CN104107375B - Chinese medicine composition that hair care is sent out admittedly and its preparation method and application - Google Patents
Chinese medicine composition that hair care is sent out admittedly and its preparation method and application Download PDFInfo
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- CN104107375B CN104107375B CN201410384684.XA CN201410384684A CN104107375B CN 104107375 B CN104107375 B CN 104107375B CN 201410384684 A CN201410384684 A CN 201410384684A CN 104107375 B CN104107375 B CN 104107375B
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Abstract
The invention discloses a kind of send out Chinese medicine composition of effect and its preparation method and application admittedly with hair care, the active ingredient of the Chinese medicine composition is prepared from by the raw material of following weight parts：7 13 parts of 5 10 parts of Radix Angelicae Sinensis, 48 parts of Ligusticum wallichii, 6 11 parts of Jehol Ligusticum Rhizome, 10 18 parts of lemon-grass, 11 19 parts of frutus cnidii, 48 parts of safflower, 13 23 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 12 20 parts of eclipta, 25 35 parts of Semen sesami nigrum, 8 15 parts of kuh-seng, 11 19 parts of the tuber of stemona, 25 35 parts of cacumen biotae, 12 20 parts of the fruit of glossy privet, 12 20 parts of mulberry fruit and tea seed bran.The Chinese medicine composition is suitable for various types of hair qualitys, such as dryness, oiliness or Combination, can significantly improve comfort level, the compliance of hair of scalp, and reduce alopecia；The preparation method of the Chinese medicine composition is simple to operation, is suitable for mass producing.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine composition and its preparation for sending out admittedly effect with hair care
Methods and applications.
Background technology
Now, in our daily life, often see that someone is worried because of epilation, had is even bald,
This has had a strong impact on the live and work of people, particularly young man.Although alopecia is a kind of normal physiological phenomenon, if not
If being controlled by, not only affect individual healthy, and affect mental health, also, the hair for coming off has an effect on
Our routine work and living environment, such as：Product on floor, bed or sofa due to hair falls, and allows people to feel uncomfortable, and clearly
Sweep loaded down with trivial details, cause the inconvenience of live and work.
At present, shampoo huge number on market, nearly all has cleaning effect, but supports the treatment of profit Anti-hair loss effect
Few, good less of effect；And in hair care treatment, usually add some medicines, but Western medicine excitant is larger, medium-height grass
Though medicine is from natural, stimulate little, existing commercially available prod hair care sent out admittedly, effect moisten is poor, although had can increase
Scalp comfort level, but do not possess and send out admittedly effect.
The traditional Chinese medical science thinks kidney, its Hua Fa, sends out after being blood again, therefore the growth that sends out is kidney, and the nutrition that sends out is essence and blood, institute
So that most people's alopecia basic reason is kidney deficiency, the deficiency of blood.Therefore, a kind of hair care for working well, profit, anticreep are now needed badly
Send out product.
Content of the invention
Be based on this, the present invention from blood-nourishing, adjust liver, kidney-nourishing to set about, the selected Chinese medicine material for returning liver and kidney channel and its proportioning are carried
For the Chinese medicine composition for sending out admittedly effect with hair care that a kind of excitant is little, effect is good.
The concrete technical scheme for solving above-mentioned technical problem is as follows：
A kind of Chinese medicine composition for sending out admittedly effect with hair care, the active ingredient of the Chinese medicine composition is by following weight
The raw material of part is prepared from：
Radix Angelicae Sinensis 5-10 parts, Ligusticum wallichii 4-8 parts, Jehol Ligusticum Rhizome 6-11 parts, lemon-grass 10-18 parts, frutus cnidii 11-19 parts, safflower 4-8
Part, RADIX POLYGONI MULTIFLORI PREPARATA 13-23 parts, eclipta 12-20 parts, Semen sesami nigrum 25-35 parts, kuh-seng 8-15 parts, tuber of stemona 11-19 parts, cacumen biotae 25-
35 parts, fruit of glossy privet 12-20 parts, mulberry fruit 12-20 parts and tea seed bran 7-13 parts.
Wherein in some embodiments, the active ingredient of the Chinese medicine composition be prepared by the raw material of following weight parts and
Into：
Radix Angelicae Sinensis 8-9 parts, Ligusticum wallichii 5-7 parts, Jehol Ligusticum Rhizome 7-9 parts, lemon-grass 14-16 parts, frutus cnidii 14-16 parts, safflower 5-7 parts,
RADIX POLYGONI MULTIFLORI PREPARATA 17-19 parts, eclipta 15-17 parts, Semen sesami nigrum 29-31 parts, kuh-seng 11-13 parts, tuber of stemona 14-16 parts, cacumen biotae 29-31
Part, fruit of glossy privet 15-17 parts, mulberry fruit 14-16 parts and tea seed bran 9-11 parts.
