CN104173748A - Orally taken medicine for treating cancer of pharynx and preparation method thereof - Google Patents
Orally taken medicine for treating cancer of pharynx and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an orally taken medicine for treating cancer of pharynx and a preparation method thereof. The medicine is prepared from the following components in parts by weight: 1-3 parts of selaginella doederleinii hieron, 1-3 parts of astragalus membranaceus, 1-3 parts of solanum lyratum, 1-3 parts of edible tulip, 1-3 parts of selfheal, 1-3 parts of flos chrysanthemi indici, 1-3 parts of subprostrate sophora, 1-3 parts of centipedes and 1-3 parts of liquorice. The preparation method of the medicine comprises the following steps: selecting high-quality selaginella doederleinii hieron, astragalus membranaceus, solanum lyratum, edible tulip, selfheal, flos chrysanthemi indici, subprostrate sophora, centipedes and liquorice according to a ratio in parts by weight, and respectively screening out impurities and dust for later use; holding the cleaned medicines in a cloth, tightening the cloth bag, soaking for 50 minutes in cold boiled water till the medicine tissues are saturated, and cleaning and slicing a proper amount of lean meat; then, putting the medicines and the soak solution as well as lean meat together in an earthen pot, adding a proper amount of cold boiled water, decocting by a big fire firstly and then decocting by a soft fire for 50 minutes in total; after the medicines are done, filtering to obtain the lean meat and 380ml of traditional Chinese medicine decoction.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of endo-medicine for the treatment of nasopharyngeal carcinoma, particularly for the field of endo-medicine of Human NPC patient and preparation method thereof.
Background technology
Doctor thinks, nasopharyngeal carcinoma is one of China's malignant tumor occurred frequently, and male is more common than women, male's sickness rate is 2～3 times of women, its age distribution is at 3～90 years old, but within 30～50 years old, is age occurred frequently district, and its cardinal symptom is that nose can occur being with blood in contracting tears in early days, cut in and out, fluid can block choana while increase, causes nasal obstruction, starts as one-sided, after transfer bilateral to, also there will be the symptom such as deep lymph node enlargement on tinnitus, the sense of deafness plug, auditory dysesthesia, headache, diplopia or neck.
So, just how finding a kind of Chinese herbal medicine that can effectively treat early stage nasopharyngeal carcinoma and extend the advanced NPC life-span and improve the quality of living, is our current problem in urgent need to solve.
Summary of the invention
The object of this invention is to provide a kind of endo-medicine for the treatment of nasopharyngeal carcinoma and preparation method thereof, the problem of getting well early or extending life cycle to solve Nasopharyngeal Carcinoma Patients.This medicine is taking common Chinese herbal medicine as raw material, have that all medicine compatibilities, the efficacy of a drug are powerful, the pathogenesis that hits, fully demonstrated heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, let out liver-fire, removing toxic substances and promoting subsidence of swelling, wind and heat dispersing, reducing swelling and alleviating pain clearly, relieving convulsion, the expelling phlegm for arresting cough of dispeling the wind, relieving spasm to stop pain and anticancer Therapeutic Principle.
For reaching the object of foregoing invention, the technical solution adopted in the present invention is: a kind of endo-medicine for the treatment of nasopharyngeal carcinoma is provided, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Herba Selaginellae Doederleinii 1-3 part;
Radix Astragali 1-3 part;
Herba Solani Lyrati 1-3 part;
Pseudobulbus Cremastrae Seu Pleiones 1-3 part;
Spica Prunellae 1-3 part;
Flos Chrysanthemi Indici 1-3 part;
Radix Sophorae Tonkinensis 1-3 part;
Scolopendra 1-3 part;
Radix Glycyrrhizae 1-3 part;
Thin pork is appropriate.
According to the endo-medicine for the treatment of nasopharyngeal carcinoma provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
1 part of Herba Selaginellae Doederleinii;
1 part of the Radix Astragali;
1 part of Herba Solani Lyrati;
1 part of Pseudobulbus Cremastrae Seu Pleiones;
1 part of Spica Prunellae;
1 part of Flos Chrysanthemi Indici;
1 part of Radix Sophorae Tonkinensis;
1 part of Scolopendra;
1 part, Radix Glycyrrhizae;
Thin pork is appropriate.
