CN104644981A - Phlegm-eliminating and stagnation-dispersing agent for nasopharyngeal carcinoma and preparation method of phlegm-eliminating and stagnation-dispersing agent - Google Patents
Phlegm-eliminating and stagnation-dispersing agent for nasopharyngeal carcinoma and preparation method of phlegm-eliminating and stagnation-dispersing agent Download PDFInfo
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Abstract
The invention discloses a phlegm-eliminating and stagnation-dispersing agent for nasopharyngeal carcinoma and a preparation method of the phlegm-eliminating and stagnation-dispersing agent. The phlegm-eliminating and stagnation-dispersing agent is prepared from the following main active pharmaceutical ingredients in parts by weight: 5-10 parts of arisaema cum bile, 5-10 parts of selaginella doederleinii, 10-20 parts of cassia twigs, 6-12 parts of crinis trachycarpi, 9-15 parts of common selfheal fruit-spike, 8-12 parts of calcined oyster shells, 9-15 parts of biond magnolia flower, 10-15 parts of Chinese fevervine herb, 9-16 parts of fructus forsythiae, 8-15 parts of dried alum, 6-9 parts of Chinese elder herb root, 8-16 parts of crab bone, 9-16 parts of charred sanguisorbae radix and 9-16 parts of rhizome of manyleaf paris. The phlegm-eliminating and stagnation-dispersing agent disclosed by the invention has the advantages of no risk, no toxicity or side effects, no production of drug resistance and relatively low treatment cost, is easy to accept by patients and can regulate the immune function of the patients and improve the quality of life of the patients.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart and method for making.
Background technology
Nasopharyngeal carcinoma refers to the malignant tumor betiding cavum nasopharyngeum top and sidewall.Be one of China's malignant tumor occurred frequently, sickness rate is first of ear,nose & throat malignant tumor.Common symptoms is for being with blood, ear suffocation sense, auditory dysesthesia, diplopia and headache etc. in nasal obstruction, tears.The pathogenic factors of nasopharyngeal carcinoma is many-sided.Clinical observation for many years and experimentation show, following factor and nasopharyngeal carcinoma have substantial connection.1. inherited genetic factors.(1) Familial aggregation phenomenon.Many Nasopharyngeal Carcinoma Patients have family to suffer from carninomatosis history.(2) ethnic susceptibility.Nasopharyngeal carcinoma is mainly seen in yellow, rare in white people; The nationality that sickness rate is high, migrate elsewhere (or emigration), its descendant still has higher sickness rate.(3) region centrality.Nasopharyngeal carcinoma mainly betides south China five province, i.e. Guangdong, Guangxi, Hunan, Fujian and Jiangxi, accounts for the first place of local head-neck malignant tumor.Country in Southeast Asia is also district occurred frequently.(4) tumor susceptibility gene.2. viral infection.3. environmental factors.Clinical manifestation: 1. primary carcinoma.(1) tears blood and epistaxis.Focus is positioned at nasopharynx top rear wall person, and when firmly inhaling nasal cavity or nasopharynx part secretions backward, the lighter can cause tears blood (i.e. " expectorant " middle band blood during rear suction nose), and severe one can cause epistaxis.It is common that tumor surface is ulcer or this symptom of fungating type person, and mucosa mo(u)ld bottom half person then tears insufficiency of blood sees.(2) ear's symptom.Tumor is in pharyngeal recess or tubal torus district, and due to tumor-infiltrated, the sings and symptoms of secretory otitis media, appears in compressing pharyngeal opening of auditory tube: namely tinnitus, auditory dysesthesia etc., clinically many Nasopharyngeal Carcinoma Patients are found because ear's symptom is gone to a doctor.(3) sniffle.Primary carcinoma infiltrates and can cause mechanicalness blocking to region choanarum, and the tumor being positioned at nasopharynx top antetheca more easily causes nasal obstruction.In onset symptom, nasal obstruction accounts for 15.9%, is then 48.0% when making a definite diagnosis.(4) headache is common symptom.Show as one-sided rest pain clinically, position is many at temporo, top more.(5) eye symptom.Although invaded by NPC eye socket or relevant to eyeball neural time belong to late period, still have some patients to go to a doctor with this symptom.Invaded by NPC eye often causes following sings and symptoms: visual disorder (can be blind), defect of visual field, diplopia, exophthalmos and limitation of activity, neuroparalytic keratitis.Examination of ocular fundus optic atrophy and edema all can be seen.(6) cranial nerve lesions symptom.Nasopharyngeal carcinoma is got involved more with nervi trigeminus, nervus abducens, nervus glossopharyngeus, nervus sublingualis in the process infiltrated towards periphery, and nervi olfactory, nervus facialis, acoustic nerve are what for get involved less.(7) Cervical Lymph Node Metastasis.The lymph node of poke is painless, matter is hard, movable in early days, late period and skin or deep tissues adhesion and fix.(8) metastasis.(9) cachexia can be dead because of systemic organs's nonfunction, also has the died because of unexpected massive hemorrhage.2. Nasopharyngeal Carcinoma with Dermatomyositis.Dermatomyositis is a kind of serious connective tissue disease.The relation of malignant tumor and dermatomyositis is not yet clear and definite, but the generation rate of malignant tumour of patient with dermatomyositis is at least higher than normal person 5 times.Therefore to patient with dermatomyositis, must careful general physical checkup be carried out, in the hope of finding the malignant tumor hidden.3. recessive nasopharyngeal carcinoma.Enlarged Cervical Lymph Nodes turns out to be metastatic carcinoma through pathological section, but repeatedly checks each Suspected Area or biopsy still fails to find primary carcinoma focus, is called the occult Primary Cancer (primary tumor is positioned at breast, abdomen or pelvic cavity person and does not belong to this type of) of incidence.