Another object of the present invention is to a kind of preparation method of the Chinese medicine composition for sending out admittedly effect with hair care is provided, bag
Include following steps：
(1) by Radix Angelicae Sinensis, Ligusticum wallichii, Jehol Ligusticum Rhizome, lemon-grass, frutus cnidii, safflower, RADIX POLYGONI MULTIFLORI PREPARATA, eclipta, Semen sesami nigrum, kuh-seng, hundred
The mixing of portion, cacumen biotae, the fruit of glossy privet, mulberry fruit and tea seed bran, adds water and is extracted, and filters, obtains filtrate；
(2) filtrate of step (1) gained is concentrated, add volume fraction for 60%-70% ethanol solution into system
The final concentration of 40%-45% of ethanol, stands, and centrifugation takes supernatant concentration to medicinal material：The weight of concentrate compares 1:0.42-
0.52, you can.
Wherein in some embodiments, 5-6 times for medicinal material amount of the addition of water described in step (1).
Wherein in some embodiments, the mode that extracts described in step (1) extracted for decoction or using extractor.
Another object of the present invention is to a kind of preparation method of the Chinese medicine composition for sending out admittedly effect with hair care is provided, bag
Include following steps：
(1) by Radix Angelicae Sinensis, Ligusticum wallichii, Jehol Ligusticum Rhizome, lemon-grass, frutus cnidii, safflower, RADIX POLYGONI MULTIFLORI PREPARATA, eclipta, Semen sesami nigrum, kuh-seng, hundred
Portion, cacumen biotae, the fruit of glossy privet, mulberry fruit and tea seed bran mix, plus the ethanol solution that volume fraction is 10%-50% is extracted, and is obtained
Extract；
(2) by the extract of step (1) gained, centrifugation takes supernatant concentration to medicinal material：The weight of concentrate compares 1:
0.42-0.52, you can.
Wherein in some embodiments, 5-6 times for medicinal material amount of the addition of ethanol solution described in step (1).
Wherein in some embodiments, the mode that extracts described in step (1) is to be extracted using supersonic extractors.
There is hair care to send out admittedly the cosmetics of effect another object of the present invention is to providing above-mentioned Chinese medicine composition in preparation
In application.
Wherein in some embodiments, the cosmetics are shampoo, massage cream or care cream.
Another object of the present invention is to providing a kind of cosmetics for sending out admittedly effect with hair care, the cosmetics include
State acceptable carrier on the Chinese medicine composition and cosmetics of effect, the Chinese medicine group is sent out admittedly with hair care obtained in preparation method
It is 4.0wt%-25.0wt% that compound accounts for the percentage by weight of cosmetics.
Wherein in some embodiments, the carrier include NMF, preservative, essence, surfactant, suspending agent and
Water.
Wherein in some embodiments, the surfactant is that stereth -2, stereth -21, glycerine are hard
At least one in resin acid ester, Texapon Special, laureth ammonium sulfate or coconut oleoyl amine MEA；The NMF is whale
At least one in wax stearyl alcohol, isopropyl myristate, 1,3- propane diols or panthenol；The preservative is methylisothiozoline
Ketone/Sensiva SC50；The suspending agent is acrylic acid (ester) analog copolymer.
Wherein in some embodiments, the carrier also includes chelating agent and/or conditioner；The chelating agent is EDTA bis-
Sodium；The conditioner is -4/ laureth -23/PEG-55 stearates of dimethiconol/laureth.
Another object of the present invention is to provide a kind of massage cream for sending out admittedly effect with hair care, the massage cream mainly by
The group of following weight percentage is grouped into：
Stereth -2：1.6wt%-2.0wt%,
Stereth -21：1.8wt%-2.2wt%,
Stearine：0.8wt%-1.2wt%,
Cetostearyl alcohol：5.1wt%-5.5wt%,
Isopropyl myristate：1.8wt%-2.2wt%,
1,3- propane diols：5.8wt%-6.2wt%,
EDETATE SODIUM：0.09wt%-0.11wt%,
Panthenol：0.4wt%-0.6wt%,
Chinese medicine composition obtained in preparation method as above：22wt%-23wt%,
Methylisothiazolinone/Sensiva SC50：0.09wt%-0.11wt%,
Essence：0.2wt%-0.4wt%,
Water：Surplus.
Another object of the present invention is to provide a kind of shampoo for sending out admittedly effect with hair care, the shampoo mainly by
The group of following weight percentage is grouped into：
EDETATE SODIUM：0.13wt%-0.17wt%,
Texapon Special：4.8wt%-5.2wt%,
Laureth ammonium sulfate：11wt%-13wt%,
Chinese medicine composition obtained in preparation method as above：5wt%-6wt%,
Coconut oleoyl amine MEA：0.7wt%-0.9wt%,
Cetostearyl alcohol：0.3wt%-0.5wt%,
Acrylic acid (ester) analog copolymer：3.8wt%-4.5wt%,
Panthenol：0.3wt%-0.5wt%,
- 4/ laureth -23/PEG-55 stearates of dimethiconol/laureth：2wt%-
3wt%,
Essence：0.4wt%-0.6wt%,
Methylisothiazolinone/Sensiva SC50：0.08wt%-0.12wt%,
Water：Surplus.
