CN104173536A - Medicine for preventing and treating flu of laying hen and improving laying rate - Google Patents
Medicine for preventing and treating flu of laying hen and improving laying rate Download PDFInfo
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Abstract
The invention relates to a medicine for preventing and treating flu of a laying hen and improving the laying rate, belonging to the technical field of preparation of veterinary medicines. The medicine provided by the invention is prepared from the following main components: artemisia apiacea, echinacea purpurea, radix bupleuri, calculus bovis factitius, rhizoma dryopteris crassirhizomae, polygonum bistorta, pericarpium citri reticulatae, hawthorn, liquorice, transfer factor solution, water-soluble bacillus coagulans and polyoxyethylene 40 hydrogenated castor oil, wherein artemisia apiacea, echinacea purpurea and transfer factor solution and water-soluble bacillus coagulans are matched in use, so that the medicine provided by the invention further has the effects of treating flu of the laying hen and improving the laying rate. The medicine provided by the invention can be used for reducing the morbidity of flu of the laying hen by 22.5% and reducing the death rate by 6.1%, and can be used for solving the problem that the laying rate of the laying hen suffering from flu is decreased, the laying peak is restored 12 days in advance, and the laying peak period is prolonged.
Description
Technical field
The present invention relates to a kind of medicine of preventing and treating laying hen influenza and improving laying rate, belong to technical field of animal remedy preparation.
Background technology
Bird flu (Avian influenza, AI) is the abbreviation of avian influenza, and it is the infectious disease being caused by a kind of hypotype of A type influenza disease (also claiming bird flu virus), is decided to be Class A passes disease by International Office of Epizootics, claims again fowl plague or European fowl plague.After laying hen generation influenza, laying rate decline 10%-90%, and the sustainable 30-60 days of whole process, when laying rate declines, mildness influenza is generally not lethal, and strong influenza can cause laying hen death, mortality rate reaches 10%-50%, causes huge economic loss to breeding layer chicken family.
At present, the domestic mode of mainly taking vaccine immunity is prevented laying hen influenza, when the vaccine of inoculation is when consistent with clinical popular strains subtype, can obtain desirable protection effect, but the vaccine of inoculation is when different from popular hypotype, just can not protect by adaptive immune.Because influenza virus sub-strain is more, and restructuring and variation easily occur, and the cross-protection of vaccine is limited, therefore, often occurs the phenomenon of still falling ill after immunity in clinical practice.
In order to make up vaccine defect, improve the control effect of influenza, be badly in need of the effective antiviral drugs of a kind of wide spectrum.Although Western medicine has antiviral drugs, because easily causing virus, it produces the problems such as drug resistance, also do not get permission to be applied at home the control of zoosis toxicity disease.Chinese medicine antiviral effect is proved; and there is the advantages such as multipath, many target spots, broad-spectrum antiviral; some products have got permission to be applied to the control of animal viral disease as Antiphlogistic Powder of Schizonepetae and Ledebouriellae, SHUANGHUANGLIAN KOUFUYE etc., but still have that prevention protective rate is low, slow, long, the ill laying rate of laying hen for the treatment of cycle of responding well to treatment recovers the problem such as slow.
Summary of the invention
the object of the present invention is to provide a kind of medicine of preventing and treating laying hen influenza and improving laying rate of chicken dual function, this medicine especially can improve the laying rate of the laying hen that suffers from influenza fast.
Technical scheme of the present invention
A medicine of preventing and treating laying hen influenza and raising laying rate, its main component is:
Herba Artemisiae Annuae 3-4kg, Echinacea 3-4kg, Radix Bupleuri 3-4kg, artificial Calculus Bovis 0.03-0.04kg, Rhizoma Dryopteris Crassirhizomatis 2-3kg, Rhizoma Bistortae 2-3kg, Pericarpium Citri Reticulatae 1-2kg, Fructus Crataegi 1-2kg, Radix Glycyrrhizae 1-2kg, transfer factor solution 1-2kg, water solublity Bacillus coagulans 0.01-0.02kg and polyoxyl 40 hydrogenated castor oil 0.3-0.5kg;
Content of peptides >=the 1mg/g of described transfer factor solution
The activity of described water solublity Bacillus coagulans is 1,000 hundred million CFU/g.
