CN104644979A - Blood-activating and toxin-removing preparation for nasopharyngeal carcinoma and preparation method thereof - Google Patents
Blood-activating and toxin-removing preparation for nasopharyngeal carcinoma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a blood-activating and toxin-removing preparation for nasopharyngeal carcinoma. The blood-activating and toxin-removing preparation is mainly prepared from the following active pharmaceutical ingredients in parts by weight: 8-15 parts of arisaema cum bile, 9-16 parts of selaginella doederleinii, 10-20 parts of cassia twigs, 5-10 parts of purpleflower holly leaves, 8-12 parts of bunge auriculate root, 9-16 parts of crinis trachycarpi, 8-14 parts of biond magnolia flower, 15-20 parts of chicken's gizzard-membrane, 15-20 parts of Mongolian snakegourd root, 15-20 parts of clematis root, 3-6 parts of manchurian wildginger (added later), 6-9 parts of rhizome of manyleaf paris, 6-9 parts of common selfheal fruit-spike, 6-10 parts of cactus and 10-15 parts of calcined oyster shells. The preparation is summarized from years of clinical practices, the blood-activating and toxin-removing preparation has the effects of clearing away heat and toxic materials as well as converging and stopping bleeding, the treatment effect is good, and the recurrence rate can be effectively reduced.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation and preparation method.
Background technology
Nasopharyngeal carcinoma is the malignant tumor being primary in mucous membrane of nasopharynx covering epithelium.Be one of common malignant tumor of China, pernicious frequency conversion is high, and Natural Survival time average is 18.7 months, and onset is hidden, is not easily found in early days.China the ground such as Guangdong, Guangxi, Fujian, Hunan be multiple district, man more than female.Age of onset is mostly middle age, also has teenager to suffer from patient.The cause of disease is relevant with ethnic susceptibility (yellow is ill compared with white people many), inherited genetic factors and ebv infection etc., and nasopharyngeal carcinoma grade malignancy is higher, can occur metastasic cervical lymph nodes in early days.Common symptoms is resorption tears blood, tinnitus, auditory dysesthesia, the inaccessible sense of in ear, headache, diplopia, face fiber crops, nasal obstruction metastasic cervical lymph nodes symptom etc.Nasopharyngeal carcinoma is most commonly in nasopharynx top, is secondly sidewall and pharyngeal recess, sometimes can be multiple.Mainly due to change that is spiritual and emotion, feelings will is not relaxed, make internal organs deficient, positive QI-insufficiency, the transition of outside climatic, environment can not be adapted to, or because virus, the suction of smog, diet are uncomfortable, caused by naso-pharynageal disease (comprising the remaining adenosis in nasopharynx position, mucosal erosion, mucosal ulcer, nasopharynx hyperplastic nodule) etc.
Notification number CN 104189558 A(application number 201410383072.9) Chinese patent literature disclose a kind of Chinese medicine decoction for the treatment of nasopharyngeal carcinoma, the weight portion of its constitutive material is: Pericarpium Zanthoxyli 15-25g, Herba Xanthii 45-55g, Flos Magnoliae 28-32g, Squama Manis 60-80g, Radix Angelicae Dahuricae 18-22g, eupolyphoge sinensis 25-35g, Semen Persicae 25-35g, Formica fusca 90-110g, Scolopendra 6-10 bar, Radix Peucedani 28-32g, Agkistrodon 40-60g, Herba Sedi 28-35g, Herba Lysimachiae 28-32g, Fructus Lycii 25-35g, Radix Glycyrrhizae 8-12g, Radix Cucurbitae 8-12g, unfolded tender leaf of Sinocalamus affinis (Rendle) Mcclure 4-6g, Radix Rumicis Crispi 1-3g and Castanea 4-6g.Publication No. CN 103768390 A(application number 201310568969.4) Chinese patent literature disclose a kind of Chinese medicinal effective-part composition for the treatment of nasopharyngeal carcinoma.Chinese medicine composition of the present invention is raw material by Flos Rhododendri Mollis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Caulis Akebiae, Rhizoma Panacis Majoris, Semen Citri Reticulatae and Mannosum Kaki, forms according to certain parts by weight.Notification number CN 103071112 A(application number 201310001820.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of nasopharyngeal carcinoma, the weight proportion of its each raw material components is: Radix vitis romanetii 8-12, Fructus Aurantii Immaturus 13-17, Fructus Akebiae 28-32, Radix Ginseng 4-15, Rhizoma Gymnadeniae 4-15, Rhizoma Coptidis 13-17, Oletum Trogopterori 8-12, Herba Duchesneae Indicae 28-32, little red Bulbus Allii root 8-12, Rhizoma Chuanxiong 13-17, Rhizoma Sparganii 4-15, Rhizoma Curcumae 13-17, huechys 28-32, Radix Aristolochiae Kaempferi 4-15, Herba Artemisiae Anomalae 8-12, Radix Tinosporae 28-32, Herba Houttuyniae 1-5, Radix seu folium abelmoschi moschati 8-12, Aster oreophilus Franch 4-15, Herba Catharanthi Rosei 1-5, Nidus Vespae 28-32, Herba Polygoni cymosi 13-17.
