CN104258332A - Chinese herb preparation for treating pigmented lichen planus and preparation method thereof - Google Patents
Chinese herb preparation for treating pigmented lichen planus and preparation method thereof Download PDFInfo
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- CN104258332A CN104258332A CN201410492896.XA CN201410492896A CN104258332A CN 104258332 A CN104258332 A CN 104258332A CN 201410492896 A CN201410492896 A CN 201410492896A CN 104258332 A CN104258332 A CN 104258332A
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Abstract
The invention discloses a Chinese herb preparation for treating pigmented lichen planus. The Chinese herb preparation is prepared from the following components according to certain weight proportions: Chinese thorowax roots, lightyellow sophora roots, common cnidium fruits, amur corktree barks, cortex dictamni, danshen roots, safflower, red paeony roots, Chinese angelica, baical skullcap roots, golden threads, dried gingers, dark plum, Chinese magnoliavine fruits, cicada slough, common ducksmeat herbs, felwort, redroot gromwell roots, oriental waterplantain rhizomes and raw licorice. The Chinese herb preparation has the functions of dispelling wind and arresting itching, removing heat and cooling blood, tonifying the liver and the spleen, and clearing damp and detoxifying, and can be used for effectively treating pigmented lichen planus.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine effervescent tablet for the treatment of pigmentosa lichen planus, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Pigmentosa lichen planus is the rare hypotype of lichen planus, and this sick pathogenic factor it be unclear that, may with infection, self cotton dress, heredity, spirit, oral relevant containing the pollution in gold and bismuth medicine and environment.Finding from the research on clinical and basis at present may be relevant with following factor: psychological factor: as patient's spiritedness trauma history, or life stress is excessive, or cultural life is hollow etc. causes the mood not smooth factor such as anxiety.Endocrine factors: female middle-aged sickness rate is higher, research finds that this disease is also relevant with trimester of pregnancy with the menstrual phase of female patient.Infective agent: hepatitis B virus, hepatitis C virus, helicobacter pylori.The disorder of diabetes, hypertension, digestive tract function, trace element disappearance etc. are relevant with morbidity.
Pigmentosa lichen planus involves the chronic inflammation disease of skin, hair follicle, first, mucosa, be mainly in middle age, skin lesion shows as pitchy macule or pimple, a little more than skin, it there is a little tiny squama, visible carefully shallow netted white stripes in the middle of part skin lesion, groin, axillary fossa symmetry taupe speckle, Histopathological changes into atrophy of epidermis, liquifaction degeneration of basal cells, the visible melanophage of intradermal, class sexual cell band-like infiltration is not obvious, visible lymphocytic infiltration around part blood vessel.Face, throat brown and dusty blue macule, differ in size, gradually expand to bilateral buccal, left collar, shirtfront, in dense distribution, be apt to occur in wrist, forearm, Lower Distal Extremities and rumpbone proparea, the conscious pruritus of patient.The traditional Chinese medical science thinks that primary disease is similar to " urticaria " or " tinea corporis ", and its morbidity and internal damage by the excessive seven emotions, affection due to external wind and heat pathogenic dryness is relevant.The traditional Chinese medical science is thought because of the spleen being the foundation of acquired constitution, main the whole body muscle and blood, and have one's ideas straightened out in mouth, liver controlling conveyance and dispersion, anger is impairing the liver then, excessive rising of liver-YANG, and consumption impairment of YIN blood, more increases endogenous dryness, the scorching generation that also can cause this disease of blood, thus primary disease often blame in spleen, liver two warp.
At present, the ointment used clinically is not fine to pigmentosa lichen planus curative effect, often can only the symptom of relieving itch, easy recurrence, cannot fundamentally treat pigmentosa lichen planus, and generally all can mix adrenal cortex hormones drug, the toxic and side effects produced health is very large, dependency is strong, brings very large misery to patient.After some oral medicines arrive skin, blood drug level cannot get a desired effect, and long action time, these medicines are all not suitable for pigmentosa patients with lichen planus and use.Chinese medicine is have original advantage at disease therapy, treatment short treating period, and no pain, treating both the principal and secondary aspects of a disease, curative effect is reliable, and the patient after healing is not easily recurred, and over the course for the treatment of, damage can not be produced to other organs, therefore in the pigmentosa lichen planus for the treatment of, truly have its distinctive feature, but also have some external application Chinese medicine lotions at present, owing to boiling certain technical requirement, need the regular hour, and carry inconvenience, be not also applicable to the use of pigmentosa patients with lichen planus.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of pigmentosa lichen planus, this Chinese medicine preparation has good effect for pigmentosa lichen planus, and cure rate is high, has no side effect, and uses easy to carry, cheap, the feature that healing time is short.
