CN104138423A - Pharmaceutical composition for treating chronic pharyngolaryngitis and preparation method thereof - Google Patents
Pharmaceutical composition for treating chronic pharyngolaryngitis and preparation method thereof Download PDFInfo
- Publication number
- CN104138423A CN104138423A CN201310178759.4A CN201310178759A CN104138423A CN 104138423 A CN104138423 A CN 104138423A CN 201310178759 A CN201310178759 A CN 201310178759A CN 104138423 A CN104138423 A CN 104138423A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- scorpio
- fructus forsythiae
- polygoni multiflori
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition for treating chronic pharyngolaryngitis and a preparation method thereof. The pharmaceutical composition comprises the following raw materials by weight: 50 to 70 parts of scorpion, 10 to 27 parts of fleece-flower root, 10 to 30 parts of root of large-flowered skullcap and 10 to 25 parts of fructus forsythiae. The preparation method comprises the following steps: heating and drying scorpion in a pan, mixing the above-mentioned four medicinal materials when the color of the scorpion is light yellow under heating and carrying out sieving with a 100-mesh sieve after processing and crushing; and subjecting sieved fine powder to cooking and sterilization for 10 min at 110 DEG C so as to obtain the powder of the pharmaceutical composition. The pharmaceutical composition has the characteristics of good targeted effects, obvious drug effects, small toxic and side effects, etc.
Description
Technical field
The present invention relates to a kind of pharmaceutical product, specifically a kind of pharmaceutical composition for the treatment of chronic pharyngolaryngitis and preparation method thereof.
Background technology
Chronic pharyngolaryngitis is for swallowing under mucosa, mucosa and adenoid chronic inflammatory disease.Diffusivity pharyngeal inflammation is often a part for upper respiratory tract chronic inflammatory disease; Limitation pharyngeal inflammation mostly is pharynx lymphoid tissue inflammation.Common during primary disease is clinical, in the majority with adult, the course of disease is longer, and and obstinate, repeatedly show effect the whole year, with autumn Mo Winter-Spring take place frequently most and seriously, live and bring serious impact to people.
Modern Chinese medicine claims that primary disease is sore throat, refers to the yang blood and qi body fluid imbalance because of internal organs, and throat loses supports, due to the turbid stasis of QI and blood expectorant, pharyngeally micro-ly doing, to itch, pain is uncomfortable etc. is the common chronic throat disease of main manifestations.
The Chinese medicine of current treatment chronic pharyngolaryngitis is mainly puji xiaodu drink, LIUSHEN WAN, LIYAN JIEDU CHONGJI, Fructus Canarii ball and Radix Isatidis granule etc.Because the paathogenic factor of chronic pharyngolaryngitis is more, although medicine kind is more, be substantially all to take after a period of time, disease slows, but it is shorter to hold time, and remains later itching throat laryngalgia, is difficult to cure completely.Therefore, also do not have at present ideal medicament to be used for the treatment of chronic pharyngolaryngitis.
Summary of the invention
One of object of the present invention is just to provide a kind of pharmaceutical composition that is used for the treatment of chronic pharyngolaryngitis, can cure fast and effectively chronic pharyngolaryngitis.
Two of object of the present invention is just to provide the preparation method of above-mentioned chronic pharyngolaryngitis medicine, to realize production and the clinical practice of medicine.
One of object of the present invention is achieved in that a kind of pharmaceutical composition that is used for the treatment of chronic pharyngolaryngitis, is made up of the raw material of following weight proportion:
Scorpio 50-70 part, Radix Polygoni Multiflori 10-27 part,
Radix Scutellariae 10-30 part, Fructus Forsythiae 10-25 part.
Preferably, formed by the raw material of following weight proportion:
Scorpio 55-60 part, Radix Polygoni Multiflori 15-25 part,
Radix Scutellariae 12-22 part, Fructus Forsythiae 12-20 part.
Medicine taking said composition as active component can be made into the various dosage forms such as powder, pill, tablet or capsule.