The large multipair radiotherapy of nasopharyngeal carcinoma has Medium sensitivity, and radiotherapy is the first-selected Therapeutic Method of nasopharyngeal carcinoma.But to comparatively well-differentiated carcinoma, the case of the more late and recurrence after radiotherapy of the course of disease, excision and chemotherapy also belong to indispensable means.1. radiotherapy.(1) indication of the indication of nasopharyngeal carcinoma radiotherapy and contraindication 1. radical radiation therapy: the medium above person of overall health of patients; Basis cranii is without obvious bone destruction person; CT or MRI shows the other nothing of nasopharynx or only has light, moderate infiltration person; Lymphonodi cervicales maximum gauge is less than 8cm, movable, the person that not yet reaches at supraclavicular fossa; Without distant metastasis of human person.2. the indication of Palliative radiotherapy: tumor KSP classification more than 60 points; Severe headache, nasopharynx has the above bleeder of middle amount; Single property metastasis person or Cervical Lymph Node Metastasis is had to be greater than 10cm.As ordinary circumstance is improved after appeasing radiation, transference cure, metastasis stove energy effector, can change radical radiation therapy into.3. radiotherapy contraindication: tumor KSP classification less than 60 points; Extensive metastasis person; Merge actute infection patient; Radioactivity cerebral spinal cord injury person.2. chemotherapy.In being mainly used in, late case.Fail after radiotherapy to control and recidivist, so be a kind of complementary or palliative treatment.Conventional administering mode has three kinds: (1) systemic chemotherapy can oral, intramuscular injection, intravenous injection.Common drug has chlormethine, cyclophosphamide, 5-fluorouracil, bleomycin, phosphinothioylidynetrisaziridine etc.Can separately with a kind of medicine or drug combination.(2) half body chemotherapy is compressing ventral aorta; temporary interruption lower part of the body blood circulation; from the therapy of veins of upper extremity fast injection chlormethine; chlormethine just produces effect after being injected in vivo 2 ~ 3 minutes; after 15 minutes, the efficacy of a drug can reduce half; so both can improve drug level above the waist, lower part of the body hemopoietic function of bone marrow can have been protected again.(3) Arterial Chemotherapy can increase nasopharynx part drug level, reduces systemic side effects.Adopt superficial temporal artery or facial artery retrograde catheterization, inject cancer therapy drug.Early stage (I, II phase) is included on single less throat depth and organizes lymphatic metastasis case, have the case that cranial nerve is got involved late period, or radiotherapy posterior nasopharynx portion's Locally persistent or recurrent cases, all there is certain short term effect.Conventional cancer therapy drug has 5-fluorouracil, Bleomycin A5, cisplatin etc.3. radiotherapy and chemotherapy combined are treated.4. operative treatment.(1) its indication is as follows: nasopharynx part Focal lesion does not disappear or recidivist after radiotherapy.Cervical metastasis lymph node, does not disappear after radiotherapy, fast in movable isolatism bag, nasopharynx part primary tumor effector, feasible Neck Dissection.(2) contraindication: have basis cranii bone destruction or the other infiltration of nasopharynx, cranial nerve lesions or metastasis.Systemic conditions is not good enough or the bad person of hepatic and renal function.There are other surgical contraindications.5. immunization therapy.There is interferon inducers, phytohaemagglutinin-tumor vaccine etc.Still be in the exploratory stage at present.
Publication number CN 101530461A(application number 200810101836.5) Chinese patent literature disclose a kind of Chinese medicine for the treatment of nasopharyngeal carcinoma, it is made up of Chinese medicines such as Oletum Trogopterori, Resina Toxicodendri, Radix Notoginseng, Herba Selaginellae Doederleinii, Ganoderma, Radix Sophorae Tonkinensis, Radix Angelicae Sinensis, Rhizoma Bolbostematis, Scolopendras.Application publication number CN 103071112 A(application number 201310001820.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of nasopharyngeal carcinoma, the weight proportion of its each raw material components is: Radix vitis romanetii 8-12, Fructus Aurantii Immaturus 13-17, Fructus Akebiae 28-32, Radix Ginseng 4-15, Rhizoma Gymnadeniae 4-15, Rhizoma Coptidis 13-17, Oletum Trogopterori 8-12, Herba Duchesneae Indicae 28-32, little red Bulbus Allii root 8-12, Rhizoma Chuanxiong 13-17, Rhizoma Sparganii 4-15, Rhizoma Curcumae 13-17, huechys 28-32, Radix Aristolochiae Kaempferi 4-15, Herba Artemisiae Anomalae 8-12, Radix Tinosporae 28-32, Herba Houttuyniae 1-5, Radix seu folium abelmoschi moschati 8-12, Aster oreophilus Franch 4-15, Herba Catharanthi Rosei 1-5, Nidus Vespae 28-32, Herba Polygoni cymosi 13-17.Application publication number CN 104189558 A(application number 201410383072.9) Chinese patent literature disclose a kind of Chinese medicine decoction for the treatment of nasopharyngeal carcinoma, the weight of its constitutive material is: Pericarpium Zanthoxyli 15-25g, Herba Xanthii 45-55g, Flos Magnoliae 28-32g, Squama Manis 60-80g, Radix Angelicae Dahuricae 18-22g, eupolyphoge sinensis 25-35g, Semen Persicae 25-35g, Formica fusca 90-110g, Scolopendra 6-10 bar, Radix Peucedani 28-32g, Agkistrodon 40-60g, Herba Sedi 28-35g, Herba Lysimachiae 28-32g, Fructus Lycii 25-35g, Radix Glycyrrhizae 8-12g, Radix Cucurbitae 8-12g, unfolded tender leaf of Sinocalamus affinis (Rendle) Mcclure 4-6g, Radix Rumicis Crispi 1-3g and Castanea 4-6g.