Treat the conventional method of nasopharyngeal carcinoma now, comprise operative treatment, radiotherapy and chemotherapy, through clinical proof, these means are large to human body side effect, it is high to damage, Chinese medicine can compensate its defect, and eliminates the toxic and side effects of chemicotherapy, therefore can study the Chinese medicine formula of more remarkable treatment effect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the wide a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation of safe and applicable and preparation method.
Technical scheme of the present invention is:
A kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is prepared from primarily of following bulk drugs, is mass parts: Arisaema Cum Bile 8-15; Herba Selaginellae Doederleinii 9-16; Ramulus Cinnamomi 10-20; Ilex purpurea Hassk.[I.chinensis Sims 5-10; Radix Cynanchi Auriculati 8-12; Charred Petiolus Trachycarpi 9-16; Flos Magnoliae 8-14; Endothelium Corneum Gigeriae Galli 15-20; Radix Trichosanthis 15-20; Radix Clematidis 15-20; Herba Asari (entering afterwards) 3-6; Rhizoma Paridis 6-9; Spica Prunellae 6-9; Caulis Echinopsis Multiplicis 6-10; Concha Ostreae (calcined) 10-15.
Preferred scheme is, Arisaema Cum Bile 10-13; Herba Selaginellae Doederleinii 11-14; Ramulus Cinnamomi 12-18; Ilex purpurea Hassk.[I.chinensis Sims 6-9; Radix Cynanchi Auriculati 9-11; Charred Petiolus Trachycarpi 11-14; Flos Magnoliae 10-12; Endothelium Corneum Gigeriae Galli 16-19; Radix Trichosanthis 17-18; Radix Clematidis 16-19; Herba Asari (entering afterwards) 4-5; Rhizoma Paridis 7-8; Spica Prunellae 7-8; Caulis Echinopsis Multiplicis 7-9; Concha Ostreae (calcined) 11-14.
What be more preferably is, Arisaema Cum Bile 11.5; Herba Selaginellae Doederleinii 12.5; Ramulus Cinnamomi 15; Ilex purpurea Hassk.[I.chinensis Sims 7.5; Radix Cynanchi Auriculati 10; Charred Petiolus Trachycarpi 12.5; Flos Magnoliae 11; Endothelium Corneum Gigeriae Galli 17.5; Radix Trichosanthis 17.5; Radix Clematidis 17.5; Herba Asari (entering afterwards) 4.5; Rhizoma Paridis 7.5; Spica Prunellae 7.5; Caulis Echinopsis Multiplicis 8; Concha Ostreae (calcined) 12.5.
Described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes and sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, decoct with water, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 22-40 minute (preferably: little fire decocts 27-35 minute; Be more preferably: little fire decocts 31 minutes), collecting by filtration filtrate;
(5) by step (3) and (4) gained medicated powder and filtrate mix homogeneously, sterilizing encapsulates and obtains decoction.
The preparation method of described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation decoction, the 5-7 that step (4) amount of water is boiled crude drug gross mass is (preferred: amount of water is 6 times of boiled crude drug gross mass) doubly.
Described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire to decoct, collecting by filtration filtrate, this filtrate of spraying dry;
(5) step (1), (2), (3) and (4) made crude drug and dry thing were pulverized 120-180 mesh sieve (preferred: to pulverize 140-160 mesh sieve; Be more preferably: pulverized 150 mesh sieves), namely subpackage obtains powder.
The preparation method of described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation powder, step (4) turns little fire and decocts 30-40 minute (preferably: turn little fire and decoct 32-38 minute; Be more preferably: turn little fire and decoct 35 minutes).
Described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes 160 mesh sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, decoct with water, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 22-40 minute (preferably: little fire decocts 27-35 minute; Be more preferably: little fire decocts 31 minutes), collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate to clear paste, add step (3) gained medicated powder, stir, obtain unguentum.
