CN101549098B - Pandan leaf extract for treating gout and preparation method thereof - Google Patents
Pandan leaf extract for treating gout and preparation method thereof Download PDFInfo
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- CN101549098B CN101549098B CN2008100664083A CN200810066408A CN101549098B CN 101549098 B CN101549098 B CN 101549098B CN 2008100664083 A CN2008100664083 A CN 2008100664083A CN 200810066408 A CN200810066408 A CN 200810066408A CN 101549098 B CN101549098 B CN 101549098B
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Abstract
The invention discloses a pandan leaf extract for treating gout and a preparation method thereof. The pandan leaf extract is prepared by taking pandan leaves as raw material, extracting the pandan leaves by polar solvent and concentrating and refining the extract. The preparation method comprises the following steps: the bandan leaves are decorated and extracted by taking alkaline ionized water assolvent, and the extract is obtained by filtering and concentrating. The invention provides the pandan leaf extract which has good treatment effect and is safer in treating gout. The pandan leaf extr act can relieve or even eliminate gout symptoms and is applied for preventing and treating gout. The preparation method has simple process and low cost.
Description
Technical field
The present invention relates to a kind of plant extract that is used to treat gout and preparation method thereof, relate in particular to a kind of Pandan leaf extract that is used to treat gout and preparation method thereof.
Background technology
Gout is a kind of common arthritis disease; The cause of disease is because personal intravital purine (Purine)---planting the uric acid material can't smooth and easy metabolism; Make the interior uric acid of blood too high, uric acid reaches to saturated level in blood, just can form metabolic arthritis salt acicular crystals; Be deposited in intraarticular or the tendon, like parts of body such as toe and finger-joint, knee, muscle aponeurosis (aponeuroses) or subcutaneous tissue.Urate accumulates in intraarticular and causes inflammation and pain, serious gout can make the joint become lopsided.Except that the joint, excessive urate also possibly accumulate in other positions of health, and for example kidney, heart etc. are located, and can cause nephropathy, coronary heart disease, possibly cause renal failure, heart disease, apoplexy etc. when serious.The diagnosis gout can be made a definite diagnosis through the content that detects uric acid in the blood; Uric acid content in the normal human blood should be at 3.6mg/dl (about 214 μ mol/l)～8.3mg/dl (about 494 μ mol/l); The uric acid saturation solubility is about 6.4mg/dl; The uric acid level that draws via blood test just can be diagnosed as hyperuricemia in case surpass 7mg/dl when above, must regularly be checked and measure.If surpass 8mg/dl, will accept Drug therapy.
The kind of treatment gout medicine can be divided into acute and chronic two kinds:
(1) acute gout disease drug: can alleviate acute joint pain Chu rapidly, it is normal that joint motion is replied.For example on-steroidal anti-inflammation analgesic (NSAID) and colchicine (Colchicine) etc.
(2) chronic gout disease drug: can prevent the gout outbreak.A kind of medicine that suppresses the uric acid generation is " uric acid synthesizes Inhibitors ", and another kind of medicine is " uricosuric drug " that impels uric acid to discharge from kidney.Medicine commonly used has probenecid (Probenecid) and allopurinol (Allopurinol) etc.
These on-steroidals commonly used are synthetic Inhibitors of anti-inflammatory analgesic, uric acid and uricosuric drug, though but mitigate the disease after the patient takes all can not effect a radical cure gout; Also have toxic and side effects in various degree, can cause dependence, also can cause gastrointestinal upset, hemolytic anemia, gastrorrhagia so that liver and renal failure etc. as taking anti-inflammatory and analgesic agents for a long time; Only to suppressing the synthetic Inhibitors of uric acid that uric acid produces, another kind is the uricosuric drug that impels uric acid to discharge to anti-uric acid medicine, and the two does not all have analgesia, antiinflammation; So it is invalid to acute gout; Also possibly have erythra, headache and the reaction of some intestines and stomaches, therefore, the use of these medicines is restricted.