Said medicine; preferably, its main component is: Herba Artemisiae Annuae 3kg, Echinacea 3kg, Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Rhizoma Bistortae 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.04kg, transfer factor solution 2kg, water solublity Bacillus coagulans 0.02k and polyoxyl 40 hydrogenated castor oil 0.3kg.Adopting under the prerequisite of identical preparation method, adopt the prepared medicine of this proportioning raw materials, more obvious to the raising of laying rate of chicken, especially there is more significantly raising to suffering from the laying rate of H5N2 bird flu hen.
Medicine of the present invention, can also contain addible excipient in the pharmacy procedure such as water, surfactant.
The present invention finds by research, Herba Artemisiae Annuae, Echinacea, transfer factor solution and water solublity Bacillus coagulans play very crucial effect in medicine of the present invention, the use of these four kinds of medicines just, the effect that makes medicine of the present invention have both treatment laying hen influenza simultaneously, improve laying rate.As well known to those skilled in the art, same prescription can adopt different preparation methoies to make Chinese medicine composition.And special preparation method of the present invention has more significantly effect to the raising of egg quality.
A preparation method for said medicine, comprises the steps:
(1) Echinacea, Rhizoma Dryopteris Crassirhizomatis, Rhizoma Bistortae, Fructus Crataegi and Radix Glycyrrhizae are extracted with Chinese medicine extracting tank, collect aqueous extract A;
(2) Herba Artemisiae Annuae, Radix Bupleuri and Pericarpium Citri Reticulatae extract with Chinese medicine extracting tank, collect respectively aqueous extract B and volatile oil;
(3) polyoxyl 40 hydrogenated castor oil is heated to 35-45 DEG C, adds volatile oil, stirring and dissolving;
(4), by aqueous extract A and aqueous extract B concentrating under reduced pressure, then add artificial Calculus Bovis, transfer factor solution, water solublity Bacillus coagulans and step (3) gained solution.
Above-mentioned preparation method, step (1), step (2), step (3) and step (4) all can adopt routine operation mode to complete.The present invention adopts concrete operations mode to be:
Step (1), Rhizoma Dryopteris Crassirhizomatis, Echinacea, Rhizoma Bistortae, Fructus Crataegi, Radix Glycyrrhizae are placed in Chinese medicine extracting tank, add 6-8 times of weight water, boil and extract 1 hour, collect extracting solution; Again add 6-8 times of weight water, boil and extract 1 hour, collect extracting solution; The extracting solution of twice is mixed, filter, obtain aqueous extract A;
Step (2), Herba Artemisiae Annuae, Pericarpium Citri Reticulatae and Radix Bupleuri, add 6-8 times of weight water, boils and extract 1h, collects respectively extracting solution and volatile oil; Again add 6-8 times of weight water, boil and extract 1 hour, collect respectively extracting solution and volatile oil; The extracting solution of twice is mixed, filter, obtain aqueous extract B; The volatile oil of twice is mixed to sealing to be deposited;
Step (3), is heated to 35-45 DEG C by polyoxyl 40 hydrogenated castor oil, adds volatile oil, stirring and dissolving;
Step (4), first, mixes aqueous extract A and aqueous extract B, and it is 1.1-1.2g/ml that liquid is evaporated to density, obtains concentrated solution; Secondly, add step (3) gained solution, artificial Calculus Bovis, transfer factor solution, water solublity Bacillus coagulans, dissolve and mix homogeneously.
beneficial effect:
1,, by Chinese medicine and transfer factor solution coupling, play the effect that improves laying hen immunity of organisms, improves laying hen influenza cure rate, supplements small molecule active albumen;
2,, by Chinese medicine and the coupling of water solublity Bacillus coagulans, play regulating intestinal canal flora structure, promote to search for food, promote the effect of absorption of nutrient ingredients;
3, polyoxyl 40 hydrogenated castor oil is mixed with traditional medicine volatile oil, play solubilization, volatile oil and Chinese medicine aqueous extract are fully mixed, performance synergism;
4, improve laying hen influenza preventive effect, reduce laying hen influenza sickness rate 22.5%, reduce mortality rate 6.1%;
5, solve and suffer from influenza laying rate of laying hen decline problem, within 12 days in advance, again recover to lay eggs peak, extend egg-laying peak.