The preparation method of described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation unguentum, step (5) heating concentrated filtrate is to relative density 1.16-1.24(65 DEG C) clear paste (preferred: heating concentrated filtrate is to the clear paste of relative density 1.18-1.22; Be more preferably: heating is concentrated into the clear paste of relative density 1.20).
Described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 30-40 minute (preferably: turn little fire and decoct 32-38 minute; Be more preferably: turn little fire and decoct 35 minutes), collecting by filtration filtrate, this filtrate of spraying dry;
(5) step (1), (2), (3) and (4) made crude drug and dry thing were pulverized 120-180 mesh sieve (preferred: to pulverize 140-160 mesh sieve; Be more preferably: pulverized 150 mesh sieves), be packed in capsule, obtain capsule.
The preparation method of described a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation capsule, the every capsules Chinese medicine powder content of step (5) is that 0.3-0.5g(is preferred: every capsules Chinese medicine powder content is 0.35-0.45g; Be more preferably: every capsules Chinese medicine powder content is 0.4g).
A kind of nasopharyngeal carcinoma promoting blood circulation and detoxication pharmaceutical formulation science provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and total effective rate is high, effectively can reduce relapse rate;
2, this formula is summed up through clinical practice for many years and is formed, and has heat-clearing and toxic substances removing, anastaltic effect;
3, Chinese crude drug selected by the present invention, side effect is little, can long-term taking, can regulate patient body function.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Arisaema Cum Bile: base is former: for the fine powder of Rhizoma Arisaematis (processed) and cattle, sheep or Fel Sus domestica process from strand, or form through fermentation processing for Arisaema Cum Bile fine powder and cattle, sheep or Fel Sus domestica.Nature and flavor: bitter, micro-pungent, cool.Gui Jing: return lung, liver, spleen channel.Function cures mainly: removing heat-phlegm, dispelling wind and relieving convulsion.For phlegm-heat cough, cough up phlegm yellow thick, middle wind-phlegm fan, demented infantile convulsion.
Herba Selaginellae Doederleinii: base is former: be the herb of Spikemoss plant selaginella doederleinii.Chemical analysis: containing hordenine-O-α-L-rhamnopyranosyloxyhy glucoside, N-methyltyramine-O-α-L-rhamnopyranosyloxyhy glucoside, (E)-hordenine-(6-O-cinnamoyl-β-D-glucopyranosyl)-(1 → 3)-α-L-rhamnopyranosyloxyhy glucoside (E)-hordenine-［ 6-O-(4-hydroxycinnamoyl)-β-D-glucopyranosyl ］-(1 → 3)-α-L-rhamnopyranosyloxyhy glucoside.Nature and flavor: sweet; Micro-hardship; Puckery; Cool; Light; Temperature.Function cures mainly: heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main laryngopharynx swelling and pain; Conjunctival congestion and swelling pain; Cough due to lung-heat; Mastitis; Jaundice due to damp-heat; Rheumatic arthralgia; Traumatic hemorrhage.
Ramulus Cinnamomi: nature and flavor with return through acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Function with cure mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Ilex purpurea Hassk.[I.chinensis Sims: base is former: be the leaf of winter plant Ilicis Purpureae.Nature and flavor: bitter; Puckery; Cool.Function cures mainly: heat-clearing and toxic substances removing; Promoting tissue regeneration and ulcer healing; Promoting blood circulation and hemostasis.Main cough due to lung-heat; Laryngopharynx swelling and pain; Dysentery; Diarrhoea; Biliary tract infection; Urinary tract infection; Angina pectoris; Burn and scald; Pyretic toxicity carbuncle; Ulcer of the lower limb; Leprelcosis; Eczema; Chilblain; Chap; Thromboangiitis obliterans; Traumatic hemorrhage.
Radix Cynanchi Auriculati: base is former: be the tuber of asclepiadaceae plant Cynanchum bungei Decne.Nature and flavor: bitter in the mouth; Common vetch is bitter; Property is put down.Gui Jing: liver; Kidney; Taste warp.Function cures mainly: invigorating the liver and kidney; Bone and muscle strengthening; Benefiting essence-blood; Strengthening the spleen to promote digestion; Detoxification sore treatment.Main soreness of the waist and knees; Impotence and seminal emission; Dizziness and tinnitus; Palpitation and insomnia; Inappetence; Infantile malnutrition; Puerperal, milk was rare; Sore, carbuncle and painful swelling; Venom.
