CN1041166C - 抗菌素与二价和/或三价金属形成的螯合物在制备抗溃疡药中的用途 - Google Patents

抗菌素与二价和/或三价金属形成的螯合物在制备抗溃疡药中的用途 Download PDF

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Publication number
CN1041166C
CN1041166C CN91101355A CN91101355A CN1041166C CN 1041166 C CN1041166 C CN 1041166C CN 91101355 A CN91101355 A CN 91101355A CN 91101355 A CN91101355 A CN 91101355A CN 1041166 C CN1041166 C CN 1041166C
Authority
CN
China
Prior art keywords
azithromycin
divalent
antibiotics
gel
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN91101355A
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English (en)
Chinese (zh)
Other versions
CN1054534A (zh
Inventor
斯罗泊丹·德约基克
斯拉克·瓦特尼尔
沃吉·克吉威斯
尼维卡·罗泊塔
利笛嘉·克拉尼-巴比克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Publication of CN1054534A publication Critical patent/CN1054534A/zh
Application granted granted Critical
Publication of CN1041166C publication Critical patent/CN1041166C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN91101355A 1990-03-07 1991-03-06 抗菌素与二价和/或三价金属形成的螯合物在制备抗溃疡药中的用途 Expired - Fee Related CN1041166C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YUP-455/90 1990-03-07
YU45590A YU45590A (sh) 1990-03-07 1990-03-07 Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN97109555A Division CN1051560C (zh) 1990-03-07 1997-04-18 抗菌素与络合金属盐的螯合物的制备方法

Publications (2)

Publication Number Publication Date
CN1054534A CN1054534A (zh) 1991-09-18
CN1041166C true CN1041166C (zh) 1998-12-16

Family

ID=25550003

Family Applications (2)

Application Number Title Priority Date Filing Date
CN91101355A Expired - Fee Related CN1041166C (zh) 1990-03-07 1991-03-06 抗菌素与二价和/或三价金属形成的螯合物在制备抗溃疡药中的用途
CN97109555A Expired - Fee Related CN1051560C (zh) 1990-03-07 1997-04-18 抗菌素与络合金属盐的螯合物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN97109555A Expired - Fee Related CN1051560C (zh) 1990-03-07 1997-04-18 抗菌素与络合金属盐的螯合物的制备方法

Country Status (20)

