CN104288566B - 降胆固醇和/或降血脂的中药组合物及其制备方法和应用 - Google Patents
降胆固醇和/或降血脂的中药组合物及其制备方法和应用 Download PDFInfo
- Publication number
- CN104288566B CN104288566B CN201410567029.8A CN201410567029A CN104288566B CN 104288566 B CN104288566 B CN 104288566B CN 201410567029 A CN201410567029 A CN 201410567029A CN 104288566 B CN104288566 B CN 104288566B
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine composition
- chinese medicine
- reducing blood
- norcholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 210000004369 blood Anatomy 0.000 title claims abstract description 46
- 239000008280 blood Substances 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract description 22
- 150000002632 lipids Chemical class 0.000 title abstract description 12
- 235000012000 cholesterol Nutrition 0.000 title abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 33
- 230000000694 effects Effects 0.000 claims abstract description 31
- 240000000249 Morus alba Species 0.000 claims abstract description 21
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 21
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 18
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 18
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 18
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 18
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 18
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 18
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 18
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 18
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 18
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 18
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 18
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 18
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 18
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 18
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 18
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims abstract description 18
- 235000011613 Pinus brutia Nutrition 0.000 claims abstract description 18
- 241000018646 Pinus brutia Species 0.000 claims abstract description 18
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 17
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 17
