CN104130110A - 白藜芦醇的提取方法及其获得的白藜芦醇和药物组合物 - Google Patents
白藜芦醇的提取方法及其获得的白藜芦醇和药物组合物 Download PDFInfo
- Publication number
- CN104130110A CN104130110A CN201410392546.6A CN201410392546A CN104130110A CN 104130110 A CN104130110 A CN 104130110A CN 201410392546 A CN201410392546 A CN 201410392546A CN 104130110 A CN104130110 A CN 104130110A
- Authority
- CN
- China
- Prior art keywords
- resveratrol
- trans
- pharmaceutical composition
- acid
- extracting method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title claims abstract description 84
- 238000000034 method Methods 0.000 title claims abstract description 44
- 239000000203 mixture Substances 0.000 title abstract description 11
- 239000003814 drug Substances 0.000 title abstract description 10
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title abstract description 7
- 235000021283 resveratrol Nutrition 0.000 title abstract description 7
- 229940016667 resveratrol Drugs 0.000 title abstract description 7
- 229940079593 drug Drugs 0.000 title abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 51
- WVTKBKWTSCPRNU-KYJUHHDHSA-N (+)-Tetrandrine Chemical compound C([C@H]1C=2C=C(C(=CC=2CCN1C)OC)O1)C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@@H]2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-KYJUHHDHSA-N 0.000 claims abstract description 26
- 238000000605 extraction Methods 0.000 claims abstract description 26
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 18
- 238000010992 reflux Methods 0.000 claims abstract description 16
- 239000002253 acid Substances 0.000 claims abstract description 11
- 238000002425 crystallisation Methods 0.000 claims abstract description 10
- 230000008025 crystallization Effects 0.000 claims abstract description 10
- 239000013078 crystal Substances 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000003513 alkali Substances 0.000 claims abstract description 7
- 230000007935 neutral effect Effects 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 235000018991 trans-resveratrol Nutrition 0.000 claims description 64
- 206010039966 Senile dementia Diseases 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 17
- 244000153955 Reynoutria sachalinensis Species 0.000 claims description 15
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims description 15
- 230000007062 hydrolysis Effects 0.000 claims description 14
- 238000006460 hydrolysis reaction Methods 0.000 claims description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 239000001509 sodium citrate Substances 0.000 claims description 6
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical group [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 6
- 229940038773 trisodium citrate Drugs 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 2
- 239000000920 calcium hydroxide Substances 0.000 claims description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000292 calcium oxide Substances 0.000 claims description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 11
- 238000004519 manufacturing process Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 9
- 239000002904 solvent Substances 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- 230000003930 cognitive ability Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract description 2
- 238000002156 mixing Methods 0.000 abstract description 2
- 241001648835 Polygonum cuspidatum Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000010419 fine particle Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- WVTKBKWTSCPRNU-UHFFFAOYSA-N rac-Tetrandrin Natural products O1C(C(=CC=2CCN3C)OC)=CC=2C3CC(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2CC2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-UHFFFAOYSA-N 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 32