Country Link
US (1) US5498699A (enExample)
EP (1) EP0445743B1 (enExample)
JP (1) JP2731636B2 (enExample)
CN (2) CN1041166C (enExample)
AT (1) ATE143266T1 (enExample)
BG (1) BG61230B1 (enExample)
CA (1) CA2037663C (enExample)
CZ (1) CZ280181B6 (enExample)
DE (1) DE69122282T2 (enExample)
DK (1) DK0445743T3 (enExample)
ES (1) ES2094763T3 (enExample)
GR (1) GR3021947T3 (enExample)
HR (1) HRP940256B1 (enExample)
HU (2) HU209455B (enExample)
PL (1) PL166279B1 (enExample)
RO (1) RO107660B1 (enExample)
RU (2) RU2039060C1 (enExample)
SI (1) SI9010455B (enExample)
SK (1) SK279278B6 (enExample)
YU (1) YU45590A (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
GB9120131D0 (en) * 1991-09-20 1991-11-06 Glaxo Group Ltd Medicaments
TW271400B (enExample) * 1992-07-30 1996-03-01 Pfizer
JPH10512877A (ja) * 1995-01-26 1998-12-08 ニコムド イメージング エイ／エス ビスマス化合物
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
US5900410A (en) * 1996-08-27 1999-05-04 Hartmann; John F. Monotherapy of peptic ulcers and gastritis
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
EP1652851A1 (en) 2001-05-22 2006-05-03 Pfizer Products Inc. New crystal form of Azithromycin
KR20040032942A (ko) * 2001-08-21 2004-04-17 화이자 프로덕츠 인코포레이티드 호흡기 감염증을 치료하기 위한 일회분량의 아지트로마이신
RU2283116C2 (ru) * 2002-05-27 2006-09-10 Курский государственный медицинский университет Способ увеличения выживаемости изолированного кожного лоскута "на ножке" у животных с пониженным антиоксидантным фоном
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060046970A1 (en) * 2004-08-31 2006-03-02 Insite Vision Incorporated Topical otic compositions and methods of topical treatment of prevention of otic infections
JP2008518025A (ja) * 2004-10-25 2008-05-29 パラテック ファーマシューティカルズ インコーポレイテッド ４−アミノテトラサイクリンおよびその使用の方法
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
CN104892694A (zh) * 2015-05-24 2015-09-09 广西师范学院 蔗糖硫酸酯铜类化合物及其制作方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862225A (en) * 1961-08-18 1975-01-21 Pfizer D-ring substituted tetracyclines
US3622627A (en) * 1967-09-13 1971-11-23 Pfizer 4-dedimethylaminatetracycline and 5a, 6-anhydro derivatives thereof
HU167946B (enExample) * 1973-04-16 1976-01-28
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
WO1986005981A1 (en) * 1985-04-18 1986-10-23 Borody Thomas J Treatment of non-ulcer dyspepsia with bismuth salts
DE3650504T2 (de) * 1985-06-13 1996-10-31 Marshall Barry James Verfahren und Zusammensetzungen zur Behandlung von gastrointestinalen Störungen
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
HU198913B (en) * 1987-09-03 1989-12-28 Pliva Pharm & Chem Works Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
JP2733849B2 (ja) * 1987-10-12 1998-03-30 ボロディー，ソーマス・ユリウス 胃腸障害治療のための改良された方法
US5246708A (en) * 1987-10-28 1993-09-21 Pro-Neuron, Inc. Methods for promoting wound healing with deoxyribonucleosides
DE391005T1 (de) * 1989-04-03 1991-04-11 Ranbaxy Laboratories, Ltd., New Delhi Verfahren zur herstellung von alpha-6-deoxytetracyclinen.
US5348946A (en) * 1991-02-28 1994-09-20 Biochem Immunosystems, Inc. Heteroanthracycline antitumor analogs
MA28714B1 (fr) * 2005-12-15 2007-07-02 Green Technlology Sarl Une arabinogalactane proteine ayant la propriete d'absorber les graisses et le procede d'obtention de cette arabinogalactane proteine

Also Published As

Publication number Publication date
BG93995A (bg) 1993-12-24
CA2037663C (en) 1999-01-19
DE69122282T2 (de) 1997-04-24
SK279278B6 (sk) 1998-09-09
EP0445743A2 (en) 1991-09-11
JPH06184186A (ja) 1994-07-05
BG61230B1 (bg) 1997-03-31
EP0445743B1 (en) 1996-09-25
DE69122282D1 (de) 1996-10-31
RO107660B1 (ro) 1993-12-30
CN1054534A (zh) 1991-09-18
HU209455B (en) 1994-06-28
CN1051560C (zh) 2000-04-19
US5498699A (en) 1996-03-12
HUT56849A (en) 1991-10-28
YU45590A (sh) 1992-07-20
JP2731636B2 (ja) 1998-03-25
PL166279B1 (pl) 1995-04-28
RU2039061C1 (ru) 1995-07-09
HU211475A9 (en) 1995-11-28
HRP940256A2 (en) 1997-06-30
DK0445743T3 (enExample) 1997-02-17
CS9100587A2 (en) 1991-10-15
GR3021947T3 (en) 1997-03-31
SI9010455B (sl) 2000-04-30
CA2037663A1 (en) 1991-09-08
ATE143266T1 (de) 1996-10-15
CN1168891A (zh) 1997-12-31
HU910740D0 (en) 1991-09-30
SI9010455A (en) 1997-08-31
RU2039060C1 (ru) 1995-07-09
CZ280181B6 (cs) 1995-11-15
ES2094763T3 (es) 1997-02-01
HRP940256B1 (en) 1998-10-31
EP0445743A3 (en) 1992-10-07

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