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 claims abstract description 17
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 17
- 240000006509 Gynostemma pentaphyllum Species 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 6
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 4
- 244000194101 Ginkgo biloba Species 0.000 claims abstract 4
- 240000007164 Salvia officinalis Species 0.000 claims description 17
- 235000005412 red sage Nutrition 0.000 claims description 17
- 240000003915 Lophatherum gracile Species 0.000 claims description 16
- 244000241872 Lycium chinense Species 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 15
- 239000004480 active ingredient Substances 0.000 claims description 10
- 230000036541 health Effects 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 3
- 229910052760 oxygen Inorganic materials 0.000 abstract description 3
- 239000001301 oxygen Substances 0.000 abstract description 3
- 244000241838 Lycium barbarum Species 0.000 abstract description 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 240000008027 Akebia quinata Species 0.000 abstract 1
- 235000007756 Akebia quinata Nutrition 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 241000745390 Lophatherum Species 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 239000000843 powder Substances 0.000 description 17
- 241001092040 Crataegus Species 0.000 description 14
- 241000218628 Ginkgo Species 0.000 description 13
- 239000006071 cream Substances 0.000 description 12
- 241000700159 Rattus Species 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 235000013305 food Nutrition 0.000 description 7
- 238000001914 filtration Methods 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 235000013402 health food Nutrition 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- 208000031226 Hyperlipidaemia Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 235000021590 normal diet Nutrition 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000037308 hair color Effects 0.000 description 2
- 230000001077 hypotensive effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 231100000682 maximum tolerated dose Toxicity 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 206010036067 polydipsia Diseases 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 231100000027 toxicology Toxicity 0.000 description 2