Because nasopharyngeal carcinoma position is special; operation risk is large; and it is very responsive to radiotherapy; so radiotherapy becomes the first-selection for the treatment of of nasopharyngeal carcinoma; but radiotherapy often can produce many toxicities such as the decline of radiodermatitis, radiation esophagitis and appetite, Nausea and vomiting, stomachache, diarrhoea or constipation; medical expense is high, and patient is difficult to accept.Carry out heavy dose of Radiotherapy chemotherapy, or again carry out chemotherapy to producing the patient of drug resistance can only to lead debilitant life more critically ill, accelerate death.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart and method for making.Devoid of risk of the present invention, has no side effect, and can not produce drug resistance, medical expense is lower, and patient is easy to accept, and can regulate patient's immune function, improves life in patients.
Technical scheme of the present invention is:
The agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, takes off the primary raw material medicine stating weight proportion and is prepared from: Arisaema Cum Bile 5-10, Herba Selaginellae Doederleinii 5-10, Ramulus Cinnamomi 10-20, charred Petiolus Trachycarpi 6-12, Spica Prunellae 9-15, Concha Ostreae (calcined) 8-12, Flos Magnoliae 9-15, Herba Paederiae 10-15, Fructus Forsythiae 9-16, dried Alumen 8-15, Radix Sambuci Chiensis 6-9, Crab bone 8-16, charred Radix Sanguisorbae 9-16, Rhizoma Paridis 9-16.
The agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Arisaema Cum Bile 6-9, Herba Selaginellae Doederleinii 6-9, Ramulus Cinnamomi 12-18, charred Petiolus Trachycarpi 7-10, Spica Prunellae 11-14, Concha Ostreae (calcined) 9-11, Flos Magnoliae 12-14, Herba Paederiae 11-13, Fructus Forsythiae 12-15, dried Alumen 9-13, Radix Sambuci Chiensis 6.5-8, Crab bone 10-14, charred Radix Sanguisorbae 11-13, Rhizoma Paridis 11-14.
The agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Arisaema Cum Bile 7, Herba Selaginellae Doederleinii 8, Ramulus Cinnamomi 15, charred Petiolus Trachycarpi 9, Spica Prunellae 12, Concha Ostreae (calcined) 10, Flos Magnoliae 13, Herba Paederiae 12, Fructus Forsythiae 14, dried Alumen 12, Radix Sambuci Chiensis 7, Crab bone 13, charred Radix Sanguisorbae 12, Rhizoma Paridis 12.
Present invention also offers the preparation method agent of aforementioned nasopharyngeal carcinoma eliminating phlegm and relaxing heart being made pharmaceutically acceptable decoction, pill, powder and capsule.
The preparation method of described decoction is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry;
(2) step (1) gained and all the other 13 taste crude drug are put into marmite, add water, amount of water is 3.1-4.5 times (preferred amount of water is 3.7 times of 14 taste crude drug gross weights) of 14 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 34-42 minute (preferably, a turn little fire decocts 36 minutes), leaches medicinal liquid;
(3) fill in the marmite of medicinal residues to step (2) and add water, amount of water is 2.5-3.5 times (preferred amount of water is 3.2 times of 14 taste crude drug gross weights) of 14 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 20-32 minute (preferably, a turn little fire decocts 28 minutes), leaches medicinal liquid;
(4) step (2) and step (3) gained medicinal liquid are merged, to obtain final product.
The preparation method of described pill is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry, be ground into fine powder, cross 100-140 mesh sieve (preferred mistake 120 mesh sieve);
(2) get Crab bone, put on tile and dry, pulverization, cross 100-140 mesh sieve (preferred mistake 120 mesh sieve);
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 100-140 mesh sieve (preferred mistake 120 mesh sieve) is crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, with water pill, the pill of the heavy 0.3g of every ball is made.
The preparation method of described powder is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry, be ground into fine powder, cross 160-200 mesh sieve (preferred mistake 180 mesh sieve);
(2) get Crab bone, put on tile and dry, pulverization, cross 160-200 mesh sieve (preferred mistake 180 mesh sieve);
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 160-200 mesh sieve (preferred mistake 180 mesh sieve) is crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, be distributed into and often wrap 6g, sterile packaged, to obtain final product.