Charred Petiolus Trachycarpi: Petiolus Trachycarpi: nature and flavor with return through: bitter, puckery, flat.Return lung, liver, large intestine channel.Function with cure mainly: astringing to arrest bleeding.For spitting blood, epistaxis, hematuria, has blood in stool, metrorrhagia.Charred Petiolus Trachycarpi: get clean Petiolus Trachycarpi, according to the charcoal processing of charcoal (calcined) method, it is irregular bulk, not of uniform size.Surface pitchy is to black, glossy, has vertical vertical bar stricture of vagina; That touches has black powdered carbon.Inner coke yellow, fibroid.Somewhat burnt odor gas, bitter and puckery flavor.
Flos Magnoliae: base is former: be the alabastrum of Magnoliacea plant Flos Magnoliae or Magnolia denudata.Chemical analysis: Magnolia denudata alabastrum containing volatile oil, in containing citral, eugenol, 1, 8-Cineole.Root is containing magnoflorine.Leaf and fruit all contains the glycoside of peonidin.Nature and flavor: pungent, temperature.Gui Jing: enter lung, stomach warp.Function cures mainly: dispel the wind, sensible.Control headache, nasal sinusitis, have a stuffy nose obstructed, toothache.
Endothelium Corneum Gigeriae Galli: base is former: be the dry gizzard tunica intima of Phasianidae animal man chicken.After chicken is killed, take out gizzard, cut open, strip inner membrance while hot, clean and dry.Nature and flavor: sweet are flat.Gui Jing: enter spleen, stomach warp.Function cures mainly: removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Radix Trichosanthis: base is former: be the root of cucurbitaceous plant Fructus Trichosanthis.Nature and flavor: sweetness and bitterness acid are cool.Gui Jing: enter lung, stomach warp.Function cures mainly: promote the production of body fluid, and quenches the thirst, and pathogenic fire reducing is moisturized, evacuation of pus, detumescence.Control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.
Radix Clematidis: base is former: be the root of cohosh Radix Clematidis.Chemical analysis: the root of Radix Clematidis is containing Anemonin, anemonol, sterol, saccharide, Saponin, lactone, phenols, aminoacid.Leaf is containing lactone, phenols, triterpene, aminoacid, organic acid.Nature and flavor: Xin Xian, temperature, poisonous.Gui Jing: enter urinary bladder channel.Function cures mainly: wind-damp dispelling, the meridian dredging, expectorant saliva, the loose hypochondriac lump.Control gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Herba Asari: base is former: be the whole herb with root of aristolochiaceae plant Herba Asari or magnificent Herba Asari.Nature and flavor with return through: pungent, temperature.GUIXIN, lung, kidney channel.There is expelling wind and cold, wind-expelling pain-stopping, sensible, effect of warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Rhizoma Paridis: base is former: be the rhizome of liliaceous plant Rhizoma Paridis, RHIZOMA PARIDIS and several congeners thereof.Chemical analysis: Rhizoma Paridis root is containing paridin, dioscin, and the 3-glycoside of diosgenin, 3-scillabiose, 3-rhamnose arabinose glycoside and 3-tetra-glucoside, the diene alcohol ketone-3-that is pregnent investigates the multiple Saponins such as solatriose glycoside.Nature and flavor: toil, cold, poisonous.Gui Jing: enter the heart, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, antiasthmatic-antitussive, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion is twitched, snake bite and insect sting.
Spica Prunellae: base is former: be the fruit ear of labiate Spica Prunellae.Nature and flavor with return through: pungent, bitter, cold.Return liver, gallbladder meridian.There is purging liver-fire, improving eyesight, effect of mass dissipating and swelling eliminating.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, acute mastitis, nodules of the breast, distending pain of the breast.
Caulis Echinopsis Multiplicis: base is former: be the stem of Cactaeous plants Caulis Echinopsis Multiplicis.Nature and flavor: sweet light are flat.Gui Jing: lung; Stomach warp.Function cures mainly: clearing and antitussive; Removing pathogenic heat from blood and toxic substance from the body; Reducing swelling and alleviating pain.Main cough due to lung-heat; Sputum mixed with blood; Epistaxis; Spit blood; Gastric ulcer; Carbuncle; Scald; Snake bite and insect sting.
