CN104254339B - 用于治疗和/或护理皮肤和/或粘膜的化合物和它们在化妆品组合物或药物组合物中的用途 - Google Patents
用于治疗和/或护理皮肤和/或粘膜的化合物和它们在化妆品组合物或药物组合物中的用途 Download PDFInfo
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PCT/EP2013/057939 WO2013156493A1 (en) | 2012-04-16 | 2013-04-16 | Compounds for the treatment and/or care of the skin and/or mucous membranes and their use in cosmetic or pharmaceutical compositions |
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CN104254339A CN104254339A (zh) | 2014-12-31 |
CN104254339B true CN104254339B (zh) | 2020-01-21 |
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EP (1) | EP2838547B1 (pro_sucht_niko_www.htm) |
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BR (1) | BR112014025621B1 (pro_sucht_niko_www.htm) |
WO (1) | WO2013156493A1 (pro_sucht_niko_www.htm) |
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US9486408B2 (en) * | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US11039997B2 (en) * | 2005-12-27 | 2021-06-22 | Ruth-Maria Korth | Cosmetic, dermatic, protective compositions comprising phospholipids, lecithins with peptides and at least one acetylating compound |
CN105189465B (zh) | 2013-03-21 | 2019-02-26 | 赛诺菲-安万特德国有限公司 | 合成含有乙内酰脲的肽产物 |
MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
WO2016063805A1 (ja) * | 2014-10-21 | 2016-04-28 | 日産化学工業株式会社 | レジスト下層膜形成組成物 |
JP6046849B1 (ja) * | 2015-07-21 | 2016-12-21 | TAK−Circulator株式会社 | 身体状態の評価方法、情報の提示方法、および身体状態を改善又は予防する物質のスクリーニング方法 |
KR20180090251A (ko) * | 2015-09-28 | 2018-08-10 | 아주라 오프탈믹스 엘티디 | 마이봄샘 지질 분비를 증가시키기 위한 티올 및 이황화물 함유 약제 |
CN108430485B (zh) * | 2015-11-26 | 2021-08-24 | Mp2化妆品解决方案有限责任公司 | 包含金盏花油性提取物和水提取物以及白花百合球茎水提取物的抗污染复合物及其应用 |
KR20180094008A (ko) * | 2015-12-10 | 2018-08-22 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | 피부, 헤어, 네일, 및/또는 점막의 치료 및/또는 케어에서 유용한 화합물 |
US10086035B2 (en) | 2016-02-04 | 2018-10-02 | ALASTIN Skincare, Inc. | Compositions and methods for invasive and non-invasive procedural skincare |
US10744174B1 (en) | 2016-03-16 | 2020-08-18 | Robert Alonso | Composition(s) and method(s) for topically treating pain |
AU2017250509B2 (en) | 2016-04-14 | 2023-03-02 | Azura Ophthalmics Ltd. | Selenium disulfide compositions for use in treating meibomian gland dysfunction |
MX2019005833A (es) | 2016-11-21 | 2019-10-30 | Eirion Therapeutics Inc | Administracion transdermica de agentes grandes. |
EP3548510B1 (en) * | 2016-11-30 | 2024-10-02 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
EP3378463A1 (fr) * | 2017-03-20 | 2018-09-26 | Total Marketing Services | Utilisation non-therapeutique d'une huile hydrocarbonee biodegradable |
EP3648784B1 (en) * | 2017-07-04 | 2021-12-22 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
WO2019028275A1 (en) | 2017-08-03 | 2019-02-07 | ALASTIN Skincare, Inc. | COMPOSITIONS AND METHODS FOR IMPROVING LAXITY OF THE SKIN AND BODY CONTOUR |
FR3078891B1 (fr) * | 2018-03-16 | 2020-12-25 | Centre Nat Rech Scient | Utilisation d’un extrait d’ilex aquifolium pour le traitement des desordres de la pigmentation et pour le blanchiment de la peau |
US10835504B2 (en) | 2018-04-18 | 2020-11-17 | G&S Laboratories, Inc. | Compositions to treat anal itch |
CN108785164B (zh) * | 2018-07-03 | 2021-09-14 | 博凯药业有限公司 | 滋润护肤乳及其制备方法和应用 |
WO2020028694A1 (en) | 2018-08-02 | 2020-02-06 | ALASTIN Skincare, Inc. | Liposomal compositions and methods of use |
CN109125107B (zh) * | 2018-09-20 | 2022-02-01 | 深圳市维琪医药研发有限公司 | 一种有效改善和修复面部激素依赖性皮炎的多肽组合物 |
AU2020217620B2 (en) * | 2019-02-08 | 2025-07-03 | Lubrizol Advanced Materials, Inc. | Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes |
EP3927349A1 (en) | 2019-02-18 | 2021-12-29 | Mary Kay, Inc. | Topical skin compositions for treating rosacea and skin redness |
US11083766B2 (en) * | 2019-05-06 | 2021-08-10 | Charsire Biotechnology Corp. | Uses of soybean seed extract composition for alleviating cancer pain and/or treating cancer skin inflammation |
TWI722443B (zh) | 2019-05-30 | 2021-03-21 | 財團法人工業技術研究院 | 用於照護及/或保養皮膚與延緩及/或抑制皮膚老化的生醫組成物及其用途 |
