CN104284675B - 具有抗肿瘤活性的新颖结合分子 - Google Patents

具有抗肿瘤活性的新颖结合分子 Download PDF

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Publication number
CN104284675B
CN104284675B CN201380014237.9A CN201380014237A CN104284675B CN 104284675 B CN104284675 B CN 104284675B CN 201380014237 A CN201380014237 A CN 201380014237A CN 104284675 B CN104284675 B CN 104284675B
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CN104284675A (zh
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S.布拉克
F.穆尔拉内
I.托勒
R.伍兹
J.贝钦格
D.格拉布洛夫斯基
B.沙德
K.克卢普施
H.哈赫米
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Cilag GmbH International
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Covagen AG
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase

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CN201380014237.9A 2012-03-16 2013-03-08 具有抗肿瘤活性的新颖结合分子 Expired - Fee Related CN104284675B (zh)

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EP12159938.5 2012-03-16
EP12159938 2012-03-16
PCT/EP2013/054768 WO2013135588A1 (en) 2012-03-16 2013-03-08 Novel binding molecules with antitumoral activity

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CN104284675B true CN104284675B (zh) 2017-07-18

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US (2) US9593314B2 (enExample)
EP (1) EP2825197B1 (enExample)
JP (1) JP6325463B2 (enExample)
KR (1) KR20140135251A (enExample)
CN (1) CN104284675B (enExample)
AU (1) AU2013231488B2 (enExample)
BR (1) BR112014022932A2 (enExample)
CA (1) CA2865597A1 (enExample)
MX (1) MX354717B (enExample)
NZ (1) NZ629283A (enExample)
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KR20140135251A (ko) 2014-11-25
EP2825197A1 (en) 2015-01-21
US9593314B2 (en) 2017-03-14
RU2627185C1 (ru) 2017-08-03
US20150047065A1 (en) 2015-02-12
CN104284675A (zh) 2015-01-14
WO2013135588A1 (en) 2013-09-19
MX354717B (es) 2018-03-16
US20170281768A1 (en) 2017-10-05
JP6325463B2 (ja) 2018-05-16
JP2015516801A (ja) 2015-06-18
AU2013231488B2 (en) 2017-12-07
AU2013231488A1 (en) 2014-09-18
NZ629283A (en) 2016-04-29
MX2014011066A (es) 2015-03-09
BR112014022932A2 (pt) 2017-07-18
CA2865597A1 (en) 2013-09-19
EP2825197B1 (en) 2018-06-06

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