01mg,

Vitamin E (in the alpha-tocopherol equivalent) 150mg α-TE.

Above-mentioned component is further mixed equably with additive such as mannitol, hydroxypropyl cellulose, aluminosilicate magnesium and the flavoring agent of appropriate amount, again the gained mixture is made 3 bag shot-like particles; Obey every day 3 times, obey a bag at every turn, serve on 10, withdrew 5, obeyed again 10.

Confirm that through animal experiment this compositions belongs to nontoxic level; The crowd takes and does not also see toxicity.

Embodiment 9: this compositions causes diabetic mice blood sugar lowering test effect relatively with each component to alloxan.

Select 60 of Kunming mouses, male female half and half; Wherein 48 mices are male female half and half, and fasting is after 16 hours, tail vein injection alloxan 70mg/kg ^-1, after 72 hours, measure fasting blood sugar, blood glucose value is higher than 16.7mmol/L ^-1The person is the hyperglycemia mice, according to blood sugar level the hyperglycemia mice is divided into 4 groups: model control group (B group), and the C group, the D group, the E group, each group of test is pressed 0.2mL/10g ^-1Continuous 10 days of body weight gastric infusion, fasting in the 10th day gastric infusion after 7 hours is measured after the administration 1 hour with method, 2 hours blood glucose value; 12 remaining mices, as normal control group (A group), model control group and normal control group irritate stomach once for the equal-volume normal saline every day.

Related data sees attached list 1.

Subordinate list 1: this compositions adds Radix Astragali component with berberine and vitamin added elements component causes diabetic mice blood sugar lowering test effect relatively to alloxan:

Embodiment 10: this compositions causes diabetes model rat blood fat reducing test effect relatively with each component to (STZ).

Selecting SD is 48 feeds of male rat high lipid food, press an intraperitoneal injection STZ of 25mg/kg body weight (streptozotocin) after raising for 4 weeks, fasting is after 8 hours after 2 weeks, gavage the 20%D-glucose solution by the 2g/kg body weight, do the oral glucose tolerance test, all 0 and 2 hour blood glucose is respectively greater than 7.0 and the rat of 11.0mmol/L, as diabetes modeling success rat.Modeling success rat is divided into 4 groups at random, 12 every group, is respectively matched group (A group), the B group, C group, D group, test is respectively organized distilled water suspension oral gavage that every day, per os gave checking matter and equivalent once, matched group gives equivalent normal saline filling stomach once every day, in administration 12 week back fasting on the 3rd 10 hours, carotid artery blood sampling, measure T-CHOL respectively, triglyceride, high density lipoprotein, three indexs.

Related data sees attached list 2.

Subordinate list 2: this compositions adds Radix Astragali component with berberine and vitamin added elements component causes diabetes model rat blood fat reducing test effect relatively to (STZ):

From table 1, can obviously find out, take this composite preparation and take berberine and add the difference that Radix Astragali component and vitamin added elements component contrast diabetic mice blood sugar lowering test effect has highly significant.

From table 2, can obviously find out, take this composite preparation and take berberine and add the difference that Radix Astragali component and vitamin added elements component contrast high blood lipid model rat blood fat reducing test effect has highly significant.

Claims (7)

1, a kind of pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0-1mg,

Vitamin B ₁₂0-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0-1.5mg,

Molybdenum 0-0.06mg,

Manganese 0-3mg,

Calcium 0-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,

Vitamin D 0-0.01mg,

Vitamin E 5-150mg a-TE.

2, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0-1mg,

Vitamin B ₁₂0-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0-0.06mg,

Manganese 0-3mg,

Calcium 0-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,

Vitamin D 0-0.01mg,

Vitamin E 5-150mg a-TE.

3, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0-1mg,

Vitamin B ₁₂0-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Manganese 0-3mg,

Calcium 0-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,

Vitamin D 0-0.01mg,

Vitamin E 5-150mg a-TE.

4, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0-1mg,

Vitamin B ₁₂0-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 0-20mg,

Biotin 0-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Manganese 1-3mg,

Calcium 0-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,

Vitamin D 0-0.01mg,

Vitamin E 5-150mg a-TE.

5, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0-1mg,

Vitamin B ₁₂0-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0.01-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Manganese 1-3mg,

Calcium 0-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,

Vitamin D 0-0.01mg,

Vitamin E 5-150mg a-TE.

6, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0.01-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Manganese 1-3mg,

Calcium 0-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 0-800 μ gRE,

Vitamin D 0-0.01mg,

Vitamin E 5-150mg a-TE.

7, the pharmaceutical composition that is used for blood sugar lowering and blood fat and treatment diabetes according to claim 1 is characterized in that it is pressed column weight amount proportioning by following bulk drugs and makes:

Berberine 600-1500mg,

Radix Astragali 6000-60000mg,

Vitamin B ₁0.5-20mg,

Vitamin B ₂0.5-20mg,

Vitamin B ₆0.5-10mg,

Folic acid 0.1-1mg,

Vitamin B ₁₂0.001-0.025mg,

Nicotiamide 5-50mg,

Pantothenic acid 2-20mg,

Biotin 0.01-0.1mg,

Vitamin C 30-500mg,

Zinc 5-20mg,

Selenium 0.015-0.1mg,

Chromium 0.015-0.15mg,

Copper 0.5-1.5mg,

Molybdenum 0.02-0.06mg,

Manganese 1-3mg,

Calcium 250-1000mg,

Magnesium 100-300mg,

Retinol equivalent [vitamin A and/or beta-carotene] 250-800 μ gRE,

Vitamin D 0.0015-0.01mg,

Vitamin E 5-150mg a-TE.