Concha Ostreae (calcined): Concha Ostreae: base is former: be the shell of Ostreidae animal Crassostrea rivularis, long Concha Ostreae or Dalian Bay Concha Ostreae etc.Nature and flavor with return through: salty, be slightly cold.Return liver, gallbladder, kidney channel.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, effect of hard masses softening and resolving.For insomnia of palpitating with fear, dizzy ear toot, scrofula sucutaneous nodule, abdominal mass abdominal mass mass in the abdomen.Concha Ostreae (calcined): by the Concha Ostreae cleaned, put on smokeless stove fire and be calcined to canescence, taking-up cools, and pulverizes.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Arisaema Cum Bile 8 parts, Herba Selaginellae Doederleinii 9 parts, Ramulus Cinnamomi 10 parts, Ilex purpurea Hassk.[I.chinensis Sims 5 parts, Radix Cynanchi Auriculati 8 parts, charred Petiolus Trachycarpi 9 parts, Flos Magnoliae 8 parts, Endothelium Corneum Gigeriae Galli 15 parts, Radix Trichosanthis 15 parts, Radix Clematidis 15 parts, Herba Asari (entering afterwards) 3 parts, Rhizoma Paridis 6 parts, Spica Prunellae 6 parts, Caulis Echinopsis Multiplicis 6 parts, Concha Ostreae (calcined) 10 parts.The preparation method of above-mentioned a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation decoction is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 15 minutes, take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes and sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire to decoct 31 minutes, collecting by filtration filtrate;
(5) by step (3) and (4) gained medicated powder and filtrate mix homogeneously, sterilizing encapsulates and obtains decoction.
embodiment 2a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Arisaema Cum Bile 15 parts, Herba Selaginellae Doederleinii 16 parts, Ramulus Cinnamomi 20 parts, Ilex purpurea Hassk.[I.chinensis Sims 10 parts, Radix Cynanchi Auriculati 12 parts, charred Petiolus Trachycarpi 16 parts, Flos Magnoliae 14 parts, Endothelium Corneum Gigeriae Galli 20 parts, Radix Trichosanthis 20 parts, Radix Clematidis 20 parts, Herba Asari (entering afterwards) 6 parts, Rhizoma Paridis 9 parts, Spica Prunellae 9 parts, Caulis Echinopsis Multiplicis 10 parts, Concha Ostreae (calcined) 15 parts.The preparation method of above-mentioned a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation powder is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 15 minutes, take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire to decoct 35 minutes, collecting by filtration filtrate, this filtrate of spraying dry;
(5) step (1), (2), (3) and (4) made crude drug and dry thing were pulverized 150 mesh sieves, namely subpackage obtains powder.
Model case: xxx, male, 41 years old.Main suit: nasal obstruction, nasal mucus band blood over the past half year, with dizziness and tinnitus; Medical history: patient found often nasal obstruction before half a year, and with the blood streak in nasal mucus, in sensation ear, have ring in a low voice, dysphoria, removes examination in hospital, finds that nasopharynx part has lump, be diagnosed as nasopharyngeal carcinoma through biopsy, after two months, the state of an illness diffuses to lymph node to operative treatment.
People is listened to recommend to take this example gained powder, each 5-10g, warm boiled water, one day twice, within 30 days, be a course for the treatment of, patient takes after two months, and patient's malaise symptoms disappears substantially, lump obviously reduces, after taking four months, patient's lump volume disappears substantially, patient experiences stable disease, follow up a case by regular visits in 1 year, for diffusing to other positions.
embodiment 3a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Arisaema Cum Bile 10 parts, Herba Selaginellae Doederleinii 11 parts, Ramulus Cinnamomi 12 parts, Ilex purpurea Hassk.[I.chinensis Sims 6 parts, Radix Cynanchi Auriculati 9 parts, charred Petiolus Trachycarpi 11 parts, Flos Magnoliae 10 parts, Endothelium Corneum Gigeriae Galli 16 parts, Radix Trichosanthis 17 parts, Radix Clematidis 16 parts, Herba Asari (entering afterwards) 4 parts, Rhizoma Paridis 7 parts, Spica Prunellae 7 parts, Caulis Echinopsis Multiplicis 7 parts, Concha Ostreae (calcined) 11 parts.The preparation method of above-mentioned a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation unguentum is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 15 minutes, take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes 160 mesh sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, decoct with water, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 31 minutes, collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate to relative density 1.20(65 DEG C) clear paste, add step (3) gained medicated powder, stir, obtain unguentum.
Model case: xxx, women, 38 years old.Medical history: patient, when unit health check-up, finds that nasopharynx part has lump, without remarkable uncomfortable disease, is diagnosed as nasopharyngeal carcinoma in early days through lab testing, because worrying chemicotherapy damage health, just seeks Chinese traditional treatment.