Summary of the invention
The technical problem that the present invention will solve is, the Pandan leaf extract that is used to treat gout that a kind of therapeutic effect is good, safer, have no side effect is provided, and this extract can alleviate even eliminate the gout symptom, is used for prevention and treatment gout.
The technical problem that the present invention further will solve is, the method for preparing of the Pandan leaf extract that a kind of technology is simple, cost is low is provided.
The technical solution adopted for the present invention to solve the technical problems is: a kind of Pandan leaf extract that is used to treat gout is a raw material with the BANLANYE, extracts the back with polar solvent and concentrates the refining extract that obtains; Said polar solvent is an alkali ion water; Said extract is to be that 8～9.5 alkali ion water decocts BANLANYE and extracts the extract that obtains through pH value; Said extract adopts silica gel g thin-layer plate to carry out chromatography according to thin layer chromatography after filtration; Wherein using volume ratio is that 4: 1: 1 butanols, the mixed solvent of second alcohol and water are done developing solvent; Chromatography is placed under the ultra-violet lamp and inspects, and active component has the Rf value in 0.29-0.35,0.40-0.44 or the 0.79-0.83 scope in the extract.
The method for preparing that is used to treat the Pandan leaf extract of gout is: add alkali ion water after selecting for use dried BANLANYE to pulverize and soak 30min～3 hour, heating decocted 1～3 hour then, perhaps selected bright BANLANYE soaking-free for use; Direct heating decocted 1～3 hour, filtered, and filtering residue adds alkali ion water once more; Decoct 30min～1 hour, filter, merge filtrating twice; Heating be concentrated into total liquid measure 25%～75% after, cooling, sterilization encapsulation.
Be used to treat the method for preparing of the Pandan leaf extract of gout; Following steps most preferably: the alkali ion water that adds 3～5 times of medical material weight after selecting for use dried BANLANYE to pulverize soaks 30min～1 hour; Select then soaking-free of bright BANLANYE for use, be heated to 80-100 ℃ then and decocted 1～1.5 hour, filter; The alkali ion water that filtering residue adds 1～1.5 times of medical material weight once more is heated to 80-100 ℃ and decocts 30min～1 hour; Merge filtrating twice, heating be concentrated into total liquid measure 25%～50% after, cooling, sterilization encapsulation.
The pH value of said alkali ion water is 8～9.5.
The dosage form for preparing of extract of the present invention is not limited to the said dosage form of above-mentioned method; Can also extract of the present invention be added different auxiliary material; Like disintegrating agent, lubricant, binding agent, cosolvent etc., and be prepared into any common formulations with the traditional pharmaceutical methods of routine.The present invention can also process medicine or health composition with many suitable pharmaceutical known in the art or health care carrier.Utilize commercial size production of the present invention, decoct above-described raw material,, add different auxiliary material again, process multi-form liquid preparations such as mixture, syrup, Emulsion through filtering, concentrating; Also can these raw materials be decocted,, process granule through filtering, after concentrated, the spray drying, adding corresponding adjuvant again; Can also prepare with excipient, inserting capsule becomes capsule; Tablet forming is processed tablet; Be dissolved in a kind of commercial applicable carrier like multi-form solid preparations such as pill, powder, drop pill; Also can these raw materials be extracted with the Spirit of variable concentrations and process medicated wine etc.
