CN104114569B - 碱基部保护寡核苷酸 - Google Patents

碱基部保护寡核苷酸 Download PDF

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Publication number
CN104114569B
CN104114569B CN201380009595.0A CN201380009595A CN104114569B CN 104114569 B CN104114569 B CN 104114569B CN 201380009595 A CN201380009595 A CN 201380009595A CN 104114569 B CN104114569 B CN 104114569B
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China
Prior art keywords
group
formula
oligonucleotide
alkyl
represent
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CN201380009595.0A
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Chinese (zh)
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CN104114569A (zh
Inventor
平井邦博
片山智
鸟居高好
中谷辽太朗
高桥大辅
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Priority to CN201610883841.0A priority Critical patent/CN106977567B/zh
Publication of CN104114569A publication Critical patent/CN104114569A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201380009595.0A 2012-02-17 2013-02-15 碱基部保护寡核苷酸 Active CN104114569B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610883841.0A CN106977567B (zh) 2012-02-17 2013-02-15 碱基部保护寡核苷酸

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012033429 2012-02-17
JP2012-033429 2012-02-17
JP2012-254718 2012-11-20
JP2012254718 2012-11-20
PCT/JP2013/053769 WO2013122236A1 (ja) 2012-02-17 2013-02-15 塩基部保護オリゴヌクレオチド

Related Child Applications (1)

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CN201610883841.0A Division CN106977567B (zh) 2012-02-17 2013-02-15 碱基部保护寡核苷酸

Publications (2)

Publication Number Publication Date
CN104114569A CN104114569A (zh) 2014-10-22
CN104114569B true CN104114569B (zh) 2017-04-26

Family

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Family Applications (2)

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CN201380009595.0A Active CN104114569B (zh) 2012-02-17 2013-02-15 碱基部保护寡核苷酸

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Country Status (5)

Country Link
EP (2) EP3296306B1 (enExample)
JP (1) JP6237237B2 (enExample)
CN (2) CN106977567B (enExample)
IN (1) IN2014DN06768A (enExample)
WO (1) WO2013122236A1 (enExample)

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JP5979139B2 (ja) 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
US9284344B2 (en) 2012-05-30 2016-03-15 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
JP6218333B2 (ja) * 2012-11-14 2017-10-25 武田薬品工業株式会社 核酸の液相合成方法
CN106795186B (zh) 2014-10-14 2021-03-02 味之素株式会社 吗啉代寡核苷酸的制备方法
EP3378869A4 (en) * 2015-11-17 2019-09-18 Nissan Chemical Corporation PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES
EP3398955A4 (en) * 2015-12-16 2019-10-16 Ajinomoto Co., Inc. OLIGONUCLEOTIDE MANUFACTURING METHOD AND NUCLEOSIDE, NUCLEOTIDE OR OLIGONUCLEOTIDE
WO2017111137A1 (ja) * 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
CN107556355B (zh) * 2016-06-30 2021-10-22 上海兆维科技发展有限公司 一种核苷双亚磷酰胺及其制备方法
TW201906855A (zh) * 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法
JP7140111B2 (ja) * 2017-05-16 2022-09-21 日産化学株式会社 オリゴヌクレオチドの製造方法
SG11202008232QA (en) * 2018-03-14 2020-09-29 Hoffmann La Roche Lna-dicarboxylic acid derivatives and process for their preparation
KR102898787B1 (ko) 2018-05-10 2025-12-11 니뽄 신야쿠 가부시키가이샤 올리고 핵산 화합물의 제조 방법
CN113166191B (zh) * 2018-05-30 2024-12-03 诺华股份有限公司 脂质修饰的核酸化合物和方法
WO2020166705A1 (ja) 2019-02-15 2020-08-20 味の素株式会社 オリゴヌクレオチドの製造方法
WO2020196890A1 (ja) 2019-03-28 2020-10-01 味の素株式会社 ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法
CN119143828A (zh) * 2019-05-08 2024-12-17 渤健马萨诸塞州股份有限公司 寡核苷酸的汇聚液相合成
JPWO2021045141A1 (enExample) * 2019-09-04 2021-03-11
EP4059944A4 (en) 2019-11-13 2024-04-10 Nippon Shinyaku Co., Ltd. METHOD FOR PREPARING AN OLIGONUCLICE ACID COMPOUND
US20230014840A1 (en) 2019-11-13 2023-01-19 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
CN111039977B (zh) * 2019-12-31 2022-11-08 广州同隽医药科技有限公司 一种亚磷酰化试剂及其在寡核苷酸合成中的应用
US20230406878A1 (en) * 2020-11-11 2023-12-21 Biogen Ma Inc. Oligonucleotides, reagents, and preparation thereof
CN117279926A (zh) 2021-04-28 2023-12-22 日本新药株式会社 低聚核酸化合物的制造方法
US20250066396A1 (en) 2021-12-27 2025-02-27 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
WO2024228396A1 (ja) * 2023-05-01 2024-11-07 株式会社ナティアス オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成
WO2025082632A1 (en) 2023-10-16 2025-04-24 Bachem Holding Ag Method and composition for oligonucleotide synthesis
WO2025153088A1 (zh) * 2024-01-18 2025-07-24 北京安龙生物医药有限公司 靶向第13型17β-羟基类固醇脱氢酶的寡核苷酸及其用途

Citations (5)

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EP0180945A2 (en) * 1984-11-05 1986-05-14 Wakunaga Seiyaku Kabushiki Kaisha Nucleotide derivative
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
WO2005070859A1 (ja) * 2004-01-27 2005-08-04 Takeshi Wada フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
JP2010275254A (ja) * 2009-05-29 2010-12-09 Tokyo Univ Of Agriculture & Technology 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
CN102191233A (zh) * 2010-03-04 2011-09-21 中国人民解放军军事医学科学院毒物药物研究所 新颖的10-23脱氧核酶类似物及其用途

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US9284344B2 (en) * 2012-05-30 2016-03-15 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support

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EP0180945A2 (en) * 1984-11-05 1986-05-14 Wakunaga Seiyaku Kabushiki Kaisha Nucleotide derivative
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
WO2005070859A1 (ja) * 2004-01-27 2005-08-04 Takeshi Wada フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
JP2010275254A (ja) * 2009-05-29 2010-12-09 Tokyo Univ Of Agriculture & Technology 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
CN102191233A (zh) * 2010-03-04 2011-09-21 中国人民解放军军事医学科学院毒物药物研究所 新颖的10-23脱氧核酶类似物及其用途

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Also Published As

Publication number Publication date
JPWO2013122236A1 (ja) 2015-05-18
CN106977567A (zh) 2017-07-25
EP3296306A1 (en) 2018-03-21
IN2014DN06768A (enExample) 2015-05-22
EP2816053B1 (en) 2021-03-24
CN106977567B (zh) 2021-02-02
WO2013122236A1 (ja) 2013-08-22
EP2816053A1 (en) 2014-12-24
CN104114569A (zh) 2014-10-22
EP3296306B1 (en) 2022-11-09
EP2816053A4 (en) 2015-07-01
JP6237237B2 (ja) 2017-11-29

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