Another object of the present invention is to provide the preparation method of the Chinese medicine preparation of the pigmentosa lichen planus of this treatment.
Inventor is in clinical treatment practice for many years, observe patient's misery in the treatment of pigmentosa lichen planus, according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of pigmentosa lichen planus repeatedly, can overcome the problem existing for existing method preferably, for patient removes slight illness.The present invention has evident in efficacy, instant effect, and cure rate is high, has no side effect, and uses easy to carry, cheap feature.
The present invention selects Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Cnidii, Cortex Phellodendri, Cortex Dictamni, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Scutellariae, Rhizoma Coptidis, Rhizoma Zingiberis, Fructus Mume, Fructus Schisandrae Chinensis, Periostracum Cicadae, Herba Spirodelae, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Rhizoma Alismatis, Radix Glycyrrhizae to combine, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is dispelling wind for relieving itching, clearing away heat and cooling blood, effect of tonifying liver spleen invigorating, damp eliminating removing toxic substances, thus can effectively treat pigmentosa lichen planus.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Bupleuri: be root or the herb of Umbelliferae herbaceos perennial Radix Bupleuri (Radix Bupleuri) or Radix Bupeuri Scorzonerfolii. (Radix Bupleuri Scorzonerifolii).Nature and flavor: bitter, pungent, be slightly cold.Return liver, gallbladder meridian.Effect: reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.Modern pharmacological research proves: Radix Bupleuri has: 1, antipyretic, antipyretic effect is steadily reliable; 2, calm, analgesia, has and removes distending pain uncomfortable in chest, dissipating depression of QI regulating menoxenia; 3, antibacterial, there is inhibitory action to tubercule bacillus; 4, anti-liver injury effect; 5, antiviral, infected by influenza has strong inhibitory action, and the cytopathy caused the 1st type poliomyelitis virus is inhibited.Radix Bupleuri is fragrant catharsis not only, is longer than the heresy of catharsis half exterior and half interior, and has the effect of good dispersing the stagnated live-QI to relieve the stagnation of QI, can eliminate the pruritus of skin for the pigmentosa lichen planus for the treatment of, again can fundamentally dispersing the stagnated live-QI to relieve the stagnation of QI, the thoroughly pigmentosa lichen planus for the treatment of.
Radix Sophorae Flavescentis: be the root of pulse family perennial fallen leaves semishrub plant Radix Sophorae Flavescentis.Nature and flavor: bitter, cold in nature.Return liver, kidney, large intestine, small intestinal, bladder, heart channel.Effect: heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.Radix Sophorae Flavescentis external can pudendal pruritus under treatment belt, and to women's leucorrhea with yellow discharge, and male's swelling of the vulva pudendal pruritus all has good therapeutical effect.Eczema scabies can also be treated.Radix Sophorae Flavescentis bath can remove damp-heat in lower-JIAO, and killing parasites for relieving itching, there is good mitigation to the skin pruritus that eczema scabies causes.Compendium of Material Medica is recorded: the bitter cold of Radix Sophorae Flavescentis, Cortex Phellodendri, all can the kidney invigorating, and lid gets its bitter dampness, and cold heat extraction also.Hot air wind producing, humidogene worm, therefore wind parasite killing can be controlled again.Again by " Records of the Historian " cloud, the sick dental caries of granary public Chunyu Yi doctor doctor Qi, moxibustion left hand yangming meridian, gargles three liters with kuh-seng soup day, careful wind of coming in and going out, and more this also got the justice that it removes the damp and hot parasite killing of pathogenic wind on five, six.
Fructus Cnidii: be the dry mature fruit of Umbelliferae perennial plant cnidium monnieri.Nature and flavor: acrid, bitter, warm.Return kidney channel.Effect: warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis." book on Chinese herbal medicine newly organized " is recorded: Fructus Cnidii, and function is quite strange, inside and outsidely all can treat, and external treatment is especially good.Clinical practice: be used for the treatment of skin eczema and pruritus, as chronic eczema acute attack, pompholyx rotten to the corn phase, eczema scrotum, pruritus vulvae, scabies, tinea etc.