In pharmaceutical composition of the present invention, Scorpio is monarch drug, and large usage quantity has the effect of dispersing pathogen accumulation and dredging collateral eliminating carbuncle; Radix Polygoni Multiflori is ministerial drug, and consumption is less, and sweet in the mouth is warm in nature, the effect of have combing irritability, preventing the attack (or recurrence) of malaria, dispeling the wind and detoxifying; Radix Scutellariae, Fructus Forsythiae are adjuvant drug, all have the effect of heat clearing and damp drying and eliminating fire and detoxication, for assisting a ruler in governing a country ministerial drug and monarch drug; Fructus Forsythiae bitter in the mouth is slightly cold, and has the effect of combing cardiopulmonary, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and dispelling wind and heat pathogens; Radix Scutellariae is returned lung meridian, and mildly bitter flavor has the effect of heat clearing and damp drying, eliminating fire and detoxication, can treat the symptom such as cough due to lung-heat, high hot excessive thirst.By the pharmaceutical composition of above-mentioned four taste Chinese medicine composition mixture modulation, can effectively regulate the negative and positive of internal organs, regulate the unbalance of qi-blood-body fluid, and can nourish throat, thereby chronic pharyngolaryngitis is had to the curative effect of extremely suiting the medicine to the illness.Pharmaceutical composition of the present invention there is with strong points, the drug effect of effect obviously and toxic and side effects dawn etc. feature.Two of object of the present invention is achieved in that a kind of preparation method of chronic pharyngolaryngitis medicine, comprises the following steps:
A, take this four Chinese medicine thing component of Scorpio, Radix Polygoni Multiflori, Radix Scutellariae and Fructus Forsythiae by the formula proportion of aforementioned pharmaceutical compositions respectively;
B, by Scorpio by pot fried dry to micro-yellow;
C, the Scorpio processing is mixed with Radix Polygoni Multiflori, Radix Scutellariae and Fructus Forsythiae after, grind to form fine powder, cross 100 mesh sieves;
D, the fine powder after sieving is carried out to ripening and sterilization treatment 10 minutes under 100-110 DEG C of condition;
E, dry in the air incapsulates to room temperature.
In made powder, add appropriate adjuvant, formulation method is made various clinical acceptable dosage forms routinely, as powder, pill, tablet, capsule etc.
The using method of pharmaceutical composition of the present invention is: adult's oral medication, every day 2 times, each 5-6 gram; That period in a medicine is avoided is pungent, tobacco and wine, seafood and donkey Equus caballus (L.), notes warmingly, avoids wind and cold fatigue, and anemia of pregnant woman's forbidding.The beneficial effect of pharmaceutical composition of the present invention can embody by following experiment:
Clinically choose 40 routine chronic pharyngolaryngitis patients, select immediately 20 patients as a control group, all the other 20 patients are treatment group.Therapeutic Method: the oral capsule of being made by pharmaceutical composition of the present invention for the treatment of group, every day 2 times, each 12 (6 grams of active components), every 7 days is a course for the treatment of, treats continuously 3 courses for the treatment of.Matched group adopts western medicine, and every 7 days is a course for the treatment of, treats continuously 3 courses for the treatment of.
Criterion of therapeutical effect:
Alleviate: patient's malaise symptoms alleviates.Cure: patient symptom all disappears, in 2 years without recurrence.Invalid: patient's malaise symptoms is without change.
The therapeutic effect for the treatment of group and matched group is as shown in table 1:
Table 1: the therapeutic effect of each compositions and matched group
Matched group has 5 routine patients with untoward reaction such as nausea and vomiting during treating; Treatment group is not found any untoward reaction and toxic and side effects.
Detailed description of the invention
Following examples are used for further illustrating the present invention, but do not limit in any form the present invention.
Embodiment 1:
Get 50 grams of Scorpios, 17 grams of Radix Polygoni Multiflori, 17 grams of Radix Scutellariaes, 17 grams of Fructus Forsythiaes.First Scorpio is put into pot heat drying, Scorpio color is heated to micro-Huang, then four Chinese medicine material is mixed, and processing is crossed 100 mesh sieves after pulverizing; Fine powder after sieving carries out ripening, sterilization treatment 10 minutes at 110 DEG C, finally obtains the powder of this pharmaceutical composition.
