CN104173235B - A kind of compound anti-acne preparations containing shale oil and preparation method thereof - Google Patents
A kind of compound anti-acne preparations containing shale oil and preparation method thereof Download PDFInfo
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- CN104173235B CN104173235B CN201410393007.4A CN201410393007A CN104173235B CN 104173235 B CN104173235 B CN 104173235B CN 201410393007 A CN201410393007 A CN 201410393007A CN 104173235 B CN104173235 B CN 104173235B
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Abstract
The invention discloses a kind of compound anti-acne preparations containing shale oil, including following components: deionized water, carbomer, hyaluronate sodium, Butyrospermum parkii fruit fatty oil, hydrogenated olive oil acid Octyl Nitrite, hydrogenated olive oil non-saponifiable matter, shale oil sulphonic acid ester sodium, Melaleuca alternifolia leaf oil, salicylic acid, arabic gum natural gum, hydrolysis chitin, nicotiamide, glycerol, butanediol, 1,2 pentanediols, xanthan gum, allantoin, EDETATE SODIUM, the smooth caprylate of Pyrusussuriensis, aminomethyl propanol.Provide the preparation method of the above-mentioned compound anti-acne preparations containing shale oil simultaneously.The present invention is not added with emulsifying agent, decrease the emulsifying agent zest to skin, use special preparation technology simultaneously, decrease strong electrolyte shale oil sulphonic acid ester sodium, salicylic acid for the impact in terms of formulation viscosity and stability, there is good anti-acne effect simultaneously.
Description
Technical field
The present invention relates to a kind of compound formulation, particularly relate to a kind of compound anti-acne preparations containing shale oil and preparation side thereof
Method, belongs to medicine, chemical industry and personal care articles industry.
Background technology
Acne is one of modal skin problem, and acne is comedo, is owing to hypersteatosis causes in a large number
Sebum pile up, pilosebaceous unit hinders, and grows offer favourable conditions for harmful bacterias such as propanoic acid Propiobacteriums, induction inflammation simultaneously
Disease, belongs to chronic inflammatory skin sick.Clinical manifestation is to be apt to occur in the pleomorphism skin lesion such as the acne of face, pimple, pustule as spy
Point.Acne is easily sent out in teenager, can negatively affect teen-age psychology and social generation significantly.
The main cause that acne is formed is that the level of androgen particularly testosterone in descendant's body that adolesces raises rapidly,
Promote that sebaceous gland is grown and produces a large amount of sebum.The dyskeratosis of pilosebaceous duct causes catheter blockage simultaneously, sebum by
Gradually swell toward cortical surface in removing barriers.Multiple-microorganism especially propionibacterium acnes amount reproduction, acne in hair follicle
The lipase that propionibacterium produces decomposes sebum and generates free fatty, and chemotactic inflammatory cell and medium, finally induce and add simultaneously
Hyperphlogosis reacts.Secondly, if skin is the driest, skin histology can the oils and fats of automatic supersecretion, cause skin oil-water unbalance,
Also acne can be induced.
How can more effectively and also the skin-protection product of acne-removing can be reached for a long time, be that current skin protection research field exists
A technical barrier.
Summary of the invention
The purpose of the present invention, it is simply that provide a kind of compound anti-acne preparations containing shale oil in order to solve the problems referred to above,
There is outstanding anti-acne effect there is high stable performance simultaneously.
Another object of the present invention also resides in the preparation side providing a kind of above-mentioned compound anti-acne preparations containing shale oil
Method.
The object of the present invention is achieved like this:
A kind of compound anti-acne preparations containing shale oil of the present invention, by weight, including following components:
Deionized water 60-80 part, carbomer 1.1-2.1 part, hyaluronate sodium 0.02-0.40 part, Butyrospermum parkii fruit fatty oil
0.6-6.0 part, hydrogenated olive oil acid Octyl Nitrite 0.5-3.5 part, hydrogenated olive oil non-saponifiable matter 0.05-0.45 part, shale oil
Sulphonic acid ester sodium 0.3-3.0 part, Melaleuca alternifolia leaf oil 1.2-4.2 part, salicylic acid 0.15-1.15 part, arabic gum natural gum
0.15-1.15 part, hydrolysis chitin 1.5-3.5 part, nicotiamide 2.4-5.4 part, glycerol 3.0-7.0 part, butanediol 3.0-8.0
Part, 1,2-pentanediol 1.5-4.5 part, xanthan gum 0.06-0.60 part, allantoin 0.07-0.70 part, EDETATE SODIUM 0.03-0.30
Part, Pyrusussuriensis smooth caprylate 0.5-3.5 part, aminomethyl propanol 0.01-0.06 part.