Cortex Phellodendri: for Rutaceae deciduous tree plant Cortex Phellodendri (Cortex Phellodendri) and wampee (Cortex Phellodendri) go out the dry bark of cork.Nature and flavor: bitter, cold.Return kidney, bladder, large intestine channel.Effect: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Modern pharmacology is studied: Cortex Phellodendri water decoction or alcohol preserved material are in vitro to staphylococcus aureus, Staphylococcus albus, Hemolytic streptococcus, Diplococcus pneumoniae, anthrax bacillus, vibrio cholera, diphtheria corynebacterium, bacillus subtilis, escherichia coli, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, meningococcus etc., all there is inhibitory action in various degree. experiment also shows, Cortex Phellodendri is to shigella flexneri, dysentery bacterium has stronger inhibitory action. in addition, Cortex Phellodendri decoct, water logging agent in external to multiple pathogenic dermatophytes, trichomonas vaginitises etc. all have inhibitory action in various degree.
Cortex Dictamni: the root bark being Rutaceae herbaceos perennial shaggy-fruited dittany and Dictamnus angustifolius.Nature and flavor: bitter, salty, cold.Return spleen, lung, small intestinal, stomach, urinary bladder channel.Function: heat clearing and damp drying; Dispelling wind for relieving itching; Removing toxic substances." property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor are yellow." modern pharmacology research; Cortex Dictamni has antibacterial action: the infusion of in vitro tests 1:4 to multiple pathomycete as trichophyton, Trichophyton concentricunm, oidium schoenleinii; all have inhibitory action in various degree, but have the ether of report this product, ethanol and water extract to be showed no effect to the coccuses such as golden yellow, escherichia coli bacillus pyocyaneus and Mycobacterium phlei.
Radix Salviae Miltiorrhizae: be the dry root and rhizome of dicotyledon Lamiaceae Salvia platymiscium Radix Salviae Miltiorrhizae.Nature and flavor: bitter, are slightly cold.Gui Jing: enter the heart, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps.Containing cryptotanshinone, dihydrotanshinone in red sage formulation, there is inhibitory action to external staphylococcus, escherichia coli, degeneration bacillus.
Flos Carthami: be the tubular corolla of feverfew Flos Carthami.Nature and flavor temperature, pungent.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The pungent loose temperature of Flos Carthami is led to, and specially enters blood system, and energy blood circulation promoting and blood stasis dispelling, stimulate the menstrual flow pulse-taking, and Flos Carthami has blood vessel dilating effect.Carthamus yellow can obviously extend blood plasma recalcification time, prothrombin time and clotting time." Amplification on Materia Medica addendum ": Flos Carthami, broken stagnant blood, nourishes blood.Multiplex then removing blood stasis is few with then nourishing blood.Normal and Radix Paeoniae Rubra, Radix Angelicae Sinensis are used together.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Nature and flavor are bitter, are slightly cold.Return Liver Channel.Effect: eliminating stasis to stop pain, clearing away heat and cooling blood, detumescence.This product hardship is fallen, and has effect of promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, row stagnation pain.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.Radix Angelicae Sinensis has inhibitory action to central nervous system, and volatile oil has the effects such as calmness, hypnosis, analgesia, anesthesia.Carry according to " book on Chinese herbal medicine is just ": " its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, can support nutrition blood, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, nothing unsuitable." modern medicine study confirmation, Radix Angelicae Sinensis has antibacterial, antiinflammation.The pain relieving of Radix Angelicae Sinensis energy promoting blood circulation and detumescence, again can tonic blood and growing muscle, therefore commonly uses for surgery more, and normal being equal to Flos Carthami is used.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.The clinical practice of Radix Scutellariae is antibacterial relatively good, and does not develop immunity to drugs.
Rhizoma Coptidis: be the rhizome of Ranunculaceae herbaceos perennial Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Nature and flavor: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Rhizoma Zingiberis: be the rhizome of Zingiberaceae herbaceos perennial Rhizoma Zingiberis Recens.Nature and flavor: pungent, hot.Return spleen, stomach, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.The pyogenic infection of Rhizoma Zingiberis external curing wound.
