CN102485270A - Traditional Chinese medicine preparation for treating gout and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating gout and preparation method thereof Download PDFInfo
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- CN102485270A CN102485270A CN2010105682901A CN201010568290A CN102485270A CN 102485270 A CN102485270 A CN 102485270A CN 2010105682901 A CN2010105682901 A CN 2010105682901A CN 201010568290 A CN201010568290 A CN 201010568290A CN 102485270 A CN102485270 A CN 102485270A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating gout and a preparation method thereof. The traditional Chinese medicine preparation is a pour traditional Chinese medicine composition. The traditional Chinese medicine preparation for treating gout comprises 30 to 200g of glabrous greenbrier rhizome, 1 to 20g of curcumol, 1 to 20g of root of doubleteeth pubescent angelica, 1 to 30g of radix clematidis, 1 to 30g of himalayan teasel root, 1 to 30g of radix cyathulae, 1 to 50g of plantain seed, 1 to 30g of pawpaw, 1 to 30g of eucommia ulmoides, 1 to 20g of frankincense, 1 to 20g of myrrh, 10 to 100g of sparganium stoloniferum, 1 to 30g of corydalis tuber and 1 to 50g of engelhardia roxburghiana wall leaf. The traditional Chinese medicine preparation for treating gout has special curative effects of thoroughly treating gout, has a high cure rate, allows a short application period and does not produce obvious side-effects.
Description
Technical field:
The present invention relates to a kind of pure Chinese medicine pharmaceutical composition and preparation method thereof, particularly a kind of Chinese medicine preparation that is used to treat gout and preparation method thereof.
Background technology:
The medicine of treating gout is mainly reflected in the following aspects both at home and abroad at present:
1, generally handles protein intake, increase the uric acid dissolubility, prevent that calculus from forming.Simultaneously, should not use the medicine that suppresses urate excretion, like hydrochlorothiazide (hydrochlorothiazide), furosemide, ethambutol, pyrazinamide and nicotinic acid etc.
2, the treatment of acute arthritis phase is used following medicine control arthritis, relief of symptoms.
(1) colchicine: when being first-selection, but should note:, should strictly take precautions against if medicine liquid leakage during intravenous injection then can cause tissue necrosis to control gouty arthritis tool significance curative effect.In addition, colchicine still can cause bone marrow depression, hepatocellular damage, alopecia, spirit depressing, ascending paralysis, respiration inhibition etc. except that causing the gastrointestinal reaction.
(2) nonsteroidal anti-inflammatory analgetic: the patient to not tolerating colchicine is suitable for.This type of medicine and colchicine share and can strengthen analgesic effect, and medicine commonly used has indomethacin, piroxicam (piroxicam), naproxen, ibuprofen, Phenylbutazone and oxyphenbutazone etc.But above these side effects of pharmaceutical drugs are: the first, side effect such as GI irritation, water-sodium retention, dizziness, erythra can be arranged; The second, idol can cause that gastrointestinal reaction and liver transaminase raise; Three, idol has leukocyte and thrombocytopenia; Four, idol has gastrointestinal reaction.Long-term prescription should notice that blood leukocytes number regulating liver-QI, renal function are understood influenced on every side.
(3) glucocorticoid: the outbreak to acute arthritis has rapid mitigation, but easy relapse after the drug withdrawal, and prolonged application is prone to cause complication such as diabetes, so unsuitable prolonged application.
3, the treatment of intermittence and chronic phase is though still should not control, send out repeatedly the author through above-mentioned treatment symptom.
(1) suppress the synthetic medicine of uric acid: mainly contain allopurinol, be xanthine oxidase inhibitor, it can suppress xanthine oxidase, makes hypoxanthine and xanthine can not be oxidized to uric acid.Small number of patients uses this medicine that irritated syndrome can take place, and shows as heating, allergic rash, stomachache, diarrhoea, leukocyte and thrombocytopenia etc.
