CN104284665B - 吡唑衍生物及其医药用途 - Google Patents

吡唑衍生物及其医药用途 Download PDF

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Publication number
CN104284665B
CN104284665B CN201380024202.3A CN201380024202A CN104284665B CN 104284665 B CN104284665 B CN 104284665B CN 201380024202 A CN201380024202 A CN 201380024202A CN 104284665 B CN104284665 B CN 104284665B
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constipation
compound
group
day
administration
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Chinese (zh)
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CN104284665A (zh
Inventor
伊佐治正幸
竹村理明
伊泽英俊
布袋之彦
宫下格
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Kissei Pharmaceutical Co Ltd
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Kissei Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201380024202.3A 2012-05-07 2013-05-02 吡唑衍生物及其医药用途 Active CN104284665B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012105847 2012-05-07
JP2012-105847 2012-05-07
PCT/JP2013/062755 WO2013168671A1 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途

Publications (2)

Publication Number Publication Date
CN104284665A CN104284665A (zh) 2015-01-14
CN104284665B true CN104284665B (zh) 2016-11-16

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ID=49550709

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CN201380024202.3A Active CN104284665B (zh) 2012-05-07 2013-05-02 吡唑衍生物及其医药用途

Country Status (15)

Country Link
US (2) US9273085B2 (cg-RX-API-DMAC7.html)
EP (1) EP2848254B1 (cg-RX-API-DMAC7.html)
JP (2) JP5663699B2 (cg-RX-API-DMAC7.html)
KR (1) KR101868991B1 (cg-RX-API-DMAC7.html)
CN (1) CN104284665B (cg-RX-API-DMAC7.html)
AU (1) AU2013258566B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014027841B1 (cg-RX-API-DMAC7.html)
CA (1) CA2872002C (cg-RX-API-DMAC7.html)
DK (1) DK2848254T3 (cg-RX-API-DMAC7.html)
ES (1) ES2601127T3 (cg-RX-API-DMAC7.html)
MX (1) MX359988B (cg-RX-API-DMAC7.html)
PL (1) PL2848254T3 (cg-RX-API-DMAC7.html)
PT (1) PT2848254T (cg-RX-API-DMAC7.html)
RU (1) RU2602739C2 (cg-RX-API-DMAC7.html)
WO (1) WO2013168671A1 (cg-RX-API-DMAC7.html)

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LT3023102T (lt) 2010-11-04 2018-09-25 Albireo Ab Ibat inhibitoriai, skirti kepenų ligų gydymui
PT2848254T (pt) * 2012-05-07 2016-10-05 Kissei Pharmaceutical Derivado de pirazol e utilização do mesmo para propósitos médicos
AU2014213251B2 (en) 2013-02-04 2017-07-20 Taisho Pharmaceutical Co., Ltd. Prophylactic or therapeutic drug for constipation
CA2952405A1 (en) * 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for stabilizing the same
KR20220082931A (ko) 2014-06-25 2022-06-17 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
CN112469407B (zh) 2018-03-28 2024-10-01 阿沃林特有限公司 用于治疗餐后低血糖症的方法
CN112449637B (zh) 2018-06-05 2024-03-19 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
PL3810581T3 (pl) 2018-06-20 2025-04-28 Albireo Ab Modyfikacje kryształu odewiksibatu
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
SMT202300020T1 (it) 2019-02-06 2023-03-17 Albireo Ab Composti di benzotiadiazepine e loro uso come modulatori degli acidi biliari
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CA3158276A1 (en) 2019-12-04 2021-06-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
CA3158181A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CR20220315A (es) 2019-12-04 2022-10-26 Albireo Ab Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar
CN114761018B (zh) 2019-12-04 2025-12-02 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
EP4188541B1 (en) 2020-08-03 2024-12-25 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
CA3196488A1 (en) 2020-11-12 2022-05-19 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
EP4255565A1 (en) 2020-12-04 2023-10-11 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2011002001A1 (ja) * 2009-07-01 2011-01-06 キッセイ薬品工業株式会社 ピラゾール誘導体とビグアナイド薬との組み合わせ医薬

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137245A (ja) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
WO2007127183A1 (en) * 2006-04-26 2007-11-08 Genentech, Inc. Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
EP2275430B1 (en) * 2008-04-16 2012-05-16 Kissei Pharmaceutical Co., Ltd. Hemifumarate of a pyrazole derivative
AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
PT2848254T (pt) * 2012-05-07 2016-10-05 Kissei Pharmaceutical Derivado de pirazol e utilização do mesmo para propósitos médicos

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2011002001A1 (ja) * 2009-07-01 2011-01-06 キッセイ薬品工業株式会社 ピラゾール誘導体とビグアナイド薬との組み合わせ医薬

Also Published As

Publication number Publication date
CN104284665A (zh) 2015-01-14
US9273085B2 (en) 2016-03-01
KR20150013671A (ko) 2015-02-05
RU2014149181A (ru) 2016-06-27
JP6105546B2 (ja) 2017-03-29
CA2872002A1 (en) 2013-11-14
US9694027B2 (en) 2017-07-04
RU2602739C2 (ru) 2016-11-20
JP5663699B2 (ja) 2015-02-04
AU2013258566A1 (en) 2014-11-27
EP2848254A1 (en) 2015-03-18
US20160129031A1 (en) 2016-05-12
ES2601127T3 (es) 2017-02-14
PT2848254T (pt) 2016-10-05
DK2848254T3 (en) 2016-10-31
MX2014013696A (es) 2015-02-05
WO2013168671A1 (ja) 2013-11-14
AU2013258566B2 (en) 2017-03-16
HK1204773A1 (en) 2015-12-04
PL2848254T3 (pl) 2017-03-31
EP2848254B1 (en) 2016-08-03
KR101868991B1 (ko) 2018-06-19
BR112014027841B1 (pt) 2022-08-09
CA2872002C (en) 2019-01-15
BR112014027841A8 (pt) 2021-09-28
US20150141631A1 (en) 2015-05-21
BR112014027841A2 (pt) 2017-06-27
EP2848254A4 (en) 2015-07-15
JPWO2013168671A1 (ja) 2016-01-07
JP2015083580A (ja) 2015-04-30
MX359988B (es) 2018-10-18

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