Fructus Mume: be the almost ripe fruit of Rosaceae deciduous tree prunus mume (sieb.) sieb.et zucc..Nature and flavor: sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for not closing up for a long time after carbuncle sore is burst, and external has the effect of removing dampness expelling pus and promoting granulation.
Fructus Schisandrae Chinensis: the mature fruit of fall leaves for Magnoliaceae is perennial bejuco Fructus Schisandrae Chinensis and schisandra chinensis.Nature and flavor: warm, sour, sweet.Return lung, the heart, kidney channel.Function: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Periostracum Cicadae: be the Cicadae shell come off when cicada Cryptotympana atrata Fabr. (Cicadae) is sprouted wings.Nature and flavor: sweet, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, rash are antipruritic, improving acuity of vision and removing nebula, endogenous wind stopping relieving convulsion.This product a surname is loose to be sent out thoroughly, wind-dispelling heat-dissipating, and rash antipruritic can be used for treats measles, eczema etc.
Herba Spirodelae: for Lemnaceae swims the whole herb with root of tiny herbaceous plant duckweed and Herba Spirodelae drying.Nature and flavor: pungent, cold.Gui Jing: enter lung, urinary bladder channel.Function: deliver rash, diuretic detumescent.Cure mainly: cat fever, macule is not saturating, skin swelling, dysuria.Clinical practice: be mainly used in rash.Measles does not indistinctly go out, or rash goes out saturating, heating and lossless, can use without other complication persons.For oral administration, washout.There is antiperspirant and body void person should not use.Also can be used for urticaria antipruritic.
Radix Gentianae: be the root and rhizome of Gentianaceae herbaceos perennial Radix Gentianae, G. triflora, Gentiana manshurica or Gentiana rigescens Franch.Nature and flavor: bitter, cold.Return liver, gallbladder meridian.Effect: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.Being used for the treatment of jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, this product Great Cold, heat clearing and damp drying, outstanding kind liver heat removing gallbladder and damp-heat in lower-JIAO, is the common medicine of clearing liver-gallbladder and damp-heat in lower-JIAO.Normal and Cortex Phellodendri, Radix Sophorae Flavescentis are equal to be used.
Radix Arnebiae (Radix Lithospermi): be the root of comfrey Radix Arnebiae (Radix Lithospermi) (gromwell root) and lithospermum euchromum Royle (Radix Arnebiae).Nature and flavor: cold, sweet, salty.Gui Jing: GUIXIN, Liver Channel.Function: removing heat from blood, invigorates blood circulation, removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention.
Rhizoma Alismatis: be the tuber of the perennial limnocryptophyte Rhizoma Alismatis of Alismataceae.Nature and flavor: sweet, cold.Return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.For edema, the dysuria of retention of water-damp in the body.
Radix Glycyrrhizae: be dicotyledon pulse family Radix Glycyrrhizae, the root and rhizome of Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Nature and flavor: sweet are flat.Enter spleen, stomach, lung meridian.Function: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for being in harmonious proportion the strong of some drugs, makes medicine at this Fang Zhongwei.