Endo-medicine of a kind of above-mentioned treatment nasopharyngeal carcinoma and preparation method thereof, is characterized in that, described method comprises the steps:
A, select high-quality clean 1 part of 1 part of 1 part of 1 part of 1 part of 1 part of 1 part of 1 part of Herba Selaginellae Doederleinii, the Radix Astragali, Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones, Spica Prunellae, Flos Chrysanthemi Indici, Radix Sophorae Tonkinensis, Scolopendra, 1 part, Radix Glycyrrhizae, sieve respectively after decontamination and dust for subsequent use;
B, will process clean medicine splendid attire after tying in cloth bag, in cold boiled water, soak 50 minutes, to soak into medicine degree of being organized as, appropriate thin pork is cleaned to stripping and slicing simultaneously, then medicine and soak and thin pork are put in sand tank in the lump, injected appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, 380 milliliters of leaching thin pork and herb liquids.
Endo-medicine of a kind of above-mentioned treatment nasopharyngeal carcinoma and preparation method thereof, is characterized in that, described instructions of taking is: fried good medicine is divided and takes once or twice it, and every day, potion, was generally sub-service sooner or later, 190 milliliters/time of dosages, taking medicine before meal.
The medicine for the treatment of nasopharyngeal carcinoma provided by the present invention is oral traditional Chinese medicine composition, and it gives full play to the property of medicine of each component taking common Chinese herbal medicine as raw material:
Herba Selaginellae Doederleinii, nature and flavor: sweet, micro-hardship, puckery, cool, light, warm, the effect with heat-clearing and toxic substances removing, expelling wind and removing dampness, anticancer, hemostasis, is used for the treatment of cancer, laryngopharynx swelling and pain, conjunctival congestion and swelling pain, cough due to lung-heat, mastitis, jaundice due to damp-heat, rheumatic arthralgia, traumatic hemorrhage;
The Radix Astragali, nature and flavor: sweet, warm, there is effect of invigorating QI to consolidate the body surface resistance, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation, be used for the treatment of that the deficiency of vital energy is weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle are difficultly burst, burst for a long time do not hold back, blood deficiency dull yellowish colored skin, interior-heat quench one's thirst, chronic nephritis proteinuria, diabetes;
Herba Solani Lyrati, nature and flavor: bitter, flat, slightly poisonous, there is clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, anticancer effect, be used for the treatment of cold, fever, icterohepatitis, cholecystitis, cholelithiasis, cancer, uterine erosion, leucorrhea, oedema due to nephritis, carbuncle furuncle and phyma poison is controlled in external;
Pseudobulbus Cremastrae Seu Pleiones, nature and flavor: sweet in the mouth, micro-pungent, cold in nature, slightly poisonous, there is effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, be used for the treatment of the suitable carbuncle on the back of carbuncle, the swollen malignant boil of furuncle, scrofula tuberculosis, carcinoma, sore throat, worm venom disease, have more active anticancer, for breast carcinoma, cervical cancer, the esophageal carcinoma, pulmonary carcinoma, skin carcinoma, lymphosarcoma, leukemia etc.;
Spica Prunellae, nature and flavor: cold in nature, sweet in the mouth, pungent, micro-hardship, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be used for the treatment of lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.;
Flos Chrysanthemi Indici, nature and flavor: bitter in the mouth, pungent, cool in nature, there is effect of wind and heat dispersing, removing toxic substances and promoting subsidence of swelling, brain nourishing and eyesight improving, be used for the treatment of treat coronary heart disease, hypertension, anemopyretic cold, pneumonia, rhinitis,
The diseases such as bronchitis, laryngopharynx swelling and pain, conjunctival congestion are fuzzy, lymphadenitis, carbuncle furuncle furunculosis, eczema, skin pruritus, aphtha, erysipelas;
Radix Sophorae Tonkinensis, nature and flavor: bitter, cold, there is effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieving constipation, be used for the treatment of acute pharyngolaryngitis, tonsillitis, gingival swelling and pain, cough due to lung-heat, jaundice due to damp-heat, the constipation of carbuncle furuncle and phyma poison;
Scolopendra, nature and flavor: pungent, warm, poisonous, there is the effect relieving convulsion, anticancer, removing toxic substances of dispeling the wind, be used as medicine to be dried Scorpio, for children's's epilepsy wind, take out the diseases such as infantum tetanus, locked mouth, erysipelas, tinea alba, tetanus, pertussis, scrofula, tuberculosis, malaria buildup piece, sore swollen toxin, tinea corporis, anal fistula, scald, snakebite;
Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of lack of appetite, weakness of the spleen and stomach, stomachache loose stool, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong.
