RU2014124531A - (1r,4r) 7-оксо-2-азабицикло[2.2.2]окт-5-ен и его производные - Google Patents
(1r,4r) 7-оксо-2-азабицикло[2.2.2]окт-5-ен и его производные Download PDFInfo
- Publication number
- RU2014124531A RU2014124531A RU2014124531A RU2014124531A RU2014124531A RU 2014124531 A RU2014124531 A RU 2014124531A RU 2014124531 A RU2014124531 A RU 2014124531A RU 2014124531 A RU2014124531 A RU 2014124531A RU 2014124531 A RU2014124531 A RU 2014124531A
- Authority
- RU
- Russia
- Prior art keywords
- group
- heteroaryl
- heterocyclyl
- aryl
- cycloalkyl
- Prior art date
Links
- -1 Ci-Cialkoxy Chemical group 0.000 claims abstract 35
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 25
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 24
- 125000001424 substituent group Chemical group 0.000 claims abstract 20
- 229910052736 halogen Inorganic materials 0.000 claims abstract 18
- 150000002367 halogens Chemical class 0.000 claims abstract 18
- 125000004185 ester group Chemical group 0.000 claims abstract 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 17
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 16
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 16
- 239000001257 hydrogen Substances 0.000 claims abstract 16
- 150000001875 compounds Chemical class 0.000 claims abstract 14
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims abstract 14
- 229910052799 carbon Inorganic materials 0.000 claims abstract 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 12
- 150000003839 salts Chemical class 0.000 claims abstract 6
- 150000001412 amines Chemical class 0.000 claims abstract 5
- 125000004122 cyclic group Chemical group 0.000 claims abstract 5
- 125000006239 protecting group Chemical group 0.000 claims abstract 5
- 229930194542 Keto Natural products 0.000 claims abstract 4
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 4
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 4
- 125000000468 ketone group Chemical group 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
- 150000002576 ketones Chemical class 0.000 claims abstract 3
- 239000002262 Schiff base Substances 0.000 claims abstract 2
- 150000004753 Schiff bases Chemical class 0.000 claims abstract 2
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims 22
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 16
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 13
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 13
- GBXQPDCOMJJCMJ-UHFFFAOYSA-M trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;bromide Chemical compound [Br-].C[N+](C)(C)CCCCCC[N+](C)(C)C GBXQPDCOMJJCMJ-UHFFFAOYSA-M 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000006242 amine protecting group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 238000005865 alkene metathesis reaction Methods 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261741798P | 2012-01-25 | 2012-01-25 | |
| US61/741,798 | 2012-01-25 | ||
| PCT/US2013/022797 WO2013112622A1 (en) | 2012-01-25 | 2013-01-23 | (1r,4r) 7-oxo-2-azabicyclo[2.2.2]oct-5-ene and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014124531A true RU2014124531A (ru) | 2016-04-10 |
Family
ID=48873876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014124531A RU2014124531A (ru) | 2012-01-25 | 2013-01-23 | (1r,4r) 7-оксо-2-азабицикло[2.2.2]окт-5-ен и его производные |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130267710A1 (enExample) |
| EP (1) | EP2807158A4 (enExample) |
| JP (1) | JP2015506371A (enExample) |
| KR (1) | KR20140117380A (enExample) |
| CN (2) | CN108912117A (enExample) |
| AU (1) | AU2013212209A1 (enExample) |
| CA (1) | CA2857969A1 (enExample) |
| HK (1) | HK1204615A1 (enExample) |
| IL (1) | IL233055A (enExample) |
| RU (1) | RU2014124531A (enExample) |
| WO (1) | WO2013112622A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2942638C (en) | 2013-03-15 | 2026-03-10 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| US9550789B2 (en) | 2014-06-18 | 2017-01-24 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| ES2867174T3 (es) | 2014-11-26 | 2021-10-20 | Demerx Inc | Métodos y composiciones para potenciar la acción de analgésicos opioides mediante el uso de alcaloides de iboga |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5821371A (en) * | 1994-10-24 | 1998-10-13 | Eli Lilly And Comany | Heterocyclic compounds and their preparation and use |
| FR2884516B1 (fr) * | 2005-04-15 | 2007-06-22 | Cerep Sa | Antagonistes npy, preparation et utilisations |
| JP2010229097A (ja) * | 2009-03-27 | 2010-10-14 | Tohoku Univ | 新規オキサゾリジン誘導体及び新規オキサゾリジン誘導体塩、並びに該オキサゾリジン誘導体塩を不斉有機分子触媒とした光学活性化合物の製造方法 |
| JP5622019B2 (ja) * | 2009-09-25 | 2014-11-12 | 国立大学法人東北大学 | アミノアルコール誘導体塩構造を有する不斉有機分子触媒及び該不斉有機分子触媒を用いた光学活性化合物の製造方法 |
| US9988377B2 (en) * | 2011-08-24 | 2018-06-05 | The Trustees Of Columbia University In The City Of New York | Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders |
-
2013
- 2013-01-23 JP JP2014554804A patent/JP2015506371A/ja active Pending
- 2013-01-23 CA CA2857969A patent/CA2857969A1/en not_active Abandoned
- 2013-01-23 RU RU2014124531A patent/RU2014124531A/ru not_active Application Discontinuation
- 2013-01-23 HK HK15105207.1A patent/HK1204615A1/xx unknown
- 2013-01-23 WO PCT/US2013/022797 patent/WO2013112622A1/en not_active Ceased
- 2013-01-23 KR KR1020147018193A patent/KR20140117380A/ko not_active Withdrawn
- 2013-01-23 AU AU2013212209A patent/AU2013212209A1/en not_active Abandoned
- 2013-01-23 EP EP13741387.8A patent/EP2807158A4/en not_active Withdrawn
- 2013-01-23 CN CN201810010846.1A patent/CN108912117A/zh active Pending
- 2013-01-23 CN CN201380004353.2A patent/CN104169279A/zh active Pending
- 2013-01-24 US US13/749,592 patent/US20130267710A1/en not_active Abandoned
-
2014
- 2014-06-10 IL IL233055A patent/IL233055A/en active IP Right Grant
-
2017
- 2017-11-13 US US15/811,549 patent/US20180319800A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180319800A1 (en) | 2018-11-08 |
| EP2807158A4 (en) | 2015-11-18 |
| AU2013212209A8 (en) | 2014-07-10 |
| KR20140117380A (ko) | 2014-10-07 |
| EP2807158A1 (en) | 2014-12-03 |
| JP2015506371A (ja) | 2015-03-02 |
| AU2013212209A1 (en) | 2014-06-26 |
| IL233055A0 (en) | 2014-08-03 |
| WO2013112622A1 (en) | 2013-08-01 |
| CA2857969A1 (en) | 2013-08-01 |
| HK1204615A1 (en) | 2015-11-27 |
| CN104169279A (zh) | 2014-11-26 |
| US20130267710A1 (en) | 2013-10-10 |
| IL233055A (en) | 2017-02-28 |
| CN108912117A (zh) | 2018-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180830 |