Under the introduction of friend, take this example gained unguentum, each 10-15g, warm boiled water, one day twice 30 days is a course for the treatment of, after patient takes one month, lump is deliquescing gradually, starts to reduce, and adheres to taking after two months, lump is vanished from sight substantially, after consolidating a course for the treatment of, return hospital's further consultation, biopsy does not find cancerous cell.
embodiment 4a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Arisaema Cum Bile 13 parts, Herba Selaginellae Doederleinii 14 parts, Ramulus Cinnamomi 18 parts, Ilex purpurea Hassk.[I.chinensis Sims 9 parts, Radix Cynanchi Auriculati 11 parts, charred Petiolus Trachycarpi 14 parts, Flos Magnoliae 12 parts, Endothelium Corneum Gigeriae Galli 19 parts, Radix Trichosanthis 18 parts, Radix Clematidis 19 parts, Herba Asari (entering afterwards) 5 parts, Rhizoma Paridis 8 parts, Spica Prunellae 8 parts, Caulis Echinopsis Multiplicis 9 parts, Concha Ostreae (calcined) 14 parts.The preparation method of above-mentioned a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation capsule is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 15 minutes, take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire to decoct 35 minutes, collecting by filtration filtrate, this filtrate of spraying dry;
(5) step (1), (2), (3) and (4) made crude drug and dry thing were pulverized 150 mesh sieves, and be packed in capsule, every capsules Chinese medicine powder content is 0.4g, obtains capsule.
Model case: xxx, male, 51 years old.Main suit: nerve tears blood 5 months, left side neck has lump, right side tinnitus, facial numbness, checks display: bilateral concha nasalis is little, without purulent secretion, thyroid not enlargement, right side neck has 4 × 3cm size lump, and matter is hard, inertia, check through lymphonodi cervicales Puncture cytology, be diagnosed as the nasopharyngeal carcinoma III phase.
Accept doctor advised, take this example gained capsule, each 3-4 grain, warm boiled water, one day twice 30 days is a course for the treatment of, after patient takes a course for the treatment of, tinnitus, pain and numbness are improved, and continue to take after two months, and the uncomfortable disease of patient is eliminated substantially, mass reduction, after consolidating again a course for the treatment of, patient experiences stable disease, can orthobiosis.
embodiment 5a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is prepared from (every part of 10g) primarily of following bulk drugs: Arisaema Cum Bile 11.5 parts, Herba Selaginellae Doederleinii 12.5 parts, Ramulus Cinnamomi 15 parts, Ilex purpurea Hassk.[I.chinensis Sims 7.5 parts, Radix Cynanchi Auriculati 10 parts, charred Petiolus Trachycarpi 12.5 parts, Flos Magnoliae 11 parts, Endothelium Corneum Gigeriae Galli 17.5 parts, Radix Trichosanthis 17.5 parts, Radix Clematidis 17.5 parts, Herba Asari (entering afterwards) 4.5 parts, Rhizoma Paridis 7.5 parts, Spica Prunellae 7.5 parts, Caulis Echinopsis Multiplicis 8 parts, Concha Ostreae (calcined) 12.5 parts.The preparation method of above-mentioned a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation decoction is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 15 minutes, take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes and sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire to decoct 31 minutes, collecting by filtration filtrate;
(5) by step (3) and (4) gained medicated powder and filtrate mix homogeneously, sterilizing encapsulates and obtains decoction.
test example 1the clinical practice of a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation (embodiment 5) of gained of the present invention:
Choose crowd: in January, 2014 in December ,-2014, according to medical case history, be diagnosed as patient 298 example of nasopharyngeal carcinoma four hospital's screenings, male patient 182 example, female patient 116 example, age 32-58 year, 41.6 ± 0.9 years old mean age, course of disease 0.5-4, wherein I phase patient 68 example, II phase 114 example, III phase 93 example, IV phase 23 example.
Before test, patient is divided into two groups at random, experimental group 198 example and matched group 100 routine, two groups in age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication of gained of the present invention preparation decoction, each 150-200ml, one day twice, warmly takes, and within 30 days, is a course for the treatment of; Matched group adopts the conventional means such as chemicotherapy or operative treatment.Treatments period carries out Continuous Observation to two groups of patients, record change of illness state.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: nasopharynx part cancerous protuberance and lymphonodi cervicales disappear, and symptom and sign disappear, and cancerous cell is not found in nasopharynx part biopsy; (2) effective: nasopharynx part cancerous protuberance and lymphonodi cervicales reduce, symptom and sign are improved, and nasopharynx part and lymphonodi cervicales biopsy still can find cancerous cell; (3) invalid: cancerous protuberance has no and reduces, continue to increase and accelerate to adjacent tissue's expansion and distally shift, dead in dyscrasia eventually.