- 241000700159 Rattus Species 0.000 description 16
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 150000001875 compounds Chemical group 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000003304 gavage Methods 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 102000011759 adducin Human genes 0.000 description 3
- 108010076723 adducin Proteins 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 239000011122 softwood Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 235000020985 whole grains Nutrition 0.000 description 3
- 235000019890 Amylum Nutrition 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920003091 Methocel™ Polymers 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 230000006933 amyloid-beta aggregation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012627 chemopreventive agent Substances 0.000 description 2
- 229940124443 chemopreventive agent Drugs 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 201000010001 Silicosis Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 201000011529 cardiovascular cancer Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- -1 hanfangchin A compound Chemical class 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000010149 post-hoc-test Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
- C07C37/88—Use of additives, e.g. for stabilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
实施例 | 实施例1 | 实施例2 | 实施例3 | 实施例4 | 对比例一 |
原料重量 | 500g | 500g | 5kg | 500kg | 500kg |
产品(白藜芦醇)重量 | 9.7g | 10.2g | 98g | 10.5kg | 8.8kg |
收率 | 1.94% | 2.04% | 1.96% | 2.10% | 1.76% |
白藜芦醇 | 25g |
汉防己甲素 | 5g |
淀粉 | 25g |
糊精 | 35g |
低取代羟丙基纤维素 | 5g |
60%乙醇 | 适量 |
硬脂酸镁 | 1g |
白藜芦醇 | 20g |
汉防己甲素 | 20g |
可压性淀粉 | 40g |
乳糖 | 30 |
低取代羟丙基纤维素 | 5g |
60%乙醇 | 适量 |
白藜芦醇 | 60g |
汉防己甲素 | 48g |
羧丙基甲基纤维素 | 30g |
乳糖 | 2.5g |
80%乙醇 | 适量 |
硬脂酸镁 | 0.12g |
组别 | n | 避暗潜伏期(s) |
模型组 | 10 | 22.64±5.63 |
对照组 | 10 | 90.53±12.65 |
白藜芦醇组 | 10 | 95.23±11.25 |
汉防己甲素组 | 10 | 95.37±11.13 |
复方组 | 10 | 125.66±12.68 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410392546.6A CN104130110B (zh) | 2014-08-12 | 2014-08-12 | 白藜芦醇的提取方法及其获得的白藜芦醇和药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410392546.6A CN104130110B (zh) | 2014-08-12 | 2014-08-12 | 白藜芦醇的提取方法及其获得的白藜芦醇和药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104130110A true CN104130110A (zh) | 2014-11-05 |
CN104130110B CN104130110B (zh) | 2015-08-26 |
Family
ID=51803018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410392546.6A Expired - Fee Related CN104130110B (zh) | 2014-08-12 | 2014-08-12 | 白藜芦醇的提取方法及其获得的白藜芦醇和药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104130110B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108849445A (zh) * | 2018-03-20 | 2018-11-23 | 刘静 | 一种花生芽中的白藜芦醇的条件培育系统及方法 |
CN111995501A (zh) * | 2020-10-28 | 2020-11-27 | 正大预混料(天津)有限公司 | 一种天然产物白藜芦醇的提取方法及其组合物 |
CN114315847A (zh) * | 2021-12-16 | 2022-04-12 | 科丝美诗(上海)检测科技有限公司 | 一种绿色环保的粉防己生物总碱的提取方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1539419A (zh) * | 2003-04-25 | 2004-10-27 | 上海纳贝生物技术有限责任公司 | 白藜芦醇复方制剂及应用 |
CN101643754A (zh) * | 2009-08-31 | 2010-02-10 | 三明华健生物工程有限公司 | 从虎杖中提取制备高纯度白藜芦醇新工艺 |
CN102320934A (zh) * | 2011-09-09 | 2012-01-18 | 四川天予植物药业有限公司 | 一种从虎杖根茎中提取白藜芦醇的新方法 |
CN102958516A (zh) * | 2009-02-20 | 2013-03-06 | N.V.努特里西阿公司 | 白藜芦醇或其他羟基化均二苯代乙烯用于保护认知功能的用途 |
CN103571891A (zh) * | 2013-11-01 | 2014-02-12 | 湖南科源生物制品有限公司 | 一种从虎杖中提取白藜芦醇的方法 |
-
2014
- 2014-08-12 CN CN201410392546.6A patent/CN104130110B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1539419A (zh) * | 2003-04-25 | 2004-10-27 | 上海纳贝生物技术有限责任公司 | 白藜芦醇复方制剂及应用 |
CN102958516A (zh) * | 2009-02-20 | 2013-03-06 | N.V.努特里西阿公司 | 白藜芦醇或其他羟基化均二苯代乙烯用于保护认知功能的用途 |
