JP2015506371A - （１ｒ，４ｒ）７−オキソ−２−アザビシクロ［２．２．２］オクタ−５−エンおよびその誘導体 - Google Patents

（１ｒ，４ｒ）７−オキソ−２−アザビシクロ［２．２．２］オクタ−５−エンおよびその誘導体 Download PDF

Info

Publication number
JP2015506371A
JP2015506371A JP2014554804A JP2014554804A JP2015506371A JP 2015506371 A JP2015506371 A JP 2015506371A JP 2014554804 A JP2014554804 A JP 2014554804A JP 2014554804 A JP2014554804 A JP 2014554804A JP 2015506371 A JP2015506371 A JP 2015506371A
Authority
JP
Japan
Prior art keywords
group
aryl
alkyl
heteroaryl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014554804A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015506371A5 (enExample
Inventor
モリアーティー，ロバート，エム．
Original Assignee
デメルクス，インコーポレイテッド
モリアーティ，ロバート エム．
モリアーティ，ロバート エム．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デメルクス，インコーポレイテッド, モリアーティ，ロバート エム．, モリアーティ，ロバート エム． filed Critical デメルクス，インコーポレイテッド
Publication of JP2015506371A publication Critical patent/JP2015506371A/ja
Publication of JP2015506371A5 publication Critical patent/JP2015506371A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2014554804A 2012-01-25 2013-01-23 （１ｒ，４ｒ）７−オキソ−２−アザビシクロ［２．２．２］オクタ−５−エンおよびその誘導体 Pending JP2015506371A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261741798P 2012-01-25 2012-01-25
US61/741,798 2012-01-25
PCT/US2013/022797 WO2013112622A1 (en) 2012-01-25 2013-01-23 (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof

Publications (2)

Publication Number Publication Date
JP2015506371A true JP2015506371A (ja) 2015-03-02
JP2015506371A5 JP2015506371A5 (enExample) 2016-03-17

Family

ID=48873876

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014554804A Pending JP2015506371A (ja) 2012-01-25 2013-01-23 （１ｒ，４ｒ）７−オキソ−２−アザビシクロ［２．２．２］オクタ−５−エンおよびその誘導体

Country Status (11)

Country Link
US (2) US20130267710A1 (enExample)
EP (1) EP2807158A4 (enExample)
JP (1) JP2015506371A (enExample)
KR (1) KR20140117380A (enExample)
CN (2) CN108912117A (enExample)
AU (1) AU2013212209A1 (enExample)
CA (1) CA2857969A1 (enExample)
HK (1) HK1204615A1 (enExample)
IL (1) IL233055A (enExample)
RU (1) RU2014124531A (enExample)
WO (1) WO2013112622A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2942638C (en) 2013-03-15 2026-03-10 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
ES2867174T3 (es) 2014-11-26 2021-10-20 Demerx Inc Métodos y composiciones para potenciar la acción de analgésicos opioides mediante el uso de alcaloides de iboga

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08225575A (ja) * 1994-10-24 1996-09-03 Eli Lilly & Co ヘテロ環化合物およびその製造法および使用法
JP2010229097A (ja) * 2009-03-27 2010-10-14 Tohoku Univ 新規オキサゾリジン誘導体及び新規オキサゾリジン誘導体塩、並びに該オキサゾリジン誘導体塩を不斉有機分子触媒とした光学活性化合物の製造方法
JP2011068587A (ja) * 2009-09-25 2011-04-07 Tohoku Univ 新規アミノアルコール誘導体塩、アミノアルコール誘導体塩構造を有する不斉有機分子触媒及び該不斉有機分子触媒を用いた光学活性化合物の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2884516B1 (fr) * 2005-04-15 2007-06-22 Cerep Sa Antagonistes npy, preparation et utilisations
US9988377B2 (en) * 2011-08-24 2018-06-05 The Trustees Of Columbia University In The City Of New York Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08225575A (ja) * 1994-10-24 1996-09-03 Eli Lilly & Co ヘテロ環化合物およびその製造法および使用法
JP2010229097A (ja) * 2009-03-27 2010-10-14 Tohoku Univ 新規オキサゾリジン誘導体及び新規オキサゾリジン誘導体塩、並びに該オキサゾリジン誘導体塩を不斉有機分子触媒とした光学活性化合物の製造方法
JP2011068587A (ja) * 2009-09-25 2011-04-07 Tohoku Univ 新規アミノアルコール誘導体塩、アミノアルコール誘導体塩構造を有する不斉有機分子触媒及び該不斉有機分子触媒を用いた光学活性化合物の製造方法

