CN109674065A - A kind of oral complete nutritional composition - Google Patents
A kind of oral complete nutritional composition Download PDFInfo
- Publication number
- CN109674065A CN109674065A CN201710976077.6A CN201710976077A CN109674065A CN 109674065 A CN109674065 A CN 109674065A CN 201710976077 A CN201710976077 A CN 201710976077A CN 109674065 A CN109674065 A CN 109674065A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- fat
- soluble
- acid
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 29
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000004615 ingredient Substances 0.000 claims abstract description 34
- 239000000470 constituent Substances 0.000 claims abstract description 28
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 22
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 22
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 22
- 229940088594 vitamin Drugs 0.000 claims abstract description 22
- 229930003231 vitamin Natural products 0.000 claims abstract description 22
- 235000013343 vitamin Nutrition 0.000 claims abstract description 22
- 239000011782 vitamin Substances 0.000 claims abstract description 22
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 22
- 239000003381 stabilizer Substances 0.000 claims abstract description 17
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 14
- 239000003765 sweetening agent Substances 0.000 claims abstract description 14
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 11
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 11
- 230000002757 inflammatory effect Effects 0.000 claims abstract description 11
- 239000011734 sodium Substances 0.000 claims abstract description 11
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000011575 calcium Substances 0.000 claims abstract description 9
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 9
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000000460 chlorine Substances 0.000 claims abstract description 8
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000011777 magnesium Substances 0.000 claims abstract description 7
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 7
- 235000015097 nutrients Nutrition 0.000 claims abstract description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000008213 purified water Substances 0.000 claims abstract description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims abstract description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000010949 copper Substances 0.000 claims abstract description 3
- 229910052802 copper Inorganic materials 0.000 claims abstract description 3
- 239000011630 iodine Substances 0.000 claims abstract description 3
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 3
- 229910052742 iron Inorganic materials 0.000 claims abstract description 3
- 229910052748 manganese Inorganic materials 0.000 claims abstract description 3
- 239000011572 manganese Substances 0.000 claims abstract description 3
- 239000011574 phosphorus Substances 0.000 claims abstract description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 3
- 239000011591 potassium Substances 0.000 claims abstract description 3
- 229910052700 potassium Inorganic materials 0.000 claims abstract description 3
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 3
- 239000011669 selenium Substances 0.000 claims abstract description 3
- 239000011701 zinc Substances 0.000 claims abstract description 3
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 32
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 32
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 23
- 239000000047 product Substances 0.000 claims description 22
- 239000011706 ferric diphosphate Substances 0.000 claims description 21
- 235000007144 ferric diphosphate Nutrition 0.000 claims description 21
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims description 21
- 229940036404 ferric pyrophosphate Drugs 0.000 claims description 21
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 20
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 20
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 20
- 230000001954 sterilising effect Effects 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 18
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 18
- 239000001527 calcium lactate Substances 0.000 claims description 18
- 229960002401 calcium lactate Drugs 0.000 claims description 18
- 235000011086 calcium lactate Nutrition 0.000 claims description 18
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 18
- 238000010008 shearing Methods 0.000 claims description 18
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 18
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 16
- 235000019486 Sunflower oil Nutrition 0.000 claims description 16
- 229930003268 Vitamin C Natural products 0.000 claims description 16
- 229930003427 Vitamin E Natural products 0.000 claims description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 16
- 239000002600 sunflower oil Substances 0.000 claims description 16
- 239000011691 vitamin B1 Substances 0.000 claims description 16
- 239000011715 vitamin B12 Substances 0.000 claims description 16
- 235000019154 vitamin C Nutrition 0.000 claims description 16
- 239000011718 vitamin C Substances 0.000 claims description 16
- 235000019165 vitamin E Nutrition 0.000 claims description 16
- 239000011709 vitamin E Substances 0.000 claims description 16
- 229940046009 vitamin E Drugs 0.000 claims description 16
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 15
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 15
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 15
- 235000019155 vitamin A Nutrition 0.000 claims description 15
- 239000011719 vitamin A Substances 0.000 claims description 15
- 229940045997 vitamin a Drugs 0.000 claims description 15
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 14
- 229960003512 nicotinic acid Drugs 0.000 claims description 14
- 235000001968 nicotinic acid Nutrition 0.000 claims description 14
- 239000011664 nicotinic acid Substances 0.000 claims description 14
- 239000011726 vitamin B6 Substances 0.000 claims description 14
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 14
- 229960001763 zinc sulfate Drugs 0.000 claims description 14
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 14
- 239000005913 Maltodextrin Substances 0.000 claims description 12
- 229920002774 Maltodextrin Polymers 0.000 claims description 12
- 229930003316 Vitamin D Natural products 0.000 claims description 12
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 12
- 210000003022 colostrum Anatomy 0.000 claims description 12
- 235000021277 colostrum Nutrition 0.000 claims description 12
- 238000011049 filling Methods 0.000 claims description 12
- 229940035034 maltodextrin Drugs 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 239000011716 vitamin B2 Substances 0.000 claims description 12
- 235000019166 vitamin D Nutrition 0.000 claims description 12
- 239000011710 vitamin D Substances 0.000 claims description 12
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 12
- 229940046008 vitamin d Drugs 0.000 claims description 12
- 238000004090 dissolution Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 10
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 10
- 108010009736 Protein Hydrolysates Proteins 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 10
- 235000014633 carbohydrates Nutrition 0.000 claims description 10
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 10
- 229960000304 folic acid Drugs 0.000 claims description 10
- 235000019152 folic acid Nutrition 0.000 claims description 10
- 239000011724 folic acid Substances 0.000 claims description 10
- 239000003292 glue Substances 0.000 claims description 10
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 10
- 229940055726 pantothenic acid Drugs 0.000 claims description 10
- 235000019161 pantothenic acid Nutrition 0.000 claims description 10
- 239000011713 pantothenic acid Substances 0.000 claims description 10
- 239000003531 protein hydrolysate Substances 0.000 claims description 10
- 235000015424 sodium Nutrition 0.000 claims description 10
- 239000001509 sodium citrate Substances 0.000 claims description 10
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 10
- 235000015921 sodium selenite Nutrition 0.000 claims description 10
- 239000011781 sodium selenite Substances 0.000 claims description 10
- 229960001471 sodium selenite Drugs 0.000 claims description 10
- 239000008107 starch Substances 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- 230000007935 neutral effect Effects 0.000 claims description 9
- 239000011772 phylloquinone Substances 0.000 claims description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
- 229960005069 calcium Drugs 0.000 claims description 8
- 238000004945 emulsification Methods 0.000 claims description 8
- 229940099596 manganese sulfate Drugs 0.000 claims description 8
- 239000011702 manganese sulphate Substances 0.000 claims description 8
- 235000007079 manganese sulphate Nutrition 0.000 claims description 8
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 8
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 7
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 7
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
- 238000013019 agitation Methods 0.000 claims description 6
- 230000001351 cycling effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000004376 Sucralose Substances 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 5
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical group O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 5
- 235000019408 sucralose Nutrition 0.000 claims description 5
- 229960002685 biotin Drugs 0.000 claims description 4
- 235000020958 biotin Nutrition 0.000 claims description 4
- 239000011616 biotin Substances 0.000 claims description 4
- 229940085298 biotin 10 mg Drugs 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- 239000003813 safflower oil Substances 0.000 claims description 2
- 229940091258 selenium supplement Drugs 0.000 claims description 2
- 239000003549 soybean oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 206010001497 Agitation Diseases 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 244000228451 Stevia rebaudiana Species 0.000 claims 1
- UGWKCNDTYUOTQZ-UHFFFAOYSA-N copper;sulfuric acid Chemical compound [Cu].OS(O)(=O)=O UGWKCNDTYUOTQZ-UHFFFAOYSA-N 0.000 claims 1
- 229930182478 glucoside Natural products 0.000 claims 1
- 150000008131 glucosides Chemical class 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 description 13
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 8
- 235000013305 food Nutrition 0.000 description 5
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- 241000209140 Triticum Species 0.000 description 4
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- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 4
- 235000019425 dextrin Nutrition 0.000 description 4
- MCAHWIHFGHIESP-UHFFFAOYSA-N selenous acid Chemical compound O[Se](O)=O MCAHWIHFGHIESP-UHFFFAOYSA-N 0.000 description 4
- 238000013112 stability test Methods 0.000 description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- MBWXNTAXLNYFJB-LKUDQCMESA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCCC(C)CCCC(C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-LKUDQCMESA-N 0.000 description 3
- 230000001376 precipitating effect Effects 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000003738 black carbon Substances 0.000 description 2
- 235000019504 cigarettes Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- -1 life Object element Chemical compound 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 235000020238 sunflower seed Nutrition 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004383 Steviol glycoside Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 208000037902 enteropathy Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000013022 formulation composition Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 235000019411 steviol glycoside Nutrition 0.000 description 1
- 229930182488 steviol glycoside Natural products 0.000 description 1
- 150000008144 steviol glycosides Chemical class 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The present invention relates to a kind of oral complete nutritional compositions, the composition contains non-fat-soluble ingredient, liposoluble constituent and purified water, the non-fat-soluble ingredient that wherein composition described in every 1000mL contains is protein 30-80g, carbohydrate 150-200g, sodium 0.5-2g, chlorine 0.4-2.0g, magnesium 0.01-0.6g, phosphorus 0.5-1.5g, potassium 1-4g, calcium 0.3-2g, iron 0.005-0.05g, zinc 0.001-0.05g, copper 0-0.01g, manganese 0-0.01g, selenium 0.01-0.5mg, iodine 0-1.5mg, citric acid 0-15g, water soluble vitamin 0.1-2g, sweetener 0-0.5g, stabilizer 2-15g；The liposoluble constituent contained is fat 10-30g, liposoluble vitamin 0.02-1g, emulsifier 2-18g.Be mainly used to for inflammatory bowel patient and other there is no the patient of particular/special requirement to provide comprehensively and balanced nutritional support nutrient.
Description
Technical field
The invention belongs to medical food fields, and in particular to a kind of oral complete nutritional composition and preparation method thereof, mainly
For for inflammatory bowel patient and other there is no the patient of particular/special requirement to provide comprehensively and balanced nutritional support nutrient.
Background technique
The bad incidence of inflammatory bowel disease (IBD) nutrition is higher, and nutrition especially enteral nutrition is that its important is controlled
Treatment measure.Essential food and non-essential food are to the curative effect of inflammatory bowel disease without significant difference, whole albumen, small peptide and amino acid list
Figure preparation has their own characteristics, and should select to apply according to the state of an illness.The mechanism of enteral nutrition treatment inflammatory bowel disease be it is various,
At present nutritional support treatment in most of patients IBD or a kind of " auxiliary supportive treatment " rather than be directed to one kind of disease itself
Primary Care is goed deep into the development of clinical nutriology and to inflammatory bowel disease understanding, and EN support will become inflammation
The base therapy measure of disease property enteropathy.
The methods of dietetic nutrition, enteral or parenteral nutritional support or nutritional supplement are selected according to patient's state of an illness, makes patient
Suitable nutrition is obtained, is the effective way for reducing complication and death.From existing inflammatory bowel disease enteral nutrition food
Kind and quantity from the point of view of, the several types such as having all nutrition type, assembly type, kind and quantity are few, and lean on import.Cause
This, China's inflammatory bowel disease nutraceutical has very big market potential.
Currently, the enteral nutrition food of alternative suitable inflammatory bowel patients also compares shortage in the market, exploitation
It is a kind of stable, easy to carry and use, and the relatively simple oral inflammatory bowel patient of preparation method is combined with full nutrient formulation
Object, for for inflammatory bowel patient and other to nutrient do not have particular/special requirement patient provide comprehensively and balanced nutritional support is outstanding
It is important.
Summary of the invention
The invention mainly relates to a kind of oral inflammatory bowel patient full nutrient formulation compositions and preparation method thereof, specifically such as
Under:
A kind of oral complete nutritional composition, it is characterised in that the composition contains non-fat-soluble ingredient, liposoluble constituent
And purified water, wherein the non-fat-soluble ingredient that composition described in every 1000mL contains is protein 30-80g, carbohydrate
150-200g, sodium 0.5-2g, chlorine 0.4-2.0g, magnesium 0.01-0.6g, phosphorus 0.5-1.5g, potassium 1-4g, calcium 0.3-2g, iron 0.005-
0.05g, zinc 0.001-0.05g, copper 0-0.01g, manganese 0-0.01g, selenium 0.01-0.5mg, iodine 0-1.5mg, citric acid 0-15g, water
Soluble vitamin 0.1-2g, sweetener 0-0.5g, stabilizer 2-15g；The liposoluble constituent contained is fat 10-30g, fat-soluble
Vitamin 0.02-1g, emulsifier 2-18g.
Further, the protein is selected from resistance to acid protein hydrolysats, neutral protein hydrolysate or its mixing；Carbohydrate choosing
From maltodextrin, fructose, starch or its mixing；Sweetener be selected from Sucralose, steviol glycoside, antierythrite, xylitol or its
Mixing；Stabilizer is edible glue；Water soluble vitamin is selected from pantothenic acid, biotin, vitamin K1, folic acid, vitamin C, vitamin
B1, vitamin B2, niacin, vitamin B6, vitamin B12Or its mixing；Fat selected from sunflower oil, soybean oil, safflower seed oil, in
Chain triglyceride or its mixing, preferably sunflower oil is mixed with medium chain triglyceride；Liposoluble vitamin is selected from vitamin E, dimension
Raw element A, vitamin D or its mixing；Emulsifier is converted starch.
A kind of oral complete nutritional composition, it is characterised in that the composition contains liposoluble constituent, non-fat-soluble ingredient
And purified water, wherein the non-fat-soluble ingredient that every 1000mL above-mentioned composition contains is protein hydrolysate 30-80g, maltodextrin
150-200g, dipotassium hydrogen phosphate 3-8g, sodium citrate 2-7g, calcium lactate 0-5g, magnesium chloride 0.3-5g, ferric pyrophosphate 20-80mg,
Zinc sulfate 20-100mg, sodium selenite 200-750 μ g, potassium iodide 0-2mg, manganese sulfate 0-5mg, copper sulphate 5-20mg, pantothenic acid 0-
30mg, biotin 0-20mg, folic acid 0-20mg, vitamin K10-2mg, vitamin C 100-300mg, vitamin B1 1-5mg、
Vitamin B21-5mg, niacin 10-20mg, vitamin B61-6mg, vitamin B120.001-0.3mg, citric acid 0-15g, sweet tea
Taste agent 0-0.5g, stabilizer 2-15g；Liposoluble constituent is sunflower oil 5-15g, medium chain triglyceride 5-15, vitamin E 20-
800mg, vitamin A 0.1-4mg, vitamin D 20-60 μ g, emulsifier 2-18g.
It is further preferred that the non-fat-soluble ingredient that every 1000mL above-mentioned composition contains is neutral protein hydrolysate 40g, wheat
Bud dextrin 186g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.622g, calcium lactate 3.0g, magnesium chloride 2.3g, ferric pyrophosphate 50mg,
Zinc sulfate 60mg, 400 μ g of sodium selenite, potassium iodide 1.3mg, manganese sulfate 2.4mg, copper sulphate 10mg, pantothenic acid 20mg, biotin
10mg, folic acid 10mg, vitamin K10.5mg, vitamin C 240mg, vitamin B12mg, vitamin B22mg, niacin 18mg,
Vitamin B61.6mg, vitamin B120.0018mg, sweetener 0.2g, stabilizer 8g；The liposoluble constituent contained is sunflower seeds
Oily 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 2mg, 40 μ g of vitamin D, emulsifier 8g.
It is further preferred that the non-fat-soluble ingredient that every 1000mL above-mentioned composition contains is neutral protein hydrolysate 40g, wheat
Bud dextrin 186g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.622g, calcium lactate 3.0g, magnesium chloride 0.34g, ferric pyrophosphate 50mg,
Zinc sulfate 60mg, 400 μ g of sodium selenite, vitamin C 240mg, vitamin B12mg, vitamin B22mg, niacin 18mg, dimension life
Plain B61.6mg, vitamin B120.0018mg, sweetener 0.2g, stabilizer 8g；Liposoluble constituent is sunflower oil 8g, middle chain
Triglycerides 8g, vitamin E 40mg, vitamin A 1mg, 40 μ g of vitamin D, emulsifier 8g.
It is further preferred that the non-fat-soluble ingredient that every 1000mL above-mentioned composition contains is the 40g of resistance to acid protein hydrolysats, wheat
Bud dextrin 186g, dipotassium hydrogen phosphate 0.83g, sodium citrate 2.85g, calcium lactate 3.0g, magnesium chloride 2.3g, ferric pyrophosphate 50mg,
Zinc sulfate 60mg, 400 μ g of sodium selenite, potassium iodide 1.3mg, manganese sulfate 2.4mg, copper sulphate 10mg, pantothenic acid 20mg, biotin
10mg, folic acid 10mg, vitamin K10.5mg, vitamin C 240mg, vitamin B12mg, vitamin B22mg, niacin 18mg,
Vitamin B616mg, vitamin B120.0018mg, citric acid 13g, sweetener 0.2g, stabilizer 8g；Contain it is fat-soluble at
It is divided into sunflower oil 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 2mg, 40 μ g of vitamin D, emulsifier 8g.
It is further preferred that the non-fat-soluble ingredient that every 1000mL above-mentioned composition contains is the 40g of resistance to acid protein hydrolysats, wheat
Bud dextrin 186g, dipotassium hydrogen phosphate 0.83g, sodium citrate 2.85g, calcium lactate 3.0g, magnesium chloride 0.34g, ferric pyrophosphate 50mg,
Zinc sulfate 60mg, 400 μ g of sodium selenite, vitamin C 240mg, vitamin B12mg, vitamin B22mg, niacin 18mg, dimension life
Plain B61.6mg, vitamin B120.0018mg, citric acid 13g, sweetener 0.2g, stabilizer 8g；Liposoluble constituent is sunflower seeds
Oily 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 1mg, 40 μ g of vitamin D, emulsifier 8g.
Further, ferric pyrophosphate is emulsification ferric pyrophosphate in composition as described above.
Meanwhile the present invention also provides the preparation methods of composition as described above comprising the steps of:
Step 1: ingredient
A) non-fat-soluble ingredient is weighed respectively by formula, for use；
B) liposoluble constituent is weighed respectively by formula, for use；
Step 2: dissolution
C) by the liposoluble constituent heating stirring claimed to Quan Rong, oil-phase solution is obtained；
D) the non-fat-soluble component protein matter and carbohydrate that claim, stabilizer is dry-mixed, with preparation total amount 60%
50-80 DEG C of water temperature shear agitation of water is to Quan Rong；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution is slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min,
The water soluble vitamin of 5min addition water dissolution, shearing are uniform before shearing terminates；
Step 4: dipotassium hydrogen phosphate adjusting product pH is 6.0-6.9 or citric acid adjusting product pH is 3.7-4.7, is settled to
Total volume is prepared, colostrum is made；
Step 5: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
In addition, the present invention also provides composition as described above be used for for inflammatory bowel patient and other do not have to nutrient
The patient of particular/special requirement provides comprehensively and the application of balanced nutritional support.
The present invention has found that the selection of each ingredient such as emulsifier etc. influences very big, cream on product stability in R&D process
Agent selection is improper, can generate a large amount of precipitatings and/or oil slick, lamination occurs, seriously then leads to product denaturation solidification.
1) selection of emulsifier:
Product Status is more stable when using converted starch as the result is shown as emulsifier, accelerate (40 DEG C of temperature, humidity:
70%) 6 months products are put in uniform liquid, a small amount of precipitating is arranged at bottom, but rocks and disappear.
2) selection of calcium
The source of calcium is also very big to the stability influence of product, in addition to being derived partly from albumen, also needs to add when necessary
Other calcium sources, the present invention carry out sample preparation screening to calcium source calcium chloride, calcium carbonate, calcium monohydrogen phosphate, calcium lactate:
The calcium lactate and calcium monohydrogen phosphate effect filtered out as the result is shown is better than other two kinds, prepares sample using it, accelerates
(40 DEG C of temperature, humidity: 70%) place 6 months, select the Product Status of calcium lactate uniform as the result is shown, Packaging Bottle bottom only has
A small amount of precipitating, slightly shakes and disappears, and the product than calcium monohydrogen phosphate is added is more stable, therefore selects calcium lactate as calcium source.
3) present invention has a small amount of black carbon powder precipitate in Packaging Bottle bottom after research and development phase discovery, product sterilizing, influences
Product quality to mineral salt screening, it is found that the sediment is to replace as caused by molysite using the emulsification ferric pyrophosphate of embedding
Ferric pyrophosphate pure powder then can avoid the generation of black carbon powder precipitate after the sample sterilizing of preparation, therefore final choice is through wrapping
The emulsification ferric pyrophosphate buried.
The present invention is a short peptide type predigestion compound composition, is a to be set according to inflammatory bowel patient's Nutrition and Metabolism feature
The enteral nutrition suspension (TPF-DM) of the full nutrition inflammatory bowel patients of meter, using protein hydrolysate as protein sources, without digesting,
It is directly absorbed and utilized, direct nutrition intestinal mucosa, Fast-Maintenance Gut barrie r efficiently supplements protein, controls to inflammatory bowel patient
The generation that complication can be more preferably reduced while nutritional support is provided in treatment；In addition, the present invention for patient to pH different demands,
Neutral and two kinds of products of slant acidity are devised, wherein acidic products are more advantageous to patient's digestion and absorption, but some patients are due to body
Matter meta-acid or hyperhydrochloria are then not suitable for drinking acid product, therefore suitable product can be selected according to sick Man's Demands.
Each component content meets regulation in composition in the present invention, selects suitable emulsifier, calcium source by experimental study
And stabilizer, while acid and neutral two kinds of products are designed according to patients ' demand, and there is stability height, it is easy to carry and use etc.
Advantage；In addition preparation method is simple, at low cost, industrialized production of being more convenient for.
Specific embodiment
Below will by embodiment, the invention will be further described, these description be not the content of present invention is made into
The restriction of one step.Those skilled in the art still falls within protection of the invention to equivalent replacement made by summary of the invention or improvement
Within the scope of.
Embodiment 1:
Preparation process:
Step 1: ingredient
A) non-fat-soluble ingredient neutrality protein hydrolysate, maltodextrin, dipotassium hydrogen phosphate, citric acid are weighed respectively by formula
Sodium, calcium lactate, magnesium chloride, emulsification ferric pyrophosphate, zinc sulfate, selenous acid acid sodium, potassium iodide, manganese sulfate, copper sulphate, pantothenic acid, life
Object element, folic acid, vitamin K1, vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, Sucralose,
Edible glue, for use；
B) liposoluble constituent sunflower oil, medium chain triglyceride, converted starch are weighed respectively by formula, for use；
Step 2: dissolution
C) by the liposoluble constituent sunflower oil claimed, medium chain triglyceride, vitamin E, vitamin A, vitamin D, change
Property heating starch is stirred to Quan Rong, obtains oil-phase solution；
D) the non-fat-soluble component protein matter and carbohydrate, the edible glue that claim is dry-mixed, with preparation total amount 60%
50-80 DEG C of water temperature shear agitation of water is to Quan Rong；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution is slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min,
The water soluble vitamin of 5min addition water dissolution, shearing are uniform before shearing terminates；
Step 4: it is 6.0-6.9 that dipotassium hydrogen phosphate, which adjusts product pH, is settled to preparation total volume, and colostrum is made；
Step 5: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
Stability test:
Embodiment 2:
Preparation process:
Step 1: ingredient
A) non-fat-soluble ingredient neutrality protein hydrolysate, maltodextrin, dipotassium hydrogen phosphate, citric acid are weighed respectively by formula
Sodium, calcium lactate, magnesium chloride, emulsification ferric pyrophosphate, zinc sulfate, selenous acid acid sodium, vitamin C, vitamin B1, vitamin B2, cigarette
Acid, vitamin B6, vitamin B12, Sucralose, edible glue, for use；
B) liposoluble constituent sunflower oil, medium chain triglyceride, vitamin E, vitamin A, dimension life are weighed respectively by formula
Plain D, converted starch, for use；
Step 2: dissolution
C) liposoluble constituent claimed and emulsifier heating stirring are obtained into oil-phase solution to Quan Rong；
D) the non-fat-soluble component protein matter and carbohydrate, the edible glue that claim is dry-mixed, with preparation total amount 60%
50-80 DEG C of water temperature shear agitation of water is to Quan Rong；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution is slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min,
The water soluble vitamin of 5min addition water dissolution, shearing are uniform before shearing terminates；
Step 4: it is 6.0-6.9 that dipotassium hydrogen phosphate, which adjusts product pH, is settled to preparation total volume, and colostrum is made；
Step 5: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
Stability test:
Embodiment 3:
Preparation process:
Step 1: ingredient
A) the resistance to acid protein hydrolysats of non-fat-soluble ingredient, maltodextrin, dipotassium hydrogen phosphate, citric acid are weighed respectively by formula
Sodium, calcium lactate, magnesium chloride, emulsification ferric pyrophosphate, zinc sulfate, selenous acid acid sodium, potassium iodide, manganese sulfate, copper sulphate, pantothenic acid, life
Object element, folic acid, vitamin K1, vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, citric acid, three
Chlorine sucrose, edible glue, for use；
B) liposoluble constituent sunflower oil, medium chain triglyceride, vitamin E, vitamin A, dimension life are weighed respectively by formula
Plain D, converted starch, for use；
Step 2: dissolution
C) liposoluble constituent claimed and emulsifier heating stirring are obtained into oil-phase solution to Quan Rong；
D) the non-fat-soluble component protein matter and carbohydrate, the edible glue that claim is dry-mixed, with preparation total amount 60%
50-80 DEG C of water temperature shear agitation of water is to Quan Rong；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution is slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min,
The water soluble vitamin of 5min addition water dissolution, shearing are uniform before shearing terminates；
Step 4: it is 3.7-4.7 that citric acid, which adjusts product pH, is settled to preparation total volume, and colostrum is made；
Step 5: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
Stability test:
Embodiment 4:
Preparation process:
Step 1: ingredient
A) the resistance to acid protein hydrolysats of non-fat-soluble ingredient, maltodextrin, dipotassium hydrogen phosphate, citric acid are weighed respectively by formula
Sodium, calcium lactate, magnesium chloride, emulsification ferric pyrophosphate, zinc sulfate, selenous acid acid sodium, vitamin C, vitamin B1, vitamin B2, cigarette
Acid, vitamin B6, vitamin B12, citric acid, Sucralose, edible glue, for use；
B) liposoluble constituent sunflower oil, medium chain triglyceride, vitamin E, vitamin A, dimension life are weighed respectively by formula
Plain D, converted starch, for use；
Step 2: dissolution
C) liposoluble constituent claimed and emulsifier heating stirring are obtained into oil-phase solution to Quan Rong；
D) the non-fat-soluble component protein matter and carbohydrate, the edible glue that claim is dry-mixed, with preparation total amount 60%
50-80 DEG C of water temperature shear agitation of water is to Quan Rong；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution is slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min,
The water soluble vitamin of 5min addition water dissolution, shearing are uniform before shearing terminates；
Step 4: it is 3.7-4.7 that citric acid, which adjusts product pH, is settled to preparation total volume, and colostrum is made；
Step 5: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilizings 10~
It is 30 seconds, filling.
Stability test:
Claims (10)
1. a kind of oral complete nutritional composition, it is characterised in that the composition contains non-fat-soluble ingredient, liposoluble constituent and
Purified water, wherein the non-fat-soluble ingredient that composition described in every 1000mL contains is protein 30-80g, carbohydrate 150-
200g, sodium 0.5-2g, chlorine 0.4-2.0g, magnesium 0.01-0.6g, phosphorus 0.5-1.5g, potassium 1-4g, calcium 0.3-2g, iron 0.005-
0.05g, zinc 0.001-0.05g, copper 0-0.01g, manganese 0-0.01g, selenium 0.01-0.5mg, iodine 0-1.5mg, citric acid 0-15g, water
Soluble vitamin 0.1-2g, sweetener 0-0.5g, stabilizer 2-15g；The liposoluble constituent contained is fat 10-30g, fat-soluble
Vitamin 0.02-1g, emulsifier 2-18g.
2. composition according to claim 1, it is characterised in that the protein is selected from resistance to acid protein hydrolysats, neutral hydrolysis
Albumen or its mixing；Carbohydrate is selected from maltodextrin, fructose, starch or its mixing；Sweetener is selected from Sucralose, stevia rebaudianum
Glucosides, antierythrite, xylitol or its mixing；Stabilizer is edible glue；Water soluble vitamin is selected from pantothenic acid, biotin, dimension life
Plain K1, folic acid, vitamin C, vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12Or its mixing；Fat is selected from certain herbaceous plants with big flowers
Flower seed oil, soybean oil, safflower seed oil, medium chain triglyceride or its mixing, preferably sunflower oil is mixed with medium chain triglyceride；Rouge
Soluble vitamin is selected from vitamin E, vitamin A, vitamin D or its mixing；Emulsifier is converted starch.
3. a kind of oral complete nutritional composition, it is characterised in that the composition contains liposoluble constituent, non-fat-soluble ingredient and
Purified water, wherein the non-fat-soluble ingredient that composition described in every 1000mL contains is neutral protein hydrolysate or resistance to acid protein hydrolysats
30-80g, maltodextrin 150-200g, dipotassium hydrogen phosphate 3-8g, sodium citrate 2-7g, calcium lactate 0-5g, magnesium chloride 0.3-5g,
Ferric pyrophosphate 20-80mg, zinc sulfate 20-100mg, sodium selenite 200-750 μ g, potassium iodide 0-2mg, manganese sulfate 0-5mg, sulfuric acid
Copper 5-20mg, pantothenic acid 0-30mg, biotin 0-20mg, folic acid 0-20mg, vitamin K10-2mg, vitamin C 100-300mg,
Vitamin B11-5mg, vitamin B21-5mg, niacin 10-20mg, vitamin B61-6mg, vitamin B120.001-0.3mg, lemon
Sour 0-15g, sweetener 0-0.5g, stabilizer 2-15g；Liposoluble constituent be sunflower oil 5-15g, medium chain triglyceride 5-15,
Vitamin E 20-800mg, vitamin A 0.1-4mg, vitamin D 20-60 μ g, emulsifier 2-18g.
4. composition according to claim 3, it is characterised in that the non-fat-soluble that composition described in every 1000mL contains at
It is divided into neutral protein hydrolysate 40g, maltodextrin 186g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.622g, calcium lactate 3.0g, chlorine
Change magnesium 2.3g, ferric pyrophosphate 50mg, zinc sulfate 60mg, 400 μ g of sodium selenite, potassium iodide 1.3mg, manganese sulfate 2.4mg, copper sulphate
10mg, pantothenic acid 20mg, biotin 10mg, folic acid 10mg, vitamin K10.5mg, vitamin C 240mg, vitamin B12mg, dimension
Raw element B22mg, niacin 18mg, vitamin B61.6mg, vitamin B120.0018mg, sweetener 0.2g, stabilizer 8g；Contain
Liposoluble constituent be sunflower oil 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 2mg, 40 μ g of vitamin D,
Emulsifier 8g.
5. composition according to claim 3, it is characterised in that the non-fat-soluble that composition described in every 1000mL contains at
It is divided into neutral protein hydrolysate 40g, maltodextrin 186g, dipotassium hydrogen phosphate 4.5g, sodium citrate 3.622g, calcium lactate 3.0g, chlorine
Change magnesium 0.34g, ferric pyrophosphate 50mg, zinc sulfate 60mg, 400 μ g of sodium selenite, vitamin C 240mg, vitamin B12mg, dimension
Raw element B22mg, niacin 18mg, vitamin B61.6mg, vitamin B120.0018mg, sweetener 0.2g, stabilizer 8g；It is fat-soluble
Ingredient is sunflower oil 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 1mg, 40 μ g of vitamin D, emulsifier
8g。
6. composition according to claim 3, it is characterised in that the non-fat-soluble that composition described in every 1000mL contains at
It is divided into the 40g of resistance to acid protein hydrolysats, maltodextrin 186g, dipotassium hydrogen phosphate 0.83g, sodium citrate 2.85g, calcium lactate 3.0g, chlorine
Change magnesium 2.3g, ferric pyrophosphate 50mg, zinc sulfate 60mg, 400 μ g of sodium selenite, potassium iodide 1.3mg, manganese sulfate 2.4mg, copper sulphate
10mg, pantothenic acid 20mg, biotin 10mg, folic acid 10mg, vitamin K10.5mg, vitamin C 240mg, vitamin B12mg, dimension
Raw element B22mg, niacin 18mg, vitamin B616mg, vitamin B120.0018mg, citric acid 13g, sweetener 0.2g, stabilizer
8g；The liposoluble constituent contained is sunflower oil 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 2mg, dimension are given birth to
Plain 40 μ g of D, emulsifier 8g.
7. composition according to claim 3, it is characterised in that the non-fat-soluble that composition described in every 1000mL contains at
It is divided into the 40g of resistance to acid protein hydrolysats, maltodextrin 186g, dipotassium hydrogen phosphate 0.83g, sodium citrate 2.85g, calcium lactate 3.0g, chlorine
Change magnesium 0.34g, ferric pyrophosphate 50mg, zinc sulfate 60mg, 400 μ g of sodium selenite, vitamin C 240mg, vitamin B12mg, dimension
Raw element B22mg, niacin 18mg, vitamin B61.6mg, vitamin B120.0018mg, citric acid 13g, sweetener 0.2g, stabilization
Agent 8g；Liposoluble constituent is sunflower oil 8g, medium chain triglyceride 8g, vitamin E 40mg, vitamin A 1mg, vitamin D
40 μ g, emulsifier 8g.
8. according to the described in any item compositions of claim 3-7, it is characterised in that the ferric pyrophosphate is emulsification ferric pyrophosphate.
9. a kind of preparation method of any one of claim 1-8 composition, it is characterised in that comprise the steps of:
Step 1: ingredient
A) non-fat-soluble ingredient is weighed respectively by formula, for use；
B) liposoluble constituent is weighed respectively by formula, for use；
Step 2: dissolution
C) by the liposoluble constituent heating stirring claimed to Quan Rong, oil-phase solution is obtained；
D) the non-fat-soluble component protein matter and carbohydrate that claim, stabilizer is dry-mixed, with the water 50- for preparing total amount 60%
80 DEG C of water temperature shear agitations are to Quan Rong；
E) the remaining non-fat-soluble ingredient in addition to water soluble vitamin claimed is added into step d) solution, stirs evenly；
Step 3: step c) solution being slowly added into step e) solution with high shear revolving speed, continues cycling through shearing 30min, shearing
The water soluble vitamin that 5min addition is dissolved with water before terminating, shearing are uniform；
Step 4: dipotassium hydrogen phosphate adjusting product pH is 6.0-6.9 or citric acid adjusting product pH is 3.7-4.7, is settled to preparation
Colostrum is made in total volume；
Step 5: by colostrum self-loopa made from step 4；It is settled to total volume, is cooled to 20 DEG C or less；
Step 6: filling, sterilizing, temperature >=100 DEG C, sterilization time >=8 minute or 130~135 DEG C of UHT sterilize 10~30 seconds,
It is filling.
10. it is inflammatory bowel patient that the described in any item compositions of claim 1-8, which are used for, and other do not have special want to nutrient
The patient asked provides comprehensively and the application of balanced nutritional support.
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2017
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