CN104114557B - 作为syk酪氨酸激酶抑制剂和gcn2丝氨酸激酶抑制剂的8‑取代2‑氨基‑[1,2,4]三唑并[1,5‑a]吡嗪 - Google Patents

作为syk酪氨酸激酶抑制剂和gcn2丝氨酸激酶抑制剂的8‑取代2‑氨基‑[1,2,4]三唑并[1,5‑a]吡嗪 Download PDF

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CN104114557B
CN104114557B CN201380010357.1A CN201380010357A CN104114557B CN 104114557 B CN104114557 B CN 104114557B CN 201380010357 A CN201380010357 A CN 201380010357A CN 104114557 B CN104114557 B CN 104114557B
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triazolo
pyrazin
spiro
ylamino
dimethyl
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CN104114557A (zh
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C.多伊奇
D.库恩
T.罗斯
L.布格多夫
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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CN201380010357.1A 2012-02-21 2013-01-22 作为syk酪氨酸激酶抑制剂和gcn2丝氨酸激酶抑制剂的8‑取代2‑氨基‑[1,2,4]三唑并[1,5‑a]吡嗪 Expired - Fee Related CN104114557B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001153.1 2012-02-21
EP12001153 2012-02-21
PCT/EP2013/000189 WO2013124026A1 (en) 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors

Publications (2)

Publication Number Publication Date
CN104114557A CN104114557A (zh) 2014-10-22
CN104114557B true CN104114557B (zh) 2017-10-24

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CN201380010357.1A Expired - Fee Related CN104114557B (zh) 2012-02-21 2013-01-22 作为syk酪氨酸激酶抑制剂和gcn2丝氨酸激酶抑制剂的8‑取代2‑氨基‑[1,2,4]三唑并[1,5‑a]吡嗪

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US (1) US9120804B2 (https=)
EP (1) EP2817310B1 (https=)
JP (2) JP6479476B2 (https=)
CN (1) CN104114557B (https=)
AR (1) AR090104A1 (https=)
AU (1) AU2013224421B2 (https=)
CA (1) CA2863723C (https=)
ES (1) ES2674451T3 (https=)
IL (1) IL233982A (https=)
TW (1) TW201339165A (https=)
WO (1) WO2013124026A1 (https=)

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CA2863723C (en) 2020-09-22
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