Natural plants BANLANYE (Latin title Pandanus latifolius, Pandanus amaryllifolius) is claimed Pandan Leaves again, is at the very general a kind of spice food materials of country in Southeast Asia, and especially utilization is the most extensive in the sweets group food.According to Flavor and Chemistry of Ethnic Foods (Proceedings of a Meeting held during the 5th Chemical Congress of North America], Cancun, Nov.11-15; 1997 (1999) meeting and Phytochemistry; 34,1159,1993 and Phytochemistry; 21; 1653-1657,1982.) secretary is carried, and contains various active compositions such as piperine type alkaloid, vitamin, mineral, flavonoid, ferment, quintessence oil in the BANLANYE:
Wherein, (a) composition such as Piperidine-type alkaloids piperine type alkaloid, like pandamarine, pandamerilactones etc.;
(b) the compounds composition of effumability: like 3-methyl-2-(5H)-furanone, 3-hexanol, 4-methylpentanol, 3-hexanone and 2-hexanone etc.;
(c) the natural materials composition of fragrant: like 2-acetyl-1-pyrroline, ethyl formiate, styrene; β-farnesene, β-caryophyllene, formylthiphene; Linalool, 1,2-dimethoxybenzene and β-selinene etc.;
Because a lot of alkaloids, flavone etc. have the pharmacology to influence to people and other animals, extract of the present invention finds to dissolve more urate crystal body clinically excretes uric acid naturally, plays the uric acid reducing effect, regulates uric acid to normal range.Wherein, mainly be that piperine type alkaloids can make the dissolubility of uric acid in blood rise, make the dissolving of urate crystal body, reduce urate in tissue and IA deposition, thereby alleviate patient's misery, for light patient preventive effect is preferably arranged.
The present invention also finds to have diuretic actions clinically, increases the urine amount, promotes kidney that the uric acid of cylinder accumulation is excreted in urine as far as possible.Because uric acid absorbs a large amount of moisture originally as water-soluble substances, when the urine amount increases; Urine will thin out, thereby reduces the concentration of blood plasma uric acid, reduces urate and in tissue, deposits; Therefore also excretion metabolism refuse simultaneously when urinating is the best diuretic that promotes that bodily tissue is sound.
The alkali ion water that the present invention adopts is exactly the alkaline water that negative pole produced after the electrolysis of water process.Wherein the water of that side of negative electrode is called " alkali ion water ", and water is broken up water clusters, diminish, arrange again under effect of electric field when electrolysis; Make wherein that the ORP of a part of water (Oxidative redox potentia oxidation-reduction potential) is positive potential, another part water ORP is nagative potential, the calcium in the water, potassium, magnesium, sodium ... wait cation to move to negative electrode; Enrichment a large amount of mineral, especially ionized calcium, alkali ion water can in body in acid poison; Changing acidic physique, is micromolecular water: the micel of general water is about 13～16 micels, and water clusters is contracted to 5～6 micels after electrolysis; And mineral is ionized, and dissolubility is big, and penetration is strong; Water clusters is very similar with the interior molecular structure water of body, is prone to participate in the mass exchange of cell, and the human absorptivity reaches more than 95%.More effectively the old refuse in scavenger cell and the blood enhances metabolism.
Alkali ion water can make the decline of uric acid concentration in the blood, and increases the dissolubility of urine uric acid, and auxiliary minimizing urate deposits in tissue.Its pH value of common people's urine is 5.5～6.0 faintly acid.Hyperuricemia patient mostly is the aciduria below 5.5.When health presented alkalescence, uric acid just was excreted than being easier to.If make body fluid be alkalescence for a long time, just early prevention of recurrence with alleviate gout.Drink the water of weak base degree, can metabolic waste be excreted, also can blood circulation promoting, make mineral such as sodium and potassium isoequilibrium between blood capillary and the cell, enhance metabolism useful whole body health.
When the mixed alkali ion water of Pandan leaf extract was drunk together, the active component in the extract and alkali ion water synergism can further promote the effect of effect uric acid resisting, regularly drink the uric acid concentration that can make in the blood and recover normally.Thereby the uric acid resisting that can effectively and have no side effect, prevention and alleviation gout.
After taking Pandan leaf extract of the present invention, have the effect of following several respects:
1. quicken to drain uric acid too much in the body, regulate uric acid to normal range;
2. improve the red and swollen situation in joint;
3. improve urate crystal and be deposited on intraarticular;
4. alleviate the pain of redness and swelling of joints;
5. shorten the time that gout continues.
Extract of the present invention belongs to natural, and character is gentle, not only is fit to treatment, no matter also be suitable for health preserving, health care, event deficiency of vital energy weak person, or take for a long time and also can not cause uncomfortable and generation adverse side effect.Take once every day, if gout outbreak, can increase as many as early, take evening.Taking flow process and effect can be along with different human body structure and metabolism and different, generally takes just to begin to produce effect in four hours, takes continuously, and effect is remarkable.
