CN104721559A - Traditional Chinese medicine composition for treating oral ulcer - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating oral ulcer. The traditional Chinese medicine composition comprises 6 to 10 parts of dandelion, 12 to 25 parts of dyers woad leaf, 8 to 10 parts of black catechu, 1 to 3 parts of borneol, 1 to 2 parts of menthol, 10 to 30 parts of cape jasmine fruit, 10 to 20 parts of baikal skullcap root, 2 to 5 parts of Chinese thorowax root, 5 to 10 parts of licorice, 8 to 15 parts of American ginseng, 8 to 10 parts of Chinese toon, 2 to 4 parts of cow-bezoar, 5 to 15 parts of common bletill, 8 to 15 parts of tree peony bark, 3 to 6 parts of Chinese magnoliavine fruit, 10 to 14 parts of fragrant solomonseal rhizome and 3 to 6 parts of frankincense. The traditional Chinese medicine composition provided by the invention is capable of clearing away heat and toxic materials and relieving swelling and pain and exerts excellent treatment effect on oral ulcer.

Description

A kind of Chinese medicine composition being used for the treatment of oral ulcer

Technical field

The present invention relates to a kind of Chinese medicine composition being used for the treatment of oral ulcer.

Background technology

Oral ulcer is a kind of disease that in oral keritonocytes, sickness rate is the highest, common cold, dyspepsia, psychentonia, the gloomy situation such as discomfort all accidentally can cause the generation of this disease, be apt to occur in lip, cheek, lingual margin etc., all can occur at any position of mucosa, but attached gingiva and hard palate are then rare completely in keratinization.Age of onset is generally between 10 ~ 30 years old, and women is more, all can occur throughout the year.Oral ulcer has self limiting, can spontaneous recovery in about 10 days.This disease has the features such as periodicity, recurrent and self limiting.

Modern medicine is thought, first oral ulcer has very close relationship with immunity.Some patients are immunodeficiency, and some patients then show as autoimmune response; Next has relation with heredity, and in clinical, the morbidity of oral ulcer, has obvious Family inherited inclination, if father and mother one side or in many ways suffer from oral ulcer, their children are just easier than common people ill; In addition, the outbreak of oral ulcer, also relevant with some diseases or symptom, such as digestive system disease: gastric ulcer, duodenal ulcer, chronic or chronic persistent hepatitis, colitis etc., in addition monophagia, dyspepsia, generate heat, do not have enough sleep, overtired, operating pressure large, the change of menstrual cycle etc.Along with one or more factors active, alternately occur that immunity of organisms declines, cause the frequent outbreak of oral ulcer.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, oral ulcer is had to the Chinese medicine composition of good therapeutic effect.

The invention provides following Chinese medicine: comprise Herba Taraxaci 6-10 part, Folium Isatidis 12-25 part, Catechu 8-10 part, Borneolum Syntheticum 1-3 part, Mentholum 1-2 part, Fructus Gardeniae 10-30 part, Radix Scutellariae 10-20 part, Indigo Naturalis 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Panacis Quinquefolii 8-15 part, Tonnae Sinensis 8-10 part, Calculus Bovis 2-4 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Cortex Moutan 8-15 part, Fructus Schisandrae Chinensis 3-6 part, Rhizoma Polygonati Odorati 10-14 part, Olibanum 3-6 part.

Above-mentioned Chinese medicine is formed by following weight parts raw material of Chinese medicine medicine system of closing: Herba Taraxaci 8 parts, Folium Isatidis 20 parts, Catechu 9 parts, Borneolum Syntheticum 2 parts, Mentholum 1 part, Fructus Gardeniae 22 parts, Radix Scutellariae 10 parts, Indigo Naturalis 8 parts, 6 parts, Radix Glycyrrhizae, Radix Panacis Quinquefolii 10 parts, 8 parts, Tonnae Sinensis, Calculus Bovis 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Cortex Moutan 10 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Polygonati Odorati 10 parts, Olibanum 4 parts.

Medical material selected by the present invention and pharmacology as follows:

Herba Taraxaci: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Folium Isatidis: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, aphtha, swollen ulcer drug.

Catechu: to protect the liver, function of gallbladder promoting, enhancing immunity.

