CN104204195B - 以记忆t细胞为主要成分的淋巴细胞群的制造方法 - Google Patents

以记忆t细胞为主要成分的淋巴细胞群的制造方法 Download PDF

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CN104204195B
CN104204195B CN201380018924.8A CN201380018924A CN104204195B CN 104204195 B CN104204195 B CN 104204195B CN 201380018924 A CN201380018924 A CN 201380018924A CN 104204195 B CN104204195 B CN 104204195B
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lymphocyte
culture
memory
individual
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CN104204195A (zh
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关根晖彬
大隅兴
大隅一兴
小森启郎
小森启一郎
清水则夫
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LYMPH TECHNOLOGY KK
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464499Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Biomedical Technology (AREA)
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  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201380018924.8A 2012-04-10 2013-04-09 以记忆t细胞为主要成分的淋巴细胞群的制造方法 Active CN104204195B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-088926 2012-04-10
JP2012088926A JP6142142B2 (ja) 2012-04-10 2012-04-10 メモリーt細胞を主成分とするリンパ球細胞群の製造方法
PCT/JP2013/002405 WO2013153800A1 (ja) 2012-04-10 2013-04-09 メモリーt細胞を主成分とするリンパ球細胞群の製造方法

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CN104204195A CN104204195A (zh) 2014-12-10
CN104204195B true CN104204195B (zh) 2017-07-18

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JP (1) JP6142142B2 (ja)
KR (1) KR101521484B1 (ja)
CN (1) CN104204195B (ja)
HK (1) HK1205181A1 (ja)
WO (1) WO2013153800A1 (ja)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
JP6424447B2 (ja) * 2014-03-28 2018-11-21 東洋製罐グループホールディングス株式会社 細胞培養方法、及び細胞培養システム
CN106796237B (zh) * 2014-07-22 2018-12-04 株式会社癌症免疫研究所 末梢循环癌细胞的检测装置
US10731122B2 (en) 2015-01-30 2020-08-04 Toyo Seikan Group Holdings, Ltd. Cell culture method and cell culture apparatus
CN107384859A (zh) * 2017-09-05 2017-11-24 四川新生命干细胞科技股份有限公司 一种高纯度nk细胞的分离培养方法
AU2018368786A1 (en) * 2017-11-17 2020-06-18 Iovance Biotherapeutics, Inc. TIL expansion from fine needle aspirates and small biopsies
WO2020032782A1 (ko) * 2018-08-10 2020-02-13 주식회사 유틸렉스 암항원 특이적 cd8+ t 세포의 제조 및 동결보존 방법
CN109628396B (zh) * 2019-01-24 2021-03-26 清华大学 记忆性淋巴细胞群在肝癌治疗中的应用
CN113005081B (zh) * 2019-12-20 2023-12-19 苏州依科赛生物科技股份有限公司 一种扩增干细胞样记忆性t细胞的培养方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
CN1363681A (zh) * 2000-12-04 2002-08-14 胡曼泰克有限公司 源于脐带血的活化淋巴细胞、含有所述淋巴细胞作为主要成分的制剂和制备所述制剂的方法与成套器具
CN1230524C (zh) * 2000-12-04 2005-12-07 株式会社淋巴技术 细胞保存液和使用该保存液的细胞保存方法
EP1066833B1 (en) * 1999-07-08 2008-10-01 Lymphotec Inc. Use of cryopreserved activated lymphocytes as a medicament
JP4389039B2 (ja) * 1998-04-09 2009-12-24 株式会社リンフォテック アロジェニックな活性化cd4陽性細胞を主成分とする医薬組成物、およびその製造方法、ならびに該医薬組成物調製用キット

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JP4385158B2 (ja) * 2000-12-04 2009-12-16 株式会社リンフォテック 細胞の保存液および該保存液を用いた細胞の保存方法
ES2589678T3 (es) * 2010-09-08 2016-11-15 Yeda Research And Development Co. Ltd. Uso de linfocitos T de memoria central anti-terceros para el tratamiento anti-leucemia/linfoma

Patent Citations (4)

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JP4389039B2 (ja) * 1998-04-09 2009-12-24 株式会社リンフォテック アロジェニックな活性化cd4陽性細胞を主成分とする医薬組成物、およびその製造方法、ならびに該医薬組成物調製用キット
EP1066833B1 (en) * 1999-07-08 2008-10-01 Lymphotec Inc. Use of cryopreserved activated lymphocytes as a medicament
CN1363681A (zh) * 2000-12-04 2002-08-14 胡曼泰克有限公司 源于脐带血的活化淋巴细胞、含有所述淋巴细胞作为主要成分的制剂和制备所述制剂的方法与成套器具
CN1230524C (zh) * 2000-12-04 2005-12-07 株式会社淋巴技术 细胞保存液和使用该保存液的细胞保存方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
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Ex vivo expansion of umbilical cord blood for transplantation;S.S.Tung 等;《Best Practice & Research Clinical Haematology》;20100630;第23卷(第2期);245-257 *

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Publication number Publication date
JP2013215141A (ja) 2013-10-24
CN104204195A (zh) 2014-12-10
HK1205181A1 (en) 2015-12-11
WO2013153800A1 (ja) 2013-10-17
KR101521484B1 (ko) 2015-06-05
KR20140145585A (ko) 2014-12-23
JP6142142B2 (ja) 2017-06-07

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