- 206010049865 Achromotrichia acquired Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 101100276976 Drosophila melanogaster Drak gene Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 241001065361 Gynostemma Species 0.000 description 1
- 108010023302 HDL Cholesterol Proteins 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- HWGBHCRJGXAGEU-UHFFFAOYSA-N Methylthiouracil Chemical compound CC1=CC(=O)NC(=S)N1 HWGBHCRJGXAGEU-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002253 anti-ischaemic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000002366 lipolytic effect Effects 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229960002545 methylthiouracil Drugs 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000003169 respiratory stimulant agent Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种具有降胆固醇和/或降血脂作用的中药组合物及其制备方法和应用，所述中药组合物的有效成分是由下述重量份的原料制备而成的：银杏叶5‑15份、山楂5‑15份、淡竹叶5‑15份、炒决明15‑25份、丹参10‑20份、枸杞子10‑20份、绞股蓝10‑20份、黄精20‑30份、桑椹10‑20份、荷叶3‑12份和松叶1‑10份；所述制备方法为：将上述药材加水或乙醇溶液提取，制成相应制剂，即可。本发明所述中药组合物安全无毒副作用，且具有显著地降低血清胆固醇、调节血脂、预防动脉粥样硬化和改善血管内血氧运送通道的作用。
Description
技术领域
本发明涉及中药领域，特别是涉及一种具有降胆固醇和/或降血脂作用的中药组合物及其制备方法和应用。
背景技术
随着人民生活水平的提高，物质和精神生活的丰富，肉类食物、油腻食物及酒的摄入增加，增减了人体胆固醇的含量；同时随着生活节奏的加快，人们长时间的精神压力，也可引起血胆固醇的升高；还有随着年龄的增长血总胆固醇的水平也在增加；而且从临床的数据也可以看出，胆固醇高的疾病是十分广泛的。众所周知，胆固醇高会严重危害人体健康，引起肥胖症、肝功能衰竭、高血脂、心血管阻塞等疾病。
2008年国家卫生部推荐了他汀类降脂药：他汀类药物能显著降低低密度脂蛋白胆固醇，同时也降低甘油三酯和轻度升高高密度脂蛋白胆固醇。近20年的临床研究显示，他汀类药物是降低胆固醇，预防心肌梗死和脑血栓有效的药物。然而是药三分毒，一般来说，降脂药都有副作用，长期用药会导致肝肾损伤。此外，还会有高胆固醇血脂症患者会对他汀类药物产生不耐受。因此，亟需一种专门针对高血脂人群的无毒副作用的药品或保健食品。
发明内容
基于此，本发明的目的在于提供一种具有降胆固醇和/或降血脂作用的中药组合物。
解决上述技术问题的具体技术方案如下：
一种具有降胆固醇和/或降血脂作用的中药组合物，所述中药组合物的有效成分是由下述重量份的原料制备而成的：银杏叶5-15份、山楂5-15份、淡竹叶5-15份、炒决明15-25份、丹参10-20份、枸杞子10-20份、绞股蓝10-20份、黄精20-30份、桑椹10-20份、荷叶3-12份、松叶1-10份。
在其中一些实施例中，所述中药组合物的有效成分是由下述重量份的原料制备而成的：银杏叶9-11份、山楂9-11份、淡竹叶9-11份、炒决明19-21份、丹参14-16份、枸杞子14-16份、绞股蓝14-16份、黄精24-26份、桑椹14-16份、荷叶7-9份、松叶4-6份。
本发明所述具有降胆固醇和/或降血脂作用的中药组合物各组分的药理如下：
银杏叶：活血化瘀，通络止痛，敛肺平喘，化浊降脂。用于瘀血阻络，胸痹心痛，中风偏瘫，肺虚咳喘，高脂血症。
山楂：消食健胃，行气散瘀，化浊降脂。山楂中的脂肪分解酶可促进脂肪类食物的消化。黄酮类和三萜类成分具有降压、增加冠脉流量、降血脂、抗心律失常等作用。
淡竹叶：清热泻火，除烦止渴，利尿通淋。用于热病烦渴，小便短赤涩痛，口舌生疮。
炒决明：清热明目，润肠通便。现代研究表明决明子具有较强降血脂、降压作用。
丹参：活血祛瘀，通经止痛，清心除烦，凉血消痈。现代研究表明丹参还具有抗缺氧、抗缺血、抗凝血、抗菌、抗肿瘤、降血压、降血脂、护肝等作用。
枸杞子：滋补肝肾，益精明目。现代研究表明枸杞子具有调节脂质代谢、降血糖、将血压，抑制呼吸兴奋、抗缺氧、促进造血功能、延缓衰老、增强免疫能力、加强肠胃功能等作用。
