CN104159607A - 用于治疗致癌病毒多肽阳性肿瘤的多核苷酸 - Google Patents

用于治疗致癌病毒多肽阳性肿瘤的多核苷酸 Download PDF

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Publication number
CN104159607A
CN104159607A CN201380012419.2A CN201380012419A CN104159607A CN 104159607 A CN104159607 A CN 104159607A CN 201380012419 A CN201380012419 A CN 201380012419A CN 104159607 A CN104159607 A CN 104159607A
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deletion
point mutation
oncogenic
polypeptide
nucleotide sequence
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Chinese (zh)
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J.H.李
D.W.弗米尔
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Sanford Health
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Sanford Research USD
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
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  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN201380012419.2A 2012-01-24 2013-01-23 用于治疗致癌病毒多肽阳性肿瘤的多核苷酸 Pending CN104159607A (zh)

Priority Applications (1)

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CN201910216555.2A CN110042110A (zh) 2012-01-24 2013-01-23 用于治疗致癌病毒多肽阳性肿瘤的多核苷酸

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US201261590089P 2012-01-24 2012-01-24
US61/590,089 2012-01-24
PCT/US2013/022696 WO2013112549A1 (en) 2012-01-24 2013-01-23 Polynucleotides for treating oncogenic viral polypeptide positive tumors

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CN201910216555.2A Pending CN110042110A (zh) 2012-01-24 2013-01-23 用于治疗致癌病毒多肽阳性肿瘤的多核苷酸

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109891405A (zh) * 2016-11-11 2019-06-14 谷歌有限责任公司 基于用户装置的消费模式来修改视频内容在用户装置上的呈现的方法、系统和介质
CN116425839A (zh) * 2023-04-03 2023-07-14 深圳锦时生物科技有限公司 人乳头瘤病毒多肽及其应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2811093T3 (es) 2014-11-13 2021-03-10 Univ Geneve Arenavirus trisegmentados como vectores de vacunas
HK1246183A1 (zh) 2015-06-10 2018-09-07 Hookipa Biotech Gmbh Hpv疫苗
WO2017076988A1 (en) 2015-11-04 2017-05-11 Hookipa Biotech Ag Vaccines against hepatitis b virus
EP3373959B1 (en) 2015-11-12 2022-06-29 Hookipa Biotech GmbH Arenavirus particles as cancer vaccines
JP2019505512A (ja) 2016-01-08 2019-02-28 バッシボディ アクスイェ セルスカプ 治療用抗癌ネオエピトープワクチン
GB201605210D0 (en) 2016-03-29 2016-05-11 Oxford Immunotec Ltd Assay
JP2019517522A (ja) * 2016-06-03 2019-06-24 エトゥビクス コーポレーション ヒトパピローマウイルス(hpv)関連疾患の処置のための組成物及び方法
CN106655327A (zh) * 2016-10-18 2017-05-10 云南中烟工业有限责任公司 一种压缩式充电装置
SG11202008539YA (en) 2018-03-06 2020-10-29 Precigen Inc Human papillomavirus vaccines and uses of the same
IL296509A (en) 2020-03-16 2022-11-01 Univ North Carolina Chapel Hill Preparations and methods for selective detection of tumor-derived viral DNA
WO2021205027A1 (en) 2020-04-09 2021-10-14 Vaccibody As Individualized therapeutic anticancer vaccine
AU2021281910C1 (en) * 2020-05-25 2024-09-19 Genematrix Inc. Structurally modified chimeric polypeptide of human papillomavirus, recombinant protein comprising same polypeptide, and use of same protein
KR102712588B1 (ko) * 2020-05-25 2024-10-02 (주)진매트릭스 사람 파필로마바이러스의 구조적으로 변형된 키메라 폴리펩타이드 및 그 폴리펩타이드를 포함하는 재조합 단백질 및 그 단백질의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061608A2 (en) * 1998-05-26 1999-12-02 Institute Of Molecular And Cell Biology Polypeptides from creb binding protein and related protein p300 for use in transcriptional regulation
CN1276833A (zh) * 1997-08-22 2000-12-13 史密丝克莱恩比彻姆生物有限公司 疫苗
CN101688223A (zh) * 2007-05-15 2010-03-31 特兰斯吉恩股份有限公司 用于多基因表达的载体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2499837C (en) * 2002-10-03 2013-12-03 Wyeth Holdings Corporation Human papillomavirus polypeptides and immunogenic compositions
WO2010129339A2 (en) * 2009-04-28 2010-11-11 The Johns Hopkins University Compositions and methods for enhancing antigen-specific immune responses
CN102002105B (zh) * 2009-09-03 2013-01-23 中国疾病预防控制中心病毒病预防控制所 Hpv 16型e7e6融合蛋白基因、表达载体、方法、细胞和用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1276833A (zh) * 1997-08-22 2000-12-13 史密丝克莱恩比彻姆生物有限公司 疫苗
WO1999061608A2 (en) * 1998-05-26 1999-12-02 Institute Of Molecular And Cell Biology Polypeptides from creb binding protein and related protein p300 for use in transcriptional regulation
CN101688223A (zh) * 2007-05-15 2010-03-31 特兰斯吉恩股份有限公司 用于多基因表达的载体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANNA-MARIJA HELT ET AL.: "Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells", 《JOURNAL OF VIROLOGY》 *
BRYANT G. WIEKING ET AL.: "A Non-oncogenic HPV 16 E6/E7 Vaccine Enhances Treatment of HPV Expressing Tumors", 《CANCER GENE THERAPY》 *
K W JEONG ET AL.: "Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulator-associated ligand and promotes E6-associated protein-mediated ubiquitination and proteasomal degradation", 《ONCOGENE》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109891405A (zh) * 2016-11-11 2019-06-14 谷歌有限责任公司 基于用户装置的消费模式来修改视频内容在用户装置上的呈现的方法、系统和介质
US11758228B2 (en) 2016-11-11 2023-09-12 Google Llc Methods, systems, and media for modifying the presentation of video content on a user device based on a consumption of the user device
CN109891405B (zh) * 2016-11-11 2023-09-26 谷歌有限责任公司 基于用户装置的消费模式来修改视频内容在用户装置上的呈现的方法、系统和介质
US12170819B2 (en) 2016-11-11 2024-12-17 Google Llc Methods, systems, and media for modifying the presentation of video content on a user device based on a consumption of the user device
CN116425839A (zh) * 2023-04-03 2023-07-14 深圳锦时生物科技有限公司 人乳头瘤病毒多肽及其应用

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EP2806889A1 (en) 2014-12-03
EP2806889B1 (en) 2017-08-16
IN2014DN06118A (enExample) 2015-08-14
JP2015506179A (ja) 2015-03-02
CN110042110A (zh) 2019-07-23
EP2806889A4 (en) 2016-04-20
US9969779B2 (en) 2018-05-15
US9492526B2 (en) 2016-11-15
JP2018038405A (ja) 2018-03-15
KR102195196B1 (ko) 2020-12-28
US20180237477A1 (en) 2018-08-23
EP3269387B1 (en) 2019-07-17
KR20140131929A (ko) 2014-11-14
HK1203833A1 (en) 2015-11-06
US20150023996A1 (en) 2015-01-22
DK2806889T3 (da) 2017-11-20
JP6219849B2 (ja) 2017-10-25
ES2646590T3 (es) 2017-12-14
WO2013112549A1 (en) 2013-08-01
JP6655051B2 (ja) 2020-02-26
US20160376324A1 (en) 2016-12-29
EP3269387A1 (en) 2018-01-17

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