CN104169279A - (1r,4r) 7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物 - Google Patents

(1r,4r) 7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物 Download PDF

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Publication number
CN104169279A
CN104169279A CN201380004353.2A CN201380004353A CN104169279A CN 104169279 A CN104169279 A CN 104169279A CN 201380004353 A CN201380004353 A CN 201380004353A CN 104169279 A CN104169279 A CN 104169279A
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CN
China
Prior art keywords
radical
group
alkyl
cycloalkyl
alkynyl
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Pending
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CN201380004353.2A
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English (en)
Chinese (zh)
Inventor
罗伯特·M·莫里亚蒂
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DemeRx Inc
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DemeRx Inc
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Publication date
Application filed by DemeRx Inc filed Critical DemeRx Inc
Priority to CN201810010846.1A priority Critical patent/CN108912117A/zh
Publication of CN104169279A publication Critical patent/CN104169279A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201380004353.2A 2012-01-25 2013-01-23 (1r,4r) 7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物 Pending CN104169279A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810010846.1A CN108912117A (zh) 2012-01-25 2013-01-23 (1r,4r)7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261741798P 2012-01-25 2012-01-25
US61/741,798 2012-01-25
PCT/US2013/022797 WO2013112622A1 (en) 2012-01-25 2013-01-23 (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810010846.1A Division CN108912117A (zh) 2012-01-25 2013-01-23 (1r,4r)7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物

Publications (1)

Publication Number Publication Date
CN104169279A true CN104169279A (zh) 2014-11-26

Family

ID=48873876

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380004353.2A Pending CN104169279A (zh) 2012-01-25 2013-01-23 (1r,4r) 7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物
CN201810010846.1A Pending CN108912117A (zh) 2012-01-25 2013-01-23 (1r,4r)7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810010846.1A Pending CN108912117A (zh) 2012-01-25 2013-01-23 (1r,4r)7-氧代-2-氮杂双环[2.2.2]辛-5-烯及其衍生物

Country Status (11)

Country Link
US (2) US20130267710A1 (enExample)
EP (1) EP2807158A4 (enExample)
JP (1) JP2015506371A (enExample)
KR (1) KR20140117380A (enExample)
CN (2) CN104169279A (enExample)
AU (1) AU2013212209A1 (enExample)
CA (1) CA2857969A1 (enExample)
HK (1) HK1204615A1 (enExample)
IL (1) IL233055A (enExample)
RU (1) RU2014124531A (enExample)
WO (1) WO2013112622A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014143201A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
WO2016086194A1 (en) 2014-11-26 2016-06-02 Demerx, Inc. Methods and compositions for potentiating the action of opioid analgesics using iboga alkaloids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821371A (en) * 1994-10-24 1998-10-13 Eli Lilly And Comany Heterocyclic compounds and their preparation and use
FR2884516B1 (fr) * 2005-04-15 2007-06-22 Cerep Sa Antagonistes npy, preparation et utilisations
JP2010229097A (ja) * 2009-03-27 2010-10-14 Tohoku Univ 新規オキサゾリジン誘導体及び新規オキサゾリジン誘導体塩、並びに該オキサゾリジン誘導体塩を不斉有機分子触媒とした光学活性化合物の製造方法
JP5622019B2 (ja) * 2009-09-25 2014-11-12 国立大学法人東北大学 アミノアルコール誘導体塩構造を有する不斉有機分子触媒及び該不斉有機分子触媒を用いた光学活性化合物の製造方法
US9988377B2 (en) * 2011-08-24 2018-06-05 The Trustees Of Columbia University In The City Of New York Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EDWARD J. HENNESSY等: "Discovery of aminopiperidine-based Smac mimetics as IAP antagonists", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *
LIONEL MOISAN,等: "Formal Synthesis of (+)-Catharanthine", 《ANGEW. CHEM. INT. ED.》 *

Also Published As

Publication number Publication date
RU2014124531A (ru) 2016-04-10
AU2013212209A1 (en) 2014-06-26
EP2807158A1 (en) 2014-12-03
JP2015506371A (ja) 2015-03-02
IL233055A (en) 2017-02-28
US20130267710A1 (en) 2013-10-10
WO2013112622A1 (en) 2013-08-01
US20180319800A1 (en) 2018-11-08
IL233055A0 (en) 2014-08-03
AU2013212209A8 (en) 2014-07-10
CN108912117A (zh) 2018-11-30
HK1204615A1 (en) 2015-11-27
EP2807158A4 (en) 2015-11-18
CA2857969A1 (en) 2013-08-01
KR20140117380A (ko) 2014-10-07

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Application publication date: 20141126

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