Clinical effectiveness: after the treatment of four courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the healing patient of experimental group is 30 examples, and cure rate is 15.2%, effective patient is 160 examples, and effective percentage is 80.8%, and total effective rate is 96.0%, and the patient that matched group is cured is 10 examples, cure rate is 10.0%, and effective patient is 61 examples, and effective percentage is 61.0%, total effective rate 71.0%, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, therapeutic effect is good.
The present invention selects the Arisaema Cum Bile of removing heat-phlegm, the Herba Selaginellae Doederleinii of heat-clearing and toxic substances removing, the Ramulus Cinnamomi of promoting the flow of QI-blood by warming the meridian, the Ilex purpurea Hassk.[I.chinensis Sims of promoting blood circulation and hemostasis, the Radix Cynanchi Auriculati of detoxification sore treatment, anastaltic charred Petiolus Trachycarpi, the Flos Magnoliae of expelling pathogenic wind and restoring the functions of orifices in face, the Endothelium Corneum Gigeriae Galli of passive spleen invigorating, the Radix Trichosanthis of evacuation of pus detumescence, the Radix Clematidis of wind-damp dispelling, the meridian dredging, the Herba Asari of expelling wind and cold, the Rhizoma Paridis of heat-clearing and toxic substances removing, the Spica Prunellae of mass dissipating and swelling eliminating, the Caulis Echinopsis Multiplicis of removing pathogenic heat from blood and toxic substance from the body, the Concha Ostreae (calcined) of hard masses softening and resolving, multiple medical material synergism, effectively eliminates lump, control diffusion, heighten the effect of a treatment.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. a nasopharyngeal carcinoma promoting blood circulation and detoxication preparation, is characterized in that, is prepared from primarily of following bulk drugs, is mass parts: Arisaema Cum Bile 8-15; Herba Selaginellae Doederleinii 9-16; Ramulus Cinnamomi 10-20; Ilex purpurea Hassk.[I.chinensis Sims 5-10; Radix Cynanchi Auriculati 8-12; Charred Petiolus Trachycarpi 9-16; Flos Magnoliae 8-14; Endothelium Corneum Gigeriae Galli 15-20; Radix Trichosanthis 15-20; Radix Clematidis 15-20; Herba Asari (entering afterwards) 3-6; Rhizoma Paridis 6-9; Spica Prunellae 6-9; Caulis Echinopsis Multiplicis 6-10; Concha Ostreae (calcined) 10-15.
2. a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation as claimed in claim 1, is characterized in that, Arisaema Cum Bile 10-13; Herba Selaginellae Doederleinii 11-14; Ramulus Cinnamomi 12-18; Ilex purpurea Hassk.[I.chinensis Sims 6-9; Radix Cynanchi Auriculati 9-11; Charred Petiolus Trachycarpi 11-14; Flos Magnoliae 10-12; Endothelium Corneum Gigeriae Galli 16-19; Radix Trichosanthis 17-18; Radix Clematidis 16-19; Herba Asari (entering afterwards) 4-5; Rhizoma Paridis 7-8; Spica Prunellae 7-8; Caulis Echinopsis Multiplicis 7-9; Concha Ostreae (calcined) 11-14(is preferably: Arisaema Cum Bile 11.5; Herba Selaginellae Doederleinii 12.5; Ramulus Cinnamomi 15; Ilex purpurea Hassk.[I.chinensis Sims 7.5; Radix Cynanchi Auriculati 10; Charred Petiolus Trachycarpi 12.5; Flos Magnoliae 11; Endothelium Corneum Gigeriae Galli 17.5; Radix Trichosanthis 17.5; Radix Clematidis 17.5; Herba Asari (entering afterwards) 4.5; Rhizoma Paridis 7.5; Spica Prunellae 7.5; Caulis Echinopsis Multiplicis 8; Concha Ostreae (calcined) 12.5).
3. a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes and sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, decoct with water, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 22-40 minute (preferably: little fire decocts 27-35 minute; Be more preferably: little fire decocts 31 minutes), collecting by filtration filtrate;
(5) by step (3) and (4) gained medicated powder and filtrate mix homogeneously, sterilizing encapsulates and obtains decoction.
