CN104144678A - 含有抗病毒活性二氢喹唑啉衍生物的药物制剂 - Google Patents

含有抗病毒活性二氢喹唑啉衍生物的药物制剂 Download PDF

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Publication number
CN104144678A
CN104144678A CN201380011670.7A CN201380011670A CN104144678A CN 104144678 A CN104144678 A CN 104144678A CN 201380011670 A CN201380011670 A CN 201380011670A CN 104144678 A CN104144678 A CN 104144678A
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China
Prior art keywords
solution
pharmaceutical composition
phenyl
fluoro
acetic acid
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Pending
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CN201380011670.7A
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English (en)
Chinese (zh)
Inventor
克斯廷·保勒斯
维尔弗里德·施瓦布
多米尼克·古朗德尔
彼得·万霍格维斯特
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Aicuris GmbH and Co KG
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Aicuris GmbH and Co KG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47757622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104144678(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris GmbH and Co KG filed Critical Aicuris GmbH and Co KG
Priority to CN201910661203.8A priority Critical patent/CN110433166A/zh
Publication of CN104144678A publication Critical patent/CN104144678A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201380011670.7A 2012-02-29 2013-02-28 含有抗病毒活性二氢喹唑啉衍生物的药物制剂 Pending CN104144678A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910661203.8A CN110433166A (zh) 2012-02-29 2013-02-28 含有抗病毒活性二氢喹唑啉衍生物的药物制剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102012101680A DE102012101680A1 (de) 2012-02-29 2012-02-29 Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101680.1 2012-02-29
PCT/EP2013/054114 WO2013127970A1 (de) 2012-02-29 2013-02-28 Pharmazeutische zubereitung enthaltend ein antiviral wirksames dihydrochinazolinderivat

Related Child Applications (1)

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CN201910661203.8A Division CN110433166A (zh) 2012-02-29 2013-02-28 含有抗病毒活性二氢喹唑啉衍生物的药物制剂

Publications (1)

Publication Number Publication Date
CN104144678A true CN104144678A (zh) 2014-11-12

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CN201910661203.8A Pending CN110433166A (zh) 2012-02-29 2013-02-28 含有抗病毒活性二氢喹唑啉衍生物的药物制剂
CN201380011670.7A Pending CN104144678A (zh) 2012-02-29 2013-02-28 含有抗病毒活性二氢喹唑啉衍生物的药物制剂

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JP (1) JP6387486B2 (enExample)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113880776A (zh) * 2021-11-16 2022-01-04 山东诚创蓝海医药科技有限公司 一种莱特莫韦中间体的制备方法
CN115322157A (zh) * 2022-06-02 2022-11-11 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN115403528A (zh) * 2021-05-27 2022-11-29 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN115515565A (zh) * 2020-02-27 2022-12-23 Aic246股份两合公司 包含2-[(4s)-8-氟-2-[4-(3-甲氧基苯基)哌嗪-1-基]-3-[2-甲氧基-5-(三氟甲基)苯基]-4h-喹唑啉-4-基]乙酸根和钠离子的药物组合物
CN115677539A (zh) * 2022-11-01 2023-02-03 南京工业大学 一种温和条件下钴催化脲基导向芳烃的高选择性单烯基化的方法
CN119731157A (zh) * 2022-08-15 2025-03-28 上海迪赛诺化学制药有限公司 一种来特莫韦无定形的制备方法

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DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra
AU2017274722A1 (en) 2016-06-03 2019-01-17 Atreya Innovations Private Limited A device for the detection and reliable capturing of the pulse characteristics
PL3592362T3 (pl) 2017-03-06 2025-06-23 VenatoRx Pharmaceuticals, Inc. Postacie stałe i kompozycje skojarzone zawierające inhibitor beta-laktamaz i ich zastosowania
UY39099A (es) * 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
CN114539085B (zh) * 2020-11-26 2023-10-20 山东诚创蓝海医药科技有限公司 一种脲基衍生物的制备
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
JP2025504136A (ja) * 2022-02-23 2025-02-06 エルジー・ケム・リミテッド イソキサゾリン誘導体を含む注射用製剤及びこの製造方法
CN119015222B (zh) * 2024-08-28 2025-12-09 石家庄四药有限公司 一种来特莫韦注射液及其制备方法

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CN1784390A (zh) * 2003-05-02 2006-06-07 拜耳医药保健股份公司 具有抗病毒性能的取代二氢喹唑啉