Side's solution of the present invention is: side in Radix Bupleuri, Radix Sophorae Flavescentis, Fructus Cnidii, Cortex Phellodendri, Cortex Dictamni, Radix Salviae Miltiorrhizae for monarch drug.Radix Bupleuri fragrance catharsis, dispersing the stagnated live-QI to relieve the stagnation of QI had both been alleviated and had been shown symptom, had and fundamentally nursed one's health health, first of monarch drug.Radix Sophorae Flavescentis, Fructus Cnidii, Cortex Phellodendri, Cortex Dictamni heat clearing and damp drying, wind dispelling insecticide, eliminating fire and detoxication, Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, six share dispelling wind for relieving itching, clearing away heat and cooling blood, and drug effect increases.Flos Carthami, Radix Paeoniae Rubra promoting blood circulation to restore menstrual flow, loose Yu Xiao wei, Radix Angelicae Sinensis reducing swelling and alleviating pain, tonic blood and growing muscle, joins the growth that Flos Carthami can promote new skin.Radix Scutellariae, Rhizoma Coptidis anti-inflammation, heat clearing and damp drying, the expectorant of Rhizoma Zingiberis dampness, Fructus Mume astringing to arrest bleeding, expelling pus and promoting granulation, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, the above medicine of kidney calming are ministerial drug altogether, auxiliary monarch drug dispelling wind for relieving itching, clearing away heat and cooling blood.Periostracum Cicadae, Herba Spirodelae dispelling wind and heat pathogens, rash is antipruritic, inducing diuresis to remove edema, Radix Gentianae heat clearing and damp drying, Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, and removing toxic substances rash, above medicine is adjuvant drug altogether, Rhizoma Alismatis, Radix Glycyrrhizae, inducing diuresis to remove edema, and coordinating the actions of various ingredients in a prescription, altogether for making medicine.All medicine compatibilities in side, the monarch and his subjects pull together, help and make auxiliary altogether, and make it to have dispelling wind for relieving itching, clearing away heat and cooling blood, tonifying liver spleen invigorating, effect of damp eliminating removing toxic substances, can effectively treat pigmentosa lichen planus.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Bupleuri 9-15 part, Radix Sophorae Flavescentis 10-20 part, Fructus Cnidii 10-20 part, Cortex Phellodendri 10-20 part, Cortex Dictamni 9-15 part, Radix Salviae Miltiorrhizae 13-23 part, Flos Carthami 6-12 part, Radix Paeoniae Rubra 6-12 part, Radix Angelicae Sinensis 9-15 part, Radix Scutellariae 9-15 part, Rhizoma Coptidis 3-9 part, Rhizoma Zingiberis 10-20 part, Fructus Mume 13-23 part, Fructus Schisandrae Chinensis 6-12 part, Periostracum Cicadae 3-9 part, Herba Spirodelae 9-15 part, Radix Gentianae 6-12 part, Radix Arnebiae (Radix Lithospermi) 9-15 part, Rhizoma Alismatis 10-20 part, Radix Glycyrrhizae 3-9 part.
Wherein be preferably: Radix Bupleuri 12 parts, Radix Sophorae Flavescentis 15 parts, Fructus Cnidii 15 parts, Cortex Phellodendri 15 parts, Cortex Dictamni 12 parts, Radix Salviae Miltiorrhizae 18 parts, 9 parts, Flos Carthami, Radix Paeoniae Rubra 9 parts, Radix Angelicae Sinensis 12 parts, Radix Scutellariae 12 parts, Rhizoma Coptidis 6 parts, Rhizoma Zingiberis 15 parts, Fructus Mume 18 parts, Fructus Schisandrae Chinensis 9 parts, Periostracum Cicadae 6 parts, 12 parts, Herba Spirodelae, Radix Gentianae 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Rhizoma Alismatis 15 parts, Radix Glycyrrhizae 6 parts.
Medicine of the present invention can adopt the conventional boiling method of Chinese medicine composition, washout and affected part after decocting compositions.Long owing to boiling Herb Time, and not portable, the preferred dosage form of the present invention is effervescent tablet.External effervescent tablet also has rapid-action rapidly because of disintegrate, be easy to the feature absorbed, and the foam that effervescent produces contributes to local bactericidal.
Above-mentioned each raw material of Chinese medicine is made the preferred production method of Chinese medicine effervescent tablet of the present invention is:
Step one: by weight proportion of the present invention, takes Radix Bupleuri, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Zingiberis extraction by steam distillation volatile oil, volatile oil and distillation after aqueous solution for subsequent use, medicinal residues were decoction 1 hour, and decocting liquid and above-mentioned aqueous solution merge, filtration;
Step 2: take Fructus Cnidii, Cortex Phellodendri, Cortex Dictamni, Radix Angelicae Sinensis, Radix Scutellariae, Rhizoma Coptidis, Fructus Mume, Fructus Schisandrae Chinensis, decoct with water twice, 2 hours first times, second time adds Herba Spirodelae, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Rhizoma Alismatis, Radix Glycyrrhizae decoction 1.5 hours, merges twice decocting liquid, filters;
Step 3: take Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Periostracum Cicadae drying and crushing to 200 mesh sieve;
Step 4: step one and step 2 gained decocting liquid are merged, it is 1.10-1.15 that filtrate is concentrated into 60-70 DEG C of mensuration relative density, room temperature to be chilled to, 80% ethanol adding 3 times amount makes precipitation, leave standstill 24 hours, get supernatant soln be condensed into 60-65 DEG C measure relative density be the clear paste of 1.05-1.20, be mixed into step 3 gained fine powder, add lauryl sodium sulfate surfactant and be dried to extract powder;
Step 5: after step 4 gained extract powder is carried out vacuum drying, be ground into fine powder, the Polyethylene Glycol parcel of acid agent sodium carbonate melting, be ground into fine powder, by other adjuvant mix homogeneously such as medicated powder, acid, alkaline agent sodium carbonate, binding agent carboxymethylstach sodium, magnesium stearate lubricants, granulation, dry, tabletting, make the effervescent tablet of 5g/ sheet.
