CN104188855A - 一种具有预防和缓解牙齿敏感作用的中药牙膏 - Google Patents
一种具有预防和缓解牙齿敏感作用的中药牙膏 Download PDFInfo
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- CN104188855A CN104188855A CN201410412687.XA CN201410412687A CN104188855A CN 104188855 A CN104188855 A CN 104188855A CN 201410412687 A CN201410412687 A CN 201410412687A CN 104188855 A CN104188855 A CN 104188855A
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Abstract
Description
测试样品 | 动物只数 | 剂量(g/kg) | 15min扭体次数 | 出现时间(s) |
实施例1 | 10 | 6 | 10.25±6.16 | 10.07±3.56 |
实施例2 | 10 | 6 | 8.93±3.02 | 12.58±4.38 |
实施例3 | 10 | 6 | 5.28±3.29 | 15.68±4.06 |
实施例4 | 10 | 6 | 9.01±5.28 | 12.07±4.56 |
空白 | 10 | 6 | 15.23±7.46 | 8.03±2.23 |
Claims (9)
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CN201410412687.XA CN104188855B (zh) | 2014-08-20 | 2014-08-20 | 一种具有预防和缓解牙齿敏感作用的中药牙膏 |
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CN201410412687.XA CN104188855B (zh) | 2014-08-20 | 2014-08-20 | 一种具有预防和缓解牙齿敏感作用的中药牙膏 |
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Publication Number | Publication Date |
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CN104188855A true CN104188855A (zh) | 2014-12-10 |
CN104188855B CN104188855B (zh) | 2017-04-12 |
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Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101015512A (zh) * | 2006-11-30 | 2007-08-15 | 广州立白企业集团有限公司 | 一种组合物及其在口腔护理产品的应用 |
CN101690699A (zh) * | 2009-09-29 | 2010-04-07 | 广东名臣有限公司 | 一种洁齿亮白牙膏组合物 |
CN102151241A (zh) * | 2011-03-31 | 2011-08-17 | 浙江农林大学 | 一种含天然植物提取物的牙膏及其制备方法 |
CN102274139A (zh) * | 2011-01-14 | 2011-12-14 | 哈药集团三精制药股份有限公司 | 双黄连中药牙膏及其制备方法 |
CN102292125A (zh) * | 2009-01-21 | 2011-12-21 | 高露洁-棕榄公司 | 减轻或消除牙齿敏感性的口腔护理组合物 |
CN102440922A (zh) * | 2010-10-09 | 2012-05-09 | 汪强 | 一种中药牙膏 |
CN102579286A (zh) * | 2012-03-29 | 2012-07-18 | 安徽两面针·芳草日化有限公司 | 中西药结合强效脱敏牙膏 |
CN102698121A (zh) * | 2012-01-10 | 2012-10-03 | 刘霞 | 用于治疗牙周炎的中药组合物、制备方法和牙膏 |
CN102772342A (zh) * | 2012-08-22 | 2012-11-14 | 柳州两面针股份有限公司 | 抗炎镇痛中药牙膏 |
CN103432062A (zh) * | 2013-09-11 | 2013-12-11 | 肖秀萍 | 一种多功能中草药牙膏及其制备方法 |
CN103536451A (zh) * | 2013-11-01 | 2014-01-29 | 广州市倩采化妆品有限公司 | 一种中药牙膏及其制备方法 |
-
2014
- 2014-08-20 CN CN201410412687.XA patent/CN104188855B/zh active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101015512A (zh) * | 2006-11-30 | 2007-08-15 | 广州立白企业集团有限公司 | 一种组合物及其在口腔护理产品的应用 |
CN102292125A (zh) * | 2009-01-21 | 2011-12-21 | 高露洁-棕榄公司 | 减轻或消除牙齿敏感性的口腔护理组合物 |
CN101690699A (zh) * | 2009-09-29 | 2010-04-07 | 广东名臣有限公司 | 一种洁齿亮白牙膏组合物 |
CN102440922A (zh) * | 2010-10-09 | 2012-05-09 | 汪强 | 一种中药牙膏 |
CN102274139A (zh) * | 2011-01-14 | 2011-12-14 | 哈药集团三精制药股份有限公司 | 双黄连中药牙膏及其制备方法 |
CN102151241A (zh) * | 2011-03-31 | 2011-08-17 | 浙江农林大学 | 一种含天然植物提取物的牙膏及其制备方法 |
CN102698121A (zh) * | 2012-01-10 | 2012-10-03 | 刘霞 | 用于治疗牙周炎的中药组合物、制备方法和牙膏 |
CN102579286A (zh) * | 2012-03-29 | 2012-07-18 | 安徽两面针·芳草日化有限公司 | 中西药结合强效脱敏牙膏 |
CN102772342A (zh) * | 2012-08-22 | 2012-11-14 | 柳州两面针股份有限公司 | 抗炎镇痛中药牙膏 |
CN103432062A (zh) * | 2013-09-11 | 2013-12-11 | 肖秀萍 | 一种多功能中草药牙膏及其制备方法 |
CN103536451A (zh) * | 2013-11-01 | 2014-01-29 | 广州市倩采化妆品有限公司 | 一种中药牙膏及其制备方法 |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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CN107496318A (zh) * | 2017-07-22 | 2017-12-22 | 李映波 | 一种含美洲大蠊提取物的脱敏牙膏 |
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CN110393680A (zh) * | 2018-04-25 | 2019-11-01 | 好维股份有限公司 | 一种抗牙齿酸蚀的口腔护理组合物 |
CN109453044B (zh) * | 2018-12-05 | 2021-12-31 | 福建爱洁丽日化有限公司 | 一种多效型牙齿抛光膏 |
CN109453044A (zh) * | 2018-12-05 | 2019-03-12 | 福建爱洁丽日化有限公司 | 一种多效型牙齿抛光膏 |
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CN111686051A (zh) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | 一种防治口臭的植物牙膏 |
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CN114588059A (zh) * | 2022-03-25 | 2022-06-07 | 湖南有美生物科技有限公司 | 一种口腔防蛀膏的制备方法及其应用 |
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