The specific embodiment
In order further to set forth technical scheme of the present invention, enumerate the specific embodiment explanation as follows at present:
The BANLANYE that uses so long as food use then have no restriction, the BANLANYE that uses in the present embodiment is the BANLANYE of Thailand.
Embodiment 1:
Add the fresh alkali ion water of 4000ml after dried BANLANYE 1kg pulverizes, its pH is 9, soaks 30min; Being heated to 100 ℃ decocted 1.5 hours; Filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 100 ℃ of decoctions 1 hour, merges filtrating twice; Heating is concentrated into amount of filtrate behind 1000ml, and mixture is promptly processed in cooling, sterilization, encapsulation.
The production of alkali ion water: general earlier with common tap water or mineral water purification, then through the positive and negative electrode electrolysis,, collect the fresh alkali ion water of negative electrode through the membrane separation technique separation, directly add decoction BANLANYE container and get final product.
Instructions of taking: every day 1～3 time, each 30～60ml also takes behind 3～5 times of the dilutable waters, and the person of being in a bad way takes the circumstances into consideration dosage.
Embodiment 2:
Bright BANLANYE 1kg adds the fresh alkali ion water of 3000ml, and its pH is 8.5, is heated to 80 ℃ and decocts 3 hours; Filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 80 ℃ of decoction 30min, merges filtrating twice; Heating is concentrated into amount of filtrate behind 1000ml, cools off subsequent use; Then with the concentrated solution of extract with after supplementary product starch, sucrose and disintegrating agent mix, add with the plain derivative solution of water-soluble adhesive fiber and mix, employing extrusion granulator method is processed soft grit with medicine; The reuse baking oven for heating is carried out dried to soft grit; Dry back forms the single-size of certain particle size through sieving, oversize is suitably pulverized the back after sieve, until processing whole homogeneous granules, promptly processes granule, is distributed into the fractional pack of 10g one bag.
The production of alkali ion water is repeated no more at this with embodiment 1.
Instructions of taking: every day 1～3 time, each 2～4 bags, the person of being in a bad way takes the circumstances into consideration dosage.
Embodiment 3:
Bright BANLANYE 1kg adds the fresh alkali ion water of 5000ml; Its pH is 9.5, is heated to 90 ℃ and decocts 2 hours, filters; The alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 80 ℃ of decoction 40min; Merge filtrating twice, heating is concentrated into amount of filtrate behind 1000ml, cools off, cools off subsequent use; Then with the concentrated solution of extract with after supplementary product starch, sucrose and disintegrating agent mix, add with water-soluble adhesive fiber element derivative solution and mix, process soft grit; The reuse oven drying is handled; Dry back forms the single-size of certain particle size through sieving, mixes with powdered filler, lubricant, bonding agent then, tabletting, be distributed into fractional pack then.
The production of alkali ion water is repeated no more at this with embodiment 1.
Instructions of taking: every day 1～3 time, each 4～6, the person of being in a bad way takes the circumstances into consideration dosage.
Embodiment 4:
Dried BANLANYE 1kg adds the fresh alkali ion water of 4000ml, and its pH is 8, soaks 3 hours; Be heated to 90 ℃ and decocted 1 hour, filter, the alkali ion water that filtering residue adds medical material weight 1000ml once more is heated to 100 ℃ of decoction 40min; Merge filtrating twice, heating is concentrated into amount of filtrate behind 1000ml, and it is subsequent use to cool off, sterilize; Add the adjustment agent then, process beverage, supply that the patient is daily to drink.
The production of alkali ion water is repeated no more at this with embodiment 1.
The extract of the embodiment of the invention 1 detects result such as following table through Hong Kong standard and calibrating center.
Annotate (*): illustrated regulations are shown in the Laws of Hong Kong's the one three two V chapter, subordinate list 2.
Test result shows that medicine of the present invention does not contain heavy metal and escherichia coli, and it is a kind of foolproof extract.