Said components is commercially available prod.
Present invention also offers the preparation method of a kind of compound anti-acne preparations containing shale oil as claimed in claim 1,
It is characterized in that, comprise the following steps:
(1) raw material is prepared according to following components and weight portion thereof: deionized water 60-80 part, carbomer 1.1-2.1 part, thoroughly
Bright matter acid sodium 0.02-0.40 part, Butyrospermum parkii fruit fatty oil 0.6-6.0 part, hydrogenated olive oil acid Octyl Nitrite 0.5-3.5 part, hydrogen
Change olive oil non-saponifiable matter 0.05-0.45 part, shale oil sulphonic acid ester sodium 0.3-3.0 part, Melaleuca alternifolia leaf oil 1.2-4.2
Part, salicylic acid 0.15-1.15 part, arabic gum natural gum 0.15-1.15 part, hydrolysis chitin 1.5-3.5 part, nicotiamide 2.4-
5.4 parts, glycerol 3.0-7.0 part, butanediol 3.0-8.0 part, 1,2-pentanediol 1.5-4.5 part, xanthan gum 0.06-0.60 part, urine
Bursin 0.07-0.70 part, EDETATE SODIUM 0.03-0.30 part, Pyrusussuriensis smooth caprylate 0.5-3.5 part, aminomethyl propanol 0.01-0.06
Part；
(2) 95% in deionized water gross weight and EDETATE SODIUM are joined in kettle, subsequently carbomer is spilt to water
Face, until carbomer after impregnation process is complete, opens and is stirred and heated to 75-80 DEG C, add hyaluronate sodium, dissolve completely
Rear addition allantoin and in advance with butanediol and glycerol dispersion after xanthan gum, prepare aqueous phase material be incubated 75-80 DEG C stand-by；
(3) by smooth pungent to Butyrospermum parkii fruit fatty oil, hydrogenated olive oil acid Octyl Nitrite, hydrogenated olive oil non-saponifiable matter, Pyrusussuriensis
Acid esters adds in oil cauldron, is heated to 75-80 DEG C, and rear miscible prepared oil phase material is stand-by；
(4) evacuation after emulsifying pot temperature being risen to 75-80 DEG C, utilize negative pressure first by 2/3 aqueous phase material suction emulsifying
Being stirred in Guo, then recycling negative pressure is by oil phase material suction emulsifying pot, last suction remaining aqueous phase material,
It is incubated homogenizing 10min at 75-80 DEG C, lowers the temperature subsequently；
(5), after being cooled to 45 DEG C, in advance with remaining deionized water dispersion hydrolysis chitin, emulsifying pot adds 1,2-
Pentanediol, nicotiamide and the most scattered hydrolysis chitin aqueous solution, stir 10min；Add aminomethyl propanol to carry out in advance
Neutralize, stir 5min；Add Melaleuca alternifolia leaf oil, shale oil sulphonic acid ester sodium, stir 5min；Detection material body after mix homogeneously
PH value, by aminomethyl propanol regulation pH value to adding salicylic acid and arabic gum natural gum after 6.0-8.0, stirring mixing is all
Even rear discharging.
The present invention select by France you draw in oil shale extract shale oil sulphonic acid ester sodium as main anti-acne composition, simultaneously
Compounding salicylic acid and Melaleuca alternifolia leaf oil.Shale oil sulphonic acid ester sodium has antibacterium, antiinflammatory, minimizing acne quantity, regulation
Sebaceous gland and the function of correction keratinization exception, can effectively treat acne.Melaleuca alternifolia leaf oil is commonly called as tea tree oil, many
Research report all it has been shown that tea tree oil has effect of antibacterial, antiviral and antiinflammatory.And salicylic acid becomes as conventional anti-acne
Point, its liposoluble characteristic, can by with liposome fusion by the way of, penetrate into horny layer and pore depths, be conducive to dissolving hair
The horny layer of old accumulation in hole, improves the situation that pore blocks.Be aided with nicotiamide again, hydrolysis chitin brings desalination pox print,
Effect of even skin tone.The present invention is not added with emulsifying agent, decreases the emulsifying agent zest to skin, uses special system simultaneously
Standby technique, decreases strong electrolyte shale oil sulphonic acid ester sodium, salicylic acid for the impact in terms of formulation viscosity and stability, with
Time there is good anti-acne effect.
