CN104138423B - It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis - Google Patents
It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis Download PDFInfo
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- CN104138423B CN104138423B CN201310178759.4A CN201310178759A CN104138423B CN 104138423 B CN104138423 B CN 104138423B CN 201310178759 A CN201310178759 A CN 201310178759A CN 104138423 B CN104138423 B CN 104138423B
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Abstract
The present invention discloses a kind of pharmaceutical composition and its preparation method that are used for the treatment of chronic pharyngolaryngitis, and described pharmaceutical composition is made up of the raw material of following weight proportion: scorpio 50-70 part, Tuber Fleeceflower Root 10-27 part, root of large-flowered skullcap 10-30 part, capsule of weeping forsythia 10-25 part. Scorpio first being put into pot heat drying, after scorpio color is heated to micro-Huang, then is mixed by four traditional Chinese medicine material, 100 order sieves are crossed in processing after pulverizing; Fine powder after sieving carries out slaking, sterilising treatment 10 minutes at 110 DEG C, finally obtains the powder of this pharmaceutical composition. Pharmaceutical composition of the present invention has the features such as effect is with strong points, drug effect is obvious and toxic side effect is little.
Description
Technical field
The present invention relates to a kind of pharmaceutical product, specifically a kind of pharmaceutical composition and its preparation method treating chronic pharyngolaryngitis.
Background technology
Chronic pharyngolaryngitis is under pharynx mucous membrane, mucous membrane and the chronic inflammatory diseases of Lymphoid tissue. The pharyngeal inflammation of diffusivity is often a part for upper respiratory tract chronic inflammatory diseases; The pharyngeal inflammation of limitation mostly then is pharynx Lymphoid tissue inflammation. During this disease is clinical common, in the majority with grownup, the course of disease is longer, and and obstinate, annual recurrent exerbation, takes place frequently with autumn Mo Winter-Spring and seriously, live to people and bring serious impact most.
Modern Chinese medicine claims this disease to be larynx numbness, refers to that the yang blood and qi body fluid because of internal organs is lacked of proper care, and throat loses supports, and caused by the turbid stasis of gas bloody sputum, pharyngeal micro-to do, to itch, pain is uncomfortable etc. is the common chronic throat disease of main performance.
The Chinese medicine of current treatment chronic pharyngolaryngitis is mainly general Ji disinfectant soup, LIUSHEN WAN, LIYAN JIEDU CHONGJI, Chinese olive ball and Radix Isatidis granule etc. Owing to the paathogenic factor of chronic pharyngolaryngitis is more, although medicine kind is more, but being substantially all after taking for some time, illness slows, but the time of maintenance is shorter, is still swallow laryngalgia of itching later, it is very difficult to cure completely. Therefore, also do not have ideal medicament to be used for the treatment of chronic pharyngolaryngitis at present.
Summary of the invention
An object of the present invention is just to provide a kind of pharmaceutical composition being used for the treatment of chronic pharyngolaryngitis, can cure chronic pharyngolaryngitis fast and effectively.
The two of the object of the present invention are just to provide the preparation method of above-mentioned chronic pharyngolaryngitis medicine, to realize production and the clinical application of medicine.
An object of the present invention is achieved in that a kind of pharmaceutical composition being used for the treatment of chronic pharyngolaryngitis, is made up of the raw material of following weight proportion:
Scorpio 50-70 part, Tuber Fleeceflower Root 10-27 part,
Root of large-flowered skullcap 10-30 part, capsule of weeping forsythia 10-25 part.
Preferably, it is made up of the raw material of following weight proportion:
Scorpio 55-60 part, Tuber Fleeceflower Root 15-25 part,
Root of large-flowered skullcap 12-22 part, capsule of weeping forsythia 12-20 part.
It is that the medicine of active ingredient can be made into the various formulations such as powder, pill, tablet or capsule taking said composition.