(2) promote the medicine of urate excretion: this type of drug main will be through suppressing the heavily absorption of renal tubules to uric acid, increases urate excretion and reduce serum uric acid level.Some drugs such as probenecid (benemid), sulfinpyrazone (sulphinpyrazone), benzbromarone etc., side effect such as erythra, heating, gastrointestinal reaction might take place in the patient.
In sum, though at present both at home and abroad the medicine of institute's production for treating gout is varied, all is that to keep health through taking medicine for a long time normal, and certain side effect is arranged.
Summary of the invention:
The purpose of this invention is to provide a kind of Chinese medicine preparation of treating gout and preparation method thereof, it has and fundamentally solves the special efficacy that wind acts on bitterly, and cure rate is high, need not to take medicine for a long time, no significant side effects.
In order to solve the existing problem of background technology, the present invention adopts following technical scheme: its prescription consists of: Rhizoma Smilacis Glabrae 30～200g, Rhizoma Curcumae 1～10g, Radix Angelicae Pubescentis 1～20g, Radix Clematidis 1～30g, Radix Dipsaci 1～30g, Radix Cyathulae 1～30g, Herba Plantaginis 1～50g, Fructus Chaenomelis 1～30g, the Cortex Eucommiae 1～30g, Olibanum 1～20g, Myrrha 1～20g, triangular 20～100g, Rhizoma Corydalis 1～30g, Folium Engelhardia roxburghina 1～50g.
Its method for preparing is:
A, the Poria that fetches earth, oven dry are pulverized the back and are crossed 120 mesh sieves, and it is subsequent use to obtain the Rhizoma Smilacis Glabrae fine powder.
B, it is in medical material and Rhizoma Smilacis Glabrae coarse powder, soaks 12 hours, decocts twice, adds 6 times of water gagings for the first time, decocts 2 hours; For the second time add 5 times of water gagings, decocted 1.5 hours, merge decoction liquor, filter, it is 1.20 (80 ℃) that filtrating is concentrated into relative density; Put coldly, add 4 times of amounts of 90% ethanol, stir, left standstill 24 hours, get supernatant concentration to relative density 1.20 ~ 1.23 (80 ℃); Vacuum drying, dried cream powder is broken into fine powder, crosses 80 mesh sieves, obtains the compositions fine powder.
The Rhizoma Smilacis Glabrae fine powder mix homogeneously that C, the compositions fine powder that step B is made and steps A make promptly obtains the Chinese medicine preparation of the present invention's treatment gout.It is an amount of to add refined honey, mixing, and drying is processed gout pill.Also can be made into tablet, granule, capsule, or all Chinese medicine preparation of other form.
The present invention has following beneficial effect: (1) medicament stops the gout acute attack; (2) prevent gout acute attack repeatedly; (3), prevent monosodium urate salt crystallization further precipitation and eliminate the tophus that has existed through reducing urate concentration in the body fluid.Preventive measure of protection should be directed against two aspects, promptly prevents bone, the corrosional deformity of articular cartilage and prevents kidney injury.
The specific embodiment:
The specific embodiment one: this specific embodiment adopts following technical scheme: its prescription consists of: Rhizoma Smilacis Glabrae 60g, Rhizoma Curcumae 15g, Radix Angelicae Pubescentis 10g, Radix Clematidis 30g, Radix Dipsaci 15g, Radix Cyathulae 15g, Herba Plantaginis 15g, Fructus Chaenomelis 15g, Cortex Eucommiae 15g, Olibanum 15g, Myrrha 15g, triangular 20g, Rhizoma Corydalis 20g, Folium Engelhardia roxburghina 30g.
Its method for preparing is:
A, the Poria that fetches earth, oven dry are pulverized the back and are crossed 120 mesh sieves, and it is subsequent use to obtain the Rhizoma Smilacis Glabrae fine powder.