In the compound anti-acne preparations of emulsifier-free, the strong electrolyte of anti-acne composition, skin protection oils and fats with stability are
Contradiction present in formula, in order to solve this technical problem, the present invention uses to be had the latest model of electrolyte-resistant effect and can oneself
Infiltration, swelling rapid card ripple homopolymer carbomer, as suspension stabilizer, are selected compatible good oils and fats simultaneously, are subtracted
It is difficult to the impact for stability of the oils and fats that is suspended less.Control the adding technology of strong electrolyte composition during low temperature, can add more
Many active component, ensure the stability of formula simultaneously.The present invention strengthens the general of formula while improving stability energy
Performance, brings outstanding acne-removing simultaneously.
Accompanying drawing explanation
Fig. 1 is long pox area skin oils and fats suppression ratio test result；
Fig. 2 is the radar map trying out test result for a long time.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1-5
In above-mentioned raw materials, deionized water (ion water making is for INSTRUMENT MODEL: DW 100, and safe)；Carbomer selects Lu Borun
Extraordinary chemical industry, trade name: Carbopol Ultrez 30；Hyaluronate sodium selects Bioland company of Korea S, trade name: Bio
Sodium Hyaluronate MMW；Butyrospermum parkii fruit fatty oil selects AAK company of Sweden, trade name: LIPEX SHEASOFT；Hydrogen
Change Fructus Canarii albi oleic acid Octyl Nitrite, hydrogenated olive oil non-saponifiable matter selects Ke Laien chemical company, trade name:
Olive LD；Shale oil sulphonic acid ester sodium selects Germany Ai Ke excellent, trade name:Melaleuca alternifolia leaf oil
Select Bronson&Jacobs company, trade name: Oil of Tea Tree；Salicylic acid, arabic gum natural gum select Germany's Bath
Husband company, trade name: BETA HYDROXYDE ACSD；Hydrolysis chitin selects YSK company, trade name: marine sweet
40；Nicotiamide selects Fan Telusi company, trade name: nicotiamide (pharmaceutical grade)；Glycerol selection section Ninghua work, trade name:
Glycerine 99.5%；Butanediol selects U.S. OXEA, trade name: 1,3 butylene glycol；1,2-pentanediol selects the fragrant public affairs of moral
Department, trade name:5；Rhodia selected by xanthan gum, trade name: RHODICARE H；Allantoin selection section
Lay grace chemical industry, trade name: Allantoin 400；EDETATE SODIUM selects Akzo Nobel, trade name: Dissolvine NA2；
The smooth caprylate of Pyrusussuriensis selects Ke Laien chemical industry, trade name: VELSON SC；Aminomethyl propanol selects Tao Shi chemical industry, trade name:
AMP-ULTRA PC 2000。
Embodiment 1-5 is prepared by following steps:
(1) 95% in deionized water gross weight and EDETATE SODIUM are joined in kettle, subsequently carbomer is spilt to water
Face, until carbomer after impregnation process is complete, opens and is stirred and heated to 75-80 DEG C, add hyaluronate sodium, dissolve completely
Rear addition allantoin and in advance with butanediol and glycerol dispersion after xanthan gum, prepare aqueous phase material be incubated 75-80 DEG C stand-by；
(2) by smooth pungent to Butyrospermum parkii fruit fatty oil, hydrogenated olive oil acid Octyl Nitrite, hydrogenated olive oil non-saponifiable matter, Pyrusussuriensis
Acid esters adds in oil cauldron, is heated to 75-80 DEG C, and rear miscible prepared oil phase material is stand-by；
(3) evacuation after emulsifying pot temperature being risen to 75-80 DEG C, utilize negative pressure first by 2/3 aqueous phase material suction emulsifying
Being stirred in Guo, then recycling negative pressure is by oil phase material suction emulsifying pot, last suction remaining aqueous phase material,
It is incubated homogenizing 10min at 75-80 DEG C, lowers the temperature subsequently；
(4), after being cooled to 45 DEG C, in advance with remaining deionized water dispersion hydrolysis chitin, emulsifying pot adds 1,2-
Pentanediol, nicotiamide and the most scattered hydrolysis chitin aqueous solution, stir 10min；Add aminomethyl propanol to carry out in advance
Neutralize, stir 5min；Add Melaleuca alternifolia leaf oil, shale oil sulphonic acid ester sodium, stir 5min；Detection material body after mix homogeneously
PH value, by adding salicylic acid and arabic gum natural gum after aminomethyl propanol (additionally add) regulation pH value to 6.0-8.0,
It is uniformly mixed rear discharging.
