IN2014DN06768A - - Google Patents

Info

Publication number
IN2014DN06768A
IN2014DN06768A IN6768DEN2014A IN2014DN06768A IN 2014DN06768 A IN2014DN06768 A IN 2014DN06768A IN 6768DEN2014 A IN6768DEN2014 A IN 6768DEN2014A IN 2014DN06768 A IN2014DN06768 A IN 2014DN06768A
Authority
IN
India
Prior art keywords
protected
protected oligonucleotide
elongation
discovered
conducted
Prior art date
Application number
Inventor
Kunihiro Hirai
Satoshi Katayama
Takayoshi Torii
Ryotaro Nakaya
Daisuke Takahashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of IN2014DN06768A publication Critical patent/IN2014DN06768A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided is a protected nucleotide for elongation that makes it possible to realize a method for producing oligonucleotides by the phosphoramidite process that allows purification to be conducted by liquid liquid extraction efficiently and at high yield. It was discovered that this can be achieved by using a specific base protected oligonucleotide and/or a specific aromatic protected oligonucleotide containing a 3 position branched chain.
IN6768DEN2014 2012-02-17 2013-02-15 IN2014DN06768A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012033429 2012-02-17
JP2012254718 2012-11-20
PCT/JP2013/053769 WO2013122236A1 (en) 2012-02-17 2013-02-15 Base-protected oligonucleotide

Publications (1)

Publication Number Publication Date
IN2014DN06768A true IN2014DN06768A (en) 2015-05-22

Family

ID=48984345

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6768DEN2014 IN2014DN06768A (en) 2012-02-17 2013-02-15

Country Status (5)

Country Link
EP (2) EP2816053B1 (en)
JP (1) JP6237237B2 (en)
CN (2) CN104114569B (en)
IN (1) IN2014DN06768A (en)
WO (1) WO2013122236A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
SG11201407967TA (en) * 2012-05-30 2015-01-29 Hokkaido System Science Co Ltd Oligonucleotide synthesis method using highly dispersible liquid-phase support
US10214555B2 (en) 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
JP6673211B2 (en) 2014-10-14 2020-03-25 味の素株式会社 Method for producing morpholino oligonucleotide
CN108350018A (en) * 2015-11-17 2018-07-31 日产化学工业株式会社 The manufacturing method of oligonucleotides
WO2017104836A1 (en) * 2015-12-16 2017-06-22 味の素株式会社 Oligonucleotide production method, and nucleoside, nucleotide, or oligonucleotide
JPWO2017111137A1 (en) * 2015-12-22 2018-10-18 味の素株式会社 Method for producing oligonucleotide
CN107556355B (en) * 2016-06-30 2021-10-22 上海兆维科技发展有限公司 Nucleoside diphosphite amide and preparation method thereof
JP7306263B2 (en) * 2017-05-02 2023-07-11 日産化学株式会社 Oligonucleotide production method
WO2018212236A1 (en) * 2017-05-16 2018-11-22 日産化学株式会社 Method for producing oligonucleotide
BR112020014494A2 (en) * 2018-03-14 2020-12-01 F. Hoffmann-La Roche Ag lna-dicarboxylic acid derivatives, process of preparing lna-dicarboxylic acid derivatives, use of lna-dicarboxylic acid derivatives, solid support and use of solid support
US11560401B2 (en) 2018-05-10 2023-01-24 Nippon Shinyaku Co., Ltd. Method for preparing oligonucleic acid compound
JP2021525801A (en) * 2018-05-30 2021-09-27 ディー・ティー・エックス・ファーマ・インコーポレイテッド Lipid-modified nucleic acid compounds and methods
JPWO2020166705A1 (en) 2019-02-15 2021-12-16 味の素株式会社 Method for producing oligonucleotide
WO2020196890A1 (en) 2019-03-28 2020-10-01 味の素株式会社 Method for producing oligonucleotide having phosphorothioate site
EP3966219A2 (en) * 2019-05-08 2022-03-16 Biogen MA Inc. Convergent liquid phase syntheses of oligonucleotides
JPWO2021045141A1 (en) * 2019-09-04 2021-03-11
US20230018780A1 (en) 2019-11-13 2023-01-19 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
US20230014840A1 (en) 2019-11-13 2023-01-19 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
CN111039977B (en) * 2019-12-31 2022-11-08 广州同隽医药科技有限公司 Phosphorylylation reagent and application thereof in oligonucleotide synthesis
US20230406878A1 (en) * 2020-11-11 2023-12-21 Biogen Ma Inc. Oligonucleotides, reagents, and preparation thereof
CA3218264A1 (en) 2021-04-28 2022-11-03 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61112093A (en) * 1984-11-05 1986-05-30 Wakunaga Seiyaku Kk Nucleotide derivative
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
WO2005070859A1 (en) * 2004-01-27 2005-08-04 Takeshi Wada Fluorous supports and processes for production of oligonucleotide derivatives with the same
JP5750209B2 (en) * 2007-03-16 2015-07-15 アプタ バイオサイエンス リミテッド Functional molecule, amidite for functional molecule synthesis, and target substance analysis method
JP5548852B2 (en) 2009-05-29 2014-07-16 国立大学法人東京農工大学 Hydrophobic group-bonded nucleoside, hydrophobic group-bonded nucleoside solution, and hydrophobic group-bonded oligonucleotide synthesis method
CN102191233B (en) * 2010-03-04 2014-06-04 中国人民解放军军事医学科学院毒物药物研究所 Novel 10-23 deoxyribozyme analogue and application thereof
JP2012033429A (en) 2010-08-02 2012-02-16 Polymatech Co Ltd Operation switch
DK2711370T3 (en) * 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
JP5760722B2 (en) 2011-06-09 2015-08-12 横浜ゴム株式会社 Pneumatic tire and manufacturing method thereof
SG11201407967TA (en) * 2012-05-30 2015-01-29 Hokkaido System Science Co Ltd Oligonucleotide synthesis method using highly dispersible liquid-phase support

Also Published As

Publication number Publication date
JPWO2013122236A1 (en) 2015-05-18
CN106977567A (en) 2017-07-25
EP2816053A1 (en) 2014-12-24
JP6237237B2 (en) 2017-11-29
CN104114569B (en) 2017-04-26
EP3296306A1 (en) 2018-03-21
WO2013122236A1 (en) 2013-08-22
EP3296306B1 (en) 2022-11-09
EP2816053A4 (en) 2015-07-01
EP2816053B1 (en) 2021-03-24
CN104114569A (en) 2014-10-22
CN106977567B (en) 2021-02-02

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