Medicine of the present invention has dispelling wind for relieving itching, clearing away heat and cooling blood, effect of damp eliminating removing toxic substances, and good effect, cure rate is high, have no side effect, use easy to carry, cheap, add up according to clinical 225 routine patient view, use medicine of the present invention the total effective rate course for the treatment of 88%, two the total effective rate course for the treatment of 96%.
Detailed description of the invention
Embodiment one, Radix Bupleuri 9 parts, Radix Sophorae Flavescentis 10 parts, Fructus Cnidii 10 parts, Cortex Phellodendri 10 parts, Cortex Dictamni 9 parts, Radix Salviae Miltiorrhizae 13 parts, 6 parts, Flos Carthami, Radix Paeoniae Rubra 6 parts, Radix Angelicae Sinensis 9 parts, Radix Scutellariae 9 parts, Rhizoma Coptidis 3 parts, Rhizoma Zingiberis 10 parts, Fructus Mume 13 parts, Fructus Schisandrae Chinensis 6 parts, Periostracum Cicadae 3 parts, 9 parts, Herba Spirodelae, Radix Gentianae 6 parts, Radix Arnebiae (Radix Lithospermi) 9 parts, Rhizoma Alismatis 10 parts, Radix Glycyrrhizae 3 parts.
Embodiment two, Radix Bupleuri 12 parts, Radix Sophorae Flavescentis 15 parts, Fructus Cnidii 15 parts, Cortex Phellodendri 15 parts, Cortex Dictamni 12 parts, Radix Salviae Miltiorrhizae 18 parts, 9 parts, Flos Carthami, Radix Paeoniae Rubra 9 parts, Radix Angelicae Sinensis 12 parts, Radix Scutellariae 12 parts, Rhizoma Coptidis 6 parts, Rhizoma Zingiberis 15 parts, Fructus Mume 18 parts, Fructus Schisandrae Chinensis 9 parts, Periostracum Cicadae 6 parts, 12 parts, Herba Spirodelae, Radix Gentianae 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Rhizoma Alismatis 15 parts, Radix Glycyrrhizae 6 parts.
Embodiment three, Radix Bupleuri 15 parts, Radix Sophorae Flavescentis 20 parts, Fructus Cnidii 20 parts, Cortex Phellodendri 20 parts, Cortex Dictamni 15 parts, Radix Salviae Miltiorrhizae 23 parts, 12 parts, Flos Carthami, Radix Paeoniae Rubra 12 parts, Radix Angelicae Sinensis 15 parts, Radix Scutellariae 15 parts, Rhizoma Coptidis 9 parts, Rhizoma Zingiberis 20 parts, Fructus Mume 23 parts, Fructus Schisandrae Chinensis 12 parts, Periostracum Cicadae 9 parts, 15 parts, Herba Spirodelae, Radix Gentianae 12 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Rhizoma Alismatis 20 parts, Radix Glycyrrhizae 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept patient's totally 450 examples of the pigmentosa lichen planus of outpatient service year January in April, 2012 to 2014 for medical treatment, patient is divided into observation group and matched group at random, wherein male 210 example, women 240 example, M-F 1:1.15, max age 80 years old, minimal ages 26 years old, 56 years old mean age, every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two: diagnosis basis
1, pathologic finding display lichen planus, but there is obvious incontinence of pigment, and epidermal melanin is visible;
2, basal layer cell hydropic degeneration, but form compensatory cellular hypertrophy without cutin, and therefore epidermis is thinning without acanthosis;
3, have a medical check-up display cervical region, trunk, extremity are dispersed in the filbert speckle of distribution or speckle, and boundary is clear, and some is Head And Face spottiness even, occurs ulcer in oral cavity.