Theory of the Chinese medicine composition of the present invention according to Chinese medicine " monarch ", by beneficial gas, blood-nourishing, adjusts liver, benefit
Kidney comes hair growth and hair care hair care.The wherein fruit of glossy privet and eclipta mutual reinforcement between, liver-kidney tonifying, nourishing yin and nourishing blood.Eclipta can benefit
Lower and in honor, strong cloudy and dark hair, both can all prevent beard and hair early de-.And with RADIX POLYGONI MULTIFLORI PREPARATA and Semen sesami nigrum filling liver kidney, benefiting essence-blood, the rhizome of Chinese monkshood
Send out.This four tastes Chinese medicine is monarch drug in a prescription altogether, for the deficiency of blood, the basic reason of kidney deficiency, gathers filling liver kidney altogether, and benefiting essence-blood, the rhizome of Chinese monkshood are sent out, Anti-hair loss
Effect.
It is equipped with cacumen biotae, growing and blacking hair；Radix Angelicae Sinensis, blood-supplementing blood-nourishing, tonifying Qi production of sperm；Ligusticum wallichii, blood-activating and qi-promoting；Mulberry fruit, enriching yin are mended
Blood, fluid dryness；It is ministerial drug altogether, with the work(of principal drug assistance.
Kuh-seng, heat-clearing and damp-drying drug, desinsection are antipruritic；The tuber of stemona, delousing desinsection；Jehol Ligusticum Rhizome, dispelling wind and eliminating dampness；Lemon-grass, antibacterial moisturizing；Snake
Machine tool, eliminating dampness wind-dispelling, desinsection are antipruritic；Tea seed bran, black hair profit are sent out, sterilizing and itch-relieving；Altogether into adjutant, solve mainly to have symptom concurrently.
Safflower, pungent, temperature, invigorate blood circulation are drawn hemodialysis and enter channels and collaterals blood vessels, have the work(of blood-nourishing skin-active again and make for assistant.
The detailed pharmacology of part Chinese medicine is as follows：
RADIX POLYGONI MULTIFLORI PREPARATA：Filling liver kidney, benefiting essence-blood, the rhizome of Chinese monkshood are sent out.For poliosis, promote hair melanin to generate, make hair crow
Dark hair is bright, be easy to combing.
Eclipta：Nourishing liver and kidney, cooling blood and hemostasis.For the deficiency of liver-yin and kidney-yin, poliosis etc..
Cacumen biotae：Cooling blood and hemostasis, growing and blacking hair.For blood-head alopecia, poliosis.Hair follicle growth development can be improved, gone
Bits, promote hair restoration, strengthen hair follicle metabolism function.
Radix Angelicae Sinensis：Return liver, the heart, the spleen channel.Replenishing and activating blood, can expand scalp capillary, stimulate circulation, and can occur admittedly
Long.
Ligusticum wallichii：Return liver, courage, pericardium channel.Blood-activating and qi-promoting.Head capillary can be expanded, stimulated circulation, increase hair
Nutrition, and make hair that there is good compliance, it is easy to combing, anti-alopecia-stopping and the disconnected generation that sends out and delay white hair, make hair
Gloss moistens.
Mulberry fruit：Nourishing yin and supplementing blood, fluid dryness, for the deficiency of liver-yin and kidney-yin, poliosis etc..
Tea seed bran：Contain natural tea saponin powder, decontamination is strong, with sterilization, removing toxic substances, anti-inflammatory, antipruritic the effect of.
Full side shares benefiting essence-blood, and the rhizome of Chinese monkshood is sent out, and Anti-hair loss, desinsection are antipruritic, moistens the work(that sends out.
Of the present invention a kind of with hair care send out admittedly Chinese medicine composition of effect and its preparation method and application have following
Advantage and beneficial effect：
The present invention through the substantial amounts of experiment of inventor and research, draw with hair care send out admittedly effect Chinese medicine composition optimal
Raw material and proportioning, the Chinese medicine composition are suitable for various types of hair qualitys, such as dryness, oiliness or Combination, can significantly improve head
The comfort level of skin, the compliance of hair, and alopecia is reduced, metabolism is may additionally facilitate, improves cerebral cortex blood circulation, and institute
The raw material for stating Chinese medicine composition is easy to get, with low cost；The preparation method of the Chinese medicine composition is simple to operation, is suitable for extensive
Production.
Specific embodiment
The raw material in raw material and cosmetics in Chinese medicine composition of the present invention is commercially available prod, wherein, described poly-
- 4/ laureth -23/PEG-55 stearates of dimethyl silica alkanol/laureth step figure purchased from the U.S..
The preparation method of Chinese medicine composition of the present invention, by various Chinese medicines, after being sufficiently mixed or crushing, adds water or not
With the ethanol solution of concentration, extracted according to general extraction methods in industry, after extract is concentrated.
