JP6153604B2 - 抗菌性キノリン誘導体 - Google Patents
抗菌性キノリン誘導体 Download PDFInfo
- Publication number
- JP6153604B2 JP6153604B2 JP2015507549A JP2015507549A JP6153604B2 JP 6153604 B2 JP6153604 B2 JP 6153604B2 JP 2015507549 A JP2015507549 A JP 2015507549A JP 2015507549 A JP2015507549 A JP 2015507549A JP 6153604 B2 JP6153604 B2 JP 6153604B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- solvate
- oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12165934 | 2012-04-27 | ||
| EP12165934.6 | 2012-04-27 | ||
| PCT/EP2013/058703 WO2013160435A1 (en) | 2012-04-27 | 2013-04-26 | Antibacterial quinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015518003A JP2015518003A (ja) | 2015-06-25 |
| JP6153604B2 true JP6153604B2 (ja) | 2017-06-28 |
Family
ID=48227271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507549A Expired - Fee Related JP6153604B2 (ja) | 2012-04-27 | 2013-04-26 | 抗菌性キノリン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9133167B2 (enExample) |
| EP (1) | EP2841425B1 (enExample) |
| JP (1) | JP6153604B2 (enExample) |
| KR (1) | KR102110355B1 (enExample) |
| CN (1) | CN104254527B (enExample) |
| AU (1) | AU2013254674B2 (enExample) |
| CA (1) | CA2869718C (enExample) |
| DK (1) | DK2841425T3 (enExample) |
| EA (1) | EA035443B1 (enExample) |
| ES (1) | ES2576491T3 (enExample) |
| IN (1) | IN2014MN02364A (enExample) |
| MX (1) | MX355050B (enExample) |
| PL (1) | PL2841425T3 (enExample) |
| WO (1) | WO2013160435A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102110366B1 (ko) * | 2012-04-27 | 2020-05-14 | 얀센 파마슈티카 엔.브이. | 항균성 퀴놀린 유도체 |
| JP2017523213A (ja) * | 2014-08-06 | 2017-08-17 | ノバルティス アーゲー | 抗菌薬としてのキノロン誘導体 |
| EA201891644A1 (ru) * | 2016-03-07 | 2019-04-30 | Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. | Антибактериальные соединения и их применение |
| KR102574912B1 (ko) * | 2016-08-17 | 2023-09-07 | 덕산네오룩스 주식회사 | 유기전기 소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 |
| US11857352B2 (en) | 2016-09-06 | 2024-01-02 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
| KR102695633B1 (ko) * | 2021-12-17 | 2024-08-14 | 한국화학연구원 | 피리미딘을 포함하는 테트라하이드로이소퀴놀린 유도체 및 이의 결핵 치료제 용도 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965572A (en) | 1996-10-28 | 1999-10-12 | The United States Of America As Respresented By The Secretary Of The Army | Methods for treating antibiotic-resistant infections |
| US6103905A (en) | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| PT1527050E (pt) | 2002-07-25 | 2010-06-22 | Janssen Pharmaceutica Nv | Derivados de quinolina e sua utilização como inibidores de micobactérias |
| KR101150172B1 (ko) | 2004-01-23 | 2012-05-25 | 얀센 파마슈티카 엔.브이. | 치환된 퀴놀린 및 마이코박테리아 저해제로서의 용도 |
| ATE444068T1 (de) | 2004-01-23 | 2009-10-15 | Janssen Pharmaceutica Nv | Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren |
| MXPA06008596A (es) | 2004-01-29 | 2006-08-28 | Janssen Pharmaceutica Nv | Derivados de quinolina para uso como inhibidores micobacterianos. |
| JO2524B1 (en) | 2004-05-28 | 2010-03-17 | جانسن فارمسيتكا ان في | Use of substituted quinoline derivatives to treat drug-resistant microbial diseases |
| WO2005123081A2 (en) | 2004-06-22 | 2005-12-29 | Janssen Pharmaceutica N.V. | (2-benzyl-4-{4-[1-(tetrahydrofuran-3-carbonyl)-pyrrolidin-3-yl]-piperazin-1-yl}-piperidin-1-yl)-(3,5-trifluoromethyl-phenyl))-methanone for the treatment of schizophrenia |
| KR101539021B1 (ko) | 2004-09-28 | 2015-07-23 | 얀센 파마슈티카 엔.브이. | 박테리아 ａｔｐ 합성효소 결합 부분 |
