HK1204615A1 - (1r,4r)7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof (1r4r)7--2-[222]-5- - Google Patents

(1r,4r)7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof (1r4r)7--2-[222]-5-

Info

Publication number
HK1204615A1
HK1204615A1 HK15105207.1A HK15105207A HK1204615A1 HK 1204615 A1 HK1204615 A1 HK 1204615A1 HK 15105207 A HK15105207 A HK 15105207A HK 1204615 A1 HK1204615 A1 HK 1204615A1
Authority
HK
Hong Kong
Prior art keywords
azabicyclo
ene
oxo
oct
derivatives
Prior art date
Application number
HK15105207.1A
Other languages
English (en)
Chinese (zh)
Inventor
Robert M Moriarty
Original Assignee
Demerx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Demerx Inc filed Critical Demerx Inc
Publication of HK1204615A1 publication Critical patent/HK1204615A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK15105207.1A 2012-01-25 2015-06-01 (1r,4r)7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof (1r4r)7--2-[222]-5- HK1204615A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261741798P 2012-01-25 2012-01-25
PCT/US2013/022797 WO2013112622A1 (en) 2012-01-25 2013-01-23 (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof

Publications (1)

Publication Number Publication Date
HK1204615A1 true HK1204615A1 (en) 2015-11-27

Family

ID=48873876

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105207.1A HK1204615A1 (en) 2012-01-25 2015-06-01 (1r,4r)7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof (1r4r)7--2-[222]-5-

Country Status (11)

Country Link
US (2) US20130267710A1 (xx)
EP (1) EP2807158A4 (xx)
JP (1) JP2015506371A (xx)
KR (1) KR20140117380A (xx)
CN (2) CN108912117A (xx)
AU (1) AU2013212209A1 (xx)
CA (1) CA2857969A1 (xx)
HK (1) HK1204615A1 (xx)
IL (1) IL233055A (xx)
RU (1) RU2014124531A (xx)
WO (1) WO2013112622A1 (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014143201A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
WO2015195673A2 (en) * 2014-06-18 2015-12-23 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
EP4279134A1 (en) 2014-11-26 2023-11-22 DemeRx, Inc. Methods and compostions for potentiating the action of opioid analgesics using iboga alkaloids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672709A (en) * 1994-10-24 1997-09-30 Eli Lilly And Company Heterocyclic compounds and their preparation and use
FR2884516B1 (fr) * 2005-04-15 2007-06-22 Cerep Sa Antagonistes npy, preparation et utilisations
JP2010229097A (ja) * 2009-03-27 2010-10-14 Tohoku Univ 新規オキサゾリジン誘導体及び新規オキサゾリジン誘導体塩、並びに該オキサゾリジン誘導体塩を不斉有機分子触媒とした光学活性化合物の製造方法
JP5622019B2 (ja) * 2009-09-25 2014-11-12 国立大学法人東北大学 アミノアルコール誘導体塩構造を有する不斉有機分子触媒及び該不斉有機分子触媒を用いた光学活性化合物の製造方法
WO2013028999A1 (en) * 2011-08-24 2013-02-28 The Trustees Of Columbia University In The City Of New York Small molecule inducers of gdnf as potential new therapeutics for neuropsychiatric disorders

Also Published As

Publication number Publication date
KR20140117380A (ko) 2014-10-07
CN104169279A (zh) 2014-11-26
CN108912117A (zh) 2018-11-30
AU2013212209A1 (en) 2014-06-26
US20180319800A1 (en) 2018-11-08
AU2013212209A8 (en) 2014-07-10
US20130267710A1 (en) 2013-10-10
CA2857969A1 (en) 2013-08-01
IL233055A (en) 2017-02-28
WO2013112622A1 (en) 2013-08-01
IL233055A0 (en) 2014-08-03
JP2015506371A (ja) 2015-03-02
RU2014124531A (ru) 2016-04-10
EP2807158A4 (en) 2015-11-18
EP2807158A1 (en) 2014-12-03

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