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Chinese medicine composition for sending out admittedly effect with hair care of the present embodiment, the active ingredient of the Chinese medicine composition be by
The raw material of following weight parts is prepared from：
5 parts of Radix Angelicae Sinensis, 8 parts of Ligusticum wallichii, 6 parts of Jehol Ligusticum Rhizome, 18 parts of lemon-grass, 11 parts of frutus cnidii, 4 parts of safflower, 23 parts of RADIX POLYGONI MULTIFLORI PREPARATA, ink drought
12 parts of lotus, 35 parts of Semen sesami nigrum, 8 parts of kuh-seng, 19 parts of the tuber of stemona, 25 parts of cacumen biotae, 20 parts of the fruit of glossy privet, 12 parts of mulberry fruit, 13 parts of tea seed bran.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
(1) above-mentioned weight portion is pressed, and each traditional Chinese medicinal material raw materials of accurate weighing are sufficiently mixed, and are placed in extractor plus 5 times of water extractions
Take, extract is filtered, filtrate is stand-by, the dregs of a decoction add water extraction 1 time, filtration merges 2 filtrates；
(2) by the filtrate of above-mentioned merging, concentration, and ethanol solution that volume fraction is 70% is added to ethanol in system
Final concentration of 40%, stand overnight, 2000r/min is centrifuged, and supernatant is concentrated into medicinal material：The weight ratio of concentrate is 1:
0.52.
Embodiment 2
A kind of Chinese medicine composition for sending out admittedly effect with hair care of the present embodiment, the active ingredient of the Chinese medicine composition be by
The raw material of following weight parts is prepared from：
8 parts of Radix Angelicae Sinensis, 6 parts of Ligusticum wallichii, 8 parts of Jehol Ligusticum Rhizome, 15 parts of lemon-grass, 15 parts of frutus cnidii, 6 parts of safflower, 18 parts of RADIX POLYGONI MULTIFLORI PREPARATA, ink drought
15 parts of lotus, 30 parts of Semen sesami nigrum, 12 parts of kuh-seng, 15 parts of the tuber of stemona, 30 parts of cacumen biotae, 15 parts of the fruit of glossy privet, 15 parts of mulberry fruit, tea seed bran 10
Part.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
(1) above-mentioned weight portion is pressed, each traditional Chinese medicinal material raw materials of accurate weighing are crushed, put in supersonic extractors, adds 6 times of amount bodies
Fraction is 50% ethanol (purified water preparations) ultrasonic extraction 1 time, releases liquid and the dregs of a decoction, and tripodia centrifugation, 2000r/min are treated
With；The dregs of a decoction are added in supersonic extractors, are added 6 times of 10% ethanol of amount to extract 1 time, are released liquid and the dregs of a decoction, and tripodia is centrifuged,
2000r/min, stand-by, merge extract twice；
(2) said extracted liquid is put in evaporimeter, reclaims ethanol, extract continues to be concentrated into medicinal material after reclaiming ethanol：Dense
The weight ratio of contracting liquid is 1:0.45, you can.
Embodiment 3
A kind of Chinese medicine composition for sending out admittedly effect with hair care of the present embodiment, the active ingredient of the Chinese medicine composition be by
The raw material of following weight parts is prepared from：
10 parts of Radix Angelicae Sinensis, 4 parts of Ligusticum wallichii, 22 parts of Jehol Ligusticum Rhizome, 10 parts of lemon-grass, 19 parts of frutus cnidii, 8 parts of safflower, 13 parts of RADIX POLYGONI MULTIFLORI PREPARATA, ink
20 parts of non-irrigated lotus, 25 parts of Semen sesami nigrum, 15 parts of kuh-seng, 11 parts of the tuber of stemona, 35 parts of cacumen biotae, 12 parts of the fruit of glossy privet, 20 parts of mulberry fruit, tea seed bran 7
Part.
The preparation method of above-mentioned Chinese medicine composition, comprises the following steps：
(1) above-mentioned weight portion is pressed, each traditional Chinese medicinal material raw materials of accurate weighing are sufficiently mixed, plus 6 times of water boiling and extractions, in collection
Clear liquid, extract are filtered, and filtrate is stand-by, and the dregs of a decoction add water decoction and extract 1 time, and filtration merges 2 filtrates；
(2) above-mentioned filtrate is concentrated, and adds the final concentration of ethanol solution to ethanol in system that volume fraction is 60%
For 45%, stand overnight, 2000r/min is centrifuged, and supernatant is concentrated into medicinal material：The weight ratio of concentrate is 1:0.42.
4 massage cream of embodiment
A kind of massage cream for sending out admittedly effect with hair care of the present embodiment, the massage cream include Chinese medicine obtained in embodiment 1
Acceptable carrier on composition and massage cream, the carrier include：Solvent, emulsifying agent, emollients, NMF, chelating agent, anti-
Rotten agent and essence；Specifically include A phase, B phase, C phase and D phases；Wherein, each component and content are referring to table 1：
The formula of 1 massage cream of table
A kind of preparation method of above-mentioned massage cream for sending out admittedly effect with hair care is as follows：
1st, Chinese medicine composition is prepared, and step is with embodiment 1；
2nd, each component of B phases is accurately weighed, emulsification pot is added, heating stirring is stirred with rotating speed 30r/min to 85 DEG C
To substantially uniformity without particle；
3rd, C phases heating water bath is stirred to substantially uniformity to 90 DEG C, and insulated sterilizing 30min, cover 200 mesh filter cloth mistakes
Filter is taken out in emulsification pot, stirs and vacuumizes homogeneous 2 minutes (maintaining vacuum -0.02-0.05Mpa), become complete and homogeneous to material body
Agranular fluid；
4th, A phases each components is accurately weighed, is added in oil phase pot, is heated with stirring to 85 DEG C, is incubated complete to all components
Dissolving, standby.