Clinical experiment
Medicine of the present invention wherein has acute gout 8 example and chronic gout 3 examples through the inventor and some volunteer's clinical experiments, drinks mixture of the present invention every day 1～3 time, and each 30～60ml takes March continuously～and 3 years.
| Case | There is not recurrence | Produce effects | Effectively | Invalid |
| Acute gout | 3 | 3 | 2 | 0 |
| Chronic gout | 0 | 2 | 1 | 0 |
Total effective rate of the present invention is 100%, produce effects and do not have the recurrence account for more than 70%.
Carry out labor with regard to three model cases below:
Case 1:
The man, 47 years old, office work was not smoked, and did not drink with not fat, and health one is to health.First outbreak is a late into the night several years ago, and is awake bitterly by right first metatarsophalangeal joints, and severe pain is like the appearance of lancinating, and with red and swollen and scorching hot, the affected part articular sensation is stiff.This moment is any to be brushed up against wind and can make all that the pain increased.Pain peaked in 24 hours, was diagnosed as " acute pain syndrome caused by wind pathogen " through the doctor, after Drug therapy, slowed down pain, but timeliness one mistake, pain is still.After four days, redness fades away, and sole of the foot toe is replied normal.Afterwards in the course of disease; Repeatedly in the outbreak at midnight, premorbid does not have any tendency, and site of pathological change also singly appears at finger-joint, ankle and knee endoprosthesis place; Have extreme arthralgia and red and swollen symptom, but not whole body heating, headache, feel sick, malaise symptoms such as cardiopalmus, shiver with cold.Pain continues after several days with red and swollen, and the state of an illness is replied improvement again.
Through the initial stage that take extract of the present invention every day, during the gout acute attack, swelling is disappeared than very fast; Pain, redness and scorching hot also than slight and alleviation in the past, recurrent interval time has also prolonged several times.Chemical examination contrast before and after wherein taking, blood uric acid concentration is by the normal low value 0.28mmol/L that takes after preceding 0.38mmol/L drops to 2 years, all transference cures, Mental Health.
Case 2:
The woman, 73 years old now, the housewife, health one is to bad, suffers from gout surplus in the of 15 year, is diagnosed as " chronic gout and rheumatic arthritis " through how tame doctor, and wrist and finger-joint portion have formed tophus, more can't work, because of gout has caused inconvenient activity.Annual can the outbreak repeatedly, DOS prolongs, so that can not alleviate fully.And increase in the joint of getting involved, and experiences all sorts of and can not treat more, very painful.Pathological changes such as more serious urate nephropathy, uric acid property lithangiuria fortunately do not take place.Take extract mixture of the present invention, blood uric acid concentration is dropped to normal value 0.31mmol/L taking by the 0.34mmol/L before taking more than a year, and all tophuses disappear, and hand activities is as usual, and health does not have discomfort, and spirit is rather good.
Case 3:
The woman, 65 years old now, the housewife, and often participate in community activity.Morning on June 12nd, 2006, first big toe pain was waken up with a start, and red and swollen heating can not be taken action anorexia.Emergency case doctor is diagnosed as " acute pain syndrome caused by wind pathogen " with metabolic arthritis 0.35mmol/L, with Drug therapy, slows down pain.In therapeutic process after being ill, the doctor uses the uric acid resisting medicine, but gastrointestinal symptom side effect such as nausea and vomiting, diarrhoea occur.Patient more worries to take for a long time and can increase the weight of renal insufficiency, influences other vitals of health.The medicine of the present invention of migrating, taking after 3～5 days does not have discomfort, and use does not have other side effect yet continuously, and is respond well.Follow up a case by regular visits to after half a year, blood uric acid is kept low level＜0.32mmol/L, and all are normal for patient's readme whole body, no abnormalities feel.
Table one: take preceding situation
Table two: take situation behind the extract of the present invention
Annotate 1: the gout degree is divided: " slightly " is meant that there is a little redness in the patient joint, just can disappear every other day." medium " expression patient arthralgia, but still freely movable." seriously " is meant patient's arthralgia, and be stiff.