Three, Therapeutic Method:
1, observation group is according to Medications Example two of the present invention, and effervescent tablet prepared by preferred preparation method, and cold water is washed open, adds appropriate warm water and is adjusted to 40-45 DEG C, sooner or later respectively once, and each a slice.It within 10th, is a course for the treatment of.
2, the decoction made according to the Chinese medicine composition for the treatment of lichen planus in CN 102166305A of matched group, twice daily, 7th is a course for the treatment of.
Four, efficacy assessment standard:
1, cure: speckle, speckle disappear, oral ulcer surface heals, pain, and pruritus phenomenon disappears, and without other clinical symptoms;
2, take a turn for the better: pain, pruritus are controlled, and speckle, speckle fade away;
3, do not heal: speckle, speckle still exist, and with pain and pruritus.
Five, observation group's result statistics
Matched group result is added up
Wherein: total effective rate=cure rate+improvement rate
Use the Comparison of therapeutic situation of two groups of patients, two courses for the treatment of
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness in the pigmentosa lichen planus for the treatment of, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Model case and curative effect: case one, Song, female, 35 years old, there is crineous macule in bilateral axillary regions and thigh root, the situation of pruritus, due to pruritus unbearably, Song is to the hospitalize in town, but doctor does not provide the concrete diagnostic result of Song yet, just gives the medicine that some are antipruritic, allow Song's external.DeGrain after medication, and the quantity of erythra is on the increase, the crineous macule that part erythema disappears and forms size gradually, shape differs, and because pruritus is hard to bear, makes Song very painful.Song went to seek medical advice to the large hospital in economizing afterwards.Diagnosis is pigmentosa lichen planus, went to a doctor in here afterwards, patient adopts embodiment two Chinese medicine composition weight ratio, and water-soluble for effervescent tablet rear temperature is spread on affected part, after 1 course for the treatment of, Relationship between maternal pruritus reduces, spot colors shoals, and continues to use 2 courses for the treatment of of this medicine, and patient's macule disappears, without the phenomenon of pruritus pain, cure completely.
Case two, Zhao, man, 55 years old, there is erythema in groin place, pruritus, pain, after remove examination in hospital, doctor, after inquiry, find there is similar disease in Zhao family, and Zhao is very healthy at ordinary times, irritated situation of also not taking medicine.Department of dermatologry inspection finds, Zhao's groin, thigh root are shown in and are dispersed in the distribution grain of rice to carapace size crineous macule, shape, not of uniform size, is dispersed in, symmetrical, above has squama.Pigmentosa lichen planus is diagnosed as again through other auxiliary examinations, the medicinal ointment therapy DeGrain that hospital outputs, I went out medical afterwards, patient adopts embodiment two Chinese medicine composition weight ratio, water-soluble for effervescent tablet rear temperature is spread on affected part, and after 15 days, patient's macule disappears, the phenomenon of pruritus, pain disappears, and cures completely.
Case three, grandson, female, 60 years old, there is erythema in cervical region, extremity near-end, and with oral lesions, and to be correlated with auxiliary examination display through hospital, grandson's epidermal hyperkeratosis, hypergranulosis, spinous layer is irregular thinning.Skin is prominent to disappear, the degeneration of basal cell obvious liquefaction, high dermis vasodilation, and Guan Zhou great amount lymphocyte is band-like infiltration, scatters pigment granule and melanophage.Hospital is diagnosed as pigmentosa lichen planus, went to a doctor in here afterwards, patient adopts embodiment two Chinese medicine composition weight ratio, water-soluble for effervescent tablet rear temperature is spread on affected part, and medicinal liquid is contained in mouth gargles 2-3 time, after 1 course for the treatment of, patient's macule disappears, the phenomenon of pruritus, pain disappears, and oral ulcer surface heals, and cures completely.
Claims (4)
1. treat the Chinese medicine preparation of pigmentosa lichen planus for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Bupleuri 9-15 part, Radix Sophorae Flavescentis 10-20 part, Fructus Cnidii 10-20 part, Cortex Phellodendri 10-20 part, Cortex Dictamni 9-15 part, Radix Salviae Miltiorrhizae 13-23 part, Flos Carthami 6-12 part, Radix Paeoniae Rubra 6-12 part, Radix Angelicae Sinensis 9-15 part, Radix Scutellariae 9-15 part, Rhizoma Coptidis 3-9 part, Rhizoma Zingiberis 10-20 part, Fructus Mume 13-23 part, Fructus Schisandrae Chinensis 6-12 part, Periostracum Cicadae 3-9 part, Herba Spirodelae 9-15 part, Radix Gentianae 6-12 part, Radix Arnebiae (Radix Lithospermi) 9-15 part, Rhizoma Alismatis 10-20 part, Radix Glycyrrhizae 3-9 part.