Embodiment 1 to 5 is carried out high/low temperature accelerated test (at-15 DEG C, at 5 DEG C and 49 DEG C, respectively test 30 days, 60 days
And 90 days), test result is as follows:
Result shows: anti-acne preparations of the present invention well stable grease and substantial amounts of active matter can include that strong electrolyte is dispelled
Pox composition, has excellent stability, can meet the demand of listing.
Embodiment 1 to 5 is tried out for a long time with commercially available product for resolving poxes.Test number is 30 people, and skin characteristic is oiliness
Skin, slight and moderate acne, test period is 28 days.Tester in the 0th day, the 7th day, the 14th day, the 28th day with Germany CK
The suppression ratio of company's MC900 skin evaluation center Instrument measuring long pox area skin oils and fats, test result is as it is shown in figure 1, simultaneously
Tester needs self assessment anti-acne antiinflammatory situation, skin to improve situation, use impression.Test result is as shown in following table and Fig. 2:
Test result shows: anti-acne and sebum are reduced effect and be better than city by the present invention compound anti-acne preparations containing shale oil
Selling product for resolving poxes, the most long-term trial effect is also substantially better than commercially available product for resolving poxes, especially eliminates in acne, skin is glossy subtracts
Less, pore shrinks, uses comfort aspect.
Above example is used for illustrative purposes only, rather than limitation of the present invention, about the technology people of technical field
Member, without departing from the spirit and scope of the present invention, it is also possible to make various conversion or modification, the most all equivalents
Technical scheme also should belong to scope of the invention, should be limited by each claim.
Claims (2)
1. the compound anti-acne preparations containing shale oil, it is characterised in that by weight, composed of the following components,
Deionized water 60-80 part, carbomer 1.1-2.1 part, hyaluronate sodium 0.02-0.40 part, Butyrospermum parkii fruit fatty oil 0.6-
6.0 parts, hydrogenated olive oil acid Octyl Nitrite 0.5-3.5 part, hydrogenated olive oil non-saponifiable matter 0.05-0.45 part, shale oil sulfonic acid
Ester sodium 0.3-3.0 part, Melaleuca alternifolia leaf oil 1.2-4.2 part, salicylic acid 0.15-1.15 part, Radix Acaciae senegalis 0.15-1.15
Part, hydrolysis chitin 1.5-3.5 part, nicotiamide 2.4-5.4 part, glycerol 3.0-7.0 part, butanediol 3.0-8.0 part, 1,2-penta 2
Alcohol 1.5-4.5 part, xanthan gum 0.06-0.60 part, allantoin 0.07-0.70 part, EDETATE SODIUM 0.03-0.30 part, Pyrusussuriensis are smooth pungent
Acid esters 0.5-3.5 part, aminomethyl propanol 0.01-0.06 part.
