CN104254527B - 抗菌的喹啉衍生物 - Google Patents
抗菌的喹啉衍生物 Download PDFInfo
- Publication number
- CN104254527B CN104254527B CN201380021790.5A CN201380021790A CN104254527B CN 104254527 B CN104254527 B CN 104254527B CN 201380021790 A CN201380021790 A CN 201380021790A CN 104254527 B CN104254527 B CN 104254527B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- alkoxy
- hydrogen
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VRJHQPZVIGNGMX-UHFFFAOYSA-N O=C1CCNCC1 Chemical compound O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 description 1
- ZJMMTYXHDGOZOV-UHFFFAOYSA-N P=C1CCNCC1 Chemical compound P=C1CCNCC1 ZJMMTYXHDGOZOV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12165934.6 | 2012-04-27 | ||
| EP12165934 | 2012-04-27 | ||
| PCT/EP2013/058703 WO2013160435A1 (en) | 2012-04-27 | 2013-04-26 | Antibacterial quinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104254527A CN104254527A (zh) | 2014-12-31 |
| CN104254527B true CN104254527B (zh) | 2017-05-31 |
Family
ID=48227271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380021790.5A Active CN104254527B (zh) | 2012-04-27 | 2013-04-26 | 抗菌的喹啉衍生物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9133167B2 (enExample) |
| EP (1) | EP2841425B1 (enExample) |
| JP (1) | JP6153604B2 (enExample) |
| KR (1) | KR102110355B1 (enExample) |
| CN (1) | CN104254527B (enExample) |
| AU (1) | AU2013254674B2 (enExample) |
| CA (1) | CA2869718C (enExample) |
| DK (1) | DK2841425T3 (enExample) |
| EA (1) | EA035443B1 (enExample) |
| ES (1) | ES2576491T3 (enExample) |
| IN (1) | IN2014MN02364A (enExample) |
| MX (1) | MX355050B (enExample) |
| PL (1) | PL2841425T3 (enExample) |
| WO (1) | WO2013160435A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104254528B (zh) * | 2012-04-27 | 2017-06-06 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| JP2017523213A (ja) * | 2014-08-06 | 2017-08-17 | ノバルティス アーゲー | 抗菌薬としてのキノロン誘導体 |
| EA201891644A1 (ru) * | 2016-03-07 | 2019-04-30 | Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. | Антибактериальные соединения и их применение |
| KR102574912B1 (ko) * | 2016-08-17 | 2023-09-07 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
| WO2018048882A1 (en) | 2016-09-06 | 2018-03-15 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| KR102695633B1 (ko) * | 2021-12-17 | 2024-08-14 | 한국화학연구원 | 피리미딘을 포함하는 테트라하이드로이소퀴놀린 유도체 및 이의 결핵 치료제 용도 |
| WO2023178035A1 (en) | 2022-03-14 | 2023-09-21 | Slap Pharmaceuticals Llc | Multicyclic compounds |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005070924A1 (en) * | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Substituted quinolines and their use as mycobacterial inhibitors |
| WO2008068270A1 (en) * | 2006-12-06 | 2008-06-12 | Janssen Pharmaceutica N.V. | Antibacterial quinoline derivatives |
| WO2008068272A2 (en) * | 2006-12-06 | 2008-06-12 | Janssen Pharmaceutica N.V. | Antibacterial quinoline derivatives |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503411A (ja) | 1996-10-28 | 2001-03-13 | ディパートメント オブ ジ アーミー，ユー．エス．ガバメント | 抗生物質耐性感染症の処置のための化合物、組成物および方法 |
| US6103905A (en) | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| RS52431B (sr) | 2002-07-25 | 2013-02-28 | Janssen Pharmaceutica N.V. | Derivati hinolina i njihova upotreba kao mikobakterijskih inhibitora |
| UA86952C2 (uk) | 2004-01-23 | 2009-06-10 | Янссен Фармацевтика Н.В. | Похідні хіноліну та їх застосування як мікобактеріальних інгібіторів |
| CN1910154B (zh) | 2004-01-29 | 2011-08-17 | 詹森药业有限公司 | 用作分枝杆菌抑制剂的喹啉衍生物 |
| ES2306146T3 (es) | 2004-05-28 | 2008-11-01 | Janssen Pharmaceutica Nv | Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a farmacos. |