绞股蓝：补虚，清热，解毒。用于体虚乏力，虚劳失精，白细胞减少症，高脂血症，病毒性肝炎，慢性胃肠炎，慢性气管炎。
黄精：性平，味甘。补气养阴，健脾，润肺，益肾。现代研究表明其提取物对麻醉动物血压具有降压作用。
桑椹：滋阴补血，生津润燥。用于肝肾阴虚，眩晕耳鸣，心悸失眠，须发早白，津伤口渴，内热消渴，肠燥便秘。
荷叶：清暑化湿，升发清阳，凉血止血。用于暑热烦渴，暑湿泄泻，脾虚泄泻，血热吐衄，便血崩漏。
松叶：祛风燥湿，杀虫止痒，活血安神。现代研究表明松叶具有降血脂，延缓衰老，镇痛，抗炎，促进肠胃运动等作用。
本发明的另一目的在于提供一种上述具有降胆固醇和/或降血脂作用的中药组合物的制备方法，包括以下步骤：
取银杏叶、山楂、淡竹叶、炒决明、丹参、枸杞子、绞股蓝、黄精、桑椹、荷叶和松叶，加水或乙醇溶液提取，过滤，得提取液。
在其中一些实施例中，所述乙醇溶液中乙醇的浓度为20％-75％(体积分数)。
在其中一些实施例中，所述乙醇溶液中乙醇的浓度为30％-45％(体积分数)。
在其中一些实施例中，所述水或乙醇溶液的添加量为总药材量的8-10倍。
在其中一些实施例中，还包括浓缩和/或干燥。
本发明的另一目的在于提供上述的中药组合物在制备具有降胆固醇和/或降血脂作用的药品或保健品中的应用。
本发明的另一目的在于提供一种具有降胆固醇和/或降血脂作用的药品或保健品，所述药品或保健品包括有上述的具有降胆固醇和/或降血脂作用的中药组合物和药品或保健品上可接受的辅料。
本发明所述的一种具有降胆固醇和/或降血脂作用的中药组合物及其制备方法和应用具有以下优点和有益效果：
(1)本发明经发明人的大量实验，精选11种药食两用及可用于保健食品的药材，得出安全无毒副作用、可显著降低胆固醇和/或降血脂的中药组合物，并确定了其最佳组分和配比；所述中药组合物集祛瘀生新、降脂消导、润心肺、滋肝补肾及瘦身养颜于一体，可有效调节血脂、降低血清胆固醇、预防动脉粥样硬化，改善血管内血氧运送通道。
(2)本发明所述中药组合物的制备方法，工艺简单，易操作，适合大规模生产。
具体实施方式
以下将结合具体实施例对本发明做进一步说明。
实施例1
本实施例一种具有降胆固醇和/或降血脂作用的中药组合物，其有效成分是由下述重量份的原料制备而成的：银杏叶15份，山楂15份，淡竹叶15份，炒决明25份，丹参20份，枸杞子20份，绞股蓝20份，黄精30份，桑椹20份，荷叶12份，松叶10份。
上述中药组合物的制备方法，包括如下步骤：
按上述重量份，称取银杏叶，山楂，淡竹叶，炒决明，丹参，枸杞子，绞股蓝，黄精，桑椹，荷叶和松叶，充分混合，置于提取罐中，加75％乙醇溶液提取2次(加乙醇溶液的量分别为原料10倍量和8倍量)，提取液滤过，合并，浓缩至相对密度1.20左右(60℃)，干燥，粉碎，得干膏粉。
实施例2
本实施例一种具有降胆固醇和/或降血脂作用的中药组合物，其有效成分是由下述重量份的原料制备而成的：银杏叶10份，山楂10份，淡竹叶10份，炒决明20份，丹参15份，枸杞子15份，绞股蓝15份，黄精25份，桑椹15份，荷叶8份，松叶5份。
上述中药组合物的制备方法，包括如下步骤：
(1)按上述重量份，称取银杏叶、山楂、淡竹叶、炒决明、丹参、枸杞子、绞股蓝、黄精、桑椹、荷叶和松叶，充分混合，置于提取罐中，加45％乙醇溶液提取2次(加乙醇溶液的量分别为原料10倍量和8倍量)，提取液滤过，合并，浓缩至相对密度1.20左右(60℃)，干燥，粉碎，得干膏粉；
(2)于干膏粉中加入常规量的预胶化淀粉和糊精，得降胆固醇和/或降血脂颗粒剂。
实施例3
本实施例一种具有降胆固醇和/或降血脂作用的中药组合物，其有效成分是由下述重量份的原料制备而成的：银杏叶5份、山楂5份、淡竹叶5份、炒决明15份、丹参10份、枸杞子10份、绞股蓝10份、黄精20份、桑椹10份、荷叶3份、松叶1份。
上述中药组合物的制备方法，包括如下步骤：
按上述重量份，称取银杏叶，山楂，淡竹叶，炒决明，丹参，枸杞子，绞股蓝，黄精，桑椹，荷叶，松叶，充分混合，置于提取罐中，加20％乙醇溶液提取2次(加乙醇溶液的量分别为原料10倍量和8倍量)，提取液滤过，合并，浓缩至相对密度1.20左右(60℃)，干燥，粉碎，得干膏粉。
实施例4
本实施例一种具有降胆固醇和/或降血脂作用的中药组合物，其有效成分的组成和重量份与实施例2所述中药组合物的有效成分的组成和重量份相同。
上述中药组合物的制备方法，包括如下步骤：
按上述重量份，称取银杏叶、山楂、淡竹叶、炒决明、丹参、枸杞子、绞股蓝、黄精、桑椹、荷叶和松叶，充分混合，置于提取罐中，加水提取2次(加水量分别为原料10倍量和8倍量)，提取液滤过，合并，浓缩至相对密度1.20左右(60℃)，干燥，粉碎，得干膏粉。
实施例5
本实施例一种具有降胆固醇和/或降血脂作用的中药组合物，其有效成分是由下述重量份的原料制备而成的：银杏叶10份、山楂10份、淡竹叶10份、炒决明20份、丹参15份、枸杞子15份、绞股蓝15份、黄精25份、桑椹15份、荷叶8份、松叶5份。
上述中药组合物的制备方法，包括如下步骤：
(1)按上述重量份，称取银杏叶、山楂、淡竹叶、炒决明、丹参、枸杞子、绞股蓝、黄精、桑椹、荷叶和松叶，充分混合粉碎，加30％乙醇溶液(加乙醇溶液的量为原料8倍量，置于超声提取，提取两次，提取液滤过，合并，浓缩至相对密度1.20左右(60℃)，干燥，粉碎，得干膏粉；