Borneolum Syntheticum: bitter, is slightly cold; GUIXIN, liver, lung meridian; Delicate fragrance a surname is loose, has refreshment of having one's ideas straightened out, the loose poison of heat clearing away, and effect of improving acuity of vision and removing nebula, cures mainly calentura unconsciousness due to high fever, heat-damp in summer hoodwinks key clearly, and sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain.

Mentholum: pungent is cool.Enter lung meridian, Liver Channel.Control influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.

Fructus Gardeniae: there is the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.

Radix Scutellariae: antiinflammatory, anti-allergy action; Hepatic cholagogic effect; Blood pressure lowering, diuresis, calmness, refrigeration function.

Indigo Naturalis: nature and flavor are salty-cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, purging liver-fire, arresting convulsion.Cure mainly: epidemic febrile disease intenseness of heat, macule, spit blood, spit blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer swells, erysipelas, snake bite and insect sting.

Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Radix Panacis Quinquefolii: sweet, micro-hardship is cool.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat.

Tonnae Sinensis: puckery, flat, enters liver, stomach, kidney channel.The diseases such as treatment of ulcer, alopecia, conjunctival congestion, cough due to lung-heat

Calculus Bovis: nature and flavor are bitter, and cool, heat-clearing and toxic substances removing, cures mainly laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furunculosis.

The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery, cold in nature, returns lung, stomach.Liver Channel.There is astringing to arrest bleeding, the merit of detumescence and promoting granulation, for all cards of interior external haemorrhage and carbuncle, scald, rhagadia manus et pedis, anal fissure etc.

Cortex Moutan: clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.There is antiinflammatory and bacteriostatic functions.

Fructus Schisandrae Chinensis: astringe the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.

Rhizoma Polygonati Odorati: property of medicine Gan Run, can support lung yin, the product be slightly cold, and slightly can clearing away lung-heat.

Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.

Detailed description of the invention

Embodiment 1:

Filter out Herba Taraxaci 8 parts, Folium Isatidis 20 parts, Catechu 9 parts, Borneolum Syntheticum 2 parts, Mentholum 1 part, Fructus Gardeniae 22 parts, Radix Scutellariae 10 parts, Indigo Naturalis 8 parts, 6 parts, Radix Glycyrrhizae, Radix Panacis Quinquefolii 10 parts, 8 parts, Tonnae Sinensis, Calculus Bovis 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Cortex Moutan 10 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Polygonati Odorati 10 parts, Olibanum 4 parts, selection, wash with water, drying, makes clean medical material for subsequent use; Get the clean medical material of each taste and decoct with water three times, each time 6 ~ 10 times of water gagings, soak, decoct, filter, second time adds 3 ~ 7 times of water gagings, decoct, filter, third time adds 2 ~ 6 times of water gagings, decoct, filter, discarded medicinal residues, merging filtrate, reduction vaporization is concentrated into the extractum of when relative density is 60 ~ 70 DEG C 1.10 ~ 1.15, and water intaking is promoted cream and pulverized, aspartame 3.5g, mix homogeneously, add 20.5g polyvidone again, as binding agent after fully dissolving, granulate, granule 40 DEG C of dryings, add the magnesium stearate of 0.6%, tabletting, obtain buccal tablet 1000.

Embodiment 2:

Filter out Herba Taraxaci 8 parts, Folium Isatidis 20 parts, Catechu 9 parts, Borneolum Syntheticum 2 parts, Mentholum 1 part, Fructus Gardeniae 22 parts, Radix Scutellariae 10 parts, Indigo Naturalis 8 parts, 6 parts, Radix Glycyrrhizae, Radix Panacis Quinquefolii 10 parts, 8 parts, Tonnae Sinensis, Calculus Bovis 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Cortex Moutan 10 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Polygonati Odorati 10 parts, Olibanum 4 parts, add the water soaking 30 minutes to 45 minutes of 5-7 times amount, heating boils 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds the water second time heating of 5-7 times amount, and boil 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds the water of 5-10 times amount again, for the third time heated and boiled 40 ~ 50 minutes, filters; Merge the decoction liquor of three times, be concentrated into the concentrated solution that relative density is 1.08; Filter, leave standstill 24 hours; Then by Borneolum Syntheticum 1500g, Herba Menthae 1500g extraction by steam distillation, obtain crystal, the ethanol mixture putting into concentrated solution and 10 times amount soaks 10 days, loads in medical spray gun, makes spray.

