ES2674451T3 - 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 - Google Patents

2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 Download PDF

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Publication number
ES2674451T3
ES2674451T3 ES13700849.6T ES13700849T ES2674451T3 ES 2674451 T3 ES2674451 T3 ES 2674451T3 ES 13700849 T ES13700849 T ES 13700849T ES 2674451 T3 ES2674451 T3 ES 2674451T3
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Prior art keywords
triazolo
pyrazin
ylamino
dimethyl
spiro
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Spanish (es)
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Carl Deutsch
Daniel Kuhn
Tatjana ROSS
Lars Burgdorf
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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ES13700849.6T 2012-02-21 2013-01-22 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 Active ES2674451T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001153 2012-02-21
EP12001153 2012-02-21
PCT/EP2013/000189 WO2013124026A1 (en) 2012-02-21 2013-01-22 8 - substituted 2 -amino - [1,2,4] triazolo [1, 5 -a] pyrazines as syk tryrosine kinase inhibitors and gcn2 serin kinase inhibitors

Publications (1)

Publication Number Publication Date
ES2674451T3 true ES2674451T3 (es) 2018-06-29

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Application Number Title Priority Date Filing Date
ES13700849.6T Active ES2674451T3 (es) 2012-02-21 2013-01-22 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2

Country Status (11)

Country Link
US (1) US9120804B2 (https=)
EP (1) EP2817310B1 (https=)
JP (2) JP6479476B2 (https=)
CN (1) CN104114557B (https=)
AR (1) AR090104A1 (https=)
AU (1) AU2013224421B2 (https=)
CA (1) CA2863723C (https=)
ES (1) ES2674451T3 (https=)
IL (1) IL233982A (https=)
TW (1) TW201339165A (https=)
WO (1) WO2013124026A1 (https=)

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NO2699580T3 (https=) 2014-01-24 2018-02-24
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DE112019001561B4 (de) * 2018-03-27 2026-03-12 Honda Motor Co., Ltd. Positives Elektroden-Aktivmaterial für Fluorid-Ion Sekundäre Batterien, positive Elektrode, die das Aktivmaterial verwendet, Fluorid-Ion Sekundäre Batterie und Verfahren zur Herstellung des Aktivmaterials
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CN119751456A (zh) 2018-04-16 2025-04-04 C4医药公司 螺环化合物
EP3578561A1 (en) * 2018-06-04 2019-12-11 F. Hoffmann-La Roche AG Spiro compounds
AU2019306532A1 (en) 2018-07-17 2021-03-04 Insmed Incorporated Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis
US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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CN117396490A (zh) * 2021-05-14 2024-01-12 Bm医药咨询有限公司 用于预防和治疗病毒感染的双环杂环化合物
CA3222277A1 (en) * 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR102659126B1 (ko) * 2022-03-24 2024-04-19 충남대학교산학협력단 항결핵 약학조성물
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