Detailed description of the invention
embodiment 1
Prepare raw material: Herba Artemisiae Annuae 3kg, Echinacea 3kg, Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Rhizoma Bistortae 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.04kg, transfer factor solution 2kg(content of peptides >=1mg/g), water solublity Bacillus coagulans (1,000 hundred million CFU/g) 0.02kg, polyoxyl 40 hydrogenated castor oil 0.3kg;
Echinacea, Rhizoma Dryopteris Crassirhizomatis, Rhizoma Bistortae, Fructus Crataegi, Radix Glycyrrhizae are placed in to Chinese medicine extracting tank, add 70kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect extracting solution; And then add 70kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract A;
Herba Artemisiae Annuae, Radix Bupleuri and Pericarpium Citri Reticulatae are placed in to Chinese medicine extracting tank, add 50kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect respectively extracting solution and volatile oil; And then add 50kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract B; Volatile oil separately sealing is deposited;
Aqueous extract A and aqueous extract B are mixed, and being evaporated to density is 1.1-1.2g/ml, obtains concentrated solution;
Volatile oil is mixed by the weight ratio of 1:5 with polyoxyl 40 hydrogenated castor oil, and 35-45 DEG C of stirring makes mix homogeneously for 10 minutes, then mixes with concentrated solution, obtains Chinese medicine mixed liquor;
Chinese medicine mixed liquor is dissolved and mixed homogeneously with transfer factor solution, artificial Calculus Bovis, water-soluble Bacillus coagulans, obtain medicine of the present invention.
embodiment 2
Prepare raw material: Herba Artemisiae Annuae 4kg, Echinacea 4kg, Radix Bupleuri 4kg, Rhizoma Dryopteris Crassirhizomatis 3kg, Rhizoma Bistortae 3kg, Pericarpium Citri Reticulatae 2kg, Fructus Crataegi 2kg, Radix Glycyrrhizae 2kg, artificial Calculus Bovis 0.03kg, transfer factor solution 1kg(content of peptides >=1mg/g), water solublity Bacillus coagulans (1,000 hundred million CFU/g) 0.01kg, polyoxyl 40 hydrogenated castor oil 0.4kg;
Rhizoma Dryopteris Crassirhizomatis, Echinacea, Rhizoma Bistortae, Fructus Crataegi, Radix Glycyrrhizae are placed in to Chinese medicine extracting tank, add 70kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect extracting solution; And then add 70kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract A;
Herba Artemisiae Annuae, Radix Bupleuri and Pericarpium Citri Reticulatae are placed in to Chinese medicine extracting tank, add 50kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect respectively extracting solution and volatile oil; And then add 50kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract B; Volatile oil separately sealing is deposited;
Aqueous extract A and aqueous extract B are mixed, and being evaporated to density is 1.1-1.2g/ml, obtains concentrated solution;
Volatile oil is mixed by the weight ratio of 1:4 with polyoxyl 40 hydrogenated castor oil, and 35-45 DEG C of stirring makes mix homogeneously for 10 minutes, then mixes with concentrated solution, obtains Chinese medicine mixed liquor;
Chinese medicine mixed liquor is dissolved and mixed homogeneously with transfer factor solution, artificial Calculus Bovis, water-soluble Bacillus coagulans, obtain medicine of the present invention.
embodiment 3
Prepare raw material: Herba Artemisiae Annuae 3kg, Echinacea 3kg, Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Rhizoma Bistortae 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.02kg, transfer factor solution 1kg(content of peptides >=1mg/g), water solublity Bacillus coagulans (1,000 hundred million CFU/g) 0.01kg, polyoxyl 40 hydrogenated castor oil 0.5kg;
Rhizoma Dryopteris Crassirhizomatis, Echinacea, Rhizoma Bistortae, Fructus Crataegi, Radix Glycyrrhizae are placed in to Chinese medicine extracting tank, add 70kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect extracting solution; And then add 70kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract A;
Herba Artemisiae Annuae, Radix Bupleuri and Pericarpium Citri Reticulatae are placed in to Chinese medicine extracting tank, add 50kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect respectively extracting solution and volatile oil; And then add 50kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract B; Volatile oil separately sealing is deposited;
Aqueous extract A and aqueous extract B are mixed, and being evaporated to density is 1.1-1.2g/ml, obtains concentrated solution;
Volatile oil is mixed by the weight ratio of 1:4 with polyoxyl 40 hydrogenated castor oil, and 35-45 DEG C of stirring makes mix homogeneously for 10 minutes, then mixes with concentrated solution, obtains Chinese medicine mixed liquor;
Chinese medicine mixed liquor is dissolved and mixed homogeneously with transfer factor solution, artificial Calculus Bovis, water-soluble Bacillus coagulans, obtain medicine of the present invention.