The preparation method of described capsule is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry, be ground into fine powder, cross 110-140 mesh sieve (preferred mistake 130 mesh sieve);
(2) get Crab bone, put on tile and dry, pulverization, cross 110-140 mesh sieve (preferred mistake 130 mesh sieve);
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 110-140 mesh sieve (preferred mistake 130 mesh sieve) is crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, drying 12 hours at the temperature of 65 DEG C, spread out in stainless steel disc, thickness is 10-20mm, microwave sterilizating 3-6 minute (preferred microwave sterilizating 4 minutes), loads zero capsule, every capsules is equipped with medicated powder 0.3g, by the capsule polishing in buffing machine installed, pressing plate, to obtain final product.
Nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent scientific formula provided by the invention is reasonable.In addition, excellent results of the present invention also shows:
1, devoid of risk, has no side effect, and can not produce drug resistance, medical expense is lower, and patient is easy to accept;
2, patient's immune function can be regulated, improve life in patients;
3, there is removing heat-phlegm, the effect such as astringing to arrest bleeding, removing toxic substances and promoting subsidence of swelling, hard masses softening and resolving, nourishing muscle and tendon are invigorated blood circulation, can kill swollen
Tumor, and effectively prevent transfer and recurrence.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, the primary raw material medicine getting following weight parts is prepared from (every part is 200g): Arisaema Cum Bile 5 parts, Herba Selaginellae Doederleinii 5 parts, Ramulus Cinnamomi 10 parts, charred Petiolus Trachycarpi 6 parts, Spica Prunellae 9 parts, Concha Ostreae (calcined) 8 parts, Flos Magnoliae 9 parts, Herba Paederiae 10 parts, Fructus Forsythiae 9 parts, dried Alumen 8 parts, Radix Sambuci Chiensis 6 parts, Crab bone 8 parts, charred Radix Sanguisorbae 9 parts, Rhizoma Paridis 9 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent decoction is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80 minutes, takes out, dries;
(2) step (1) gained and all the other 13 taste crude drug are put into marmite, add water, amount of water is 3.1 times of 14 taste crude drug gross weights, first boils to boiling with big fire, and rear turn of little fire decocts 34 minutes, leaches medicinal liquid;
(3) fill in the marmite of medicinal residues to step (2) and add water, amount of water is 2.5 times of 14 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 20 minutes afterwards, leaches medicinal liquid;
(4) step (2) and step (3) gained medicinal liquid are merged, to obtain final product.
The instructions of taking of gained nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent decoction of the present invention: oral, every day twice, each 160mL is warm.
embodiment 2the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, the primary raw material medicine getting following weight parts is prepared from (every part is 200g): Arisaema Cum Bile 10 parts, Herba Selaginellae Doederleinii 10 parts, Ramulus Cinnamomi 20 parts, charred Petiolus Trachycarpi 12 parts, Spica Prunellae 15 parts, Concha Ostreae (calcined) 12 parts, Flos Magnoliae 15 parts, Herba Paederiae 15 parts, Fructus Forsythiae 16 parts, dried Alumen 15 parts, Radix Sambuci Chiensis 9 parts, Crab bone 16 parts, charred Radix Sanguisorbae 16 parts, Rhizoma Paridis 16 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent pill is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 95 minutes, takes out, dries, be ground into fine powder, crosses 120 mesh sieves;
(2) get Crab bone, put on tile and dry, pulverization, cross 120 mesh sieves;
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 120 mesh sieves are crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, with water pill, the pill of the heavy 0.3g of every ball is made.
model case one:yellow XX, man, 62 years old.Main suit: nasopharyngeal carcinoma 2 years.Before 2 years there is nasal bleeding in patient, with dizziness, headache, tinnitus, become thin, weak, be diagnosed as nasopharyngeal carcinoma in local hospital biopsy.After six courses for the treatment of of chemotherapy, effect is bad, and health extremely feeble, oral cavity severe ulceration can not be taken food, and symptom does not significantly take a turn for the better, and comes to go to a doctor.Examine see patient's nasal bleeding, dizziness, headache, tinnitus, become thin, weak.Through nasopharynx part biopsy, and nasopharynx magnetic resonance examination is diagnosed as nasopharyngeal carcinoma.Take the present embodiment gained nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent pill, every day three times, each 5 balls, warm water takes.Take two months, above-mentioned symptom disappears, and spirit, muscle power take a turn for the better.Continue to take two months, check nasopharynx part lump disappears.Follow up a case by regular visits to patient experiences stable disease, without occurring recurrence and transfer.