CN101643754A (zh) * | 2009-08-31 | 2010-02-10 | 三明华健生物工程有限公司 | 从虎杖中提取制备高纯度白藜芦醇新工艺 |
CN102320934A (zh) * | 2011-09-09 | 2012-01-18 | 四川天予植物药业有限公司 | 一种从虎杖根茎中提取白藜芦醇的新方法 |
CN103571891A (zh) * | 2013-11-01 | 2014-02-12 | 湖南科源生物制品有限公司 | 一种从虎杖中提取白藜芦醇的方法 |
Non-Patent Citations (4)
Title |
---|
FU QIAN HE ET AL.: "Tetrandrine suppresses amyloid-β-induced inflammatory cytokines by inhibiting NF-κB pathway in murine BV2 microglial cells", 《INTERNATIONAL IMMUNOPHARMACOLOGY》 * |
FU-QIAN HE ET AL.: "Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimers disease induced by amyloid-β(1–42)", 《BRAIN RESEARCH》 * |
GERDA BRUNHOFER ET AL.: "Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine", 《BIOORGANIC & MEDICINAL CHEMISTRY》 * |
罗莉等: "白藜芦醇对老年性痴呆小鼠认知功能的影响", 《中南大学学报医学版》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108849445A (zh) * | 2018-03-20 | 2018-11-23 | 刘静 | 一种花生芽中的白藜芦醇的条件培育系统及方法 |
CN111995501A (zh) * | 2020-10-28 | 2020-11-27 | 正大预混料(天津)有限公司 | 一种天然产物白藜芦醇的提取方法及其组合物 |
CN111995501B (zh) * | 2020-10-28 | 2021-01-01 | 正大预混料(天津)有限公司 | 一种天然饲料添加剂白藜芦醇的提取方法 |
CN114315847A (zh) * | 2021-12-16 | 2022-04-12 | 科丝美诗(上海)检测科技有限公司 | 一种绿色环保的粉防己生物总碱的提取方法 |
CN114315847B (zh) * | 2021-12-16 | 2024-05-03 | 科丝美诗(上海)检测科技有限公司 | 一种绿色环保的粉防己生物总碱的提取方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104130110B (zh) | 2015-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104258193B (zh) | 一种治疗神经衰弱和预防老年痴呆症的药物组合物 | |
CN102382082B (zh) | 一种炎琥宁化合物及其药物组合物 | |
CN104130110B (zh) | 白藜芦醇的提取方法及其获得的白藜芦醇和药物组合物 | |
CN102304501A (zh) | 一种复合酶制剂及其用于提取植物多糖的应用和方法 | |
CN102784182A (zh) | 红参多糖提取物的制备方法 | |
CN102784181A (zh) | 一种红参多糖的制备方法 | |
CN1850142A (zh) | 金银花配方颗粒的制备方法 | |
CN102370901A (zh) | 一种治疗肾病的药物组合物及其制备方法 | |
CN101781215A (zh) | 棓丙酯原料药化学半合成制备方法 | |
CN101812242B (zh) | 海胆棘壳色素的制备方法 | |
CN101396389A (zh) | 一种返魂草有效成分提取方法及其颗粒剂制备方法 | |
CN105998104B (zh) | 一种榆钱提取物在制备治疗神经保护药物方面的用途 | |
CN110872359A (zh) | 一种利用半仿生学原理提取黄芪多糖的制备方法 | |
CN103565960B (zh) | 一种半仿生提取技术制备枳椇子提取物的方法 | |
CN101991722B (zh) | 一种石歧外感中药胶囊 | |
CN107692236B (zh) | 轻质碳酸钙在制备食品、保健品或药品中的应用 | |
CN102093457A (zh) | 一种从枇杷叶中提取科罗索酸的方法 | |
CN101450962B (zh) | 从秋茄叶片中提取齐墩果酸的方法 | |
CN108452012B (zh) | 三黄片黄芩浸膏粉的制备方法 | |
CN103652912B (zh) | 一种淫羊藿龙眼肉山药咀嚼片及制备方法 | |
CN104087623A (zh) | 一种从虎杖中酶解提取白藜芦醇的方法 | |
CN103073479B (zh) | 从植物芜青中提取纯化分离制备一种天然吡咯衍生物的方法 | |
CN103156878A (zh) | 一种桑黃多糖opc缓释微囊 | |
CN103626811B (zh) | 一种从锁阳中提取分离根皮苷的方法 | |
CN102552383A (zh) | 一种复方海蜇降压分散片及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: ZOU JINXIN Effective date: 20150212 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20150212 Address after: Taiping Town Dazhou city Sichuan province 636350 Wanyuan County River Street No. 40 Lane Road Zongmao Applicant after: Sichuan Tianyu Vegetable Pharmaceutical Co., Ltd. Applicant after: Zou Jinxin Address before: Taiping Town Dazhou city Sichuan province 636350 Wanyuan County River Street No. 40 Lane Road Zongmao Applicant before: Sichuan Tianyu Vegetable Pharmaceutical Co., Ltd. |
|
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: ZOU JINXIN Effective date: 20150730 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20150730 Address after: Taiping Town Dazhou city Sichuan province 636350 Wanyuan County River Street No. 40 Lane Road Zongmao Applicant after: Sichuan Tianyu Vegetable Pharmaceutical Co., Ltd. Address before: Taiping Town Dazhou city Sichuan province 636350 Wanyuan County River Street No. 40 Lane Road Zongmao Applicant before: Sichuan Tianyu Vegetable Pharmaceutical Co., Ltd. Applicant before: Zou Jinxin |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150826 Termination date: 20170812 |
|
CF01 | Termination of patent right due to non-payment of annual fee |