In pharmaceutical composition of the present invention, scorpio is monarch's medicine, large usage quantity, has a dispersing pathogen accumulation and logical network disappears the effect of carbuncle; Tuber Fleeceflower Root is ministerial drug, and consumption is less, and taste is sweet warm in nature, has combing irritability, preventing malaria, effect of dispeling the wind and detoxifying; The root of large-flowered skullcap, the capsule of weeping forsythia are adjutant, all have the effect of heat-clearing and damp-drying drug and eliminating fire and detoxication, for assisting a ruler in governing a country ministerial drug and monarch's medicine; Capsule of weeping forsythia bitter is micro-cold, has the effect of combing cardiopulmonary, clearing heat and detoxicating, dispersing swelling and dissipating binds and dispelling wind and heat pathogens; Lung channel returned by the root of large-flowered skullcap, mildly bitter flavor, has the effect of heat-clearing and damp-drying drug, eliminating fire and detoxication, can treat the symptom such as cough due to lung-heat, high hot polydipsia. By the pharmaceutical composition of above-mentioned four taste Chinese medicine composition mixture modulation, can effectively regulate the negative and positive of internal organs, regulate the unbalance of qi-blood-body fluid, and throat can be nourished, thus chronic pharyngolaryngitis is had the curative effect extremely suited the medicine to the illness. Pharmaceutical composition of the present invention have with strong points, the drug effect of effect obviously and toxic side effect dawn etc. feature. The two of the object of the present invention are achieved in that the preparation method of a kind of chronic pharyngolaryngitis medicine, comprise the following steps:
A, take this four traditional Chinese medicine thing group part of scorpio, Tuber Fleeceflower Root, the root of large-flowered skullcap and the capsule of weeping forsythia by the formula rate of aforementioned pharmaceutical compositions respectively;
B, by scorpio by pot fried dry to micro-yellow;
C, the scorpio processed is mixed with Tuber Fleeceflower Root, the root of large-flowered skullcap and the capsule of weeping forsythia after, grind to form fine powder, cross 100 orders sieve;
D, the fine powder after sieving is carried out under 100-110 DEG C of condition slaking and sterilising treatment 10 minutes;
E, drying in the air to normal temperature loads capsule.
In made powder, add appropriate auxiliary material, various clinical acceptable formulation can be made by formulation method routinely, such as powder, pill, tablet, capsule etc.
The using method of pharmaceutical composition of the present invention is: adult's oral medication, every day 2 times, each 5-6 gram; Pungent, tobacco and wine, seafood and donkey horseflesh is avoided, it is noted that warming between medication period, tired from chill, and pregnant woman's forbidding. The useful effect of pharmaceutical composition of the present invention embodies by following experiment:
Clinical choose 40 example chronic pharyngolaryngitis patients, immediately select 20 patients as a control group, all the other 20 patients are treatment group. Methods for the treatment of: the oral capsule being made up of pharmaceutical composition of the present invention for the treatment of group, every day 2 times, each 12 (6 grams of active principles) every 7 days is a course for the treatment of, continuously 3 courses for the treatment of of treatment. Control group adopts western medicine, within every 7 days, is a course for the treatment of, continuously 3 courses for the treatment of of treatment.
Criterion of therapeutical effect:
Alleviate: patient's malaise symptoms alleviates. Cure: patient symptom all disappears, without recurrence situation in 2 years. Invalid: patient's malaise symptoms is without change.
The result for the treatment of of treatment group and control group is as shown in table 1:
Table 1: the result for the treatment of of each composition and control group
Control group has 5 example patients with untoward reactions such as nausea and vomiting during treating; Treatment group does not find any untoward reaction and toxic side effect.
Embodiment
Following examples are used for the present invention is described further, but do not limit the present invention in any form.
Embodiment 1:
Get scorpio 50 grams, Tuber Fleeceflower Root 17 grams, the root of large-flowered skullcap 17 grams, the capsule of weeping forsythia 17 grams. Scorpio is first put into pot heat drying, and scorpio color is heated to micro-Huang, then is mixed by four traditional Chinese medicine material, and 100 order sieves are crossed in processing after pulverizing; Fine powder after sieving carries out slaking, sterilising treatment 10 minutes at 110 DEG C, finally obtains the powder of this pharmaceutical composition.
The powder of this pharmaceutical composition being loaded capsule, makes capsule, every capsules is containing pharmaceutical composition of the present invention 0.5 gram.
Embodiment 2:
Get scorpio 60 grams, Tuber Fleeceflower Root 15 grams, the root of large-flowered skullcap 25 grams, the capsule of weeping forsythia 20 grams. Scorpio is first put into pot heat drying, and scorpio color is heated to micro-Huang, then is mixed by four traditional Chinese medicine material, and 100 order sieves are crossed in processing after pulverizing; Fine powder after sieving carries out slaking, sterilising treatment 10 minutes at 105 DEG C, finally obtains the powder of this pharmaceutical composition.
Getting the powder 55 grams of this pharmaceutical composition, mixed by 45 grams of honey that itself and heating have been refined, can be modulated into honeyed bolus, every honeyed bolus weighs 6 grams.