embodiment 3the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, the primary raw material medicine getting following weight parts is prepared from (every part is 200g): Arisaema Cum Bile 6 parts, Herba Selaginellae Doederleinii 6 parts, Ramulus Cinnamomi 12 parts, charred Petiolus Trachycarpi 7 parts, Spica Prunellae 11 parts, Concha Ostreae (calcined) 9 parts, Flos Magnoliae 12 parts, Herba Paederiae 11 parts, Fructus Forsythiae 12 parts, dried Alumen 9 parts, Radix Sambuci Chiensis 6.5 parts, Crab bone 10 parts, charred Radix Sanguisorbae 11 parts, Rhizoma Paridis 11 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent powder is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 95 minutes, takes out, dries, be ground into fine powder, crosses 180 mesh sieves;
(2) get Crab bone, put on tile and dry, pulverization, cross 180 mesh sieves;
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 180 mesh sieves are crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, be distributed into and often wrap 6g, sterile packaged, to obtain final product.
model case two:time XX, man, 48 years old.Main suit: nasopharyngeal carcinoma 1 year.Before 1 year, patient occurs that nasal cavity flows out stench turbid tears, time have the blood streak, companioned with headache is had a stuffy nose.Go to a doctor to local hospital, through row Maxillary region CT examination, get the inspection of living tissue disease and be diagnosed as nasopharyngeal carcinoma, enclosed mass size 2.5 × 3.6cm, make a definite diagnosis rear patient and be unwilling to accept doctor trained in Western medicine radiotherapy chemotherapy.Asking about the method treatment for seeking beyond chemicotherapy everywhere, introducing to come to go to a doctor through friend.Through nasopharynx part biopsy, and nasopharynx magnetic resonance examination is diagnosed as nasopharyngeal carcinoma.Take the present embodiment gained nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent powder, every day twice, each 6g, boiled water is taken after mixing it with water.After taking 1 month, headache alleviates, and nasal obstruction, nasal cavity stench secretions obviously reduce, and spiritual appetite takes a turn for the better.Continue to take four months, above-mentioned symptom disappears, and check CT shows: head is normal, and nasopharynx part enclosed mass disappears, and whole body does not find transfer.Follow up a case by regular visits to so far, do not occur recurrence and transfer.
embodiment 4the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, the primary raw material medicine getting following weight parts is prepared from (every part is 200g): Arisaema Cum Bile 9 parts, Herba Selaginellae Doederleinii 9 parts, Ramulus Cinnamomi 18 parts, charred Petiolus Trachycarpi 10 parts, Spica Prunellae 14 parts, Concha Ostreae (calcined) 11 parts, Flos Magnoliae 14 parts, Herba Paederiae 13 parts, Fructus Forsythiae 15 parts, dried Alumen 13 parts, Radix Sambuci Chiensis 8 parts, Crab bone 14 parts, charred Radix Sanguisorbae 13 parts, Rhizoma Paridis 14 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent capsules agent is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 95 minutes, takes out, dries, be ground into fine powder, crosses 130 mesh sieves;
(2) get Crab bone, put on tile and dry, pulverization, cross 130 mesh sieves;
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 130 sieves are crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, drying 12 hours at the temperature of 65 DEG C, spread out in stainless steel disc, thickness is 10-20mm, microwave sterilizating 4 minutes, loads zero capsule, every capsules is equipped with medicated powder 0.3g, by the capsule polishing in buffing machine installed, pressing plate, to obtain final product.
model case three:feng XX, female, 56 years old.Left neck swells thing 3 years.Without obvious inducement, patient occurred that cervical region swelled thing before 3 years, start as Semen arachidis hypogaeae size, do not arouse attention, do not go to a doctor, and swollen thing increases gradually afterwards, and feel pain and constriction, can occur hoarseness sometimes, remaining without special discomfort.Body weight is without significant change.Give antiinflammatory and pain relieving etc. anti symptom treatment always, have no and be clearly better, come to go to a doctor.Body is looked into: vital sign is normal, the swollen thing of the about 8cm × 4cm × 5cm size of left neck visible, and matter is real, neat in edge, with surrounding tissue without obvious adhesion, touches a tender spot, without oozing of blood, suppurates, vascular-less noise.Cardiopulmonary abdomen body is looked into normally, and pathology is levied and do not drawn.Make pathologic finding: make a definite diagnosis nasopharyngeal carcinoma.Take the agent of the present embodiment gained nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent capsules, every day three times, each 6, warm water takes.Take 2 months, the left neck thing that swells obviously reduces.Continue to take four months, swollen thing disappears.Follow up a case by regular visits to so far, do not occur recurrence and transfer.
embodiment 5the agent of a kind of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, the primary raw material medicine getting following weight parts is prepared from (every part is 200g): Arisaema Cum Bile 7 parts, Herba Selaginellae Doederleinii 8 parts, Ramulus Cinnamomi 15 parts, charred Petiolus Trachycarpi 9 parts, Spica Prunellae 12 parts, Concha Ostreae (calcined) 10 parts, Flos Magnoliae 13 parts, Herba Paederiae 12 parts, Fructus Forsythiae 14 parts, dried Alumen 12 parts, Radix Sambuci Chiensis 7 parts, Crab bone 13 parts, charred Radix Sanguisorbae 12 parts, Rhizoma Paridis 12 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent decoction is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 95 minutes, takes out, dries;
(2) step (1) gained and all the other 13 taste crude drug are put into marmite, add water, amount of water is 3.7 times of 14 taste crude drug gross weights, first boils to boiling with big fire, and rear turn of little fire decocts 36 minutes, leaches medicinal liquid;
(3) fill in the marmite of medicinal residues to step (2) and add water, amount of water is 3.2 times of 14 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 28 minutes afterwards, leaches medicinal liquid;
(4) step (2) and step (3) gained medicinal liquid are merged, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Arisaema Cum Bile: for the fine powder of Rhizoma Arisaematis (processed) and cattle, sheep or Fel Sus domestica process from strand, or form through fermentation processing for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.This product is square or cylindric.Brown color, taupe brown or brownish black.Matter is hard.Feeble QI raw meat, bitter in the mouth.The property of medicine: bitter, micro-pungent, cool.Return lung, liver, spleen channel.Function cures mainly: removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.