Annotate 2: behind physical examination, major organs comprises that eight kinds of main organs such as the heart, liver, spleen, lung, kidney are normal.
Effective evaluation:
(1) extract of the present invention is significantly effective to goat, and joint function recovery is fast, can alleviate the inflammatory reaction that local uric acid deposition is caused, has alleviated pathology damage.
(2) thing of the present invention has diuresis, obviously increases at the voided volume of taking in 4 hours.
(3) take front and back patient's blood uric acid difference own control relatively, significant difference explains that extract of the present invention can have the effect of reduction blood uric acid in various degree.
(4) with take preceding comparison, each side all has improvement.Prolong 7～15 times before wherein each recurrent interval time is taken, effective percentage is 100%.
The approach of above-mentioned case administered through oral is effective uric acid resisting just, prevention and alleviate gout, its effectiveness can be the same with the anti-uric acid medicine of Western medicine, but in not having, the toxic and side effects of Western medicine occurs.Its principle is to nurse one's health uric acid to normal range, drains uric acid too much in the body, reduces urate crystal Shen and amasss at intraarticular, thereby alleviate patient's misery.
In sum, administered through oral of the present invention just can the regulating body function uric acid resisting, prevention and alleviate gout, and its each composition is all from natural plants, and human body is not had any toxicity and side effect, meets the condition of patent of invention, proposes application for a patent for invention in accordance with the law at present.The above is merely preferred embodiment of the present invention, and the equivalence that every those of ordinary skill in the art do according to creation spirit of the present invention is modified or changed, and all should be encompassed in the application's the protection domain.
Claims (4)
1. a Pandan leaf extract that is used to treat gout is characterized in that, the alkali ion water that adds 3～5 times of medical material weight after selecting for use dried BANLANYE to pulverize soaks 30min～1 hour; Select then soaking-free of bright BANLANYE for use; Be heated to 80-100 ℃ then and decocted 1～1.5 hour, filter, the alkali ion water that filtering residue adds 1～1.5 times of medical material weight once more is heated to 80-100 ℃ and decocts 30min～1 hour; Merge filtrating twice; Heating be concentrated into total liquid measure 25%～50% after, cooling, sterilization encapsulation obtain Pandan leaf extract.
2. the method for preparing of a Pandan leaf extract is characterized in that, the alkali ion water that adds 3～5 times of medical material weight after selecting for use dried BANLANYE to pulverize soaks 30min～1 hour; Select then soaking-free of bright BANLANYE for use, be heated to 80-100 ℃ then and decocted 1～1.5 hour, filter; The alkali ion water that filtering residue adds 1～1.5 times of medical material weight once more is heated to 80-100 ℃ and decocts 30min～1 hour; Merge filtrating twice, heating be concentrated into total liquid measure 25%～50% after, cooling, sterilization encapsulation.
3. the method for preparing of Pandan leaf extract according to claim 2 is characterized in that, the pH value of said alkali ion water is 8～9.5.
4. the method for preparing of Pandan leaf extract according to claim 3 is characterized in that, Pandan leaf extract is prepared into all dosage forms that allow on the pharmaceutics after concentrating.
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| CN104338054A (en) * | 2014-11-07 | 2015-02-11 | 成都华熹科技有限公司 | Traditional Chinese medicine composition containing pandan leaves for treating gout |
| CN107929450A (en) * | 2018-01-12 | 2018-04-20 | 王生标 | A kind of application using Pandan Leaves in gout is treated |
| CN109699775A (en) * | 2018-12-03 | 2019-05-03 | 杭州娃哈哈科技有限公司 | A kind of sugar-free golden flower black tea drink and preparation method thereof using electrolysis water extraction tea |
| CN113208019A (en) * | 2021-05-27 | 2021-08-06 | 海南国椰食品有限公司 | Multicolored coconut juice and preparation method thereof |
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Non-Patent Citations (1)
| Title |
|---|
| 黄丹民.痛风病从脾胃论治的探讨.《北京中医药大学硕士研究生学位论文》.北京中医药大学,2006,全文. * |
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