| WO2005123081A2 (en) | 2004-06-22 | 2005-12-29 | Janssen Pharmaceutica N.V. | (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia |
| DK1797115T3 (en) | 2004-09-28 | 2017-10-02 | Janssen Pharmaceutica Nv | BACTERIAL ATP SYNTHASE BINDING DOMAIN. |
| EE05394B1 (et) | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| CA2528849C (en) | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| AP2547A (en) | 2005-06-28 | 2012-12-26 | Janssen Pharmaceutica Nv | Quinoline derivatives as antibacterial agents |
| JO3270B1 (ar) | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| JO3077B1 (ar) | 2005-07-28 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينولين مضادة للبكتيريا |
| JO2837B1 (en) | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2952B1 (en) | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2685B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2684B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| US20110059948A1 (en) * | 2008-01-14 | 2011-03-10 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivatives as anti-mycobacterial agents |
| CN104254528B (zh) * | 2012-04-27 | 2017-06-06 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
-
2013
- 2013-04-26 US US14/391,045 patent/US9133167B2/en active Active
- 2013-04-26 CA CA2869718A patent/CA2869718C/en active Active
- 2013-04-26 EA EA201491982A patent/EA035443B1/ru not_active IP Right Cessation
- 2013-04-26 KR KR1020147031040A patent/KR102110355B1/ko active Active
- 2013-04-26 CN CN201380021790.5A patent/CN104254527B/zh active Active
- 2013-04-26 ES ES13719524.4T patent/ES2576491T3/es active Active
- 2013-04-26 WO PCT/EP2013/058703 patent/WO2013160435A1/en not_active Ceased
- 2013-04-26 IN IN2364MUN2014 patent/IN2014MN02364A/en unknown
- 2013-04-26 PL PL13719524.4T patent/PL2841425T3/pl unknown
- 2013-04-26 MX MX2014013056A patent/MX355050B/es active IP Right Grant
- 2013-04-26 JP JP2015507549A patent/JP6153604B2/ja active Active
- 2013-04-26 DK DK13719524.4T patent/DK2841425T3/en active
- 2013-04-26 EP EP13719524.4A patent/EP2841425B1/en active Active
- 2013-04-26 AU AU2013254674A patent/AU2013254674B2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005070924A1 (en) * | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Substituted quinolines and their use as mycobacterial inhibitors |
| WO2008068270A1 (en) * | 2006-12-06 | 2008-06-12 | Janssen Pharmaceutica N.V. | Antibacterial quinoline derivatives |
| WO2008068272A2 (en) * | 2006-12-06 | 2008-06-12 | Janssen Pharmaceutica N.V. | Antibacterial quinoline derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| EA035443B1 (ru) | 2020-06-17 |
| MX2014013056A (es) | 2014-12-10 |
| US20150065502A1 (en) | 2015-03-05 |
| AU2013254674B2 (en) | 2017-02-02 |
| KR20150013156A (ko) | 2015-02-04 |
| CN104254527A (zh) | 2014-12-31 |
| US9133167B2 (en) | 2015-09-15 |
| EP2841425B1 (en) | 2016-03-23 |
| WO2013160435A1 (en) | 2013-10-31 |
| EP2841425A1 (en) | 2015-03-04 |
| KR102110355B1 (ko) | 2020-05-14 |
| AU2013254674A1 (en) | 2014-10-16 |
| IN2014MN02364A (enExample) | 2015-08-14 |
| ES2576491T3 (es) | 2016-07-07 |
| CA2869718A1 (en) | 2013-10-31 |
| EA201491982A1 (ru) | 2015-02-27 |
| PL2841425T3 (pl) | 2016-10-31 |
| CA2869718C (en) | 2021-05-11 |
| HK1205514A1 (en) | 2015-12-18 |
| MX355050B (es) | 2018-04-02 |
| JP6153604B2 (ja) | 2017-06-28 |
| DK2841425T3 (en) | 2016-06-27 |
| JP2015518003A (ja) | 2015-06-25 |
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Legal Events
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| REG | Reference to a national code |
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