(2)于干膏粉加入常规量的预胶化淀粉和糊精，得颗粒剂，即可。
实施例6
一、实验目的
通过对比分析评价实施例2制得的干膏粉的降胆固醇和降血脂药效实验。
二、实验方法
取大鼠70只，体重200-240g，雌雄各半。按随机分组分成七组，分别为实施例2(干膏粉)高剂量组(1000mg/kg)、实施例2(干膏粉)中剂量组(500mg/kg)、实施例2(干膏粉)低剂量组(250mg/kg)、病理模型组(以等量生理盐水灌胃，按照《保健食品检验与评价技术规范(2003版)》中的指导方法进行造模)、阳性对照组(辛伐他汀mg/kg)、空白对照组和对比例1(其为干膏粉，具体配方、制备方法与实施例2基本相同，区别在于不含桑椹和荷叶；剂量为1000mg/kg)；除空白对照组用普通饲料以外其他组均用高脂饲料喂养，喂养15d后灌胃给药给药，给药21d后取血测定大鼠胆固醇含量和甘油三酯含量。
高脂饲料配方：胆固醇0.03wt％、猪油0.1wt％、蛋黄粉0.1wt％、胆酸钠0.002wt％、甲基硫氧嘧啶0.01wt％、普通饲料75.8wt％。
普通饲料配方：玉米73.5wt％，麦麸20wt％，鱼粉5wt％，谷粉1wt％，食盐0.5wt％。
三、实验结果
结果参见表1：从表1可知，与各对照组相比，实施例2的干膏粉能显著降低大鼠血清的总胆固醇和甘油三酯含量，即其具有显著的调节血脂的功效，可进一步开发成保健食品；其中，与对比例1相比可知：实施例2所述配方中各组分是相互协同的，其共同起到降低总胆固醇和甘油三酯含量的功效。
表1各组别大鼠中总胆固醇和甘油三酯含量结果表
*P<0.05，表示与模型组比较有显著性差异。
实施例7急性毒理实验
1.实验目的
通过急性毒理实验分析评价实施例2所制得的干膏粉的安全性。
2.方法和结果
2.1实验方法
取wistar大鼠20只，雌雄各半，体重250g左右，动物购买后观察3-5天，试验前实验动物隔夜空腹，即禁食16h(不禁水)，一次性给予大鼠最大灌胃容量的干膏粉水溶液，灌胃容量为20mL/kg BW，灌胃剂量为20g/kg BW，灌胃后持续观察，每天上、下午各观察1次，连续观察7～14天，观察记录实验大鼠毛色情况、活动情况、摄食情况、排泄情况及有无死亡等情况，若有死亡小鼠及时进行病理检验。
2.2实验结果
用最大使用浓度和最大灌胃容量给予20只大鼠灌胃后，观察大鼠，外观、毛色、光泽正常，社会行为、反应均正常，摄食、排泄正常；连续观察7-14天，未见任何大鼠死亡，则大鼠最大耐受剂量(Maximum Tolerated Dose，MTD)大于20g/kg BW，根据《保健食品检验与评价技术规范(2003版)》中急性毒性实验评价方法，确定药粉安全性级别为无毒级别。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对本发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。
Claims (7)
1.一种具有降胆固醇和/或降血脂作用的中药组合物，其特征在于，所述中药组合物的有效成分是由下述重量份的原料制备而成的：银杏叶5-15份、山楂5-15份、淡竹叶5-15份、炒决明15-25份、丹参10-20份、枸杞子10-20份、绞股蓝10-20份、黄精20-30份、桑椹10-20份、荷叶3-12份、松叶1-10份。
2.根据权利要求1所述的具有降胆固醇和/或降血脂作用的中药组合物，其特征在于，所述中药组合物的有效成分是由下述重量份的原料制备而成的：银杏叶9-11份、山楂9-11份、淡竹叶9-11份、炒决明19-21份、丹参14-16份、枸杞子14-16份、绞股蓝14-16份、黄精24-26份、桑椹14-16份、荷叶7-9份、松叶4-6份。
3.一种权利要求1或2所述的具有降胆固醇和/或降血脂作用的中药组合物的制备方法，其特征在于，包括以下步骤：
取银杏叶、山楂、淡竹叶、炒决明、丹参、枸杞子、绞股蓝、黄精、桑椹、荷叶和松叶，加水或乙醇溶液提取，过滤，得提取液。
4.根据权利要求3所述的具有降胆固醇和/或降血脂作用的中药组合物的制备方法，其特征在于，所述乙醇溶液中乙醇的浓度为20％-75％。
5.根据权利要求3或4所述的具有降胆固醇和/或降血脂作用的中药组合物的制备方法，其特征在于，还包括浓缩和/或干燥。
6.权利要求1或2所述的中药组合物在制备具有降胆固醇和/或降血脂作用的药品或保健品中的应用。
7.一种具有降胆固醇和/或降血脂作用的药品或保健品，其特征在于，所述药品或保健品包括有权利要求1或2所述的具有降胆固醇和/或降血脂作用的中药组合物和药品或保健品上可接受的辅料。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410567029.8A CN104288566B (zh) | 2014-10-22 | 2014-10-22 | 降胆固醇和/或降血脂的中药组合物及其制备方法和应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410567029.8A CN104288566B (zh) | 2014-10-22 | 2014-10-22 | 降胆固醇和/或降血脂的中药组合物及其制备方法和应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104288566A CN104288566A (zh) | 2015-01-21 |