While taking, fried good medicine is divided and takes once or twice it, every day, potion, was generally sub-service sooner or later, 190 milliliters/time of dosages, taking medicine before meal.This medicine is taking common Chinese herbal medicine as raw material, have that all medicine compatibilities, the efficacy of a drug are powerful, the pathogenesis that hits, fully demonstrated heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, let out liver-fire, removing toxic substances and promoting subsidence of swelling, wind and heat dispersing, reducing swelling and alleviating pain clearly, relieving convulsion, the expelling phlegm for arresting cough of dispeling the wind, relieving spasm to stop pain and anticancer Therapeutic Principle.
Detailed description of the invention
Below embodiments of the present invention are described in detail
Doctor thinks, nasopharyngeal carcinoma is one of China's malignant tumor occurred frequently, and male is more common than women, male's sickness rate is 2～3 times of women, its age distribution is at 3～90 years old, but within 30～50 years old, is age occurred frequently district, and its cardinal symptom is that nose can occur being with blood in contracting tears in early days, cut in and out, fluid can block choana while increase, causes nasal obstruction, starts as one-sided, after transfer bilateral to, also there will be the symptom such as deep lymph node enlargement on tinnitus, the sense of deafness plug, auditory dysesthesia, headache, diplopia or neck.
The present invention is exactly a kind of Chinese herbal medicine formula proposing for the treatment of above-mentioned nasopharyngeal carcinoma, and the medicine effect that adopts this formula to prepare is good, and the cycle is short, instant effect, and cure rate is high, and toxic and side effects is little, can effectively cure above-mentioned nasopharyngeal carcinoma or extend life cycle.Below specific embodiment provided by the present invention is described in detail.
Embodiment 1:
Select high-quality clean 3 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 40 grams of Herba Selaginellae Doederleiniis, the Radixs Astragali, Herba Solani Lyratis, Pseudobulbus Cremastrae Seu Pleioness, Spica Prunellaes, Flos Chrysanthemi Indicis, Radix Sophorae Tonkinensiss, Scolopendras, 8 grams, Radix Glycyrrhizae, sieve respectively after decontamination and dust for subsequent use; To process clean medicine splendid attire after tying in cloth bag, in cold boiled water, soak 50 minutes, to soak into medicine degree of being organized as, appropriate thin pork is cleaned to stripping and slicing simultaneously, then medicine and soak and thin pork are put in sand tank in the lump, injected appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, 380 milliliters of leaching thin pork and herb liquids.While taking, fried good medicine is divided and takes once or twice it, every day, potion, was generally sub-service sooner or later, 190 milliliters/time of dosages, and taking medicine before meal, takes medicine after 15-18 agent, and the swollen thing of bottleneck throat can disappear.
Embodiment 2:
Select high-quality clean 2.5 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 38 grams of Herba Selaginellae Doederleiniis, the Radixs Astragali, Herba Solani Lyratis, Pseudobulbus Cremastrae Seu Pleioness, Spica Prunellaes, Flos Chrysanthemi Indicis, Radix Sophorae Tonkinensiss, Scolopendras, 6 grams, Radix Glycyrrhizae, sieve respectively after decontamination and dust for subsequent use; To process clean medicine splendid attire after tying in cloth bag, in cold boiled water, soak 50 minutes, to soak into medicine degree of being organized as, appropriate thin pork is cleaned to stripping and slicing simultaneously, then medicine and soak and thin pork are put in sand tank in the lump, injected appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, 380 milliliters of leaching thin pork and herb liquids.While taking, fried good medicine is divided and takes once or twice it, every day, potion, was generally sub-service sooner or later, 190 milliliters/time of dosages, and taking medicine before meal, takes medicine after 15-22 agent, and the swollen thing of bottleneck throat can disappear.
Embodiment 3:
Select high-quality clean 3 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 40 grams of Herba Selaginellae Doederleiniis, the Radixs Astragali, Herba Solani Lyratis, Pseudobulbus Cremastrae Seu Pleioness, Spica Prunellaes, Flos Chrysanthemi Indicis, Radix Sophorae Tonkinensiss, Scolopendras, 8 grams, Radix Glycyrrhizae, sieve respectively after decontamination and dust for subsequent use; To process clean medicine splendid attire after tying in cloth bag, in cold boiled water, soak 50 minutes, to soak into medicine degree of being organized as, appropriate thin pork is cleaned to stripping and slicing simultaneously, then medicine and soak and thin pork are put in sand tank in the lump, injected appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, 380 milliliters of leaching thin pork and herb liquids.While taking, fried good medicine is divided and takes once or twice it, every day, potion, was generally sub-service sooner or later, 190 milliliters/time of dosages, and taking medicine before meal, takes medicine after 15-19 agent, and the swollen thing of bottleneck throat can disappear.