B, it is in medical material and Rhizoma Smilacis Glabrae coarse powder, soaks 12 hours, decocts twice, adds 6 times of water gagings for the first time, decocts 2 hours; For the second time add 5 times of water gagings, decocted 1.5 hours, merge decoction liquor, filter, it is 1.20 (80 ℃) that filtrating is concentrated into relative density; Put coldly, add 4 times of amounts of 90% ethanol, stir, left standstill 24 hours, get supernatant concentration to relative density 1.20 ~ 1.23 (80 ℃); Vacuum drying, dried cream powder is broken into fine powder, crosses 80 mesh sieves, obtains the compositions fine powder.
The Rhizoma Smilacis Glabrae fine powder mix homogeneously that C, the compositions fine powder that step B is made and steps A make promptly obtains the Chinese medicine preparation of the present invention's treatment gout.It is an amount of to add refined honey, mixing, and drying is processed gout pill.Also can be made into tablet, granule, capsule, or all Chinese medicine preparation of other form.
The specific embodiment two: this specific embodiment is that with the specific embodiment one difference its prescription ratio is: Rhizoma Smilacis Glabrae 30g, Rhizoma Curcumae 3g, Radix Angelicae Pubescentis 12g, Radix Clematidis 16g, Radix Dipsaci 16g, Radix Cyathulae 12g, Herba Plantaginis 10g, Fructus Chaenomelis 12g, Cortex Eucommiae 12g, Olibanum 10g, Rhizoma Corydalis 10g, Folium Engelhardia roxburghina 15g, Myrrha 16g, triangular 10g.
Its method for preparing is: A, preparation Rhizoma Smilacis Glabrae fine powder: fetch earth Poria 10 grams, oven dry, and pulverize the back and cross 110～120 mesh sieves, it is subsequent use to obtain the Rhizoma Smilacis Glabrae fine powder;
B, preparation compositions fine powder: it was soaked 10～12 hours in medical material and Rhizoma Smilacis Glabrae coarse powder, decocted twice, added 5～6 times of water gagings for the first time; Decocted 2～3 hours, and added 4～5 times of water gagings for the second time, decocted 1～1.5 hour, merge decoction liquor; Filter, it is 1.20～1.23 (80 ℃) that filtrating is concentrated into relative density, puts coldly, adds 3～4 times of amounts of 85～95% ethanol; Stir, left standstill 18～24 hours, get supernatant concentration to relative density 1.20～1.23 (80 ℃), vacuum drying; Dried cream powder is broken into fine powder, crosses 80～90 mesh sieves, obtains the compositions fine powder.
The Rhizoma Smilacis Glabrae fine powder mix homogeneously that C, the compositions fine powder that step B is made and steps A make promptly obtains the Chinese medicine preparation of the present invention's treatment gout.
The specific embodiment three: this specific embodiment is that with the specific embodiment two differences its prescription consists of: Rhizoma Smilacis Glabrae 40g, Rhizoma Curcumae 8g, Radix Angelicae Pubescentis 10g, Radix Clematidis 11g, Radix Dipsaci 11g, Radix Cyathulae 11g, Herba Plantaginis 15g, Fructus Chaenomelis 18g, Cortex Eucommiae 18g, Olibanum 16g, Rhizoma Corydalis 15g, Folium Engelhardia roxburghina 18g, Myrrha 16g, triangular 15g; Its method for preparing is identical with the specific embodiment two.
The specific embodiment four: this specific embodiment is that with the specific embodiment three differences its prescription consists of: Rhizoma Smilacis Glabrae 50g, Rhizoma Curcumae 6g, Radix Angelicae Pubescentis 15g, Radix Clematidis 13g, Radix Dipsaci 13g, Radix Cyathulae 13g, Herba Plantaginis 20g, Fructus Chaenomelis 14g, Cortex Eucommiae 13g, Olibanum 13g, Rhizoma Corydalis 20g, Folium Engelhardia roxburghina 20g, Myrrha 14g, triangular 20g; Its method for preparing is identical with the specific embodiment three.