embodiment 4
Prepare raw material: Herba Artemisiae Annuae 3kg, Echinacea 3kg, Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Rhizoma Bistortae 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.04kg, transfer factor solution 2kg(content of peptides >=1mg/g), water solublity Bacillus coagulans (1,000 hundred million CFU/g) 0.02kg, tween 80 is appropriate;
Rhizoma Dryopteris Crassirhizomatis, Echinacea, Rhizoma Bistortae, Fructus Crataegi, Radix Glycyrrhizae are placed in to Chinese medicine extracting tank, add 70kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect extracting solution; And then add 701kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract A;
Herba Artemisiae Annuae, Radix Bupleuri and Pericarpium Citri Reticulatae are placed in to Chinese medicine extracting tank, add 50kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect respectively extracting solution and volatile oil; And then add 50kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract B; Volatile oil separately sealing is deposited;
Aqueous extract A, aqueous extract B, volatile oil, spleen transfer factor lyophilized powder, artificial Calculus Bovis are mixed with tween 80, obtain water preparation; The weight ratio of volatile oil and tween 80 is 1:5.
comparative example 1
Prepare raw material: Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.03kg, polyoxyl 40 hydrogenated castor oil 0.3kg;
Rhizoma Dryopteris Crassirhizomatis, Fructus Crataegi, Radix Glycyrrhizae are placed in to Chinese medicine extracting tank, add 30kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect extracting solution; And then add 30kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract A;
Radix Bupleuri and Pericarpium Citri Reticulatae are placed in to Chinese medicine extracting tank, add 25kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect respectively extracting solution and volatile oil; And then add 25kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract B; Volatile oil separately sealing is deposited;
Volatile oil is mixed by the weight ratio of 1:5 with polyoxyl 40 hydrogenated castor oil, and 35-45 DEG C of stirring makes mix homogeneously in 10 minutes, obtains volatile oil solution; Then mix with aqueous extract A, aqueous extract B, obtain Chinese medicine mixed liquor;
Aqueous extract A, aqueous extract B, volatile oil solution are mixed with artificial Calculus Bovis, obtain tcm product.
comparative example 2
Prepare raw material: Herba Artemisiae Annuae 3kg, Echinacea 3kg, Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.03g, transfer factor solution 2kg(content of peptides >=1mg/g), water solublity Bacillus coagulans (1,000 hundred million CFU/g) 0.02kg, polyoxyl 40 hydrogenated castor oil 0.3kg;
Herba Artemisiae Annuae, Echinacea, Radix Bupleuri, Rhizoma Dryopteris Crassirhizomatis, Pericarpium Citri Reticulatae, Fructus Crataegi and Radix Glycyrrhizae are placed in to Chinese medicine extracting tank, add 120kg water, be heated to boiling, then keep fluidized state, extract 1 hour, collect extracting solution; And then add 120kg water, repeat said extracted operation; The extracting solution of twice collection is mixed, be aqueous extract;
Aqueous extract is mixed with artificial Calculus Bovis, transfer factor lyophilized powder, water solublity Bacillus coagulans (1,000 hundred million CFU/g) and polyoxyl 40 hydrogenated castor oil, obtain tcm product.
the test of pesticide effectiveness
1. prevention protection test
Subjects: breeding layer chicken field, 68 of Heze Prefectures, breed variety is the blue brown laying hen in sea, 120 to 220 ages in days, 3000 to 14000 of cultivation scales, cultivation total amount is 390,000;
Test period: in October, 2013 is to December;
Therapeutic regimen:
In the situation that original immune programme for children is constant, wherein,
Test 1 group: select at random 24 plants, amount to 15.1 ten thousand laying hens, use the medicine of the embodiment of the present invention 1, mixed drink, the every 1000ml of this product is watered 500kg, stops 4 days with 3 days, uses continuously 3 months;
Test 2 groups: select at random 22 plants, amount to 13.2 ten thousand laying hens, use the medicine of the embodiment of the present invention 4, mixed drink, the every 1000ml of this product is watered 500kg, stops 4 days with 3 days, uses continuously 3 months;
Matched group: remain 22 plants, 11.4 ten thousand laying hens, by label description regulation, are used the tcm product of other producer, use continuously 3 months.
