CN104244977A - Mica结合剂 - Google Patents

Mica结合剂 Download PDF

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Publication number
CN104244977A
CN104244977A CN201380017820.5A CN201380017820A CN104244977A CN 104244977 A CN104244977 A CN 104244977A CN 201380017820 A CN201380017820 A CN 201380017820A CN 104244977 A CN104244977 A CN 104244977A
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China
Prior art keywords
antibody
mica
seq
antibodies
polypeptide
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Pending
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CN201380017820.5A
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English (en)
Chinese (zh)
Inventor
M·布莱瑞
L·高蒂尔
I·佩罗特
C·邦纳福斯
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Innate Pharma SA
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Innate Pharma SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380017820.5A 2012-02-07 2013-02-07 Mica结合剂 Pending CN104244977A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261595902P 2012-02-07 2012-02-07
US61/595,902 2012-02-07
US201261625841P 2012-04-18 2012-04-18
US61/625,841 2012-04-18
PCT/EP2013/052439 WO2013117647A1 (en) 2012-02-07 2013-02-07 Mica binding agents

Publications (1)

Publication Number Publication Date
CN104244977A true CN104244977A (zh) 2014-12-24

Family

ID=47714068

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380017820.5A Pending CN104244977A (zh) 2012-02-07 2013-02-07 Mica结合剂

Country Status (11)

Country Link
US (2) US10577416B2 (https=)
EP (1) EP2812027A1 (https=)
JP (1) JP6405242B2 (https=)
CN (1) CN104244977A (https=)
AU (1) AU2013218017B2 (https=)
BR (1) BR112014019611A2 (https=)
CA (1) CA2862101A1 (https=)
IL (1) IL233793B (https=)
RU (1) RU2656183C2 (https=)
SG (1) SG11201404177PA (https=)
WO (1) WO2013117647A1 (https=)

Cited By (10)

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Publication number Priority date Publication date Assignee Title
CN107779433A (zh) * 2016-08-30 2018-03-09 天津市康婷生物工程有限公司 便捷的刺激nk细胞增殖和分化的饲养层制备方法
CN107964041A (zh) * 2016-10-20 2018-04-27 中国科学院广州生物医药与健康研究院 高稳定性和高亲和力的dmic及其制法
CN110088137A (zh) * 2016-10-19 2019-08-02 诺瓦罗技科斯生物科技有限公司 针对mica和micb蛋白的抗体
CN111465614A (zh) * 2017-07-10 2020-07-28 先天制药公司 使用人siglec-9抗体和人nkg2a抗体治疗癌症的组合疗法
CN111542539A (zh) * 2017-10-06 2020-08-14 先天制药公司 通过cd39/cd73轴恢复t细胞活性
CN111718416A (zh) * 2020-06-25 2020-09-29 菲鹏生物股份有限公司 抗硫氧还蛋白的抗体、其应用和诊断试剂盒
CN114369161A (zh) * 2021-12-28 2022-04-19 合肥天港免疫药物有限公司 Mica抗体及其应用
CN115611982A (zh) * 2021-07-14 2023-01-17 浙江大学 一种抗人MICA/Bα3区的单克隆抗体及其应用
WO2023124857A1 (zh) * 2021-12-28 2023-07-06 合肥天港免疫药物有限公司 抗体及其应用
RU2847334C2 (ru) * 2021-12-28 2025-10-03 Хефеи Тг Иммунофарма Ко., Лтд. Антитело и его применение

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KR20180088458A (ko) * 2015-12-04 2018-08-03 다나-파버 캔서 인스티튜트 인크. 암의 치료를 위한 mica/b 알파 3 도메인의 백신접종
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CN111471099B (zh) * 2020-03-31 2022-04-12 长沙学院 MICA胞外区突变体及其筛选的方法、scFv-MICA融合抗体及其制备方法和应用
CA3184940A1 (en) 2020-07-07 2022-01-13 Jennifer Donglan WU Mic antibodies and binding agents and methods of using the same
CN116547301A (zh) 2020-08-10 2023-08-04 先天制药公司 使用抗体进行的细胞表面mica和micb检测
CN112694532B (zh) * 2021-01-12 2023-04-18 倍而达药业（苏州）有限公司 抗Siglec-15的抗体或其抗原结合片段及应用
CN113502265B (zh) * 2021-05-25 2024-05-28 昭泰英基生物医药（香港）有限公司 将t细胞重编程为类nk细胞的诱导剂及其应用
CN118027195B (zh) * 2023-05-06 2025-07-04 合肥天港免疫药物有限公司 亲和力成熟的mica抗体及其应用

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107779433A (zh) * 2016-08-30 2018-03-09 天津市康婷生物工程有限公司 便捷的刺激nk细胞增殖和分化的饲养层制备方法
CN110088137A (zh) * 2016-10-19 2019-08-02 诺瓦罗技科斯生物科技有限公司 针对mica和micb蛋白的抗体
CN107964041B (zh) * 2016-10-20 2023-08-01 中国科学院广州生物医药与健康研究院 高稳定性和高亲和力的dmic及其制法
CN107964041A (zh) * 2016-10-20 2018-04-27 中国科学院广州生物医药与健康研究院 高稳定性和高亲和力的dmic及其制法
CN109890837A (zh) * 2016-10-20 2019-06-14 中国科学院广州生物医药与健康研究院 高稳定性和高亲和力的dmic及其制法
CN109890837B (zh) * 2016-10-20 2023-09-08 中国科学院广州生物医药与健康研究院 高稳定性和高亲和力的dmic及其制法
CN111465614A (zh) * 2017-07-10 2020-07-28 先天制药公司 使用人siglec-9抗体和人nkg2a抗体治疗癌症的组合疗法
CN111542539A (zh) * 2017-10-06 2020-08-14 先天制药公司 通过cd39/cd73轴恢复t细胞活性
CN111542539B (zh) * 2017-10-06 2023-10-20 先天制药公司 通过cd39/cd73轴恢复t细胞活性
CN111718416A (zh) * 2020-06-25 2020-09-29 菲鹏生物股份有限公司 抗硫氧还蛋白的抗体、其应用和诊断试剂盒
CN115611982A (zh) * 2021-07-14 2023-01-17 浙江大学 一种抗人MICA/Bα3区的单克隆抗体及其应用
CN115611982B (zh) * 2021-07-14 2024-05-10 浙江大学 一种抗人MICA/Bα3区的单克隆抗体及其应用
WO2023124857A1 (zh) * 2021-12-28 2023-07-06 合肥天港免疫药物有限公司 抗体及其应用
CN114369161A (zh) * 2021-12-28 2022-04-19 合肥天港免疫药物有限公司 Mica抗体及其应用
RU2847334C2 (ru) * 2021-12-28 2025-10-03 Хефеи Тг Иммунофарма Ко., Лтд. Антитело и его применение

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EP2812027A1 (en) 2014-12-17
AU2013218017B2 (en) 2017-12-07
US20150191542A1 (en) 2015-07-09
BR112014019611A2 (pt) 2017-06-27
JP6405242B2 (ja) 2018-10-17
WO2013117647A1 (en) 2013-08-15
RU2656183C2 (ru) 2018-05-31
AU2013218017A2 (en) 2014-10-16
US20200299380A1 (en) 2020-09-24
IL233793A0 (en) 2014-09-30
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AU2013218017A1 (en) 2014-09-11
RU2014131317A (ru) 2016-03-27

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