Herba Selaginellae Doederleinii: base is former: be the herb of Spikemoss plant selaginella doederleinii.The property of medicine: sweet; Micro-hardship; Puckery; Cool; Light; Temperature.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness.Main laryngopharynx swelling and pain, conjunctival congestion and swelling pain, cough due to lung-heat, mastitis, jaundice due to damp-heat, rheumatic arthralgia, traumatic hemorrhage.
Ramulus Cinnamomi: base is former: be the twig of canella Cortex Cinnamomi.Ramulus Cinnamomi is containing volatile oil 0.69%, and in oil, main component is cinnamic aldehyde 64.75%, also has benzyl benzoate, cinnamyl acetate, β-cadinene, Chang Pu alkene, coumarin etc.The property of medicine: acrid, sweet, warm.Return bladder, the heart, lung meridian.Function cures mainly: expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.For activating YANG and prormoting functioning of QI exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen lumps, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria.
Petiolus Trachycarpi: base is former: this product is the dry petiole of babassu Petiolus Trachycarpi.The property of medicine: bitter, puckery, flat.Return lung, liver, large intestine channel.Function cures mainly: hemostasis with astringents.For spitting blood, epistaxis, hematuria, has blood in stool, metrostaxis.Charred Petiolus Trachycarpi is that sheath fiber (i.e. the palm fiber of petiole base) the calcination sustainability of Palmae aithullium palm forms.The property of medicine: bitter, puckery, flat.Return liver, lung, large intestine channel.Effect: astringing to arrest bleeding.Application: this product mild in medicine property and, bitter in the mouth and puckery, is the key medicine of astringing to arrest bleeding, is widely used in various hemorrhage card, be especially used for metrorrhagia.Because its convergence is strong, therefore be advisable without the stagnant person of the stasis of blood to control hemorrhage.In addition, the convergence of this product bitterness, and energy antidiarrheal leukorrhagia stopping, still can be used for chronic diarrhea chronic dysentery, married woman's leukorrhagia.
Spica Prunellae: base is former: be the dry fruit ear of labiate Spica Prunellae.The property of medicine: pungent, bitter, cold.Return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache, thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Concha Ostreae: be the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.The property of medicine: salty, is slightly cold.Return liver, gallbladder, kidney channel.Function cures mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, and hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.Concha Ostreae (calcined): by the Concha Ostreae cleaned, put on smokeless stove fire and be calcined to canescence, taking-up cools, and pulverizes.Effect: restrain astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache, tranquillization with heavy prescription, hard masses softening and resolving.Application: all cards of slippage (spontaneous perspiration, night sweat, frequent micturition, leukorrhagia, metrorrhagia, seminal emission etc.), stomachache pantothenic acid, irritability, insomnia, excessive rising of liver-YANG, has a dizzy spell.
Flos Magnoliae: base is former: be the dry flower of Magnoliacea plant Y biondii(Pamp)D.L.Fu., Magnolia denudata, Flos Magnoliae etc.The property of medicine: pungent; Warm in nature.Attach to the lung and stomach meridians.Function cures mainly: dispersing wind and cold, clearing the nasal passage.Main nasal sinusitis, the headache of anemofrigid cold, nasal obstruction, watery nasal discharge.
Herba Paederiae: base is former: be herb and the root of dicotyledon medicine Maguireothamnus speciosus Herba Paederiae.The property of medicine: sweet acid; Flat.GUIXIN, liver,spleen,kidney warp.Function cures mainly: expelling wind and removing dampness, promoting digestion and removing stagnation, removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain.Cure mainly rheumatic arthralgia, dyspeptic abdominal distention, infantile malnutrition, diarrhoea, dysentery, heatstroke, jaundice, hepatitis, hepatosplenomegaly, cough, scrofula, acute appendicitis, innominate toxic swelling, foot damp-edema is rotten, burn and scald, eczema, dermatitis, traumatic injury, Serpentis flood dragon scorpion sting.
Fructus Forsythiae: base is former: be the dry fruit of Oleaceae plants Fructus Forsythiae.The property of medicine: bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Dried Alumen: another name: calcined Alumen, process Alumen, alumen ustum.For irregular crystalline solid, not of uniform size.Colourless, transparent or semitransparent, surface is slightly level and smooth or uneven, and the fine and closely woven vertical rib of tool, has hyaloid gloss.Matter is hard and crisp, easily smashes.White with color, transparent, matter is hard and crisp, free from admixture person is good.Sour-puckery flavor, cold in nature.Return lung, spleen, stomach, large intestine channel.There is expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, effect of parasite killing.For controlling epilepsy, sore throat, remorse saliva is stopped up very, hepatitis, jaundice, general edema with yellowish skin, taste-blindness rate, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite.