The maximum feature of the present invention is quickly alleviating pain, heat-clearing and toxic substances removing, and reducing swelling and alleviating pain, pathogenic fire purging solution cold expelling, promoting diuresis to eliminate damp pathogen, effect of removing dampness and killing parasites merit is oral cavity medicine oral ulcer being had to good therapeutic effect.The treatment feature of said preparation is Chinese medicine, giving consideration to both the incidental and fundamental.This medicine for treating oral cavity ulcer good water solubility, patient under stage of attack takes medicine rinsing the mouth posterior phraynx, thus accomplishes the combination of topical therapeutic and whole body therapeutic by special method of administration.

medication is avoided:

(1) contraindication in pregnancy.

clinical experiment is observed:

Physical data:

Treatment group 50 example, wherein light-duty oral ulcer accounts for 80%, general diameter 2-4mm, round or oval, clear around, isolate and be dispersed in, number is few, each 1 ~ 5 not etc., be apt to occur in the region that keratinization degree is poor, as lip cheek mucosa, the gum palatine that keratinization degree is high is less, during outbreak, ulcer has " recessed, red, yellow, feature bitterly ", i.e. ulcer concavity, substrate is not hard, periphery is with the congested blush band of about 1mm, surface is covered with light yellow pseudomembrane, causalgia sense is obvious, submandibular lymph nodes is accompanied to swell and ache when infecting serious, heating, general lasting 1-2 week, intermission is different in size, language is affected because stimulating pain, feed, mood, thus quality of life is had a negative impact, heavy oral ulcer accounts for 20%, during outbreak, ulcer is large and dark, " like crater " diameter 10-30mm, and dark and tela submucosa is until muscle layer, and periphery redness protuberance, the substrate of laying one's hand on is comparatively hard, but neat in edge is clear, normal single generation, and stage of attack can to reach more than the moon the even several months, and pain is heavier, can stay cicatrix more.

Therapeutic Method:

Treatment group one: every day twice, evenly imposes on spray in ulcer.Two days courses for the treatment of, 3 courses for the treatment of of continuous administration.

Treatment group two: every day twice, each a slice, water nozzle takes.Two days courses for the treatment of, 3 courses for the treatment of of continuous administration.

Matched group: adopt general duty nursing, normal saline flushing oral cavity.

Therapeutic outcome:

Therapeutic outcome is as following table:

	Number	Effective number	Significant figure	Invalid number	Effective percentage
						Treatment group one	50	30	49	0	98%
Treatment group two	50	32	50	0	100%
						Matched group	50	0	36	14	72%

Compare through statistical procedures two groups and have significant difference, the medicament for the treatment of oral ulcer is described, than gargling merely, nursing therapeutic effect is remarkable.

Claims (2)

1. one kind is used for the treatment of the Chinese medicine composition of oral ulcer; it is characterized in that: it is formed by following weight parts raw material of Chinese medicine Pharmaceutical formulations: Herba Taraxaci 6-10 part, Folium Isatidis 12-25 part, Catechu 8-10 part, Borneolum Syntheticum 1-3 part, Mentholum 1-2 part, Fructus Gardeniae 10-30 part, Radix Scutellariae 10-20 part, Indigo Naturalis 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Panacis Quinquefolii 8-15 part, Tonnae Sinensis 8-10 part, Calculus Bovis 2-4 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Cortex Moutan 8-15 part, Fructus Schisandrae Chinensis 3-6 part, Rhizoma Polygonati Odorati 10-14 part, Olibanum 3-6 part.

2. a kind of Chinese medicine composition being used for the treatment of oral ulcer according to claim 1, is characterized in that: it is formed by following weight parts raw material of Chinese medicine Pharmaceutical formulations: Herba Taraxaci 8 parts, Folium Isatidis 20 parts, Catechu 9 parts, Borneolum Syntheticum 2 parts, Mentholum 1 part, Fructus Gardeniae 22 parts, Radix Scutellariae 10 parts, Indigo Naturalis 8 parts, 6 parts, Radix Glycyrrhizae, Radix Panacis Quinquefolii 10 parts, 8 parts, Tonnae Sinensis, Calculus Bovis 2 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Cortex Moutan 10 parts, Fructus Schisandrae Chinensis 4 parts, Rhizoma Polygonati Odorati 10 parts, Olibanum 4 parts.