CN112098569B (zh) * | 2019-06-17 | 2021-09-24 | 国药集团同济堂(贵州)制药有限公司 | 一种威灵仙提取物的制备方法及其质量测定方法 |
US11529300B2 (en) * | 2019-07-03 | 2022-12-20 | Jamrm, Llc | Formulations for enhancing skin firmness, density and thickness |
WO2021102072A1 (en) * | 2019-11-19 | 2021-05-27 | Rythera Therapeutics, Inc. | Composition and method for skin treatment |
JP2023510499A (ja) | 2020-01-10 | 2023-03-14 | アズーラ オフサルミックス エルティーディー. | 組成物および過敏症のための指示 |
KR102221141B1 (ko) * | 2020-08-10 | 2021-02-26 | 주식회사 달담 | 여드름 피부 개선용 화장료 조성물 |
KR102266613B1 (ko) * | 2020-09-21 | 2021-06-18 | 자안바이오 주식회사 | 항염증 활성을 갖는 신규한 펩티드 및 이의 용도 |
US20220218584A1 (en) * | 2021-01-13 | 2022-07-14 | Allergan Sales, Llc | Topical composition and method of use |
IT202100016622A1 (it) * | 2021-06-24 | 2022-12-24 | Thinking Woman Srl | Formulazione cosmetica con attivita’ antimicrobica sinergica |
CN116964071B (zh) * | 2021-12-31 | 2024-10-29 | 深圳市维琪科技股份有限公司 | 一种六肽及其组合物和用途 |
KR102495269B1 (ko) * | 2022-04-06 | 2023-02-06 | 이해경 | 가교 히알루론산 함유 피부 필러 조성물 및 그 제조방법 |
KR102643334B1 (ko) * | 2022-08-23 | 2024-03-05 | 주식회사 큐에이치바이오 | 가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법 |
KR102649055B1 (ko) * | 2022-09-22 | 2024-03-20 | 주식회사 큐에이치바이오 | 히알루론산-글라이신 하이드로겔 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법 |
CN115364039B (zh) * | 2022-09-28 | 2023-07-25 | 佛山天韵化妆品科技有限公司 | 一种痤疮皮肤修复组合物及其应用 |
CN116731111A (zh) * | 2022-10-14 | 2023-09-12 | 深圳市维琪科技股份有限公司 | 合成肽及其组合物和用途 |
CN115844756A (zh) * | 2022-12-07 | 2023-03-28 | 麦吉丽生物科技有限公司 | 一种具有改善皮肤光泽的组合物、脂质体及其制备方法和应用 |
KR102752384B1 (ko) * | 2024-01-16 | 2025-01-10 | 주식회사 큐에이치바이오 | 에피브로모히드린-가교 히알루론산 및 생체 적합성 미립자를 포함하는 피부 필러 조성물, 및 그 제조방법 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101501062A (zh) * | 2005-07-26 | 2009-08-05 | 康哲医药研究(深圳)有限公司 | 新型生物活性肽及其新用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7807182B2 (en) * | 1996-12-31 | 2010-10-05 | Colorado State University Research Foundation | Early detection of mycobacterial disease using peptides |
US20040071656A1 (en) * | 2001-12-26 | 2004-04-15 | Felix Wieland | Modulation of heat-shock-protein-based immunotherapies |
WO2007104062A2 (en) * | 2006-03-09 | 2007-09-13 | The Board Of Regents Of The University Of Texas System | Compositions and methods based on peptide binding profiling |
JP5065635B2 (ja) * | 2006-08-08 | 2012-11-07 | ロート製薬株式会社 | 新規ペプチド |
CA2701420C (en) * | 2007-10-29 | 2016-02-09 | Helix Biomedix Inc. | Protective skin care tetrapeptides |
ES2324192B1 (es) * | 2008-01-30 | 2010-06-17 | PUIG BEAUTY & FASHION GROUP, S.L. | Derivados peptidicos utiles en el tratamiento, cuidado o limpieza de la piel, mucosa, cuero cabelludo o uñas. |
ES2330291B1 (es) * | 2008-02-29 | 2010-10-18 | Lipotec Sa | Peptidos utiles en el tratamiento de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosmeticas o farmaceuticas. |
ES2342754B1 (es) * | 2008-10-03 | 2011-05-11 | Lipotec, S.A. | Peptidos utiles en el tratamiento y/o cuidado de la piel, mucosas, cuero cabelludo y/o cabello y su uso en composiciones cosmeticas o farmaceuticas. |
ES2349972B1 (es) * | 2009-02-16 | 2011-11-24 | Lipotec, S.A. | Péptidos útiles en el tratamiento y/o cuidado de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosméticas o farmacéuticas. |
US20110086806A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that Bind IL-23R |
US8420387B2 (en) * | 2009-11-06 | 2013-04-16 | Agrivida, Inc. | Intein-modified enzymes, their production and industrial applications |
US10706955B2 (en) * | 2010-03-23 | 2020-07-07 | Iogenetics, Llc | Bioinformatic processes for determination of peptide binding |
ES2625847T3 (es) * | 2011-11-04 | 2017-07-20 | Lipotec, S.A. | Péptidos que inhiben la actividad de receptores activados y su uso en composiciones cosméticas o farmacéuticas |
US9046530B2 (en) * | 2011-12-02 | 2015-06-02 | Board Of Regents, The University Of Texas System | Methods and compositions for chlamydial antigens as reagents for diagnosis of tubal factor infertility and chlamydial infection |
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