2. the Chinese medicine preparation of the pigmentosa lichen planus for the treatment of according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Bupleuri 12 parts, Radix Sophorae Flavescentis 15 parts, Fructus Cnidii 15 parts, Cortex Phellodendri 15 parts, Cortex Dictamni 12 parts, Radix Salviae Miltiorrhizae 18 parts, 9 parts, Flos Carthami, Radix Paeoniae Rubra 9 parts, Radix Angelicae Sinensis 12 parts, Radix Scutellariae 12 parts, Rhizoma Coptidis 6 parts, Rhizoma Zingiberis 15 parts, Fructus Mume 18 parts, Fructus Schisandrae Chinensis 9 parts, Periostracum Cicadae 6 parts, 12 parts, Herba Spirodelae, Radix Gentianae 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Rhizoma Alismatis 15 parts, Radix Glycyrrhizae 6 parts.
3. the Chinese medicine preparation of the pigmentosa lichen planus for the treatment of according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is effervescent tablet.
4. treat the preparation method of the Chinese medicine preparation of pigmentosa lichen planus for one kind, it is characterized in that, its preparation method is as follows: step one: by weight proportion of the present invention, take Radix Bupleuri, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Zingiberis extraction by steam distillation volatile oil, volatile oil and distillation after aqueous solution for subsequent use, medicinal residues were decoction 1 hour, and decocting liquid and above-mentioned aqueous solution merge, and filtered; Step 2: take Fructus Cnidii, Cortex Phellodendri, Cortex Dictamni, Radix Angelicae Sinensis, Radix Scutellariae, Rhizoma Coptidis, Fructus Mume, Fructus Schisandrae Chinensis, decoct with water twice, 2 hours first times, second time adds Herba Spirodelae, Radix Gentianae, Radix Arnebiae (Radix Lithospermi), Rhizoma Alismatis, Radix Glycyrrhizae decoction 1.5 hours, merges twice decocting liquid, filters; Step 3: take Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae, Periostracum Cicadae drying and crushing to 200 mesh sieve; Step 4: step one and step 2 gained decocting liquid are merged, it is 1.10-1.15 that filtrate is concentrated into 60-70 DEG C of mensuration relative density, room temperature to be chilled to, 80% ethanol adding 3 times amount makes precipitation, leave standstill 24 hours, get supernatant soln be condensed into 60-65 DEG C measure relative density be the clear paste of 1.05-1.20, be mixed into step 3 gained fine powder, add lauryl sodium sulfate surfactant and be dried to extract powder; Step 5: after step 4 gained extract powder is carried out vacuum drying, be ground into fine powder, the Polyethylene Glycol parcel of acid agent sodium carbonate melting, be ground into fine powder, by other adjuvant mix homogeneously such as medicated powder, acid, alkaline agent sodium carbonate, binding agent carboxymethylstach sodium, magnesium stearate lubricants, granulation, dry, tabletting, make the effervescent tablet of 5g/ sheet.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716291A (en) * | 2009-11-17 | 2010-06-02 | 王茂基 | Oral traditional Chinese medicine for treating skin diseases |
| CN101843862A (en) * | 2010-06-23 | 2010-09-29 | 邱宏亮 | Mouthwash capable of clearing lichen planus and Candida albicans of oral cavity |
| CN102166305A (en) * | 2011-03-11 | 2011-08-31 | 杨萍萍 | Traditional Chinese medicine composition for treating lichen planus and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101716291A (en) * | 2009-11-17 | 2010-06-02 | 王茂基 | Oral traditional Chinese medicine for treating skin diseases |
| CN101843862A (en) * | 2010-06-23 | 2010-09-29 | 邱宏亮 | Mouthwash capable of clearing lichen planus and Candida albicans of oral cavity |
| CN102166305A (en) * | 2011-03-11 | 2011-08-31 | 杨萍萍 | Traditional Chinese medicine composition for treating lichen planus and preparation method thereof |
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Application publication date: 20150107 |