Result of the test is in table 1,
Entirety death rate, the chicken number while referring to on-test deducts last day residue chicken difference of counting gained, and the chicken number during divided by on-test, is multiplied by 100%, to obtain final product;
Egg-laying peak average egg production, egg-laying peak refers generally to the time maintaining when laying rate is greater than 90%, and the average egg production of this test statistics 230-290 of each plant age in days, as egg-laying peak average egg production.
The prevention protection test result of table 1 the present invention to laying hen influenza
2. therapeutic test
Subjects: 323 ages in days, the blue brown laying hen in sea that raise in Laiwu City chicken farm,, influenza occurs by totally 7000, chicken mortality rate rises, spirit is depressed, fried hair, and feed intake declines, draw green excrement, cockscomb darkens and is partly lavender, the puffiness of the eyes, and laying rate declines, eggshell color is thin out, and abnormal-shape egg, husky shell egg, soft-shelled egg increase; Dead chicken is cutd open inspection and sees ovary diffuse hemorrhage, and yolk reddens, glandular stomach thelorrhagia, and pancreas edge is hemorrhage, and trachea ring-type is hemorrhage, fallopian tube adularescent mucus; Be defined as after diagnosing influenza; Test chicken is equally divided into 7 groups (wherein four groups is test group, and three groups is matched group), and every group of individuality do not have notable difference, adopts identical feeding manner under identical environment, has comparability;
Test period: continuous use 7-14 days, observes 45 days;
Test method:
Test group 1-4, the medicine of feeding embodiment 1-4 respectively, mixed drink, each set product is all watered the consumption of 250kg by every 1000ml, and point morning, evening are used for 2 times, coordinate ampicillin soluble powder to use simultaneously;
Matched group 1-2, the medicine of feeding comparative example 1 and 2 respectively, mixed drink, every 1000ml medicine is watered 250kg, and point morning, evening are used for 2 times, coordinate ampicillin soluble powder to use simultaneously;
Matched group 3, mixed drink uses the SHUANGHUANGLIAN KOUFUYE of preventing and treating influenza, every chicken medication every day 5ml, point morning, evening are used for 2 times, coordinate ampicillin soluble powder to use simultaneously;
Result of the test is as shown in table 2, table 3;
In table,
Mortality rate, refers to that medication rose in 14 days the same day, and every group of dead sum of laying hen, divided by 1000, is multiplied by 100%;
The course for the treatment of, refer to from morbidity and all return to normal level to feed intake, mortality rate, the needed time;
Search for food recovery time, refer to that average daily feed intake returns to health level, the required time;
Mortality rate recovery time, refer to that mortality rate returns to below 0.05%, the required time;
Egg product recovery time, refers to husky shell egg, abnormal-shape egg, soft-shelled egg ratio, returns to the required time of normal level;
Laying rate, refers to that the egg number on the same day is divided by chicken sum;
Laying rate recovery time, refer to that laying rate returns to be not less than 92.4%, required time;
Minimum laying rate, refers to that each group of laying hen is in minimum laying rate during one's sickness;
Laying rate before sick, the laying rate of this premorbid healthy chicken of plant, overall laying rate is 92.4%;
Table 2
；
Table 3
。
Claims (7)
1. a medicine of preventing and treating laying hen influenza and raising laying rate, is characterized in that, its main component is:
Herba Artemisiae Annuae 3-4kg, Echinacea 3-4kg, Radix Bupleuri 3-4kg, artificial Calculus Bovis 0.03-0.04kg, Rhizoma Dryopteris Crassirhizomatis 2-3kg, Rhizoma Bistortae 2-3kg, Pericarpium Citri Reticulatae 1-2kg, Fructus Crataegi 1-2kg, Radix Glycyrrhizae 1-2kg, transfer factor solution 1-2kg, water solublity Bacillus coagulans 0.01-0.02kg and polyoxyl 40 hydrogenated castor oil 0.3-0.5kg;
Content of peptides >=the 1mg/g of described transfer factor solution
The activity of described water solublity Bacillus coagulans is 1,000 hundred million CFU/g.
