CN104230887A - 达比加群酯新中间体及其制备方法 - Google Patents
达比加群酯新中间体及其制备方法 Download PDFInfo
- Publication number
- CN104230887A CN104230887A CN201310242565.6A CN201310242565A CN104230887A CN 104230887 A CN104230887 A CN 104230887A CN 201310242565 A CN201310242565 A CN 201310242565A CN 104230887 A CN104230887 A CN 104230887A
- Authority
- CN
- China
- Prior art keywords
- compound
- benzene sulfonate
- prepare
- formula
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (9)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201710153249.XA CN106946846B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
CN201310242565.6A CN104230887B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310242565.6A CN104230887B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710153249.XA Division CN106946846B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104230887A true CN104230887A (zh) | 2014-12-24 |
CN104230887B CN104230887B (zh) | 2018-06-01 |
Family
ID=52219890
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310242565.6A Active CN104230887B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
CN201710153249.XA Active CN106946846B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710153249.XA Active CN106946846B (zh) | 2013-06-19 | 2013-06-19 | 达比加群酯新中间体及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (2) | CN104230887B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111253369A (zh) * | 2018-11-30 | 2020-06-09 | 上海医药集团股份有限公司 | 一种苯磺酸盐、其制备方法及其在制备达比加群酯中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1861596A (zh) * | 2005-12-16 | 2006-11-15 | 复旦大学 | 一种合成非手性,非肽类的抗凝血酶抑制剂的方法 |
WO2012077136A2 (en) * | 2010-12-06 | 2012-06-14 | Msn Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977077A (zh) * | 2012-11-28 | 2013-03-20 | 浙江燎原药业有限公司 | 一种达比加群酯中间体的制备方法 |
-
2013
- 2013-06-19 CN CN201310242565.6A patent/CN104230887B/zh active Active
- 2013-06-19 CN CN201710153249.XA patent/CN106946846B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1861596A (zh) * | 2005-12-16 | 2006-11-15 | 复旦大学 | 一种合成非手性,非肽类的抗凝血酶抑制剂的方法 |
WO2012077136A2 (en) * | 2010-12-06 | 2012-06-14 | Msn Laboratories Limited | Process for the preparation of benzimidazole derivatives and its salts |
Non-Patent Citations (1)
Title |
---|
NORBERT H. HAUEL ET.AL.: "Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors", 《J. MED. CHEM.》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111253369A (zh) * | 2018-11-30 | 2020-06-09 | 上海医药集团股份有限公司 | 一种苯磺酸盐、其制备方法及其在制备达比加群酯中的应用 |
Also Published As
Publication number | Publication date |
---|---|
CN106946846A (zh) | 2017-07-14 |
CN106946846B (zh) | 2019-11-29 |
CN104230887B (zh) | 2018-06-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103930419B (zh) | 阿齐沙坦的晶型及其制备方法 | |
CN102985416B (zh) | 制备凝血酶特异性抑制剂的方法 | |
CN105622535B (zh) | 一种lcz696的制备方法 | |
CN106896164A (zh) | 一种利伐沙班及有关物质的测定方法 | |
CN103613558B (zh) | 一种缬沙坦的制备方法 | |
CN102395591B (zh) | 一种合成普拉格雷的方法 | |
CN110467580B (zh) | 雷西纳德轴手性对映体的拆分方法 | |
CN104277053B (zh) | 一种头孢地嗪及其中间体头孢地嗪酸的制备方法 | |
CN104011029B (zh) | 一种制备盐酸苯达莫司汀的改进方法 | |
CN103145636B (zh) | 一种1,4-二酰基-3,6-二苯基-1,4-二氢均四嗪类化合物及其制备方法和应用 | |
CN111646971A (zh) | 一种合成4-(羟甲基)-5-甲基-[1,3]二氧杂环戊烯-2-酮的方法 | |
CN104230887A (zh) | 达比加群酯新中间体及其制备方法 | |
CN106279207A (zh) | 一种头孢地尼的合成方法 | |
CN111362873B (zh) | 一种加替沙星代谢物的合成方法 | |
CN103450157A (zh) | 一种高纯度盐酸法舒地尔半水合物的制备方法 | |
CN105566296A (zh) | 一种制备达比加群酯酰胺化杂质的方法 | |
JP5501054B2 (ja) | 3,3−ジアミノアクリル酸(1−ジフェニルメチルアゼチジン−3−イル)エステル酢酸塩の製造方法 | |
CN101492388A (zh) | 一种合成米曲肼药物原料的方法 | |
CN103159751A (zh) | 苯酮酸酰胺缩酮衍生物的制备方法 | |
CN105859748B (zh) | 多环化合物钠盐及其多晶型、制备方法及应用 | |
KR101019201B1 (ko) | 덱시부프로펜 알지닌염의 제조방법 | |
CN102020602B (zh) | 盐酸乐卡地平晶型及其制备方法和含有该晶型的药物组合物 | |
CN109280050B (zh) | 一种医药化合物阿伐那非的制备方法 | |
CN103896919A (zh) | 一种氘代达比加群的制备方法 | |
CN106187886B (zh) | 一种制备高纯度伯舒替尼一水合物的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20160412 Address after: 200040 Beijing West Road, Shanghai, No. 1320, No. Applicant after: Shanghai Institute of pharmaceutical industry Applicant after: China State Institute of Pharmaceutical Industry Applicant after: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Address before: 200040 Beijing West Road, Shanghai, No. 1320, No. Applicant before: Shanghai Institute of pharmaceutical industry Applicant before: China State Institute of Pharmaceutical Industry |
|
GR01 | Patent grant | ||
GR01 | Patent grant |