5th, under the mixing speed of 30r/min, the component in oil cauldron is crossed in the main emulsification pot of 200 mesh filter cloth suction, is taken out true
Sky, high speed homogenization 8 minutes (maintaining vacuum -0.02-0.05Mpa), stirring is cooled to 45 DEG C, adds each component of D phases one by one, takes out
Vacuum homogeneous is sufficiently stirred for for 2 minutes to (maintaining vacuum -0.02-0.05Mpa), makes product complete and homogeneous.
6th, continue to be cooled to 37 DEG C of sampling censorships, qualified discharging simultaneously seals lotion, moves to semi-finished product storeroom.
5 shampoo of embodiment
A kind of shampoo for sending out admittedly effect with hair care of the present embodiment, the shampoo include Chinese medicine obtained in embodiment 2
Acceptable carrier on composition and shampoo, the carrier include：Solvent, chelating agent, surfactant, emollients, suspension
Agent, NMF, preservative, conditioner and essence；Specifically include A phase, B phase, C phase, D phases, E phases, F phases, G phases and H phases；Wherein,
Each component and its content are referring to table 2：
Shampoo is sent out in 2 hair care of table admittedly
The preparation method of above-mentioned shampoo is as follows：
Preposition process：E, F phase is distinguished dispersed with stirring to homogeneous or pellucidity first, standby.C phases Chinese medical concrete is heated
To 90 DEG C, insulated sterilizing 30 minutes, 200 mesh are filtered, standby.
1st, Chinese medical extract is prepared, and step is with embodiment 2；
2nd, successively B phase components are added in A phase agitated kettles, stirring is heated to 85 DEG C, until dissolving is completely, constant temperature according to
Secondary addition C, D phase each component, continues stirring to being completely dissolved, constant temperature 5 minutes；
3rd, 60 DEG C are cooled to, E, F phase component is slowly added to successively, 25r/min dispersed with stirring is uniform, continues cooling；
4th, 50 DEG C are down to, the G phase components of preposition process are sequentially added, 25r/min dispersed with stirring is uniform, continues cooling；
5th, temperature is down to 45 DEG C, sequentially adds H phase each components, and after 20r/min stirs, sampling detects viscosity and pH value
If (unqualified according to actual conditions regulation), continues stirring；
6th, confirm stir, detect qualified after can (filtrations of 100 mesh) discharging, while sealing bung, labelled mark
Know, send between semi-finished product preservation.
Embodiment 6
A kind of shampoo for sending out admittedly effect with hair care of the present embodiment, the shampoo include Chinese medicine obtained in embodiment 3
Acceptable carrier on composition and shampoo, the carrier include solvent, chelating agent, surfactant, emollients, suspension
Agent, NMF, preservative, conditioner and essence；Specifically include A phase, B phase, C phase, D phases, E phases, F phases, G phases and H phases；Wherein,
Each component and its content are referring to table 3：
Shampoo is sent out in 3 hair care of table admittedly
Shampoo preparation method described in the present embodiment is with embodiment 5.
7 massage cream of embodiment and the stability of shampoo
First, experiment purpose
The heat resistance and cold resistance that the cosmetics obtained by embodiment 4-6 are studied by observation analysis, and then evaluate described
The stability of cosmetics.
2nd, experimental technique
By the shampoo obtained by the massage cream obtained by embodiment 4, embodiment 5 and the shampoo obtained by embodiment 6,
Investigated through 30 days heat-resisting (40 DEG C) and cold-resistant (- 10 DEG C) respectively, observed which whether there is lamination.
3rd, experimental configuration
It is observed that obtained by shampoo and embodiment 6 obtained by the massage cream obtained by above-described embodiment 4, embodiment 5
Shampoo without lamination, illustrate which has good stability.
8 massage cream of embodiment is to Rabbits with Acute irritation test
First, experiment purpose
By excitant of the massage cream obtained by comparative analysis evaluation embodiment 4 to skin.
2nd, experimental technique
Rabbits with Acute irritation test is carried out using the massage cream of embodiment 4.Healthy new zealand white rabbit totally 4,
Test for acute skin irritation, body weight 2.0-3.0kg, animal credit number：SCXK (Guangdong) 2013-0026.
Acute skin irritation experimental technique and step according to《Cosmetics health specification 2007 editions》In skin irritation
Experimental technique is carried out with step.Wherein test group is to smear the massage cream with foster profit hair care effect of the present embodiment 4, control group
Any sample is not smeared.