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WO2001091751A1 (en) * 2000-05-30 2001-12-06 Novo Nordisk A/S New pharmaceutical composition and the process for its preparation
CN1784390A (zh) * 2003-05-02 2006-06-07 拜耳医药保健股份公司 具有抗病毒性能的取代二氢喹唑啉

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115515565A (zh) * 2020-02-27 2022-12-23 Aic246股份两合公司 包含2-[(4s)-8-氟-2-[4-(3-甲氧基苯基)哌嗪-1-基]-3-[2-甲氧基-5-(三氟甲基)苯基]-4h-喹唑啉-4-基]乙酸根和钠离子的药物组合物
CN115403528A (zh) * 2021-05-27 2022-11-29 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN113880776A (zh) * 2021-11-16 2022-01-04 山东诚创蓝海医药科技有限公司 一种莱特莫韦中间体的制备方法
CN115322157A (zh) * 2022-06-02 2022-11-11 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
WO2023231826A1 (zh) * 2022-06-02 2023-12-07 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN119731157A (zh) * 2022-08-15 2025-03-28 上海迪赛诺化学制药有限公司 一种来特莫韦无定形的制备方法
CN115677539A (zh) * 2022-11-01 2023-02-03 南京工业大学 一种温和条件下钴催化脲基导向芳烃的高选择性单烯基化的方法
CN115677539B (zh) * 2022-11-01 2023-10-24 南京工业大学 一种温和条件下钴催化脲基导向芳烃的高选择性单烯基化的方法

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PL3556350T3 (pl) 2024-05-06
PT3556350T (pt) 2024-02-15
CA2865203A1 (en) 2013-09-06
JP6387486B2 (ja) 2018-09-12
SMT201900458T1 (it) 2019-11-13
SMT202400068T1 (it) 2024-03-13
NZ628444A (en) 2016-07-29
ES2741698T3 (es) 2020-02-12
DK3556350T3 (da) 2024-02-12
CA2865203C (en) 2019-11-05
PH12014501937B1 (en) 2022-07-15
HUE045949T2 (hu) 2020-01-28
HRP20191369T1 (hr) 2019-11-01
PH12014501937A1 (en) 2014-11-24
EP3556350B1 (de) 2024-01-10
TN2014000345A1 (en) 2015-12-21
MY172310A (en) 2019-11-21
EA201400963A1 (ru) 2015-02-27
EP3556350A1 (de) 2019-10-23
EP2819648A1 (de) 2015-01-07
ES2972133T3 (es) 2024-06-11
DK2819648T3 (da) 2019-08-26
HK1205462A1 (en) 2015-12-18
SI3556350T1 (sl) 2024-03-29
KR20140130683A (ko) 2014-11-11
UA111415C2 (uk) 2016-04-25
KR102149561B1 (ko) 2020-08-31
MX369666B (es) 2019-11-14
ME03448B (me) 2020-01-20
CO7061076A2 (es) 2014-09-19
CY1121910T1 (el) 2020-10-14
EP4328218A3 (de) 2024-04-10
JP2015508801A (ja) 2015-03-23
US10603384B2 (en) 2020-03-31
IN2014MN01892A (enExample) 2015-07-10
FI3556350T3 (fi) 2024-02-14
US20150133461A1 (en) 2015-05-14
RS59157B1 (sr) 2019-10-31
SG11201405294XA (en) 2014-11-27
AU2013224947A1 (en) 2014-09-18
LT3556350T (lt) 2024-02-26
EP4328218A2 (de) 2024-02-28
EA026584B1 (ru) 2017-04-28
BR112014020946A2 (enExample) 2017-06-20
PT2819648T (pt) 2019-09-05
IL234363B (en) 2020-04-30
MA35941B1 (fr) 2014-12-01
AU2013224947B2 (en) 2017-06-29
DE102012101680A1 (de) 2013-08-29
CN110433166A (zh) 2019-11-12
HRP20240197T1 (hr) 2024-04-26
SI2819648T1 (sl) 2019-10-30
LT2819648T (lt) 2019-09-10
EP2819648B1 (de) 2019-05-29
CL2014002306A1 (es) 2014-11-28
ZA201405949B (en) 2021-07-28
PL2819648T3 (pl) 2019-10-31
MX2014010364A (es) 2014-12-05
HUE065553T2 (hu) 2024-06-28
RS65137B1 (sr) 2024-02-29
WO2013127970A1 (de) 2013-09-06
BR112014020946B1 (pt) 2022-04-05

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