Radix Sambuci Chiensis: base is former: be the root of caprifoliaceae plant Herba Sambuci Chiensis.The property of medicine: sweet in the mouth; Acid; Property is put down.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and detoxication.Cure mainly wind syndrome of head pain, lumbago and skelalgia, jaundice, edema, dysuria, beriberi, leucorrhea with red and white discharge, injury and bone fracture, rubella pruritus, skin ulcer swells.
Crab bone: base is former: the ectoskeleton of Eriocheir sinensis.Function cures mainly: Psoralen adds marrow, and nourishing muscle and tendon is invigorated blood circulation, the meridian dredging, sharp podomere, and continuous wound absolutely, is mainly used in treatment traumatic injury etc. clinically.
Radix Sanguisorbae: base is former: be the root of rosaceous plant Radix Sanguisorbae, the Radix Sanguisorbae that comes into leaves.The property of medicine: bitter, sour, cold, nontoxic.Return liver, lung, kidney, large intestine channel.Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.Main haematemesis, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.Charred Radix Sanguisorbae is the Preparation process product of Radix Sanguisorbae.Getting Radix Sanguisorbae decoction pieces is put in frying pan, fries and presents coke black to medical surfaces, take out, cool during inner sepia with big fire.Its hemostasis and sore effect can be strengthened after Radix Sanguisorbae parch to black.Charred Radix Sanguisorbae cooling blood for hemostasis, removing toxic substances sore.For having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.
Rhizoma Paridis: base is former: be the rhizome of liliaceous plantization Rhizoma Paridis, Rhizoma Paridis or Rhizoma Paridis.The property of medicine: bitter; Cold; Mild toxicity.Return Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Main carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis, snake bite and insect sting, traumatic pain, liver-heat is twitched.
test example: the clinical practice of gained nasopharyngeal carcinoma eliminating phlegm and relaxing heart of the present invention agent (embodiment 5): in March ,-2010 in January, 2007, screen 258 routine Nasopharyngeal Carcinoma Patients in 6 hospitals, wherein male 138 example, women 120 example, oldest 72 years old, minimum 32 years old of age.Be divided into two groups at random, experimental group and matched group (often organizing 129 people), two groups of cases there was no significant difference in the physical data such as sex, age, the state of an illness, has comparability.Experimental group uses products obtained therefrom of the present invention, using method: oral, every day twice, and each 160mL is warm.Matched group uses the medicine (as FUFANG KUSHEN ZHUSHEYE, BIYAN QINGDU KELI, doxifluridine capsule etc.) of conventional therapy nasopharyngeal carcinoma.
Curative effect situation criterion: complete incidence graph (CR): nasopharynx and tumor colli disappear completely, maintains more than 4 weeks; Partial rcsponse (PR): nasopharynx and tumor colli reduce more than 50%; Get nowhere (NC): nasopharynx and tumor colli reduce < 50%; Worsen (PD): nasopharynx and tumor colli increase > 25% or occur new pathological changes.Always effectively comprise complete incidence graph and partial rcsponse.Result is as shown in table 1.
Table 1: gained nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent compliance test result of the present invention [example (%)]
Therapeutic effect: in 129 routine patients of experimental group, complete incidence graph 82 example, accounts for 63.57%; Partial rcsponse 45 example, accounts for 34.88%; Get nowhere 2 examples, accounts for 1.55%; Total effective rate reaches 98.45%.In 129 routine patients of matched group, complete incidence graph 37 example, accounts for 28.68%; Partial rcsponse 50 example, accounts for 38.76%; Get nowhere 34 examples, accounts for 26.36%; Worsen 8 examples, account for 6.20%; Total effective rate is 67.44%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.
The present invention selects Arisaema Cum Bile, Herba Selaginellae Doederleinii, Ramulus Cinnamomi and charred Petiolus Trachycarpi etc. to be primary raw material medicine, makes the agent of nasopharyngeal carcinoma eliminating phlegm and relaxing heart.Arisaema Cum Bile removing heat-phlegm in side, dispelling wind and relieving convulsion.Ramulus Cinnamomi expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.Charred Petiolus Trachycarpi is the key medicine of astringing to arrest bleeding.Spica Prunellae relieves inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache, tranquillization with heavy prescription, hard masses softening and resolving.Magnoliae Powder wind and cold, clearing the nasal passage.Herba Paederiae expelling wind and removing dampness, promoting digestion and removing stagnation, removing toxic substances and promoting subsidence of swelling, promoting blood circulation and stopping pain.Fructus Forsythiae heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Dried Alumen has expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, effect of parasite killing.Radix Sambuci Chiensis expelling wind and removing dampness, promoting blood circulation and detoxication.Crab bone Psoralen adds marrow, and nourishing muscle and tendon is invigorated blood circulation, the meridian dredging, sharp podomere, continuous wound absolutely.Charred Radix Sanguisorbae cooling blood for hemostasis, removing toxic substances sore.Rhizoma Paridis heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.All medicines share, the effect such as have removing heat-phlegm, astringing to arrest bleeding, removing toxic substances and promoting subsidence of swelling, hard masses softening and resolving, nourishing muscle and tendon are invigorated blood circulation, and can kill tumor, and effectively prevent recurrence.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the agent of nasopharyngeal carcinoma eliminating phlegm and relaxing heart, is characterized in that, takes off the primary raw material medicine stating weight proportion and is prepared from: Arisaema Cum Bile 5-10, Herba Selaginellae Doederleinii 5-10, Ramulus Cinnamomi 10-20, charred Petiolus Trachycarpi 6-12, Spica Prunellae 9-15, Concha Ostreae (calcined) 8-12, Flos Magnoliae 9-15, Herba Paederiae 10-15, Fructus Forsythiae 9-16, dried Alumen 8-15, Radix Sambuci Chiensis 6-9, Crab bone 8-16, charred Radix Sanguisorbae 9-16, Rhizoma Paridis 9-16.
2. nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Arisaema Cum Bile 6-9, Herba Selaginellae Doederleinii 6-9, Ramulus Cinnamomi 12-18, charred Petiolus Trachycarpi 7-10, Spica Prunellae 11-14, Concha Ostreae (calcined) 9-11, Flos Magnoliae 12-14, Herba Paederiae 11-13, Fructus Forsythiae 12-15, dried Alumen 9-13, Radix Sambuci Chiensis 6.5-8, Crab bone 10-14, charred Radix Sanguisorbae 11-13, Rhizoma Paridis 11-14.
3. nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Arisaema Cum Bile 7, Herba Selaginellae Doederleinii 8, Ramulus Cinnamomi 15, charred Petiolus Trachycarpi 9, Spica Prunellae 12, Concha Ostreae (calcined) 10, Flos Magnoliae 13, Herba Paederiae 12, Fructus Forsythiae 14, dried Alumen 12, Radix Sambuci Chiensis 7, Crab bone 13, charred Radix Sanguisorbae 12, Rhizoma Paridis 12.
4. the nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable decoction is made in this nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent, and the preparation method of described decoction is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry;
(2) step (1) gained and all the other 13 taste crude drug are put into marmite, add water, amount of water is 3.1-4.5 times (preferred amount of water is 3.7 times of 14 taste crude drug gross weights) of 14 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 34-42 minute (preferably, a turn little fire decocts 36 minutes), leaches medicinal liquid;
(3) fill in the marmite of medicinal residues to step (2) and add water, amount of water is 2.5-3.5 times (preferred amount of water is 3.2 times of 14 taste crude drug gross weights) of 14 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 20-32 minute (preferably, a turn little fire decocts 28 minutes), leaches medicinal liquid;
(4) step (2) and step (3) gained medicinal liquid are merged, to obtain final product.
5. the nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable pill is made in this nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent, and the preparation method of described pill is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry, be ground into fine powder, cross 100-140 mesh sieve (preferred mistake 120 mesh sieve);
(2) get Crab bone, put on tile and dry, pulverization, cross 100-140 mesh sieve (preferred mistake 120 mesh sieve);
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 100-140 mesh sieve (preferred mistake 120 mesh sieve) is crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, with water pill, the pill of the heavy 0.3g of every ball is made.
6. the nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable powder is made in this nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent, and the preparation method of described powder is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute (preferred big fire turns moderate heat after vapour and steam 95 minutes), take out, dry, be ground into fine powder, cross 160-200 mesh sieve (preferred mistake 180 mesh sieve);
(2) get Crab bone, put on tile and dry, pulverization, cross 160-200 mesh sieve (preferred mistake 180 mesh sieve);
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 160-200 mesh sieve (preferred mistake 180 mesh sieve) is crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, be distributed into and often wrap 6g, sterile packaged, to obtain final product.
7. the nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable capsule is made in this nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent, and the preparation method of described capsule is:
(1) cleaned by Rhizoma Paridis, fibrous root of pruning, puts into food steamer, big fire turns moderate heat after vapour and steams 80-110 minute, take out, dry, be ground into fine powder, cross 110-140 mesh sieve;
(2) get Crab bone, put on tile and dry, pulverization, cross 110-140 mesh sieve (preferred mistake 130 mesh sieve);
(3) by all the other the 12 taste crude drug pulverization respectively except Rhizoma Paridis and Crab bone, 110-140 mesh sieve (preferred mistake 130 mesh sieve) is crossed;
(4) by step (1), step (2) and step (3) gained mix homogeneously, drying 12 hours at the temperature of 65 DEG C, spread out in stainless steel disc, thickness is 10-20mm, microwave sterilizating 3-6 minute, loads zero capsule, every capsules is equipped with medicated powder 0.3g, by the capsule polishing in buffing machine installed, pressing plate, to obtain final product.
8. the preparation method of nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent capsules agent as claimed in claim 7, is characterized in that, in step (1), big fire turns moderate heat after vapour and steams 95 minutes.
9. the preparation method of nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent capsules agent as claimed in claim 7, is characterized in that, crosses 130 mesh sieves in step (1).
10. the preparation method of nasopharyngeal carcinoma eliminating phlegm and relaxing heart agent capsules agent as claimed in claim 7, is characterized in that, microwave sterilizating 4 minutes in step (4).
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