The powder of this pharmaceutical composition is incapsulated, make capsule, every capsules is containing 0.5 gram of pharmaceutical composition of the present invention.
Embodiment 2:
Get 60 grams of Scorpios, 15 grams of Radix Polygoni Multiflori, 25 grams of Radix Scutellariaes, 20 grams of Fructus Forsythiaes.First Scorpio is put into pot heat drying, Scorpio color is heated to micro-Huang, then four Chinese medicine material is mixed, and processing is crossed 100 mesh sieves after pulverizing; Fine powder after sieving carries out ripening, sterilization treatment 10 minutes at 105 DEG C, finally obtains the powder of this pharmaceutical composition.
Get 55 grams of the powders of this pharmaceutical composition, 45 grams of Mel that it has been refined with heating mix, and can be modulated into honeyed pill, and every honeyed pill weighs 6 grams.
In embodiment 3-10, each drug component sees the following form:
Unit: gram
| Embodiment | Scorpio | Radix Polygoni Multiflori | Radix Scutellariae | Fructus Forsythiae |
| 3 | 55 | 23 | 22 | 12 |
| 4 | 57 | 25 | 20 | 16 |
| 5 | 58 | 18 | 15 | 20 |
| 6 | 60 | 15 | 12 | 15 |
| 7 | 50 | 27 | 28 | 10 |
| 8 | 62 | 20 | 30 | 22 |
| 9 | 65 | 10 | 24 | 25 |
| 10 | 70 | 14 | 10 | 13 |
Capture respectively the each medical material component in embodiment 3-10 according to the listed drug component of upper table and dosage, in each embodiment, respectively Scorpio is put into pot heat drying, Scorpio color is heated to micro-Huang, after four Chinese medicine material is mixed, grind, cross 100 mesh sieves, become fine powder.At 110 DEG C, carry out ripening, sterilization treatment 10 minutes, finally obtain the powder of the pharmaceutical composition in an embodiment.
The powder of pharmaceutical composition made in embodiment 3-10, according to conventional tablet preparation method, is made to tablet, and every tablet is containing 500 milligrams of pharmaceutical compositions of the present invention.
The pharmaceutical composition that embodiment 1-10 is made, after on probation, all can reach the essentially identical therapeutic effect shown in table 1.
At medicine, not in time in the situation that, the Radix Scutellariae in pharmaceutical composition of the present invention can substitute with Cortex Phellodendri, and Fructus Forsythiae can substitute with Flos Lonicerae.Scorpio Radix Polygoni Multiflori can not substitute with other drug, can not lack.
Claims (4)
1. a pharmaceutical composition that is used for the treatment of chronic pharyngolaryngitis, is characterized in that, is made up of the raw material of following weight proportion:
Scorpio 50-70 part, Radix Polygoni Multiflori 10-27 part,
Radix Scutellariae 10-30 part, Fructus Forsythiae 10-25 part.
2. pharmaceutical composition according to claim 1, is characterized in that, is made up of the raw material of following weight proportion:
Scorpio 55-60 part, Radix Polygoni Multiflori 15-22 part,
Radix Scutellariae 12-25 part, Fructus Forsythiae 12-20 part.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that, the medicine taking said composition as active component can be made into powder, pill, tablet or capsule.