| EE05394B1 (et) | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| EE05697B1 (et) | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| CA2612614C (en) | 2005-06-28 | 2017-07-25 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| JO3270B1 (ar) | 2005-06-28 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات كوينولين بصفة عوامل مضادة للبكتيريا |
| JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO3077B1 (ar) | 2005-07-28 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينولين مضادة للبكتيريا |
| JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2837B1 (en) | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| JO2952B1 (en) | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2683B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2725B1 (en) * | 2006-12-06 | 2013-09-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2684B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2685B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| CA2711912A1 (en) * | 2008-01-14 | 2009-07-23 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents |
| KR102110366B1 (ko) * | 2012-04-27 | 2020-05-14 | 얀센 파마슈티카 엔.브이. | 항균성 퀴놀린 유도체 |
-
2013
- 2013-04-26 US US14/391,045 patent/US9133167B2/en active Active
- 2013-04-26 MX MX2014013056A patent/MX355050B/es active IP Right Grant
- 2013-04-26 DK DK13719524.4T patent/DK2841425T3/en active
- 2013-04-26 PL PL13719524.4T patent/PL2841425T3/pl unknown
- 2013-04-26 AU AU2013254674A patent/AU2013254674B2/en not_active Ceased
- 2013-04-26 EA EA201491982A patent/EA035443B1/ru not_active IP Right Cessation
- 2013-04-26 WO PCT/EP2013/058703 patent/WO2013160435A1/en not_active Ceased
- 2013-04-26 ES ES13719524.4T patent/ES2576491T3/es active Active
- 2013-04-26 JP JP2015507549A patent/JP6153604B2/ja not_active Expired - Fee Related
- 2013-04-26 CN CN201380021790.5A patent/CN104254527B/zh not_active Expired - Fee Related
- 2013-04-26 IN IN2364MUN2014 patent/IN2014MN02364A/en unknown
- 2013-04-26 CA CA2869718A patent/CA2869718C/en active Active
- 2013-04-26 KR KR1020147031040A patent/KR102110355B1/ko not_active Expired - Fee Related
- 2013-04-26 EP EP13719524.4A patent/EP2841425B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104254527A (zh) | 2014-12-31 |
| MX355050B (es) | 2018-04-02 |
| US20150065502A1 (en) | 2015-03-05 |
| CA2869718C (en) | 2021-05-11 |
| US9133167B2 (en) | 2015-09-15 |
| EP2841425A1 (en) | 2015-03-04 |
| ES2576491T3 (es) | 2016-07-07 |
| EA201491982A1 (ru) | 2015-02-27 |
| PL2841425T3 (pl) | 2016-10-31 |
| CN104254527B (zh) | 2017-05-31 |
| WO2013160435A1 (en) | 2013-10-31 |
| KR20150013156A (ko) | 2015-02-04 |
| EP2841425B1 (en) | 2016-03-23 |
| HK1205514A1 (en) | 2015-12-18 |
| IN2014MN02364A (enExample) | 2015-08-14 |
| DK2841425T3 (en) | 2016-06-27 |
| AU2013254674B2 (en) | 2017-02-02 |
| EA035443B1 (ru) | 2020-06-17 |
| JP2015518003A (ja) | 2015-06-25 |
| CA2869718A1 (en) | 2013-10-31 |
| KR102110355B1 (ko) | 2020-05-14 |
| MX2014013056A (es) | 2014-12-10 |
| AU2013254674A1 (en) | 2014-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
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| A977 | Report on retrieval |
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| A521 | Request for written amendment filed |
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| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
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| A61 | First payment of annual fees (during grant procedure) |
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| LAPS | Cancellation because of no payment of annual fees |