| CN104288566B true CN104288566B (zh) | 2017-05-10 |
Family
ID=52308677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410567029.8A Active CN104288566B (zh) | 2014-10-22 | 2014-10-22 | 降胆固醇和/或降血脂的中药组合物及其制备方法和应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104288566B (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267431A (zh) * | 2015-09-30 | 2016-01-27 | 李文 | 一种具有即饮特点的，有降血脂作用的中药保健品组合物 |
| CN107950899A (zh) * | 2017-12-15 | 2018-04-24 | 柳州飞升鹏科技有限公司 | 一种降脂绿豆糕及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102423381A (zh) * | 2011-12-30 | 2012-04-25 | 苏州爱斯欧蒂生物科技有限公司 | 具有降脂功效的保健茶 |
-
2014
- 2014-10-22 CN CN201410567029.8A patent/CN104288566B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102423381A (zh) * | 2011-12-30 | 2012-04-25 | 苏州爱斯欧蒂生物科技有限公司 | 具有降脂功效的保健茶 |
Non-Patent Citations (1)
| Title |
|---|
| 血脂异常中医病因病机及辨证论治初步探讨;陶亮等;《辽宁中医药大学学报》;20120430;第14卷(第4期);第105-107页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104288566A (zh) | 2015-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108837036A (zh) | 一种降脂降压、防治心脑血管疾病的制剂及其制备方法 | |
| CN105395919A (zh) | 一种含有黑木耳提取物、具有降血脂作用的组合物及其制备方法 | |
| CN106262890A (zh) | 一种具有降血脂功能的茶油保健品及其制作方法 | |
| CN112137079A (zh) | 利用酒曲发酵工艺的健康食品组合物及其制造方法 | |
| CN104857154A (zh) | 一种治疗“三高”症的中药组合物及其制备方法 | |
| CN104288566B (zh) | 降胆固醇和/或降血脂的中药组合物及其制备方法和应用 | |
| CN107302996A (zh) | 一种辅助降脂溶栓抗动脉硬化的保健食品及其制备方法 | |
| CN107551001A (zh) | 一种用于防治酒精性肝损伤的中药复合物及其制法 | |
| CN103690819A (zh) | 一种预防和治疗心脑血管疾病及具有减肥功能的中药组合物 | |
| CN108066384A (zh) | 一种具有增强免疫力功能的中药制剂及其制备方法 | |
| CN106509894A (zh) | 一种辣木三七含片及其制备工艺 | |
| CN106262953A (zh) | 一种含有大枣膳食纤维的食品 | |
| CN105943617A (zh) | 全麻素在制备抗肝炎药物中的应用 | |
| CN103100028A (zh) | 有利于降低酒精性肝损伤危害的软胶囊及其制备方法 | |
| CN102125124A (zh) | 防治高血压的中药保健茶 | |
| CN103611051B (zh) | 防治冠心病中药制剂及其制备方法 | |
| CN1115159C (zh) | 一种含紫丹参的药物组合物及其制备方法和应用 | |
| CN106729518A (zh) | 一种降血压的茶饮料及其制备方法与应用 | |
| CN104587300A (zh) | 用于治疗急性白血病的中药组合物及其制备方法 | |
| CN107960582A (zh) | 一种辅助降血脂的海带红曲固体饮品制备方法 | |
| CN103656012B (zh) | 一种治疗冠心病心绞痛的药物组合物的制备方法 | |
| CN108433051A (zh) | 一种安神养胃助消化的天然型功能食品 | |
| CN105617038A (zh) | 一种具有保健功能的天麻灵芝组合物 | |
| CN104585767A (zh) | 一种降低血脂的保健品及制备工艺 | |
| CN108066496A (zh) | 一种护肝中药保健食品 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |