CN104144935B - 6，6’-[[3，3’，5，5’-四(1，1-二甲基乙基)-[1，1’-联苯]-2，2’-二基]双(氧基)]双-二苯并[d，f][1，3，2]-二氧杂磷杂庚因的结晶溶剂化物和非溶剂化形式 - Google Patents
6，6’-[[3，3’，5，5’-四(1，1-二甲基乙基)-[1，1’-联苯]-2，2’-二基]双(氧基)]双-二苯并[d，f][1，3，2]-二氧杂磷杂庚因的结晶溶剂化物和非溶剂化形式 Download PDFInfo
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- CN104144935B CN104144935B CN201280066197.8A CN201280066197A CN104144935B CN 104144935 B CN104144935 B CN 104144935B CN 201280066197 A CN201280066197 A CN 201280066197A CN 104144935 B CN104144935 B CN 104144935B
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- 150000001925 cycloalkenes Chemical class 0.000 description 1
- ZXIJMRYMVAMXQP-UHFFFAOYSA-N cycloheptene Chemical compound C1CCC=CCC1 ZXIJMRYMVAMXQP-UHFFFAOYSA-N 0.000 description 1
- URYYVOIYTNXXBN-UPHRSURJSA-N cyclooctene Chemical compound C1CCC\C=C/CC1 URYYVOIYTNXXBN-UPHRSURJSA-N 0.000 description 1
- 239000004913 cyclooctene Substances 0.000 description 1
- 150000001941 cyclopentenes Chemical class 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- ZJIPHXXDPROMEF-UHFFFAOYSA-N dihydroxyphosphanyl dihydrogen phosphite Chemical compound OP(O)OP(O)O ZJIPHXXDPROMEF-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical compound CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- GEAWFZNTIFJMHR-UHFFFAOYSA-N hepta-1,6-diene Chemical compound C=CCCCC=C GEAWFZNTIFJMHR-UHFFFAOYSA-N 0.000 description 1
- PYGSKMBEVAICCR-UHFFFAOYSA-N hexa-1,5-diene Chemical compound C=CCCC=C PYGSKMBEVAICCR-UHFFFAOYSA-N 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000004137 mechanical activation Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- GEMHFKXPOCTAIP-UHFFFAOYSA-N n,n-dimethyl-n'-phenylcarbamimidoyl chloride Chemical compound CN(C)C(Cl)=NC1=CC=CC=C1 GEMHFKXPOCTAIP-UHFFFAOYSA-N 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 239000003345 natural gas Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 229910000510 noble metal Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- QYZLKGVUSQXAMU-UHFFFAOYSA-N penta-1,4-diene Chemical compound C=CCC=C QYZLKGVUSQXAMU-UHFFFAOYSA-N 0.000 description 1
- YWAKXRMUMFPDSH-UHFFFAOYSA-N pentene Chemical group CCCC=C YWAKXRMUMFPDSH-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000002407 reforming Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003284 rhodium compounds Chemical class 0.000 description 1
- 238000000373 single-crystal X-ray diffraction data Methods 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 238000004227 thermal cracking Methods 0.000 description 1
- 150000003613 toluenes Chemical class 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11196188.4 | 2011-12-30 | ||
| EP11196188 | 2011-12-30 | ||
| PCT/EP2012/077021 WO2013098370A1 (en) | 2011-12-30 | 2012-12-28 | Crystalline solvate and non-solvated forms of 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-dibenzo [d,f] [1,3,2]-dioxaphosphepine |
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| Publication Number | Publication Date |
|---|---|
| CN104144935A CN104144935A (zh) | 2014-11-12 |
| CN104144935B true CN104144935B (zh) | 2016-07-06 |
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| CN201280066197.8A Active CN104144935B (zh) | 2011-12-30 | 2012-12-28 | 6，6’-[[3，3’，5，5’-四(1，1-二甲基乙基)-[1，1’-联苯]-2，2’-二基]双(氧基)]双-二苯并[d，f][1，3，2]-二氧杂磷杂庚因的结晶溶剂化物和非溶剂化形式 |
