EP2675468A4 - Method for treating breast cancer by decreasing the expression of adenine nucleotide translocator 2 mrna - Google Patents

Method for treating breast cancer by decreasing the expression of adenine nucleotide translocator 2 mrna

Info

Publication number
EP2675468A4
EP2675468A4 EP11858532.2A EP11858532A EP2675468A4 EP 2675468 A4 EP2675468 A4 EP 2675468A4 EP 11858532 A EP11858532 A EP 11858532A EP 2675468 A4 EP2675468 A4 EP 2675468A4
Authority
EP
European Patent Office
Prior art keywords
mrna
decreasing
expression
breast cancer
treating breast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11858532.2A
Other languages
German (de)
French (fr)
Other versions
EP2675468A1 (en
Inventor
Chul Woo Kim
Ji Young Jang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioinfra Inc
Original Assignee
Bioinfra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinfra Inc filed Critical Bioinfra Inc
Publication of EP2675468A1 publication Critical patent/EP2675468A1/en
Publication of EP2675468A4 publication Critical patent/EP2675468A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP11858532.2A 2011-02-18 2011-10-20 Method for treating breast cancer by decreasing the expression of adenine nucleotide translocator 2 mrna Withdrawn EP2675468A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110014820A KR20120095263A (en) 2011-02-18 2011-02-18 Method for treating breast cancer by decreasing the expression of adenine nucleotide translocator 2 mrna
PCT/KR2011/007849 WO2012111900A1 (en) 2011-02-18 2011-10-20 Method for treating breast cancer by decreasing the expression of adenine nucleotide translocator 2 mrna

Publications (2)

Publication Number Publication Date
EP2675468A1 EP2675468A1 (en) 2013-12-25
EP2675468A4 true EP2675468A4 (en) 2014-10-22

Family

ID=46672787

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11858532.2A Withdrawn EP2675468A4 (en) 2011-02-18 2011-10-20 Method for treating breast cancer by decreasing the expression of adenine nucleotide translocator 2 mrna

Country Status (5)

Country Link
EP (1) EP2675468A4 (en)
JP (1) JP2014506888A (en)
KR (1) KR20120095263A (en)
CN (1) CN103379914B (en)
WO (1) WO2012111900A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263676A (en) * 2013-02-07 2013-08-28 魏敏杰 Method for reversing drug resistance of breast cancer by using miR-487a
KR101681597B1 (en) * 2014-01-17 2016-12-01 주식회사 바이오인프라 Composition for overcoming resistance to her2 inhibitor comprising ant2 sirna
KR102211972B1 (en) * 2018-08-02 2021-02-04 엑소젠 피티이. 엘티디 Method for early diagnosis of breast cancer and monitoring after treatment using liquid biopsy multi-cancer gene biomarkers
CN112516317B (en) * 2020-12-10 2021-12-17 暨南大学附属第一医院（广州华侨医院） Pharmaceutical composition for preventing and treating cancer and application thereof
KR102604882B1 (en) 2021-07-01 2023-11-21 인천대학교 산학협력단 A novel specific anti-cancer and anti-inflammation siRNA and use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067558A1 (en) * 2003-01-21 2004-08-12 Theraptosis Means for regulating the expression of human isoforms of ant
WO2007117121A2 (en) * 2006-04-11 2007-10-18 Bioinfra Inc. Gene therapy for cancer using small interfering rna specific to ant2 and a method to overcome tolerance to antitumor agent
WO2008026946A2 (en) * 2006-08-30 2008-03-06 Genesis Research And Development Corporation Limited Compositions and methods for the treatment and prevention of neoplastic disorders
WO2009126335A2 (en) * 2008-04-08 2009-10-15 University Of Florida Research Foundation, Inc. Ant2 inhibitor compounds and methods of use thereof
US20110207798A1 (en) * 2006-04-11 2011-08-25 Bioinfra Inc. Method for treating breast cancer using adenine nucleotide translocator 2 (ant2) sirna or ant2 shrna

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1599196A4 (en) * 2003-01-17 2006-05-31 Threshold Pharmaceuticals Inc Combination therapies for the treatment of cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067558A1 (en) * 2003-01-21 2004-08-12 Theraptosis Means for regulating the expression of human isoforms of ant
WO2007117121A2 (en) * 2006-04-11 2007-10-18 Bioinfra Inc. Gene therapy for cancer using small interfering rna specific to ant2 and a method to overcome tolerance to antitumor agent
US20110207798A1 (en) * 2006-04-11 2011-08-25 Bioinfra Inc. Method for treating breast cancer using adenine nucleotide translocator 2 (ant2) sirna or ant2 shrna
WO2008026946A2 (en) * 2006-08-30 2008-03-06 Genesis Research And Development Corporation Limited Compositions and methods for the treatment and prevention of neoplastic disorders
WO2009126335A2 (en) * 2008-04-08 2009-10-15 University Of Florida Research Foundation, Inc. Ant2 inhibitor compounds and methods of use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FAURE-VIGNY H ET AL: "EXPRESSION OF OXIDATIVE PHOSPHORYLATION GENES IN RENAL TUMORS AND TUMORAL CELL LINES", MOLECULAR CARCINOGENESIS, ALAN LISS, NEW YORK, NY, US, vol. 16, no. 3, 1 January 1996 (1996-01-01), pages 165 - 172, XP009022330, ISSN: 0899-1987, DOI: 10.1002/(SICI)1098-2744(199607)16:3<165::AID-MC7>3.0.CO;2-G *
LE BRAS MORGANE ET AL: "Chemosensitization by knockdown of adenine nucleotide translocase-2", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 66, no. 18, 15 September 2006 (2006-09-15), pages 9143 - 9152, XP002603476, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-05-4407 *
See also references of WO2012111900A1 *

Also Published As

Publication number Publication date
WO2012111900A1 (en) 2012-08-23
KR20120095263A (en) 2012-08-28
EP2675468A1 (en) 2013-12-25
CN103379914B (en) 2016-02-17
CN103379914A (en) 2013-10-30
JP2014506888A (en) 2014-03-20

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20130912

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20140922

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 38/16 20060101AFI20140916BHEP

Ipc: A61P 35/00 20060101ALI20140916BHEP

Ipc: C12N 15/113 20100101ALI20140916BHEP

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 20150421