Embodiment 4:
Select high-quality clean 2.5 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 10 grams of 38 grams of Herba Selaginellae Doederleiniis, the Radixs Astragali, Herba Solani Lyratis, Pseudobulbus Cremastrae Seu Pleioness, Spica Prunellaes, Flos Chrysanthemi Indicis, Radix Sophorae Tonkinensiss, Scolopendras, 6 grams, Radix Glycyrrhizae, sieve respectively after decontamination and dust for subsequent use; To process clean medicine splendid attire after tying in cloth bag, in cold boiled water, soak 50 minutes, to soak into medicine degree of being organized as, appropriate thin pork is cleaned to stripping and slicing simultaneously, then medicine and soak and thin pork are put in sand tank in the lump, injected appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, 380 milliliters of leaching thin pork and herb liquids.While taking, fried good medicine is divided and takes once or twice it, every day, potion, was generally sub-service sooner or later, 190 milliliters/time of dosages, and taking medicine before meal, takes medicine after 15-22 agent, and the swollen thing of bottleneck throat can disappear.
The present invention is through the treatment to nearly one hundred routine patient, and effect is remarkable, and toxic and side effects is little, and part allusion quotation shape case is as follows.
1, patient: Wu XX, man, 72 years old, address: Chengdu, Sichuan Province
Illness symptom: patient feels pharyngeal discomfort on the 15th in JIUYUE in 2012, checks and finds that there is swollen thing in throat in Sichuan tumour hospital, and invade epiglottis, through check pathological section, is diagnosed as squamous cell carcinoma.But excessive because of patient age, disagree with the treatments such as operation and radiotherapy, therefore ask Chinese traditional treatment.
Treatment: throw we, every day potion, sooner or later sub-service, the check after 6 doses of taking medicine, its pharyngeal sense of discomfort alleviates, and advises it to enter after 16 doses of medicines again, the swollen thing of bottleneck throat disappears.Visit 1 year, have no recurrence.
2, patient: rely XX, female, 45 years old, address: Langzhong City, Sichuan Province
Illness symptom: over the past two years, patient felt pharyngeal discomfort, and with auditory dysesthesia, headache, in river, certain examination in hospital finds that there is swollen thing in throat, through check pathological section, is diagnosed as nasopharyngeal carcinoma early stage.But because fearing, patient asks the traditional Chinese medical science.
Treatment: throw we, every day potion, sooner or later sub-service, the check after 10 doses of taking medicine, its headache and pharyngeal sense of discomfort disappear substantially, advise it to enter after 11 doses of medicines again, transference cure and fully recovering.Visit no abnormality seen 2 years.
3, patient: Liao XX, man, 65 years old, address: Guanghan City of Sichuan Province
Illness symptom: patient feels pharyngeal discomfort, and with the sense of deafness plug, check and find that there is swollen thing in throat in Sichuan tumour hospital, through check pathological section, be diagnosed as squamous cell carcinoma.But excessive because of patient age, should not perform the operation and the treatment such as radiotherapy, therefore ask Chinese traditional treatment.
Treatment: throw we, every day potion, sooner or later sub-service, the check after 6 doses of taking medicine, pharyngeal sense of discomfort alleviates, and advises it to enter after 16 doses of medicines again, the swollen thing of bottleneck throat disappears.Visit 1 year, have no recurrence.
4, patient: XX, female, 37 years old, address: Chengdu, Sichuan Province
Illness symptom: in recent years, patient feels pharyngeal discomfort, and occur being with blood in contracting tears, cuts in and out, and finds that through city's examination in hospital there is swollen thing in throat, through check pathological section, is diagnosed as nasopharyngeal carcinoma, school's mobilization operative treatment, but ask the traditional Chinese medical science because of fear.
Treatment: throw we, every day potion, sooner or later sub-service, takes medicine after 7 doses, its symptom disappears substantially, advises it to enter after 14 doses of medicines, transference cure, and recovery from illness again.Visit one and half, have no recurrence.