The specific embodiment five: this specific embodiment is that with the specific embodiment four differences its prescription consists of: Rhizoma Smilacis Glabrae 60g, Rhizoma Curcumae 4g, Radix Angelicae Pubescentis 13g, Radix Clematidis 14g, Radix Dipsaci 14g, Radix Cyathulae 13g, Herba Plantaginis 22g, Fructus Chaenomelis 16g, Cortex Eucommiae 16g, Olibanum 15g, Rhizoma Corydalis 25g, Folium Engelhardia roxburghina 25g, Myrrha 15g, triangular 30g; Its method for preparing is identical with the specific embodiment four.
This specific embodiment has following beneficial effect:
1, can effectively control purine oxidase (XO) increases.Increase the activity of uricolytic enzymes, promote urate excretion, make purine metabolism normal.
2, eliminate buoyant uric acid in the blood, tophaceous deposition in the dissolving the tissues and joints is sent the membrane of the kidney permeability, promotes the uric acid granule to discharge from renal tubules.
3, can remove the sedimentary material of kidney rapidly, improving blood and membrane of the kidney can passing through property, fundamentally reduces uratic content in the blood, recovers kidney self and drains the uric acid ability.
4, correct fast gout with complication, gouty renal calculus, renal insufficiency, the comprehensive adjustment body promotes tissue regeneration.
5, treating both the principal and secondary aspects of a disease, short treating period, instant effect.
In sum, the present invention has and fundamentally solves special efficacy that wind acts on bitterly and high cure rate, and general patient only needs need not to take medicine for a long time no significant side effects once curing to four courses of treatment.
Rhizoma Smilacis Glabrae: meridian distribution of property and flavor: sweet, light, flat.Return liver, stomach warp.
Function: detoxifcation, dehumidifying, easing joint movement.
Rhizoma Curcumae: meridian distribution of property and flavor: hot, bitter, warm.Return liver, spleen channel.
Function: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
Radix Angelicae Pubescentis: meridian distribution of property and flavor: hot, bitter, tepor.Return kidney, urinary bladder channel.
Function: expelling wind and removing dampness, numbness relieving and pain relieving.
Radix Clematidis: meridian distribution of property and flavor: hot, salty, warm.Return urinary bladder channel.
Function: wind-damp dispelling, the meridian dredging.
Radix Dipsaci: meridian distribution of property and flavor: bitter, hot, tepor.Return liver, kidney channel.
Function: invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.
Radix Cyathulae: meridian distribution of property and flavor: bitter, sweet, sour, flat.Return liver, kidney channel.
Function: eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.
Herba Plantaginis: meridian distribution of property and flavor: sweet, be slightly cold.Return lung; Liver; Kidney; Urinary bladder channel.
Function: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Make eye bright; Eliminate the phlegm.
Fructus Chaenomelis: meridian distribution of property and flavor: sour, warm.Return liver, stomach warp.
Function: relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness.
The Cortex Eucommiae: meridian distribution of property and flavor: sweet, warm.Return liver, kidney channel.
Function: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Olibanum: meridian distribution of property and flavor: hot, bitter, warm.GUIXIN, liver, spleen channel.
Function: the analgesic therapy of invigorating blood circulation, detumescence and promoting granulation.
Myrrha: meridian distribution of property and flavor: hot, bitter, flat.GUIXIN, liver, spleen channel.
Function: dissipating blood stasis analgesic therapy, detumescence and promoting granulation.
Triangular: meridian distribution of property and flavor: hot, bitter, flat.Return liver, spleen channel.
Function: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.
Rhizoma Corydalis: meridian distribution of property and flavor: arduous, temperature is returned liver, stomach warp.
Function: invigorate blood circulation, dissipating blood stasis is regulated the flow of vital energy, pain relieving.
Folium Engelhardia roxburghina: meridian distribution of property and flavor: little hardship, cold.