2. the preparation method of an as claimed in claim 1 compound anti-acne preparations containing shale oil, it is characterised in that include with
Lower step:
(1) according to following components and weight portion preparation raw material thereof: deionized water 60-80 part, carbomer 1.1-2.1 part, hyalomitome
Acid sodium 0.02-0.40 part, Butyrospermum parkii fruit fatty oil 0.6-6.0 part, hydrogenated olive oil acid Octyl Nitrite 0.5-3.5 part, hydrogenation olive
Olive oil non-saponifiable matter 0.05-0.45 part, shale oil sulphonic acid ester sodium 0.3-3.0 part, Melaleuca alternifolia leaf oil 1.2-4.2 part, water
Poplar acid 0.15-1.15 part, Radix Acaciae senegalis 0.15-1.15 part, hydrolysis chitin 1.5-3.5 part, nicotiamide 2.4-5.4 part, sweet
Oil 3.0-7.0 part, butanediol 3.0-8.0 part, 1,2-pentanediol 1.5-4.5 part, xanthan gum 0.06-0.60 part, allantoin 0.07-
0.70 part, EDETATE SODIUM 0.03-0.30 part, Pyrusussuriensis smooth caprylate 0.5-3.5 part, aminomethyl propanol 0.01-0.06 part；
(2) 95% in deionized water gross weight and EDETATE SODIUM are joined in kettle, subsequently carbomer is spilt to the water surface, treat
Carbomer, after impregnation process is complete, is opened and is stirred and heated to 75-80 DEG C, adds hyaluronate sodium, adds after dissolving completely
Enter allantoin and in advance with the xanthan gum after butanediol and glycerol dispersion, prepare aqueous phase material insulation 75-80 DEG C stand-by；
(3) by Butyrospermum parkii fruit fatty oil, hydrogenated olive oil acid Octyl Nitrite, hydrogenated olive oil non-saponifiable matter, the smooth caprylate of Pyrusussuriensis
Adding in oil cauldron, be heated to 75-80 DEG C, rear miscible prepared oil phase material is stand-by；
(4) evacuation after emulsifying pot temperature being risen to 75-80 DEG C, utilizes negative pressure first by the aqueous phase material suction emulsifying pot of 2/3
Being stirred, then recycling negative pressure is by oil phase material suction emulsifying pot, and last suction remaining aqueous phase material, at 75-80
It is incubated homogenizing 10min at DEG C, lowers the temperature subsequently；
(5), after being cooled to 45 DEG C, in advance with remaining deionized water dispersion hydrolysis chitin, emulsifying pot adds 1,2-penta 2
Alcohol, nicotiamide and the most scattered hydrolysis chitin aqueous solution, stir 10min；Add aminomethyl propanol and carry out pre-neutralized,
Stirring 5min；Add Melaleuca alternifolia leaf oil, shale oil sulphonic acid ester sodium, stir 5min；The pH of detection material body after mix homogeneously
Value, adds salicylic acid and Radix Acaciae senegalis by aminomethyl propanol regulation pH value to 6.0-8.0, goes out after being uniformly mixed
Material.
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| CN105411880B (en) * | 2015-12-11 | 2019-03-29 | 广东龙湖科技股份有限公司 | A kind of mild makeup removing breast and preparation method thereof without emulsifier |
| CN106389220A (en) * | 2016-11-10 | 2017-02-15 | 喻时 | Essence for removing acnes and preparation method thereof |
| CN107157881B (en) * | 2017-05-26 | 2020-08-07 | 广州鹰远生物科技有限公司 | Composition with acne removing effect and cosmetic |
| CN109771330A (en) * | 2019-03-12 | 2019-05-21 | 中美杜克(广州)护肤研究中心(普通合伙) | A kind of oil-control is antibacterial, pore cleanser, skin care item for restraining pore and preparation method thereof |
| CN111514083A (en) * | 2020-05-14 | 2020-08-11 | 珠海越美科技有限公司 | Powerful acne-removing skin-care cosmetic and preparation method thereof |
| CN113546011A (en) * | 2021-02-26 | 2021-10-26 | 云南柏脉生物科技有限公司昆明分公司 | Compound acne-removing preparation containing tanshinone and preparation method thereof |
| CN114288229A (en) * | 2022-01-07 | 2022-04-08 | 广州市渝崧精细化工有限公司 | Acne-removing composition and preparation method and application thereof |
| CN114344218B (en) * | 2022-01-25 | 2022-12-02 | 康柏利科技（苏州）有限公司 | Acne-removing emulsion and preparation method thereof |
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| CN102283792B (en) * | 2011-08-24 | 2013-01-16 | 迪特克(济源)绿色生物科技有限公司 | Natural anti-acne cream |
| CN102940589A (en) * | 2012-11-19 | 2013-02-27 | 山东华琦澳雪药物科技有限公司 | Infant hip protection gel |
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