5, patient: recklessly XX, man, 69 years old, address: Sichuan Province's Nanchong City
Illness symptom: patient feels pharyngeal discomfort on June 12nd, 2011, and with bilateral nasal obstruction, tinnitus, auditory dysesthesia, headache, find that through economizing certain examination in hospital there is swollen thing in throat, through check pathological section, be diagnosed as nasopharyngeal carcinoma.But excessive because of patient age, disagree with operation and radiotherapy, therefore ask Chinese traditional treatment.
Treatment: throw we, every day potion, sooner or later sub-service, the check after 8 doses of taking medicine, its symptom disappears substantially, advises it to enter after 14 doses of medicines again, symptom all disappears.Visit no abnormality seen 2 years.
Claims (3)
1. an endo-medicine for the treatment of nasopharyngeal carcinoma, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Herba Selaginellae Doederleinii 1-3 part;
Radix Astragali 1-3 part;
Herba Solani Lyrati 1-3 part;
Pseudobulbus Cremastrae Seu Pleiones 1-3 part;
Spica Prunellae 1-3 part;
Flos Chrysanthemi Indici 1-3 part;
Radix Sophorae Tonkinensis 1-3 part;
Scolopendra 1-3 part;
Radix Glycyrrhizae 1-3 part;
Thin pork is appropriate.
2. the Orally-administered decoction medicine for the treatment of nasopharyngeal carcinoma according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
1 part of Herba Selaginellae Doederleinii;
1 part of the Radix Astragali;
1 part of Herba Solani Lyrati;
1 part of Pseudobulbus Cremastrae Seu Pleiones;
1 part of Spica Prunellae;
1 part of Flos Chrysanthemi Indici;
1 part of Radix Sophorae Tonkinensis;
1 part of Scolopendra;
1 part, Radix Glycyrrhizae;
Thin pork is appropriate.
3. endo-medicine of the treatment nasopharyngeal carcinoma described in a claim 1 or 2 and preparation method thereof, is characterized in that, described method comprises the steps:
A, according to mass parts than selecting high-quality clean Herba Selaginellae Doederleinii, the Radix Astragali, Herba Solani Lyrati, Pseudobulbus Cremastrae Seu Pleiones, Spica Prunellae, Flos Chrysanthemi Indici, Radix Sophorae Tonkinensis, Scolopendra, Radix Glycyrrhizae, sieve respectively after decontamination and dust for subsequent use;
B, will process clean medicine splendid attire after tying in cloth bag, in cold boiled water, soak 50 minutes, to soak into medicine degree of being organized as, appropriate thin pork is cleaned to stripping and slicing simultaneously, then medicine and soak and thin pork are put in sand tank in the lump, injected appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, 380 milliliters of leaching thin pork and herb liquids.
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Cited By (5)
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| CN104644981A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Phlegm-eliminating and stagnation-dispersing agent for nasopharyngeal carcinoma and preparation method of phlegm-eliminating and stagnation-dispersing agent |
| CN104645113A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Traditional Chinese medicine preparation for treating nasopharyngeal carcinoma and preparation method of traditional Chinese medicine preparation |
| CN104645112A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Nasopharyngeal carcinoma hard mass softening and phlegm eliminating preparation and preparation method thereof |
| CN104644979A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Blood-activating and toxin-removing preparation for nasopharyngeal carcinoma and preparation method thereof |
| CN107158282A (en) * | 2017-08-01 | 2017-09-15 | 刘建飞 | A kind of Chinese medicine preparation for treating rhinocarcinoma |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644981A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Phlegm-eliminating and stagnation-dispersing agent for nasopharyngeal carcinoma and preparation method of phlegm-eliminating and stagnation-dispersing agent |
| CN104645113A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Traditional Chinese medicine preparation for treating nasopharyngeal carcinoma and preparation method of traditional Chinese medicine preparation |
| CN104645112A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Nasopharyngeal carcinoma hard mass softening and phlegm eliminating preparation and preparation method thereof |
| CN104644979A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Blood-activating and toxin-removing preparation for nasopharyngeal carcinoma and preparation method thereof |
| CN107158282A (en) * | 2017-08-01 | 2017-09-15 | 刘建飞 | A kind of Chinese medicine preparation for treating rhinocarcinoma |
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Application publication date: 20141203 |
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| WD01 | Invention patent application deemed withdrawn after publication |