4. a preparation method for the treatment of chronic pharyngolaryngitis pharmaceutical composition described in claim 1, is characterized in that, comprises the following steps:
A, take this four Chinese medicine thing component of Scorpio, Radix Polygoni Multiflori, Radix Scutellariae and Fructus Forsythiae by the formula proportion of aforementioned pharmaceutical compositions respectively;
B, by Scorpio by pot fried dry to micro-yellow;
C, the Scorpio processing is mixed with Radix Polygoni Multiflori, Radix Scutellariae and Fructus Forsythiae after, grind to form fine powder, cross 100 mesh sieves;
D, the fine powder after sieving is carried out to ripening and sterilization treatment 10 minutes under 100-110 DEG C of condition;
E, dry in the air incapsulates to room temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310178759.4A CN104138423B (en) | 2013-05-08 | 2013-05-08 | It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310178759.4A CN104138423B (en) | 2013-05-08 | 2013-05-08 | It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104138423A true CN104138423A (en) | 2014-11-12 |
| CN104138423B CN104138423B (en) | 2016-06-08 |
Family
ID=51847875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310178759.4A Expired - Fee Related CN104138423B (en) | 2013-05-08 | 2013-05-08 | It is used for the treatment of pharmaceutical composition and its preparation method of chronic pharyngolaryngitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104138423B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1149468A (en) * | 1995-11-09 | 1997-05-14 | 阳灵广 | Powder for laryngopharyngitis |
| CN101229321A (en) * | 2008-01-04 | 2008-07-30 | 盖欣 | Chinese traditional medicine granule for treating chronic pharyngitis |
-
2013
- 2013-05-08 CN CN201310178759.4A patent/CN104138423B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1149468A (en) * | 1995-11-09 | 1997-05-14 | 阳灵广 | Powder for laryngopharyngitis |
| CN101229321A (en) * | 2008-01-04 | 2008-07-30 | 盖欣 | Chinese traditional medicine granule for treating chronic pharyngitis |
Non-Patent Citations (1)
| Title |
|---|
| 张辉等: "复方双黄连喷剂的制备及临床应用", 《中原医刊》, vol. 30, no. 3, 28 February 2003 (2003-02-28) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104138423B (en) | 2016-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101829293A (en) | Traditional Chinese medicine composite for treating cough disease and preparation method thereof | |
| CN102846918A (en) | Drug for treating faucitis | |
| CN101422579B (en) | Traditional Chinese medicine preparation for treating oral ulcer | |
| CN104547496B (en) | A kind of Chinese medicine composition to moisten the lung and relieve the cough and preparation method thereof | |
| CN101983675A (en) | Traditional Chinese medicine composition for treating asthma and preparation method thereof | |
| CN102228626B (en) | Traditional Chinese medicine for treating tinnitus and deafness | |
| CN105362491A (en) | External-use medicine for treating cervical vertebra hyperosteogeny | |
| CN104983968B (en) | Antipyretic traditional Chinese medicine composition and preparation method thereof | |
| CN101757516A (en) | Prescription of traditional Chinese medicine for treating infantile allergic asthma | |
| CN104288477A (en) | Traditional Chinese medicine preparation curing infantile asthma | |
| CN103520559A (en) | Internal herbaceous medicine compound used for treating toothache | |
| CN102600391A (en) | Traditional Chinese medicine composition for treating pediatric acute tonsillitis | |
| CN102727773B (en) | Traditional Chinese medicinal capsule for treating blood mucoviscidosis | |
| CN102552560B (en) | Compound combination medicament for effectively treating hand-foot-and-mouth disease | |
| CN105381291A (en) | Traditional Chinese medicine composition for preventing and treating pneumonia, preparation method and applications thereof | |
| CN105521332A (en) | Traditional Chinese medicinal composition for treating anal fissure, and preparation method and application thereof | |
| CN105396017A (en) | Traditional Chinese medicine preparation used for treating fatty liver, and preparation method thereof | |
| CN104873911A (en) | Traditional Chinese medicine for oral administration for adjunctively treating sepsis | |
| CN104138423A (en) | Pharmaceutical composition for treating chronic pharyngolaryngitis and preparation method thereof | |
| CN104042872B (en) | Traditional Chinese medicine composition for treating common cold of children and preparation method thereof | |
| CN103721028B (en) | One treats anginal medicine and preparation method | |
| CN104474154A (en) | Traditional Chinese medicine for treating cold fever and preparation method of traditional Chinese medicine | |
| CN105079425A (en) | Composition preparation for treating infantile hand-foot-mouth disease, and preparation method of composition preparation | |
| CN105125786A (en) | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands and preparation method thereof | |
| CN102755576B (en) | Traditional Chinese medicine spray for treating respiratory tract inflammation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160608 Termination date: 20170508 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |