Summary of the invention
The present invention provides a kind of full nutrition half digestion special medicine purposes formula food; purpose is in that to make full use of postoperative partial digested function, and protection, maintenance, the comprehensive of promotion people digest's function recover, and regulate immunologic function; enhancing body resistance against diseases, thus affecting advancing of disease and lapsing to.
The first aspect of the invention is to provide a kind of full nutrition half digestion special medicine purposes formula food, contains in full nutrition described in every 100g half digestion special medicine purposes formula food:
Lact albumin hydrolysate 5-15g,
Albumen 3-8g,
Soybean protein isolate 1-4g,
Concentrated lactoalbumin 1-4g,
Sodium caseinate 0.5-2g,
Low GI value carbohydrate 37-60g,
Oligofructose 1-4g,
Carboxymethyl pachyman 0.005-0.05g,
Vegetable oil powder 15-22g,
Medium-chain fatty acid 4-10g,
Mineral substance premix 3-8g,
Vitamin premix 0.2-1.4g.
Wherein, described vegetable oil powder is made up of vegetable oil and edible carrier, and the weight ratio of the two is (40-60): (40-60), vegetable oil and edible carrier is mixed, and spray drying is made powder and namely obtained described vegetable oil powder.
Wherein, described vegetable oil can be one or more in Oleum Arachidis hypogaeae semen, Oleum Glycines, oleum lini, Oleum Gossypii semen, Oleum Ricini, rapeseed oil, Oleum sesami, olive oil, Oleum Camelliae etc.
Preferably, described edible carrier is maltodextrin.
Wherein, described low GI value carbohydrate refers to the carbohydrate of glycemic index≤55.
Wherein
Preferably, described low GI value carbohydrate is isomaltulose and maltodextrin mixture, and the ratio of the two can arbitrarily regulate.
It is further preferred that containing isomaltulose 25-40g, maltodextrin 12-20g in full nutrition half digestion special medicine purposes formula food described in every 100g.
Preferably, in full nutrition described in every 100g half digestion special medicine purposes formula food, the content of described low GI value carbohydrate is 42-56g, more preferably 46-53g, it is most preferred that for 49.76g.
Preferably, full nutrition described in every 100g half digestion special medicine purposes formula food contains:
Lact albumin hydrolysate 7-14g,
Albumen 4-6g,
Soybean protein isolate 0.8-3g,
Concentrated lactoalbumin 0.8-3g,
Sodium caseinate 0.6-1.5g,
Isomaltulose 28-38g,
Maltodextrin 14-18g,
Oligofructose 0.8-3g,
Carboxymethyl pachyman 0.008-0.04g,
Vegetable oil powder 16-20g,
Medium-chain fatty acid 5-8g,
Mineral substance premix 3.5-6g,
Vitamin premix 0.5-1.2g.
It is further preferred that full nutrition half digestion special medicine purposes formula food described in every 100g contains:
Lact albumin hydrolysate 9-10g,
Albumen 4-5g,
Soybean protein isolate 1-2g,
Concentrated lactoalbumin 1.2-2.2g,
Sodium caseinate 0.8-1.2g,
Isomaltulose 30-35g,
Maltodextrin 16-17g,
Oligofructose 1-2g,
Carboxymethyl pachyman 0.01-0.04g,
Vegetable oil powder 17-18g,
Medium-chain fatty acid 6-7g,
Mineral substance premix 4-5g,
Vitamin premix 0.6-1g.
Most preferably, full nutrition described in every 100g half digestion special medicine purposes formula food contains:
Lact albumin hydrolysate 9.54g,
Albumen 4.73g,
Soybean protein isolate 1.66g,
Concentrated lactoalbumin 1.86g,
Sodium caseinate 0.97g,
Isomaltulose 32.86g,
Maltodextrin 16.90g,
Oligofructose 1.70g,
Carboxymethyl pachyman 0.03g,
Vegetable oil powder 17.22g,
Medium-chain fatty acid 6.83g,
Mineral substance premix 4.88g,
Vitamin premix 0.82g.
Preferably, mineral substance premix described in every 1g comprises tricalcium phosphate 18-30mg, calcium carbonate 5-15mg, six hydrated chromium trichloride 0.004-0.01mg, anhydrous cupric sulfate 0.05-0.3mg, Feromax 1-2mg, magnesium chloride 12-25mg, manganese sulfate 0.1-0.5mg, two molybdic acid hydrate sodium 0.005-0.02mg, potassium chloride 18-30mg, dipotassium hydrogen phosphate 70-100mg, sodium selenite 0.001-0.01mg, Zinc sulfate monohydrate 0.8-1.5mg, sodium fluoride 0.05-0.2mg, edible salt 50-70mg, sodium citrate 18-26mg, and surplus is mineral substance premix carrier.
Further preferably, mineral substance premix described in every 1g comprises tricalcium phosphate 22-25mg, calcium carbonate 8-12mg, six hydrated chromium trichloride 0.006-0.008mg, anhydrous cupric sulfate 0.1-0.2mg, Feromax 1.3-1.8mg, magnesium chloride 15-20mg, manganese sulfate 0.2-0.4mg, two molybdic acid hydrate sodium 0.008-0.015mg, potassium chloride 22-25mg, dipotassium hydrogen phosphate 80-90mg, sodium selenite 0.004-0.008mg, Zinc sulfate monohydrate 1-1.2mg, sodium fluoride 0.08-0.12mg, edible salt 55-65mg, sodium citrate 20-24mg, surplus is mineral substance premix carrier.
Most preferably, mineral substance premix described in every 1g comprises tricalcium phosphate 23.368mg, calcium carbonate 10.531mg, six hydrated chromium trichloride 0.007mg, anhydrous cupric sulfate 0.155mg, Feromax 1.505mg, magnesium chloride 18.681mg, manganese sulfate 0.313mg, two molybdic acid hydrate sodium 0.010mg, potassium chloride 23.052mg, dipotassium hydrogen phosphate 87.606mg, sodium selenite 0.006mg, Zinc sulfate monohydrate 1.129mg, sodium fluoride 0.103mg, edible salt 61.122mg, sodium citrate 22.373mg, and surplus is mineral substance premix carrier.
Preferably, described mineral substance premix carrier is maltodextrin.
Preferably, vitamin premix described in every 1g comprises phylloxanthin 0.8-1.5mg, vitamin A acid esters 1500-2500IU, vitamin D3200-300U, Vitamin E acetate 10-18mg, vitamin K1 0.01-0.1mg, thiamine nitrate 1-2mg, riboflavin 0.8-1.5mg, pyridoxine hydrochloride 1-2mg, ascorbic acid 60-100mg, D-VB5 calcium 2-8mg, biotin 28-40mg, folic acid 0.1-0.5mg, nicotiamide 8-15mg, vitamin B12 1-4mg, potassium iodide 0.05-0.1mg, choline 150-300mg, taurine 40-60mg, surplus is vitamin premix carrier.
It is further preferred that vitamin premix described in every 1g comprises phylloxanthin 1-1.2mg, vitamin A acid esters 1800-2200IU, vitamin D3220-250IU, Vitamin E acetate 12-15mg, vitamin K1 0.04-0.06mg, thiamine nitrate 1.2-1.5mg, riboflavin 1-1.2mg, pyridoxine hydrochloride 1.3-1.8mg, ascorbic acid 72-85mg, D-VB5 calcium 4-5mg, biotin 32-35mg, folic acid 0.2-0.3mg, nicotiamide 11-13mg, vitamin B12 1.5-3mg, potassium iodide 0.06-0.09mg, choline 200-250mg, taurine 50-58mg, surplus is vitamin premix carrier.
Most preferably, vitamin premix described in every 1g comprises phylloxanthin 1.195mg, vitamin A acid esters 2043.474IU, vitamin D3240.707IU, Vitamin E acetate 13.869mg, vitamin K1 0.042mg, thiamine nitrate 1.437mg, riboflavin 1.194mg, pyridoxine hydrochloride 1.539mg, ascorbic acid 80.722mg, D-VB5 calcium 4.614mg, biotin 32.501mg, folic acid 0.234mg, nicotiamide 12.471mg, vitamin B12 1.837mg, potassium iodide 0.084mg, choline 210.682mg, taurine 56.942mg, surplus is vitamin premix carrier.
Preferably, described vitamin premix carrier is maltodextrin.
Wherein, in foregoing of the present invention, the preparation method of described carboxymethyl pachyman is known in the art, such as Chen Chun rosy clouds etc. are at " chemical research of carboxymethyl pachyman " (edible fungi of china, 1994,13 (5): 35-36) disclose hydrophily method and two kinds of methods of solvent method prepare carboxymethyl pachyman, and for example Cheng Jin life etc. also discloses that the simple and convenient process for preparing of a kind of carboxymethyl pachyman in " preparation of carboxymethyl pachyman and antitumor pharmacodynamic study " (Youjiang River medical journal, volume 4 phase August 36 in 2008).
Wherein, described full nutrition half digestion special medicine purposes formula food can be granule or electuary. Full nutrition half digestion special medicine purposes formula food can also be made the liquid forms such as beverage.
Full nutrition provided by the invention half digestion special medicine purposes formula food contains the small peptides such as protein and lact albumin hydrolysate such as soybean protein isolate, Chicken Albumin, casein and concentrated lactoalbumin, there is multi-form nitrogenous source, it is prone to digest and assimilate, rich in unsaturated fatty acids such as EPA, DHA, patient's body function and gastrointestinal function are recovered have important function.
Full nutrition provided by the invention half digestion special medicine purposes formula food is especially added with the modified Poria extract carboxymethyl pachyman of integration of edible and medicinal herbs, contributes to improving patient's immunity.
Full nutrition provided by the invention half digestion special medicine purposes formula food adopts the carbohydrate of the low GI such as maltodextrin, isomaltulose, contributes to the control of glucose.
Full nutrition provided by the invention half digestion special medicine purposes formula food is a kind of complex food, it combines soybean protein isolate, Chicken Albumin, casein, concentrated lactoalbumin, the nitrogenous source that lact albumin hydrolysate etc. are multi-form, it is prone to digest and assimilate, patient's immunity is improved in conjunction with carboxymethyl pachyman, in conjunction with maltodextrin, the carbohydrate of the low GI such as isomaltulose, control glucose, synergism by various compositions, postoperative partial digested function can be made full use of, protection, maintain, promote comprehensive recovery of people digest's function, regulate immunologic function, enhancing body resistance against diseases, thus affecting advancing of disease and lapsing to. this full nutrition half digestion special medicine purposes formula food can not only be used for nutraceutical provides nutritional support for gastrointestinal dysfunction patient, also can as the nutritional support food of common patient, being also used as bread and cheese is that normal population or weak crowd eat, and supplements daily required more comprehensive nutrition and functional component.
Embodiment 1
A kind of full nutrition half digestion special medicine purposes formula food, contains in full nutrition described in every 100g half digestion special medicine purposes formula food:
Lact albumin hydrolysate 9.54g,
Albumen 4.73g,
Soybean protein isolate 1.66g,
Concentrated lactoalbumin 1.86g,
Sodium caseinate 0.97g,
Isomaltulose 32.86g,
Maltodextrin 16.90g,
Oligofructose 1.70g,
Carboxymethyl pachyman 0.03g,
Vegetable oil powder 17.22g,
Medium-chain fatty acid 6.83g,
Mineral substance premix 4.88g,
Vitamin premix 0.82g.
Ratio is weighed raw material, raw material is dry mixed to mix homogeneously, namely prepare finished product.
Wherein, described vegetable oil powder is made up of vegetable oil and maltodextrin, and the weight ratio of the two is 1:1, is mixed with maltodextrin by vegetable oil, and spray drying is made powder and get final product. Wherein, described vegetable oil can be one or more in Oleum Arachidis hypogaeae semen, Oleum Glycines, oleum lini, Oleum Gossypii semen, Oleum Ricini, rapeseed oil, Oleum sesami, olive oil, Oleum Camelliae etc.
Wherein, mineral substance premix described in every 1g comprises tricalcium phosphate 23.368mg, calcium carbonate 10.531mg, six hydrated chromium trichloride 0.007mg, anhydrous cupric sulfate 0.155mg, Feromax 1.505mg, magnesium chloride 18.681mg, manganese sulfate 0.313mg, two molybdic acid hydrate sodium 0.010mg, potassium chloride 23.052mg, dipotassium hydrogen phosphate 87.606mg, sodium selenite 0.006mg, Zinc sulfate monohydrate 1.129mg, sodium fluoride 0.103mg, edible salt 61.122mg, sodium citrate 22.373mg, and surplus is maltodextrin.
Wherein, vitamin premix described in every 1g comprises phylloxanthin 1.195mg, vitamin A acid esters 2043.474IU, vitamin D3240.707IU, Vitamin E acetate 13.869mg, vitamin K1 0.042mg, thiamine nitrate 1.437mg, riboflavin 1.194mg, pyridoxine hydrochloride 1.539mg, ascorbic acid 80.722mg, D-VB5 calcium 4.614mg, biotin 32.501mg, folic acid 0.234mg, nicotiamide 12.471mg, vitamin B12 1.837mg, potassium iodide 0.084mg, choline 210.682mg, taurine 56.942mg, surplus is maltodextrin.
Wherein, carboxymethyl pachyman is prepared from by the following method: poria cocos sclerotium is carried out micronizing, obtains Poria superfine powder, then with edible ethanol room temperature lixiviate, filters to obtain filter cake; Then with volume ratio be 15-10: 1 water and alcohol mixture for medium, filter cake reacts with monoxone and excessive sodium hydroxide, and purification obtains carboxymethyl pachyman.
Embodiment 6
The present embodiment and embodiment 1 are different in that, described mineral substance premix delicatessen food mineral substance premix, described vitamin premix is delicatessen food vitamin premix.
Comparative example 1
This comparative example and embodiment 1 are different in that, do not contain carboxymethyl pachyman.
Comparative example 2
This comparative example and embodiment 1 are different in that, do not contain maltodextrin, resistant dextrin and isomaltulose.
The full nutrition provided by the invention half digestion special medicine purposes formula food impact on mouse intestinal function:
Example 1-6 and comparative example 1-2 tests, and sets negative control group, negative control group gavage normal saline simultaneously. SPF level BALB/C mice, male, body weight 18-22g, often group 10. According to 0.05g/10g dosage gavage every day mice, continuous 10 days. To cage nursing single during mice lavage, measure it every day and take in appetite, within every 3 days, claim 1 body weight, finally calculate the increase of each group of food ration, body weight increase, calculate food exchange share. Food utilization=body weight increases (g) ÷ food weight (g) × 100%. Mouse Weight is affected result in Table 2 by full nutrition half digestion special medicine purposes formula food, and mouse chow usage factor is affected result in Table 3.
Example 1-6 and comparative example 1-2 tests, according to 0.05g/10g dosage gavage every day mice, and continuous 7 days. Can't help water 24h to fasting in the 6th of nutritional solution the day, last giving to 1h after nutritional solution takes blood with 50g/L D-xylose liquid 20mL/kg, 1h posterior orbit, separates serum. Take out 40L serum and add 4ml developer (take phloroglucinol 0.5g and add 100ml glacial acetic acid and 6ml concentrated hydrochloric acid), mixing, 100 DEG C of heating in water bath 10min, flowing water is cooled to room temperature, use 554nm wavelength, add developer pipe with distilled water and reset, measure the trap of each pipe. What mouse small intestine was absorbed by full nutrition half digestion special medicine purposes formula food affects result in Table 4.
The full nutrition of the table 2 half digestion special medicine purposes formula food impact on Mouse Weight
|
First body weight (g) |
Whole body weight (g) |
Weightening finish (g) |
Embodiment 1 |
23.16 |
28.78 |
5.62 |
Embodiment 2 |
23.40 |
28.92 |
5.52 |
Embodiment 3 |
22.94 |
28.66 |
5.72 |
Embodiment 4 |
22.82 |
28.80 |
5.98 |
Embodiment 5 |
23.56 |
29.08 |
5.52 |
Embodiment 6 |
22.56 |
28.12 |
5.64 |
Comparative example 1 |
23.05 |
28.51 |
5.46 |
Comparative example 2 |
22.65 |
27.69 |
5.14 |
Negative control group |
23.12 |
21.66 |
5.54 |
As shown in Table 2, comparing with negative control group, the body weight increase of embodiment 1-6 group mice there was no significant difference (P > 0.05);Compared with comparative example 1-2, the body weight increase of embodiment 1-6 group mice also there was no significant difference (P > 0.05). Visible, Mouse Weight growth is had no and significantly affects by said preparation, it is possible to maintain the normal physiological function of mice.
The full nutrition of the table 3 half digestion special medicine purposes formula food impact on mouse chow usage factor
|
Food exchange share (%) |
Embodiment 1 |
4.23. |
Embodiment 2 |
4.01 |
Embodiment 3 |
4.11 |
Embodiment 4 |
3.94 |
Embodiment 5 |
3.89 |
Embodiment 6 |
4.18 |
Comparative example 1 |
2.45 |
Comparative example 2 |
2.68 |
Negative control group |
2.07 |
As shown in Table 3, full nutrition provided by the invention half digestion special medicine purposes formula food can significantly improve mouse chow usage factor, is conducive to digesting and assimilating.
The impact that mouse small intestine is absorbed by the full nutrition of table 4 half digestion special medicine purposes formula food
|
Number of animals |
OD value |
Embodiment 1 |
10 |
0.91 |
Embodiment 2 |
10 |
0.86 |
Embodiment 3 |
10 |
0.85 |
Embodiment 4 |
10 |
0.82 |
Embodiment 5 |
10 |
0.79 |
Embodiment 6 |
10 |
0.88 |
Comparative example 1 |
10 |
0.54 |
Comparative example 2 |
10 |
0.48 |
Negative control group |
10 |
0.41 |
As shown in Table 4, digesting and assimilating of mice is had obvious promotion functions by full nutrition provided by the invention half digestion special medicine purposes formula food.
The full nutrition provided by the invention half digestion special medicine purposes formula food impact on immune function of mice:
Adopt mouse spleen lymphocyte transformation experiment, with reference to the method for Ministry of Public Health " health food inspection and value disciplines " (version in 2003). Mice spleen lymphocytes proliferation ability is affected result in Table 5 by full nutrition half digestion special medicine purposes formula food.
Adopt mice carbon particle clearance test, with reference to the method for Ministry of Public Health " health food inspection and value disciplines " (version in 2003). Mice Mus monocytes/macrophages function is affected result in Table 6 by full nutrition half digestion special medicine purposes formula food.
The full nutrition of the table 5 half digestion special medicine purposes formula food impact on mice spleen lymphocytes proliferation ability
|
Number of animals |
Optical density value |
Embodiment 1 |
10 |
0.183 |
Embodiment 2 |
10 |
0.172 |
Embodiment 3 |
10 |
0.174 |
Embodiment 4 |
10 |
0.162 |
Embodiment 5 |
10 |
0.159 |
Embodiment 6 |
10 |
0.179 |
Comparative example 1 |
10 |
0.084 |
Comparative example 2 |
10 |
0.114 |
As shown in Table 5, compared with comparative example 1 and 2, full nutrition provided by the invention half digestion special medicine purposes formula food can significantly improve spleen lymphocyte proliferation rate, illustrate that full nutrition provided by the invention half digestion special medicine purposes formula food can be remarkably reinforced the Cell-mediated Immunity of body, improve the suppressed state of human body immune function, the specific immune function of enhancing body.
The full nutrition of the table 6 half digestion special medicine purposes formula food impact on mouse monokaryon-macrophage function
|
Number of animals |
Phagocytic index |
Embodiment 1 |
10 |
6.23 |
Embodiment 2 |
10 |
6.10 |
Embodiment 3 |
10 |
6.12 |
Embodiment 4 |
10 |
5.86 |
Embodiment 5 |
10 |
5.98 |
Embodiment 6 |
10 |
6.15 |
Comparative example 1 |
10 |
4.32 |
Comparative example 2 |
10 |
5.28 |
As shown in Table 6, compared with comparative example 1 and 2, full nutrition provided by the invention half digestion special medicine purposes formula food can significantly improve the phagocytic index of monocytes/macrophages, illustrate that full nutrition provided by the invention half digestion special medicine purposes formula food is likely to be of the effect promoting monocytes/macrophages phagocytic function, the non-specific immunity of enhancing body.
Above specific embodiments of the invention being described in detail, but it is intended only as example, the present invention is not restricted to particular embodiments described above. To those skilled in the art, any equivalent modifications that the present invention is carried out and replacement are also all among scope of the invention. Therefore, the equalization made without departing from the spirit and scope of the invention converts and amendment, all should contain within the scope of the invention.