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BAXTER, E. W. ET AL, J. AM. CHEM. SOC., vol. 112, JPN7016002357, 1990, pages 7682 - 7692, ISSN: 0003377932 *
BAXTER, E. W. ET AL, J. ORG. CHEM., vol. 54, JPN6016030736, 1989, pages 2893 - 2904, ISSN: 0003377929 *
HODGSON, D. M. ET AL, ORGANIC LETTERS, vol. 7, no. 11, JPN6016030729, 2005, pages 2221 - 2224, ISSN: 0003377930 *
KROW, G. R. ET AL, J. ORG. CHEM., vol. 53, JPN7016002359, 1988, pages 2258 - 2262, ISSN: 0003377934 *
MEHMANDOUST, M. ET AL, TETRAHEDRON LETTERS, vol. 29, no. 35, JPN7016002358, 1988, pages 4423 - 4426, ISSN: 0003377933 *
MOISAN, L. ET AL, ANGEW. CHEM. INT. ED., vol. 45, JPN6016030726, 2006, pages 5334 - 5336, ISSN: 0003377927 *
NAKANO, H. ET AL, CHEM. COMMUN., vol. 46, JPN6016030728, 2010, pages 4827 - 4829, ISSN: 0003377928 *
SUTTIBUT, C. ET AL, TETRAHEDRON LETTERS, vol. 52, JPN6016030732, 2011, pages 4745 - 4748, ISSN: 0003377931 *

Also Published As

Publication number Publication date
US20180319800A1 (en) 2018-11-08
EP2807158A4 (en) 2015-11-18
AU2013212209A8 (en) 2014-07-10
KR20140117380A (ko) 2014-10-07
EP2807158A1 (en) 2014-12-03
AU2013212209A1 (en) 2014-06-26
RU2014124531A (ru) 2016-04-10
IL233055A0 (en) 2014-08-03
WO2013112622A1 (en) 2013-08-01
CA2857969A1 (en) 2013-08-01
HK1204615A1 (en) 2015-11-27
CN104169279A (zh) 2014-11-26
US20130267710A1 (en) 2013-10-10
IL233055A (en) 2017-02-28
CN108912117A (zh) 2018-11-30

Similar Documents

Publication Publication Date Title
US20180319800A1 (en) (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof
Felpin et al. Recent advances in the total synthesis of piperidine and pyrrolidine natural alkaloids with ring‐closing metathesis as a key step
Bott et al. Preparation and synthetic applications of azetidines
EP1005465A2 (de) Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
Crumbie et al. . alpha.-Nitro ketones and esters from acylimidazoles
WO2004033462A2 (en) METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS
EP2184283A1 (en) Process for preparing compounds useful as intermediates for the preparation of modulators of chemokine receptor activity
US9216977B2 (en) Antofine and cryptopleurine derivatives as anticancer agents
HUP9903583A2 (hu) Eljárás 2-azadihidroxi-biciklo[2.2.1]heptán vegyületek és ezek L-borkősav-sói előállítására
WO2015195673A2 (en) Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
JP2008530144A (ja) リネゾリド中間体の結晶フォーム
EP3227306B1 (en) Process for the preparation of tert-butyl 4-((2s,5r)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof
Mizutani et al. A formal synthesis of a muscarinic M1 receptor antagonist,(-)-TAN1251A
Obydennov et al. Synthesis of 4-oxothiazolidine-2, 5-diylidenes containing thioamide group based on dithiomalonamides
US7285686B2 (en) Process for the preparation of 1,3-substituted indenes
Chiacchio et al. Recent advances in the synthesis of isoxazolidines
JP6841453B2 (ja) ３−ピロリジンカルボン酸誘導体の簡便な調製方法
Cadwallader Epimeric L-Proline Derived Imidazolone Chiral Auxiliaries for the Stereoselective Alkylative Birch Reduction of Aromatic Esters and Benzonitriles
CA2591330A1 (en) 1, 2, 3, 3a, 8, 8a-hexahydro-2, 7a-diada-cyclopenta [a] inden-7-one derivatives which bind to neuronal nicotinic acetylcholine specific receptor sites and are useful in modulatingcholinergic function and in the treatment of addictive disorders
Ma Synthetic Studies Towards the Spirocyclic Imine Moiety of Cyclic Imine Marine Toxins
KR100743256B1 (ko) 6-바이닐라이덴-헥사하이드로-파이롤리진-3-온 유도체 및그의 제조방법
EP4540239A1 (en) Chiral synthesis of nornicotine and nicotine
Lu Lewis acid-mediated alkylations of N, O-acetals and applications to the total syntheses of alkaloids
Carlson Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis
Chellat Studies Toward the Total Synthesis and Structure Determination of Leiodelide A

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160120

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20160120

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160120

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160810

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160816

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161102

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170111

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170411