Function: clearing away heat to alleviate pain
Through clinical trial case case curative effect of the present invention is described further:
Test Example one: patient Luo Xiansheng, 48 years old, suffer from gouty arthritis, gouty calculus 7 years; Originally took throughout the year and use Western medicine, the state of an illness is not felt any better, day by day serious along with the state of an illness, and liver, stomach, kidney are badly damaged; Whenever suffering from cold and overwork, the right crus of diaphragm thumb began pain and spreaded all over the whole body joint then night, and is painful unusual, the gout pill of processing according to the disposable above-mentioned Chinese medicine composition of opening three courses of treatment of the state of an illness; By the suitable polydipsia water of doctor's advice period in a medicine, increase the urine amount, after taking medicine 18 days, clinical symptoms disappears; Blood uric acid is reduced to 350ummol/L, and during liver, renal function were normal, recurrence was not seen in drug withdrawal so far.
Test Example two: patient 5 certain, man, 39 years old, gout medical history 6 years; Acute gout arthritis was shown effect 11 times repeatedly over the past two years, arrived examination in hospital, the slight hypertrophy of two thumb joints, swelling through expert advice; The part is kermesinus, and obvious tenderness is arranged, and the renal function mile abnormality is made a definite diagnosis: gouty arthritis.All swelling disappears after taking this gout medicine, and after two weeks of taking medicine, the hematuria acid number is reduced to normally.
Test Example three: patient Huang Xiansheng, the man 44 years old, suffered from gout nearly 10 years; Medication is effective during treatment, and drug withdrawal is recurrence just, open four the course of treatment gout medicine of the present invention; Take that pain numbness obviously alleviates after about 10 days, finish all malaise symptoms of back and all disappear four course of treatment, follows up a case by regular visits to so far to lose recurrence in 1 year.
Test Example four: Gong, 40 years old, the woman suffered from goat for many years, the frequent outbreak at midnight of left foot knee joint, sharp ache, stiff numbness is alleviated with colchicine frequently, because the toxic and side effects of Western medicine is nauseating, vomiting, the people is out of spirits.And get better when seeking medical advice medication, drug withdrawal is violated again.Introduced through friend afterwards and use this gout medicine its pain course of treatment to disappear, and added a course of treatment and consolidate, drug withdrawal is not recurrence so far.
Test Example five: Guangdong Zhang, the man, 36 years old, the many places redness and swelling of joints, burning pain, persistence outbreak, subcutaneous have a scleroma.Be diagnosed as gouty arthritis, obey Western medicine certainly, local injection hormone blockade treatment, blood uric acid is located 620umol/L always, routine urinalysis: erythrocyte (+), albumen (++), urate crystal a little.Begin to take one the course of treatment gout medicine of the present invention, sx.Subcutaneous scleroma diminishes, blood uric acid 480umol/L, routine urinalysis: erythrocyte (-), albumen (+); Take medicine again 2 courses of treatment, symptom completely without, subcutaneous scleroma disappears, blood uric acid 330umol/L; Routine urinalysis, renal function is normal, and the state of an illness does not have recurrence one year over, has thoroughly cured goat.
Test Example six: patient Liu, the man, 54 years old, right crus of diaphragm halluces joint severe pain, pain unbearably, work life can't be normal, to the examination in hospital treatment, renal function is slightly impaired, complication appears in hypertension.Because pay attention to treatment in early days, the state of an illness further develops deterioration, it is frequent to show effect during by 08 year, and outbreak in every month once.Receive treatment after 2 courses of treatment, Mr. Liu's uric acid is normal, and graft function, blood pressure are also normal, has consolidated a course of treatment as requested again, thoroughly rehabilitation at present, and uric acid still is in steady normal range so far.
Claims (3)
1. treat Chinese medicine preparation of gout and preparation method thereof for one kind, it is characterized in that its prescription consists of: Rhizoma Smilacis Glabrae 30～200g, Rhizoma Curcumae 1～20g, Radix Angelicae Pubescentis 1～20g, Radix Clematidis 1～30g, Radix Dipsaci 1～30g, Radix Cyathulae 1～30g, Herba Plantaginis 1～50g, Fructus Chaenomelis 1～30g, the Cortex Eucommiae 1～30g, Olibanum 1～20g, Myrrha 1～20g, triangular 10～100g, Rhizoma Corydalis 1～30g, Folium Engelhardia roxburghina 1～50g.