According to《Cosmetics health specification 2007 editions》, time point top average is respectively observed with 24,48 and 72h, judge skin
Skin stimulus intensity.
3rd, experimental result
Acute skin irritation result of the test is referring to table 4-A and table 4-B.
Massage cream obtained by embodiment 4 be can be seen that to Rabbits with Acute irritation test from table 4-A and table 4-B
Reaction is 0.25 in 24,48 and 72h tops, less than 0.5.Obtained by this explanation embodiment 4 to no skin irritation, pacify
Quan Xinggao.
The acute skin irritation result of the test of table 4-A1h and 24h
The acute skin irritation result of the test of table 4-B48h and 72h
The eye irritation experiment of shampoo is sent out in 9 hair care of embodiment admittedly
First, experiment purpose
Thorn of the shampoo to eye is sent out in the hair care that is evaluated obtained by embodiment 5 and embodiment 6 by comparative analysis admittedly
Sharp property.
2nd, experimental technique
The eye irritation experiment that rabbit cosmetics are carried out using the shampoo obtained by embodiment 5 and embodiment 6.Take health
NZw totally 6, body weight 1.8-2.5kg, animal credit number：SCXK (Guangdong) 2013-0033, is classified as 2 groups, is used for
Eye irritation is tested.
Eye irritation experimental technique and step according to《Cosmetics health specification 2007 editions》In eye irritation experimental technique
Carry out with step.All used as test group, right eye as a control group, is instilled wherein in the conjunctival sac of test group the left eye of rabbit
The sample of 5/ embodiment 6 of 0.1ml embodiments, control group are not added dropwise any sample.Rinse after tested material 30s, rinse after 1h,
Observe after 24h, 48h, 72h, 4d, 7d, according to《Cosmetics health specification 2007 editions》Scoring.
3rd, experimental result
Massage cream obtained by embodiment 5 carries out eye irritation result referring to table 5 to rabbit.
Can be drawn by table 5：Shampoo obtained in embodiment 5 is microstimulation to eye, belongs to the normal index model for the treatment of
Enclose.
Can be drawn by table 6：Shampoo obtained in embodiment 6 is microstimulation to eye, belongs to the normal index model for the treatment of
Enclose.
5 shampoo of table reacts integral result table to eye irritation
6 embodiment of table, 6 shampoo reacts integral result table to eye irritation
The clinical trial result of shampoo is sent out in 10 hair care of embodiment admittedly
First, experiment purpose
The effect that the hair care that the shampoo obtained by embodiment 5 and 6 is evaluated by comparative analysis is sent out admittedly.
2nd, experimental technique
(1) subject enrollment standard
A, men and women do not limit, and use cooperatively；
B, trier exist alopecia, disconnected send out, white hair, damage, the different degrees of hair scalp problems such as uninteresting, thin and delicate, collection
In alopecia, disconnected send out, damage, uninteresting；
C, cycle on probation are one month, it is desirable to which trier is revealed with hair care hair care and hair cleaning by hair washing custom at ordinary times.
(2) experiment packet and trial method
A, this experiment are divided into experimental group and control group, and the experimental group is：Washing obtained by 1 embodiment 5 of experimental group
Become visible, the shampoo obtained by 2 embodiment 6 of experimental group, respectively 200ml/ bottles；
The control group is：The a certain commercially available shampoo for sending out admittedly effect with hair care of control group 1；
A kind of 2 shampoo of control group, its component and content and preparation method are substantially the same manner as Example 5, distinguish
In：The active ingredient of the C phases Chinese medicine composition is prepared from by the raw material of following weight parts：18 parts of RADIX POLYGONI MULTIFLORI PREPARATA, ink drought
10 parts of 15 parts of lotus, 30 parts of Semen sesami nigrum, 8 parts of Radix Angelicae Sinensis, 6 parts of safflower, 30 parts of cacumen biotae, 15 parts of the fruit of glossy privet, 15 parts of mulberry fruit and tea seed bran,
The preparation method of the Chinese medicine composition is with reference to embodiment 2；
A kind of 3 shampoo of control group, its component and content and preparation method are substantially the same manner as Example 5, distinguish
In：The active ingredient of the C phases Chinese medicine composition is prepared from by the raw material of following weight parts：6 parts of Ligusticum wallichii, 8 parts of Jehol Ligusticum Rhizome,
15 parts of 15 parts of lemon-grass, 15 parts of frutus cnidii, 12 parts of kuh-seng and the tuber of stemona, the preparation method of the Chinese medicine composition is with reference to embodiment 2；
B, trial method：Method by shampoo hair washing is just commonly used at ordinary times；
C, using front, it is desirable to the hair on user's family ground is cleaned up, and facilitates trier oneself to sentence on trial
The situation of disconnected alopecia, the alopecia can be judged from the situation on comb, hair washing, ground etc..
(3) course for the treatment of is tested
Time on probation is one month, collects trial effect feedback information after one month.