2. the medicine of stating according to claim 1; it is characterized in that, its main component is: Herba Artemisiae Annuae 3kg, Echinacea 3kg, Radix Bupleuri 3kg, Rhizoma Dryopteris Crassirhizomatis 2kg, Rhizoma Bistortae 2kg, Pericarpium Citri Reticulatae 1kg, Fructus Crataegi 1kg, Radix Glycyrrhizae 1kg, artificial Calculus Bovis 0.04kg, transfer factor solution 2kg, water solublity Bacillus coagulans 0.02k and polyoxyl 40 hydrogenated castor oil 0.3kg.
3. a preparation method for medicine described in claim 1 or 2, is characterized in that, comprises the steps:
(1) Echinacea, Rhizoma Dryopteris Crassirhizomatis, Rhizoma Bistortae, Fructus Crataegi and Radix Glycyrrhizae are extracted with Chinese medicine extracting tank, collect aqueous extract A;
(2) Herba Artemisiae Annuae, Radix Bupleuri and Pericarpium Citri Reticulatae extract with Chinese medicine extracting tank, collect respectively aqueous extract B and volatile oil;
(3) polyoxyl 40 hydrogenated castor oil is heated to 35-45 DEG C, adds volatile oil, stirring and dissolving;
(4), by aqueous extract A and aqueous extract B concentrating under reduced pressure, then add artificial Calculus Bovis, transfer factor solution, water solublity Bacillus coagulans and step (3) gained solution.
4. preparation method according to claim 3, is characterized in that, the concrete operations mode that step (1) adopts is:
Rhizoma Dryopteris Crassirhizomatis, Echinacea, Rhizoma Bistortae, Fructus Crataegi, Radix Glycyrrhizae are placed in Chinese medicine extracting tank, add 6-8 times of weight water, boil and extract 1 hour, collect extracting solution; Again add 6-8 times of weight water, boil and extract 1 hour, collect extracting solution; The extracting solution of twice is mixed, filter, obtain aqueous extract A.
5. preparation method according to claim 3, is characterized in that, the concrete operations mode that step (2) adopts is:
Herba Artemisiae Annuae, Pericarpium Citri Reticulatae and Radix Bupleuri, add 6-8 times of weight water, boils and extract 1h, collects respectively extracting solution and volatile oil; Again add 6-8 times of weight water, boil and extract 1 hour, collect respectively extracting solution and volatile oil; The extracting solution of twice is mixed, filter, obtain aqueous extract B; The volatile oil of twice is mixed to sealing to be deposited.
6. preparation method according to claim 3, is characterized in that, the concrete operations mode that step (3) adopts is:
Polyoxyl 40 hydrogenated castor oil is heated to 35-45 DEG C, adds volatile oil, stirring and dissolving.
7. preparation method according to claim 3, is characterized in that, the concrete operations mode that step (4) adopts is:
First, aqueous extract A and aqueous extract B are mixed, it is 1.1-1.2g/ml that liquid is evaporated to density, obtains concentrated solution; Secondly, add step (3) gained solution, artificial Calculus Bovis, transfer factor solution, water solublity Bacillus coagulans, dissolve and mix homogeneously.
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| CN105076898A (en) * | 2015-10-10 | 2015-11-25 | 江苏康威科技饲料有限公司 | Eco-nutritional compound feed for laying hens at egg-laying peak and preparation method of eco-nutritional compound feed |
| CN106344912A (en) * | 2016-08-26 | 2017-01-25 | 青岛润达生物科技有限公司 | Technique for compounding transfer factor and traditional Chinese medicine oral liquid |
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| CN101543262A (en) * | 2009-04-20 | 2009-09-30 | 邹振可 | Chinese medicinal herb additive for egg chickens and application |
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| CN105076898A (en) * | 2015-10-10 | 2015-11-25 | 江苏康威科技饲料有限公司 | Eco-nutritional compound feed for laying hens at egg-laying peak and preparation method of eco-nutritional compound feed |
| CN106344912A (en) * | 2016-08-26 | 2017-01-25 | 青岛润达生物科技有限公司 | Technique for compounding transfer factor and traditional Chinese medicine oral liquid |
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