In embodiment 3-10, each drug component sees the following form:
Unit: gram
| Embodiment | Scorpio | Tuber Fleeceflower Root | The root of large-flowered skullcap | The capsule of weeping forsythia |
| 3 | 55 | 23 | 22 | 12 |
| 4 | 57 | 25 | 20 | 16 |
| 5 | 58 | 18 | 15 | 20 |
| 6 | 60 | 15 | 12 | 15 |
| 7 | 50 | 27 | 28 | 10 |
| 8 | 62 | 20 | 30 | 22 |
| 9 | 65 | 10 | 24 | 25 |
| 10 | 70 | 14 | 10 | 13 |
Capture each medicinal material group part in embodiment 3-10 according to the drug component listed by upper table and dosage respectively, in embodiments, respectively scorpio is put into pot heat drying, scorpio color is heated to micro-Huang, grind after four traditional Chinese medicine material is mixed, cross 100 order sieves, become fine powder. At 110 DEG C, carry out slaking, sterilising treatment 10 minutes, finally obtain the powder of the pharmaceutical composition in an embodiment.
By the powder conveniently method for preparing tablet thereof of pharmaceutical composition made in embodiment 3-10, making tablet, every tablet is containing pharmaceutical composition of the present invention 500 milligrams.
Pharmaceutical composition made by embodiment 1-10, after on probation, all can reach the substantially identical result for the treatment of shown in table 1.
When medicine not in time, the root of large-flowered skullcap in pharmaceutical composition of the present invention can substitute with golden cypress, and the capsule of weeping forsythia can substitute with Japanese Honeysuckle. Scorpio Tuber Fleeceflower Root can not substitute with other drug, can not lack.
Claims (4)
1. the pharmaceutical composition being used for the treatment of chronic pharyngolaryngitis, is characterized in that, is made up of the raw material of following weight proportion:
Scorpio 50-70 part, Tuber Fleeceflower Root 10-27 part,
Root of large-flowered skullcap 10-30 part, capsule of weeping forsythia 10-25 part.
2. pharmaceutical composition according to claim 1, is characterized in that, is made up of the raw material of following weight proportion:
Scorpio 55-60 part, Tuber Fleeceflower Root 15-22 part,
Root of large-flowered skullcap 12-25 part, capsule of weeping forsythia 12-20 part.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that, is that the medicine of active ingredient can be made into powder, pill, tablet or capsule taking said composition.
4. treat a preparation method for chronic pharyngolaryngitis pharmaceutical composition described in claim 1, it is characterized in that, comprise the following steps:
A, take this four traditional Chinese medicine thing component of scorpio, Tuber Fleeceflower Root, the root of large-flowered skullcap and the capsule of weeping forsythia by the formula rate of aforementioned pharmaceutical compositions respectively;
B, by scorpio by pot fried dry to micro-yellow;
C, the scorpio processed is mixed with Tuber Fleeceflower Root, the root of large-flowered skullcap and the capsule of weeping forsythia after, grind to form fine powder, cross 100 orders sieve;
D, the fine powder after sieving is carried out under 100-110 DEG C of condition slaking and sterilising treatment 10 minutes;
E, drying in the air to normal temperature loads capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310178759.4A CN104138423B (en) | 2013-05-08 | 2013-05-08 | It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310178759.4A CN104138423B (en) | 2013-05-08 | 2013-05-08 | It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104138423A CN104138423A (en) | 2014-11-12 |
| CN104138423B true CN104138423B (en) | 2016-06-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310178759.4A Expired - Fee Related CN104138423B (en) | 2013-05-08 | 2013-05-08 | It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1149468A (en) * | 1995-11-09 | 1997-05-14 | 阳灵广 | Powder for laryngopharyngitis |
| CN101229321A (en) * | 2008-01-04 | 2008-07-30 | 盖欣 | Chinese traditional medicine granule for treating chronic pharyngitis |
-
2013
- 2013-05-08 CN CN201310178759.4A patent/CN104138423B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1149468A (en) * | 1995-11-09 | 1997-05-14 | 阳灵广 | Powder for laryngopharyngitis |
| CN101229321A (en) * | 2008-01-04 | 2008-07-30 | 盖欣 | Chinese traditional medicine granule for treating chronic pharyngitis |
Non-Patent Citations (1)
| Title |
|---|
| 复方双黄连喷剂的制备及临床应用;张辉等;《中原医刊》;20030228;第30卷(第3期);第39页 * |
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| CN104138423A (en) | 2014-11-12 |
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Granted publication date: 20160608 Termination date: 20170508 |