(4) criterion
Scalp comfort level：Itself feel scalp comfortable, without itch, be effective without dandruff；Itself feel not too big change or
Person's itching of the scalp increases or dandruff increase is invalid；
Hair compliance：Hair is easily combed, and is difficult to knot, and hair is glossy effectively；Itself feel not too many change or easy
Knot, it is invalid that hair is matt；
Alopecia degree：The hair that falls during hair washing is reduced or the hair that falls when combing one's hair is reduced and the hair on the ground that drops
It is reduced to than in the past effectively；The quantity of epilation does not have significant change or alopecia to increase for invalid.
(5) trial effect feedback information
Totally 225 people participate in trying out, and withdraw 218 triers altogether by interview or communication tool every group of trier of contact anti-
The information of feedback.
3rd, experimental result
The clinical test results of the shampoo obtained by above-mentioned experimental group and control group, can from table 7 referring to table 7 and table 8
Go out：Either dry hair, oily hair or Combination hair, the shampoo obtained by embodiment 5-6 effectively can increase
The comfort level of scalp, the compliance of hair reduce alopecia；As can be seen from Table 8：Shampoo is sent out in the hair care of embodiment 6 admittedly can be effective
The comfort level of ground increase scalp, the compliance of hair,
Reduce alopecia.Wherein, to send out admittedly shampoo effect better than embodiment 6 for the hair care of embodiment 5.
The clinic trial result of the shampoo obtained by 7 experimental group of table and control group
The result on trial of the shampoo obtained by 8 experimental group of table and control group
The clinical trial result that 11 massage cream of embodiment and shampoo are shared
First, experiment purpose
The clinical effectiveness shared by massage cream and shampoo obtained in embodiment 5 obtained in observation evaluation embodiment 4.
2nd, test method
Experimenter：Embodiment 10 tried out wherein 45 triers of embodiment 5 (i.e. experimental group 1) shampoo.
Given the test agent：Massage cream obtained by embodiment 4 and the shampoo of embodiment 5
Trial method：After wetting hair, take this product in right amount, be applied on scalp, massaging scalp touched everywhere with finger pulp, band
After upper bathing cap stops 15 minutes, washed down with warm water, then cleaned with the shampoo of embodiment 5 again.
The test course for the treatment of and criterion and formation gathering method are with embodiment 10.
3rd, experimental result
The clinical effectiveness that massage cream obtained in embodiment 4 and shampoo obtained in embodiment 5 are shared, can from table 9 referring to table 9
Know：Embodiment 4 and embodiment 5 coordinate on probation, more effectively can the reduce alopecia comfort level of increase scalp and hair simultaneously
Compliance.Observe through clinic trial, embodiment 4 and the collocation of embodiment 5 energy maximum on probation play hair care and send out admittedly effect.
The clinic trial result that 9 massage cream of table and shampoo are shared
Embodiment described above only expresses the several embodiments of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformations and improvement can also be made, these belong to the guarantor of the present invention
Shield scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (10)
1. a kind of Chinese medicine composition for sending out admittedly effect with hair care, it is characterised in that the active ingredient of the Chinese medicine composition is
It is prepared from by the raw material of following weight parts：
Radix Angelicae Sinensis 5-10 parts, Ligusticum wallichii 4-8 parts, Jehol Ligusticum Rhizome 6-11 parts, lemon-grass 10-18 parts, frutus cnidii 11-19 parts, safflower 4-8 parts, system
Tuber of multiflower knotweed 13-23 parts, eclipta 12-20 parts, Semen sesami nigrum 25-35 parts, kuh-seng 8-15 parts, tuber of stemona 11-19 parts, cacumen biotae 25-35 parts,
Fruit of glossy privet 12-20 parts, mulberry fruit 12-20 parts and tea seed bran 7-13 parts.
2. the Chinese medicine composition for sending out admittedly effect with hair care according to claim 1, it is characterised in that the Chinese traditional medicine composition
The active ingredient of thing is prepared from by the raw material of following weight parts：
Radix Angelicae Sinensis 8-9 parts, Ligusticum wallichii 5-7 parts, Jehol Ligusticum Rhizome 7-9 parts, lemon-grass 14-16 parts, frutus cnidii 14-16 parts, safflower 5-7 parts, system are first
Black 17-19 parts, eclipta 15-17 parts, Semen sesami nigrum 29-31 parts, kuh-seng 11-13 parts, tuber of stemona 14-16 parts, cacumen biotae 29-31 parts,
Fruit of glossy privet 15-17 parts, mulberry fruit 14-16 parts and tea seed bran 9-11 parts.
3. the preparation method of the Chinese medicine composition for sending out admittedly effect with hair care described in a kind of claim 1 or 2, its feature exist
In comprising the following steps：
(1) by Radix Angelicae Sinensis, Ligusticum wallichii, Jehol Ligusticum Rhizome, lemon-grass, frutus cnidii, safflower, RADIX POLYGONI MULTIFLORI PREPARATA, eclipta, Semen sesami nigrum, kuh-seng, the tuber of stemona, side
The mixing of CedarLeaves, the fruit of glossy privet, mulberry fruit and tea seed bran, adds water and is extracted, and filters, obtains filtrate；
(2) filtrate of step (1) gained is concentrated, and ethanol solution that volume fraction is 60%-70% is added to second in system
The final concentration of 40%-45% of alcohol, stands, and centrifugation takes weight of the supernatant concentration to medicinal material with concentrate and compares 1:0.42-
0.52, you can.