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| EP (1) | EP2797937B1 (es) |
| JP (1) | JP6522341B2 (es) |
| KR (1) | KR102036162B1 (es) |
| CN (1) | CN104144935B (es) |
| BR (1) | BR112014016137B1 (es) |
| CA (1) | CA2862100C (es) |
| ES (1) | ES2931047T3 (es) |
| MX (1) | MX361677B (es) |
| MY (1) | MY181121A (es) |
| RU (1) | RU2660899C2 (es) |
| WO (1) | WO2013098370A1 (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2876539A1 (en) | 2012-06-15 | 2013-12-19 | Basf Se | Multicomponent crystals comprising dasatinib and selected co-crystal formers |
| EP2864313A1 (en) | 2012-06-22 | 2015-04-29 | Basf Se | Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers |
| WO2014060449A1 (en) | 2012-10-19 | 2014-04-24 | Basf Se | Multicomponent crystalline system comprising nilotinib and selected co-crystal formers |
| WO2015175158A1 (en) | 2014-05-14 | 2015-11-19 | Dow Technology Investments Llc | Stabilized organophosphorous compounds |
| CA2990035A1 (en) * | 2015-06-19 | 2016-12-22 | Dow Technology Investments Llc | Crystalline form of 6,6'[[3,3', 5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)bisdibenzo[d,f][1,3,2]-dioxaphosphepin with improved thermal stability |
| TWI709568B (zh) * | 2015-09-30 | 2020-11-11 | 美商陶氏科技投資公司 | 用於製造有機磷化合物的方法 |
| TWI709566B (zh) | 2015-09-30 | 2020-11-11 | 美商陶氏科技投資公司 | 用於製造有機磷化合物的方法 |
| CN113845547A (zh) * | 2021-10-29 | 2021-12-28 | 山东京博石油化工有限公司 | 一种Biphephos的结晶溶剂化物和非溶剂化结晶形式及其制备方法和应用 |
| CN113845546A (zh) * | 2021-10-29 | 2021-12-28 | 山东京博石油化工有限公司 | 一种二氧杂磷杂庚英衍生物的结晶乙腈溶剂化物及其制备方法和应用 |
Citations (3)
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| CN1327881A (zh) * | 1993-11-23 | 2001-12-26 | 纳幕尔杜邦公司 | 催化剂前身组合物 |
| CN101684130A (zh) * | 2008-09-25 | 2010-03-31 | 上海焦化有限公司 | 一种亚磷酸酯的制备方法 |
| CN102266796A (zh) * | 2006-12-22 | 2011-12-07 | 中国科学院上海有机化学研究所 | 一种丙烯氢甲酰化催化体系和方法 |
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| US4885401A (en) | 1985-09-05 | 1989-12-05 | Union Carbide Corporation | Bis-phosphite compounds |
| US4748261A (en) | 1985-09-05 | 1988-05-31 | Union Carbide Corporation | Bis-phosphite compounds |
| US4668651A (en) | 1985-09-05 | 1987-05-26 | Union Carbide Corporation | Transition metal complex catalyzed processes |
| US4835299A (en) | 1987-03-31 | 1989-05-30 | Union Carbide Corporation | Process for purifying tertiary organophosphites |
| TW213465B (es) | 1991-06-11 | 1993-09-21 | Mitsubishi Chemicals Co Ltd | |
| JP3093863B2 (ja) * | 1992-04-15 | 2000-10-03 | 株式会社上野製薬応用研究所 | 結晶化粉末ソルビトールの製法 |
| US5312996A (en) * | 1992-06-29 | 1994-05-17 | Union Carbide Chemicals & Plastics Technology Corporation | Hydroformylation process for producing 1,6-hexanedials |
| US5288918A (en) | 1992-09-29 | 1994-02-22 | Union Carbide Chemicals & Plastics Technology Corporation | Hydroformylation process |
| US5663403A (en) | 1995-01-24 | 1997-09-02 | Mitsubishi Chemical Corporation | Bisphosphite compound and method for producing aldehydes |
| JPH0977713A (ja) * | 1995-09-19 | 1997-03-25 | Mitsubishi Chem Corp | アルデヒド類の製造方法 |
| US5767321A (en) | 1995-12-06 | 1998-06-16 | Union Carbide Chemicals & Plastics Technology Corporation | Metal-ligand complex catalyzed processes |
| US5786517A (en) | 1995-12-06 | 1998-07-28 | Union Carbide Chemicals & Plastics Technology Corporation | Metal-ligand complex catalyzed processes |
| SK68698A3 (en) | 1995-12-06 | 1999-02-11 | Union Carbide Chem Plastic | Improved metal-ligand complex catalyzed processes |
| US5741944A (en) | 1995-12-06 | 1998-04-21 | Union Carbide Chemicals & Plastics Technology Corporation | Hydroformaylation processes |
| US5789625A (en) | 1995-12-06 | 1998-08-04 | Union Carbide Chemicals & Plastics Technology Corporation | Metal-ligand complex catalyzed processes |
| MY124170A (en) | 1997-07-29 | 2006-06-30 | Invista Tech Sarl | Hydrocyanation processes and multidentate phosphite ligand and nickel catalyst compositions therefor |
| JP3812095B2 (ja) | 1997-10-28 | 2006-08-23 | 三菱化学株式会社 | アルデヒド類の製造方法及びこれに用いるビスホスファイト |
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| MY138064A (en) | 2002-01-24 | 2009-04-30 | Basf Ag | Method for the separation of acids from chemical reaction mixtures by means of ionic fluids |
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| EP2773649B1 (en) * | 2011-10-31 | 2017-07-12 | Dow Technology Investments LLC | Preventing solvent of crystallization in production of polyphosphite ligands |
| MX363617B (es) * | 2011-12-30 | 2019-03-28 | Basf Se | Metodo para la purificacion de compuestos de difosfitos organicos. |
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- 2012-12-28 RU RU2014131297A patent/RU2660899C2/ru active
- 2012-12-28 EP EP12808848.1A patent/EP2797937B1/en active Active
- 2012-12-28 MY MYPI2014001802A patent/MY181121A/en unknown
- 2012-12-28 BR BR112014016137-2A patent/BR112014016137B1/pt active IP Right Grant
- 2012-12-28 WO PCT/EP2012/077021 patent/WO2013098370A1/en active Application Filing
- 2012-12-28 ES ES12808848T patent/ES2931047T3/es active Active
- 2012-12-28 JP JP2014549475A patent/JP6522341B2/ja active Active
- 2012-12-28 MX MX2014007876A patent/MX361677B/es active IP Right Grant
- 2012-12-28 KR KR1020147020981A patent/KR102036162B1/ko active IP Right Grant
- 2012-12-28 CN CN201280066197.8A patent/CN104144935B/zh active Active
- 2012-12-28 CA CA2862100A patent/CA2862100C/en active Active
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| CN1327881A (zh) * | 1993-11-23 | 2001-12-26 | 纳幕尔杜邦公司 | 催化剂前身组合物 |
| CN102266796A (zh) * | 2006-12-22 | 2011-12-07 | 中国科学院上海有机化学研究所 | 一种丙烯氢甲酰化催化体系和方法 |
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2660899C2 (ru) | 2018-07-11 |
| KR20140112530A (ko) | 2014-09-23 |
| RU2014131297A (ru) | 2016-02-20 |
| EP2797937B1 (en) | 2022-08-31 |
| WO2013098370A1 (en) | 2013-07-04 |
| JP2015510498A (ja) | 2015-04-09 |
| ES2931047T3 (es) | 2022-12-23 |
| EP2797937A1 (en) | 2014-11-05 |
| BR112014016137A8 (pt) | 2017-07-04 |
| KR102036162B1 (ko) | 2019-10-24 |
| MY181121A (en) | 2020-12-18 |
| BR112014016137B1 (pt) | 2021-02-09 |
| BR112014016137A2 (pt) | 2017-06-13 |
| MX2014007876A (es) | 2014-09-22 |
| CA2862100C (en) | 2021-12-21 |
| CN104144935A (zh) | 2014-11-12 |
| MX361677B (es) | 2018-12-13 |
| JP6522341B2 (ja) | 2019-05-29 |
| CA2862100A1 (en) | 2013-07-04 |
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