4. the preparation method of a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation decoction as claimed in claim 3, is characterized in that, the 5-7 that step (4) amount of water is boiled crude drug gross mass is (preferred: amount of water is 6 times of boiled crude drug gross mass) doubly.
5. a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire to decoct, collecting by filtration filtrate, this filtrate of spraying dry;
(5) step (1), (2), (3) and (4) made crude drug and dry thing were pulverized 120-180 mesh sieve (preferred: to pulverize 140-160 mesh sieve; Be more preferably: pulverized 150 mesh sieves), namely subpackage obtains powder.
6. the preparation method of a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation powder as claimed in claim 5, is characterized in that, step (4) turns little fire and decocts 30-40 minute (preferably: turn little fire and decoct 32-38 minute; Be more preferably: turn little fire and decoct 35 minutes).
7. a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried, and pulverizes 160 mesh sieves together with step (1) and (2) made crude drug;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, decoct with water, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 22-40 minute (preferably: little fire decocts 27-35 minute; Be more preferably: little fire decocts 31 minutes), collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate to clear paste, add step (3) gained medicated powder, stir, obtain unguentum.
8. the preparation method of a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation unguentum as claimed in claim 7, it is characterized in that, step (5) heating concentrated filtrate is to relative density 1.16-1.24(65 DEG C) clear paste (preferred: heating concentrated filtrate is to the clear paste of relative density 1.18-1.22; Be more preferably: heating is concentrated into the clear paste of relative density 1.20).
9. a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Ramulus Cinnamomi removing crust, clean and slightly moisten, shred, be placed in parch container, slow fire heats 5 minutes, takes out and puts into Sucus Glycyrrhizae immersion, pull oven dry out;
(2) get Ilex purpurea Hassk.[I.chinensis Sims and Herba Selaginellae Doederleinii, remove residual leaf and impurity, be cut into silk, add Sucus Zingberis and infiltrate 10-20 minute (preferably: infiltrate 12-18 minute; Be more preferably: infiltrate 15 minutes), take out and dry;
(3) get Flos Magnoliae and Spica Prunellae, be placed in parch container, moderate heat heats, and it is burned black for frying to surface, spray vinegar liquid, and taking-up is dried;
(4) by Arisaema Cum Bile, Radix Cynanchi Auriculati, charred Petiolus Trachycarpi, Endothelium Corneum Gigeriae Galli, Radix Trichosanthis, Radix Clematidis, Rhizoma Paridis, Caulis Echinopsis Multiplicis and Concha Ostreae (calcined), clean and put into marmite, add the soak by water of boiled crude drug gross mass 6 times, moderate heat is heated to boiling, add Herba Asari (entering afterwards) again, turn little fire and decoct 30-40 minute (preferably: turn little fire and decoct 32-38 minute; Be more preferably: turn little fire and decoct 35 minutes), collecting by filtration filtrate, this filtrate of spraying dry;
(5) step (1), (2), (3) and (4) made crude drug and dry thing were pulverized 120-180 mesh sieve (preferred: to pulverize 140-160 mesh sieve; Be more preferably: pulverized 150 mesh sieves), be packed in capsule, obtain capsule.
10. the preparation method of a kind of nasopharyngeal carcinoma promoting blood circulation and detoxication preparation capsule as claimed in claim 9, is characterized in that, the every capsules Chinese medicine powder content of step (5) is that 0.3-0.5g(is preferred: every capsules Chinese medicine powder content is 0.35-0.45g; Be more preferably: every capsules Chinese medicine powder content is 0.4g).
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| US6187315B1 (en) * | 1995-03-03 | 2001-02-13 | Atajje, Inc. | Compositions and methods of treating cancer with tannin complexes |
| CN101530461A (en) * | 2008-03-13 | 2009-09-16 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating nasopharyngeal cancer |
| CN104173748A (en) * | 2014-09-06 | 2014-12-03 | 成都市飞龙水处理技术研究所 | Orally taken medicine for treating cancer of pharynx and preparation method thereof |
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Address after: Shanghai Road, Xingqing District of Yinchuan city the Ningxia Hui Autonomous Region 750000 District 2 Building No. 485 treasure 1-401 Applicant after: Wang Lihu Address before: 250000 Shandong Province, Ji'nan City District nanxinzhuang Street No. 37 Longhai Garden Applicant before: Wang Lihu |
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Application publication date: 20150527 |