4. the preparation method of the Chinese medicine composition for sending out admittedly effect with hair care described in a kind of claim 1 or 2, its feature exist
In comprising the following steps：
(1) by Radix Angelicae Sinensis, Ligusticum wallichii, Jehol Ligusticum Rhizome, lemon-grass, frutus cnidii, safflower, RADIX POLYGONI MULTIFLORI PREPARATA, eclipta, Semen sesami nigrum, kuh-seng, the tuber of stemona, side
CedarLeaves, the fruit of glossy privet, mulberry fruit and tea seed bran mix, plus the ethanol solution that volume fraction is 10%-50% is extracted, and must be extracted
Liquid；
(2) by the extract of step (1) gained, centrifugation takes weight of the supernatant concentration to medicinal material with concentrate and compares 1:0.42-
0.52, you can.
5. Chinese medicine composition as claimed in claim 1 or 2 there is hair care to send out admittedly the application in the cosmetics of effect in preparation.
6. Chinese medicine composition according to claim 5 there is hair care to send out admittedly the application in the cosmetics of effect in preparation, its
It is characterised by, the cosmetics are shampoo, massage cream or care cream.
7. a kind of cosmetics for sending out admittedly effect with hair care, it is characterised in that the cosmetics are included such as 3 or 4 institute of claim
Acceptable carrier on Chinese medicine composition obtained in the preparation method that states and cosmetics, the Chinese medicine composition account for the weight of cosmetics
Amount percentage is 4.0wt%-25.0wt%.
8. cosmetics for sending out admittedly effect with hair care according to claim 7, it is characterised in that the carrier includes moisturizing
Agent, preservative, essence, surfactant, suspending agent and water.
9. a kind of massage cream for sending out admittedly effect with hair care, it is characterised in that the massage cream is mainly by following weight percentage
Group be grouped into：
Stereth -2：1.6wt%-2.0wt%,
Stereth -21：1.8wt%-2.2wt%,
Stearine：0.8wt%-1.2wt%,
Cetostearyl alcohol：5.1wt%-5.5wt%,
Isopropyl myristate：1.8wt%-2.2wt%,
1,3- propane diols：5.8wt%-6.2wt%,
EDETATE SODIUM：0.09wt%-0.11wt%,
Panthenol：0.4wt%-0.6wt%,
Chinese medicine composition obtained in preparation method as described in claim 3 or 4：22wt%-23wt%,
Methylisothiazolinone/Sensiva SC50：0.09wt%-0.11wt%,
Essence：0.2wt%-0.4wt%,
Water：Surplus.
10. a kind of shampoo for sending out admittedly effect with hair care, it is characterised in that the shampoo is mainly by following weight percentage
Group be grouped into：
EDETATE SODIUM：0.13wt%-0.17wt%,
Texapon Special：4.8wt%-5.2wt%,
Laureth ammonium sulfate：11wt%-13wt%,
Chinese medicine composition obtained in preparation method as described in claim 3 or 4：5wt%-6wt%,
Coconut oleoyl amine MEA：0.7wt%-0.9wt%,
Cetostearyl alcohol：0.3wt%-0.5wt%,
Acrylic acid (ester) analog copolymer：3.8wt%-4.5wt%,
Panthenol：0.3wt%-0.5wt%,
- 4/ laureth -23/PEG-55 stearates of dimethiconol/laureth：2wt%-3wt%,
Essence：0.4wt%-0.6wt%,
Methylisothiazolinone/Sensiva SC50：0.08wt%-0.11wt%,
Water：Surplus.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104490642B (en) * | 2014-11-20 | 2018-07-06 | 中国林业科学研究院资源昆虫研究所 | Natural insect wax hair protection trichogen and preparation method thereof |
| CN106039155A (en) * | 2016-06-06 | 2016-10-26 | 赵龙伟 | Anti-hair-loss liquid and preparation method thereof |
| CN106806301A (en) * | 2016-12-20 | 2017-06-09 | 萨斐国际集团控股有限公司 | A kind of leaves shampoo of high salinity and Chinese herbal medicine |
| CN107823044A (en) * | 2017-11-15 | 2018-03-23 | 陈荷芬 | A kind of Chinese medicine preparation shampoo |
| CN108704113A (en) * | 2018-08-07 | 2018-10-26 | 王旺才 | A kind of Chinese medicine preparation and preparation method thereof of pure Chinese medicine blackening and generating hair hair care |
| CN111956587B (en) * | 2020-09-16 | 2021-05-04 | 孙开军 | Black-hair and bright-hair shampoo and preparation method thereof |
| FR3122579B1 (en) * | 2021-05-10 | 2023-03-24 | Li Wencai | Composition for traditional Chinese medicine and process for its preparation |
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