2. a kind of Chinese medicine preparation of treating gout according to claim 1 and preparation method thereof is characterized in that its method for preparing is: A, the Poria that fetches earth, oven dry, and pulverize the back and cross 120 mesh sieves, it is subsequent use to obtain the Rhizoma Smilacis Glabrae fine powder; B, it is in medical material and Rhizoma Smilacis Glabrae coarse powder, soaks 12 hours, decocts twice, adds 6 times of water gagings for the first time, decocts 2 hours; For the second time add 5 times of water gagings, decocted 1.5 hours, merge decoction liquor, filter, it is 1.20～1.40 (80 ℃) that filtrating is concentrated into relative density; Put coldly, add 4 times of amounts of 90% ethanol, stir, left standstill 24 hours, get supernatant concentration to relative density 1.20 ~ 1.40 (80 ℃); Vacuum drying, dried cream powder is broken into fine powder, crosses 80 mesh sieves, obtains the compositions fine powder; The Rhizoma Smilacis Glabrae fine powder mix homogeneously that C, the compositions fine powder that step B is made and steps A make promptly obtains the Chinese medicine preparation of the present invention's treatment gout.It is an amount of to add refined honey, mixing, and drying is processed gout pill.Also can be made into the lamellar or the Chinese medicine preparation of other form.
3. a kind of Chinese medicine preparation of treating gout according to claim 1 and preparation method thereof is characterized in that its prescription consists of: Rhizoma Smilacis Glabrae 130～160g, Rhizoma Curcumae 4～7g, Radix Angelicae Pubescentis 10～13g, Radix Clematidis 13～16g, Radix Dipsaci 13～16g, Radix Cyathulae 13～16g, Herba Plantaginis 10～30g, Fructus Chaenomelis 13～16g, the Cortex Eucommiae 13～16g, Olibanum 13～16g, Myrrha 13～16g, triangular 10～50g, Rhizoma Corydalis 15～25g, Folium Engelhardia roxburghina 20～40g.
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| CN201010568290.1A CN102485270B (en) | 2010-12-01 | 2010-12-01 | A kind of Chinese medicine preparation for the treatment of gout and preparation method thereof |
| CN201510626908.8A CN105233147A (en) | 2010-12-01 | 2010-12-01 | Preparation method of traditional Chinese medicine preparation for treating gout |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104338054A (en) * | 2014-11-07 | 2015-02-11 | 成都华熹科技有限公司 | Traditional Chinese medicine composition containing pandan leaves for treating gout |
| CN107715082A (en) * | 2017-09-26 | 2018-02-23 | 吴建萍 | A kind of logical compound health preserving tea of profit |
| CN110755560A (en) * | 2019-10-10 | 2020-02-07 | 广州市康宁汇生物科技有限公司 | Tea bag for conditioning gout and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101703708A (en) * | 2009-11-10 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof |
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| CN101837093B (en) * | 2006-10-13 | 2012-02-15 | 吴洵邦 | Chinese medicinal composition for curing gout |
| JP2008115138A (en) * | 2006-11-08 | 2008-05-22 | Lotte Co Ltd | Leukotriene production retarder, and food and drink containing the same |
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| CN101703708A (en) * | 2009-11-10 | 2010-05-12 | 卢速江 | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof |
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| Title |
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| 周世芬等: "《中医药治疗痛风近况》", 《吉林中医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104338054A (en) * | 2014-11-07 | 2015-02-11 | 成都华熹科技有限公司 | Traditional Chinese medicine composition containing pandan leaves for treating gout |
| CN107715082A (en) * | 2017-09-26 | 2018-02-23 | 吴建萍 | A kind of logical compound health preserving tea of profit |
| CN110755560A (en) * | 2019-10-10 | 2020-02-07 | 广州市康宁汇生物科技有限公司 | Tea bag for conditioning gout and preparation method thereof |
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| CN102485270B (en) | 2015-11-25 |
| CN105233147A (en) | 2016-01-13 |
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